Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.12.2 (MEK)
 18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEK 0.700
MEK1 0.229
ERK 0.078
ERK1 0.030
MKK4 0.029
RAF 0.027
MEK2 0.023
MKK6 0.023
MAPK 0.022
BRAF 0.020
MKK7 0.019
extracellular signal-regulated kinase 0.015
MAP kinase 0.014
p38 0.010
ERK2 0.010
MKK3 0.009
Raf-1 0.009
mitogen-activated protein 0.008
MEKK 0.008
PI3K 0.006
JNK 0.006
p42 0.004
p44 0.004
c-Jun 0.003
MAP2K1 0.003
AKT 0.003
JNK1 0.002
MEKK1 0.002
phosphatidylinositol 3-kinase 0.002
KRAS 0.002
NRAS 0.002
NS5 0.002
mitogen-activated protein kinase kinase 1 0.002
extracellular signal-regulated kinase 1 0.002
mTOR 0.002
p38 MAP kinase 0.002
MAPK/ERK kinase 0.002
MAP 0.001
B-RAF 0.001
MKK5 0.001
PKC 0.001
PI3 0.001
MEK5 0.001
EGFR 0.001
RSK 0.001
AP-1 0.001
tyrosine kinase 0.001
ribosomal S6 kinase 0.001
JNK2 0.001
KSR1 0.001
ERK5 0.001
p90 0.001
p38 mitogen-activated protein kinase 0.001
MyD118 0.001
MLK3 0.001
extracellular signal regulated kinase 0.001
C-RAF 0.001
phosphoinositide 3-kinase 0.001
epidermal growth factor 0.001
kinase suppressor of Ras 0.001
MAP kinase kinase 1 0.001
ASK1 0.001
EGF 0.001
Elk1 0.001
MAP kinase kinase 4 0.001
PP2 0.001
epidermal growth factor receptor 0.001
p38MAPK 0.001
MKP-1 0.001
KSR 0.001
MKP-3 0.001
MEKK2 0.000
EGF receptor 0.000
Ras inhibitor 0.000
PKA 0.000
PI3-kinase 0.000
MAP2K2 0.000
mitogen-activated protein kinase kinase kinase 0.000
SEK 0.000
RSK1 0.000
more...
Disease
melanoma 0.001
metastatic melanoma 0.001
cancer 0.001
tumor 0.001
Melanoma 0.000
tumor growth 0.000
tumorigenesis 0.000
pertussis 0.000
Costello syndrome 0.000
cardiofaciocutaneous syndrome 0.000
tumor progression 0.000
non-small cell lung cancer 0.000
breast cancer 0.000
colorectal cancer 0.000
hepatocellular carcinoma 0.000
RP27 0.000
stage IV melanoma 0.000
pancreatic cancer 0.000
lung cancer 0.000
MCF 0.000
carcinogenesis 0.000
colon cancer 0.000
anthrax 0.000
leukemia 0.000
Blocking 0.000
carcinoma 0.000
NRC1 0.000
adenocarcinoma 0.000
neuroblastoma 0.000
Papillary craniopharyngioma 0.000
anaplastic thyroid cancer 0.000
Malignant peripheral nerve sheath tumor 0.000
glioma 0.000
ovarian cancer 0.000
cutaneous melanoma 0.000
Congenital melanocytic nevus 0.000
AGS 0.000
skin cancer 0.000
thyroid cancer 0.000
acute myeloid leukemia 0.000
retinoblastoma 0.000
prostate cancer 0.000
HGF 0.000
Histiocytic neoplasms 0.000
HPC3 0.000
Precursor T-cell lymphoblastic lymphoma 0.000
Malignant peripheral nerve sheath tumor 0.000
ABL 0.000
Conjunctival melanoma 0.000
metastases 0.000
Opsismodysplasia 0.000
glioblastoma 0.000
Pilocytic astrocytoma 0.000
EMT 0.000
Erdheim-Chester disease 0.000
uveal melanoma 0.000
tumor angiogenesis 0.000
neurofibromatosis type 1 0.000
pheochromocytoma 0.000
squamous cell carcinoma 0.000
FDC 0.000
neoplastic transformation 0.000
gastric cancer 0.000
Mucinous Neoplasm 0.000
adult pilocytic astrocytoma 0.000
Leukemia 0.000
papillary thyroid cancer 0.000
ATM 0.000
Langerhans cell histiocytosis 0.000
juvenile myelomonocytic leukemia 0.000
Jaagsiekte 0.000
ischemia 0.000
JIP 0.000
Gastrointestinal anthrax 0.000
multiple myeloma 0.000
chronic myeloid leukemia 0.000
Pleomorphic xanthoastrocytoma 0.000
phakoma 0.000
liver cancer 0.000
astrocytoma 0.000
more...
Symptom
starvation 0.000
brittle nails 0.000
Beau's lines 0.000
Organ failure 0.000
pain 0.000
onychomadesis 0.000
Scratch 0.000
nausea 0.000
orofacial pain 0.000
scaly skin 0.000
fatigue 0.000
rundown 0.000
Neuropathic pain 0.000
skin damage 0.000
diarrhea 0.000
functional recovery 0.000
collapse 0.000
seizures 0.000
hypotonia 0.000
bladder pain 0.000
hyperoxia 0.000
dry skin 0.000
cachexia 0.000
Anoxia 0.000
fasciculation 0.000
arthralgia 0.000
despair 0.000
bone pain 0.000
hypothermia 0.000
general problem 0.000
memory loss 0.000
blurred vision 0.000
pelvic pain 0.000
emaciation 0.000
muscle rigidity 0.000
splenomegaly 0.000
exhaustion 0.000
urinary frequency 0.000
analgesia 0.000
abnormal gait 0.000
acute stress 0.000
dry eye 0.000
decreased appetite 0.000
night sweats 0.000
dental pain 0.000
muscle stiffness 0.000
vomiting 0.000
Sedation 0.000
cancer pain 0.000
myalgia 0.000
enuresis 0.000
neuralgia 0.000
acute pain 0.000
ataxia 0.000
weakness 0.000
chills 0.000
myoclonus 0.000
leg pain 0.000
twitching 0.000
respiratory distress 0.000
bradykinesia 0.000
hepatomegaly 0.000
asthenia 0.000
sore throat 0.000
headache 0.000
knee pain 0.000
HSA 0.000
erythema 0.000
cerebellar ataxia 0.000
dysarthria 0.000
dyspnea 0.000
numbness 0.000
ENT 0.000
back pain 0.000
paresis 0.000
spasticity 0.000
vertigo 0.000
abdominal pain 0.000
tremor 0.000
regurgitation 0.000
more...
Drug
MAP 0.001
Sorafenib 0.000
Nexavar 0.000
Xaliproden 0.000
NVP 0.000
ROS 0.000
Ipilimumab 0.000
Gefitinib 0.000
Quazinone 0.000
ICI 0.000
Arsenic trioxide 0.000
Angiotensin II 0.000
RAL 0.000
Sulfamide 0.000
ETS 0.000
Lonafarnib 0.000
Dasatinib 0.000
TAK 0.000
Tipifarnib 0.000
Taxol 0.000
2-Butanol 0.000
Cetuximab 0.000
Ilomastat 0.000
IL-2 0.000
Activin 0.000
CSF 0.000
Myricetin 0.000
Ciglitazone 0.000
K-252a 0.000
Forskolin 0.000
Imatinib 0.000
Scutellaria root 0.000
uPA 0.000
PDL 0.000
Epigallocatechin 0.000
p75 0.000
Ouabain 0.000
Cilengitide 0.000
Everolimus 0.000
Tarceva 0.000
IFN-gamma 0.000
Gleevec 0.000
Panitumumab 0.000
2-Methoxyestradiol 0.000
Azacytidine 0.000
Troglitazone 0.000
lysine 0.000
Mevastatin 0.000
Erlotinib 0.000
Glycyrrhiza 0.000
Temodal 0.000
Casodex 0.000
ETA 0.000
Romidepsin 0.000
Flavopiridol 0.000
Dermatol 0.000
Retinoic acid 0.000
Herceptin 0.000
Verteporfin 0.000
Gel 0.000
Tykerb 0.000
Lercanidipine 0.000
CCL 0.000
Butaprost 0.000
Midostaurin 0.000
Rosiglitazone 0.000
GNA 0.000
IL-11 0.000
PTC 0.000
R1881 0.000
Tianeptine 0.000
3-Methyladenine 0.000
Emodin 0.000
Glucagon 0.000
Histamine 0.000
Vesnarinone 0.000
Simvastatin 0.000
Growth hormone 0.000
Growth hormone 0.000
Heme 0.000
more...
Enzyme
MEK 1.000
mitogen-activated protein kinase 0.065
ERK 0.027
MEKK1 0.010
protein kinase 0.004
phosphatidylinositol 3-kinase 0.002
protein kinase C 0.002
MAP 0.001
phosphoinositide 3-kinase 0.001
focal adhesion kinase 0.001
IKK 0.000
caspase-3 0.000
luciferase 0.000
calcineurin 0.000
GSK 0.000
cdc2 0.000
farnesyltransferase 0.000
phospholipase C 0.000
PARP 0.000
PDK1 0.000
CaMKII 0.000
CLK1 0.000
farnesyltransferase 0.000
protein phosphatase 2A 0.000
NADPH oxidase 0.000
inositol 3-kinase 0.000
NADPH oxidase 0.000
proteasome 0.000
caspase-9 0.000
MMP 0.000
AMPK 0.000
AMP-activated protein kinase 0.000
urokinase-type plasminogen activator 0.000
phospholipase A2 0.000
caspase-8 0.000
AMPK 0.000
eEF2 kinase 0.000
NO synthase 0.000
collagenase 0.000
PKG 0.000
NSY 0.000
glutathione S-transferase 0.000
GRK5 0.000
CEP 0.000
glucuronosyltransferase I 0.000
myosin light chain kinase 0.000
adenylate cyclase 0.000
MPP 0.000
MMP-3 0.000
caspase-7 0.000
caspase-7 0.000
phospholipase D 0.000
thrombin 0.000
CEP 0.000
DCF 0.000
prenylated protein methyltransferase 0.000
small monomeric GTPase 0.000
GRK2 0.000
polo-like kinase 1 0.000
phosphatidylinositol-4,5-bisphosphate 3-kinase 0.000
tyrosinase 0.000
duodenase 0.000
ATPase 0.000
catalase 0.000
PI-PLC 0.000
gamma-glutamylcysteine synthetase 0.000
sphingosine kinase 0.000
TOR 0.000
matrix metalloproteinase 9 0.000
biliverdin reductase 0.000
guanylate cyclase 0.000
PTPase 0.000
NOS 0.000
3-hydroxy-3-methylglutaryl-CoA lyase 0.000
protein L-isoaspartyl methyltransferase 0.000
matrix metalloproteinase 2 0.000
MIP 0.000
interstitial collagenase 0.000
matrix metalloproteinase 14 0.000
12-lipoxygenase 0.000
more...
Compound
MEK 0.576
MAP 0.001
tyrosine 0.001
LY 294002 0.001
threonine 0.000
Wortmannin 0.000
serine 0.000
cAMP 0.000
GF 109203X 0.000
DNA 0.000
PMA 0.000
ATF 0.000
acetate 0.000
PMA 0.000
MDA 0.000
calcium 0.000
GTP 0.000
Ang II 0.000
Catenarin 0.000
N-acetylcysteine 0.000
oxygen 0.000
THP 0.000
THP 0.000
MTT 0.000
TNF 0.000
Cajanin 0.000
Insulin 0.000
ATP 0.000
Dec 0.000
TPA 0.000
N-(2-pyridinyl)benzamide 0.000
Xanthoxyletin 0.000
4-(4-chlorophenyl)-4-piperidinol 0.000
Rapamycin 0.000
Genistein 0.000
Phorbol 12-myristate 13-acetate 0.000
TPA 0.000
Telocinobufagin 0.000
PGE 0.000
3-quinolinecarbonitrile 0.000
Phosphatidylinositol 0.000
nitric oxide 0.000
retinoic acid 0.000
Rocaglamide 0.000
3,4-D 0.000
NH2 0.000
PGJ2 0.000
BCR 0.000
ICI 0.000
Anisomycin 0.000
Dracorhodin 0.000
ABL 0.000
methionine 0.000
Angiotensin II 0.000
Rottlerin 0.000
Tyrosine 0.000
AMP 0.000
DG 2 0.000
2-butanone 0.000
2-butanone 0.000
H2O2 0.000
Rottlerin 0.000
2,4,5-trimethoxybenzaldehyde 0.000
1,2,4-trimethylcyclohexane 0.000
1,2,4-trimethylcyclohexane 0.000
Ginkgolide C 0.000
glucose 0.000
TPCK 0.000
Rottlerin 0.000
1H-imidazole 0.000
COS 0.000
HOG 0.000
Nobiletin 0.000
alanine 0.000
Tanshinone 0.000
Cyclovirobuxine D 0.000
Malabaricone C 0.000
Senegenin 0.000
Ethyl ferulate 0.000
Phorbol 0.000
more...