Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.12.2 (MEK)
 18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

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Human Gene/Protein
CNN2 protein 10.8
MEK 10.8
TMEM55A 10.8
jumonji C domain containing histone demethylase 1 homolog D 10.8
FAM73A 10.8
MRIP-1 10.8
G6f protein 10.8
HMGCL protein 10.8
RIT1 protein 10.8
TCF2 protein 10.8
topoisomerase III beta 10.8
PLA2G16 protein 10.8
MAP3K8 protein 10.8
SNAP25-interacting protein 10.8
guanine nucleotide-releasing factor 2 10.8
MEK1 10.8
Signal protein 10.8
PTPN5 protein 10.8
MEK2 10.7
MKK6 10.7
MKK7 10.6
MKK4 10.4
MKK5 10.3
Mitogen-activated protein kinase kinase 1 10.2
erythrocyte membrane glycopeptide 10.2
Kinase suppressor of Ras 1 10.1
MAP kinase kinase 4 10.1
MKK3 9.8
RAF 9.8
G5c 9.8
KLB protein 9.8
Male germ cell-associated kinase 9.8
zinc finger protein 32 9.8
golgin, RAB6-interacting 9.8
Sma- and Mad-related protein 1 9.8
zinc finger protein 16 9.8
TANK protein 9.8
CEBPB protein 9.8
DUS3 9.8
chemokine (C-C motif) receptor 4 9.8
UEV-3 9.8
Ataxin 10 9.8
ZNF767 9.8
TBC1D7 protein 9.8
HDJ2 protein 9.8
C1QL4 9.8
GPCR40 9.8
opsin 4 9.8
RNF149 9.8
MEK kinase 4 9.8
RNF157 9.8
KSR1 9.7
MAPKK6 9.6
SPRK 9.6
MAP kinase 1 9.6
MyD118 9.5
MAP kinase kinase 2 9.5
MEK partner 1 9.5
C-RAF 9.4
kinase suppressor of Ras 9.4
mitogen-activated protein kinase kinase 1 9.4
MEKK 9.3
MAP kinase kinase 1 9.2
MAP2K1 9.2
protein tyrosine phosphatase, receptor type, F 9.2
RAB19 9.2
apoptosis repressor with CARD domain 9.2
dual-specificity phosphatase 2 9.2
p53-regulated apoptosis-inducing protein 1 9.2
NOMO2 9.2
smoothelin-like 2 9.2
SAPKK2 9.2
Mitogen-activated protein kinase kinase 6 9.2
HCC-3 9.2
Nesca 9.2
craniofacial development protein 1 9.2
coiled-coil domain containing 134 9.2
NRP2 protein 9.2
GLPE 9.2
serine/threonine protein kinase MST4 9.2
more...
Disease
RP27 10.2
Papillary craniopharyngioma 9.8
NRC1 8.8
Histiocytic neoplasms 8.8
Precursor T-cell lymphoblastic lymphoma 8.8
HPC3 8.8
Opsismodysplasia 8.5
Congenital melanocytic nevus 8.3
cardiofaciocutaneous syndrome 8.1
adult pilocytic astrocytoma 8.0
Mucinous Neoplasm 8.0
Gastrointestinal anthrax 7.8
phakoma 7.6
Conjunctival melanoma 7.5
Malignant Peripheral Nerve Sheath Tumor 7.5
Costello syndrome 7.4
DSCR 7.2
Pilocytic astrocytoma 6.9
Gastrointestinal mucositis 6.9
Neutrophilic panniculitis 6.9
stage IV melanoma 6.8
grade II meningioma 6.8
Invasive bladder cancer 6.7
metastatic melanoma 6.6
WWS 6.6
PGL2 6.5
onychorrhexis 6.5
Pleomorphic xanthoastrocytoma 6.5
Myelokathexis 6.5
Malignant peripheral nerve sheath tumor 6.4
Ph-positive acute lymphoblastic leukemia 6.4
Eosinophilic meningitis 6.3
Multiple cancer 6.3
Jaagsiekte 6.3
Malignant peripheral nerve sheath tumor 6.3
Congenital myotonic dystrophy 6.2
Leydig cell hypoplasia 6.0
EDS5 6.0
Gastric infection 6.0
anaplastic thyroid cancer 5.9
JIP 5.9
SCCD 5.9
Rhabdoid meningioma 5.9
Philadelphia chromosome positive chronic myelogenous leukemia 5.8
Anaplastic Lymphoma 5.7
PCH2 5.7
Erdheim-Chester disease 5.7
stage III melanoma 5.7
Melanoma 5.7
Chordoid glioma 5.6
PCP abuse 5.6
AAPC 5.6
LEOPARD syndrome 5.5
juvenile myelomonocytic leukemia 5.5
FDC 5.4
Pulmonary Langerhans cell histiocytosis 5.4
EDS1 5.4
multiple nevi 5.3
precancerous polyps 5.3
Reovirus infection 5.3
Histiocytic sarcoma 5.3
Ganglioglioma 5.3
grade I meningioma 5.3
Pancreatic Ductal Adenocarcinoma 5.2
Pancreatic Ductal Adenocarcinoma 5.2
paronychia 5.2
anthrax 5.1
AGS 5.0
melanoma 5.0
FHL3 5.0
nRNA 5.0
stage II melanoma 5.0
FHL2 5.0
epidemic encephalitis 4.9
Fibrosarcoma 4.9
uveal melanoma 4.9
pancreatic fibrosis 4.9
Gram-positive bacterial infection 4.9
AML progression 4.9
pediatric solid tumor 4.9
more...
Symptom
brittle nails 5.8
Beau's lines 5.0
Organ failure 4.8
onychomadesis 4.3
Scratch 3.7
scaly skin 3.3
orofacial pain 2.9
rundown 2.8
Neuropathic pain 2.3
skin damage 2.2
bladder pain 2.2
starvation 2.1
dry skin 1.8
Anoxia 1.7
fasciculation 1.4
despair 1.1
hypotonia 1.1
general problem 1.0
hyperoxia 1.0
cachexia 0.9
nausea 0.8
functional recovery 0.8
blurred vision 0.8
bone pain 0.8
emaciation 0.7
muscle rigidity 0.7
urinary frequency 0.6
abnormal gait 0.6
decreased appetite 0.6
night sweats 0.6
arthralgia 0.5
dental pain 0.5
memory loss 0.5
muscle stiffness 0.5
dry eye 0.4
Sedation 0.4
pelvic pain 0.4
cancer pain 0.2
acute stress 0.2
enuresis 0.1
collapse 0.1
fatigue 0.0
neuralgia 0.0
splenomegaly -0.2
acute pain -0.2
diarrhea -0.2
leg pain -0.2
twitching -0.2
chills -0.3
myoclonus -0.3
hypothermia -0.3
myalgia -0.3
exhaustion -0.4
bradykinesia -0.4
pain -0.5
asthenia -0.6
sore throat -0.7
seizures -0.7
knee pain -0.7
hepatomegaly -0.7
HSA -0.8
analgesia -0.8
ataxia -0.9
vomiting -1.0
cerebellar ataxia -1.0
dysarthria -1.1
respiratory distress -1.2
erythema -1.3
weakness -1.4
numbness -1.6
ENT -1.6
paresis -1.7
back pain -1.8
spasticity -1.9
dyspnea -2.0
headache -2.0
vertigo -2.0
regurgitation -2.2
tremor -2.4
syncope -2.4
more...
Drug
Xaliproden 9.2
Quazinone 8.8
Nexavar 7.7
Sulfamide 7.7
2-Butanol 7.3
Lonafarnib 7.2
Sorafenib 6.7
Tipifarnib 6.6
Ilomastat 6.5
Scutellaria root 6.4
RAL 6.1
Ipilimumab 6.1
Ciglitazone 6.1
NVP 5.8
MAP 5.6
Cilengitide 5.6
Gefitinib 5.4
Mevastatin 5.3
Dasatinib 5.3
Myricetin 5.3
Temodal 5.3
Azacytidine 5.2
K-252a 5.2
Arsenic trioxide 5.2
Tarceva 5.0
Panitumumab 5.0
Tykerb 5.0
TAK 5.0
2-Methoxyestradiol 5.0
Romidepsin 4.9
Cetuximab 4.9
Lercanidipine 4.9
Butaprost 4.8
Midostaurin 4.8
Casodex 4.8
Epigallocatechin 4.8
Flavopiridol 4.7
Verteporfin 4.6
PDL 4.6
Vesnarinone 4.5
ETS 4.5
Tianeptine 4.5
3-Methyladenine 4.4
Everolimus 4.3
Troglitazone 4.3
GNA 4.3
Bimatoprost 4.3
Batimastat 4.3
Batimastat 4.3
CMZ 4.2
Bosutinib 4.2
ICI 4.2
Activin 4.2
Angiotensin II 4.1
Taxol 4.1
Perphenazine 4.1
Erlotinib 4.0
Onconase 4.0
Ulinastatin 3.9
Fluticasone propionate 3.9
Sodium citrate 3.9
Morphine sulfate 3.9
Sodium citrate 3.9
Red ginseng 3.9
uPA 3.9
Fulvestrant 3.9
Vorinostat 3.9
Emodin 3.9
Idebenone 3.8
Celebrex 3.8
Imatinib 3.8
Forskolin 3.8
FSH-beta 3.8
R1881 3.8
Magnesium sulfate 3.8
FSH-beta 3.8
Aliskiren 3.7
Gleevec 3.7
Pertuzumab 3.7
Hyperforin 3.7
more...
Enzyme
MEK 10.8
MEKK1 9.1
mitogen-activated protein kinase 7.6
glucuronosyltransferase I 7.5
CLK1 7.3
ERK 7.0
inositol 3-kinase 6.9
NSY 6.9
prenylated protein methyltransferase 6.8
phosphatidylinositol 3-kinase 6.8
MAP 6.7
small monomeric GTPase 6.6
farnesyltransferase 6.4
phosphoinositide 3-kinase 6.4
eEF2 kinase 6.2
duodenase 6.1
farnesyltransferase 5.9
protein kinase 5.7
IKK 5.7
protein kinase C 5.6
PDK1 5.6
3-hydroxy-3-methylglutaryl-CoA lyase 5.5
protein L-isoaspartyl methyltransferase 5.5
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.5
protein phosphatase 2A 5.3
matrix metalloproteinase 14 5.3
CaMKII 5.2
GSK 5.2
CEP 5.1
biliverdin reductase 5.0
cdc2 5.0
GRK5 4.9
collagenase 3 4.8
cathepsin V 4.8
caspase-7 4.8
focal adhesion kinase 4.7
caspase-7 4.7
phosphoenolpyruvate synthase 4.7
isochorismate synthase 4.6
PI-PLC 4.6
MMP 4.6
GRK2 4.6
CEP 4.6
calcineurin 4.6
PKG 4.5
HCS 4.4
caspase-4 4.4
sphingosine kinase 4.4
PARP 4.4
MPP 4.4
Omi/HtrA2 4.4
deoxycytidine deaminase 4.3
caspase-9 4.3
phospholipase C 4.3
caspase-4 4.3
caspase-10 4.3
CYP8B1 4.3
NADPH oxidase 4.3
caspase-10 4.2
myosin light chain kinase 4.2
caspase-3 4.2
polo-like kinase 1 4.2
NADPH oxidase 4.2
DCF 4.2
caspase-8 4.1
PTPase 4.1
luciferase 4.1
15-hydroxyprostaglandin dehydrogenase 4.1
interstitial collagenase 4.1
factor C 4.1
12-lipoxygenase 4.0
ceramide kinase 4.0
gamma-glutamylcysteine synthetase 4.0
caspase-2 4.0
AMPK 4.0
neutral sphingomyelinase 4.0
ceramidase 4.0
TOR 4.0
caspase-2 3.9
STK11 3.9
more...
Compound
Catenarin 10.8
MEK 10.6
Cajanin 9.8
Xanthoxyletin 9.2
N-(2-pyridinyl)benzamide 9.2
4-(4-chlorophenyl)-4-piperidinol 9.2
Telocinobufagin 8.8
LY 294002 8.3
DG 2 8.0
3-quinolinecarbonitrile 7.8
Ginkgolide C 7.8
1,2,4-trimethylcyclohexane 7.8
1,2,4-trimethylcyclohexane 7.8
Dracorhodin 7.8
3,4-D 7.7
Rocaglamide 7.7
2,4,5-trimethoxybenzaldehyde 7.5
Malabaricone C 7.5
Ethyl ferulate 7.5
Senegenin 7.5
Cyclovirobuxine D 7.5
Gossypin 7.3
Euxanthone 7.3
Tectoridin 7.3
Butin 7.2
Benzo[a]pyrene-7,8-diol 7.1
2,4-pyrimidinediamine 7.1
GF 109203X 7.1
Wortmannin 7.0
1-piperidinecarboxamide 7.0
3,4-dichloro-5-hydroxy-2(5H)-furanone 6.9
Sangivamycin 6.9
Ginkgolide C 6.9
S152 6.9
delta12,14-PGJ2 6.9
Tylophorine 6.9
Pentalenolactone 6.8
Purpurogallin 6.7
Ailanthone 6.7
[6]-Shogaol 6.7
Gallein 6.7
Gallein 6.6
Bisdemethoxycurcumin 6.6
4-methoxybenzenesulfonamide 6.6
butylcyclohexane 6.5
Taurodeoxycholic acid 6.5
Eupatilin 6.5
Trimethyltin chloride 6.5
Santonin 6.4
Ailanthone 6.4
MAP 6.3
Anisomycin 6.3
Camphorquinone 6.3
3-methylpiperidine 6.3
Stachydrine 6.3
3-methylpiperidine 6.3
Farrerol 6.2
1,2-dithiane 6.1
Manumycin 6.1
2-aminoethyl diphenylborinate 6.1
2-aminoethyl diphenylborinate 6.1
2-hexanol 6.1
Nobiletin 6.1
Propyl gallate 6.1
8-Bromo-cyclic AMP 6.1
Tautomycin 6.1
Rottlerin 6.1
15(S)-HETE 6.1
Rottlerin 6.0
Delphinidin 6.0
Dibenzyl 6.0
Glycochenodeoxycholic acid 6.0
Rottlerin 5.9
Acetylshikonin 5.9
(trifluoromethyl)benzene 5.9
Morusin 5.9
Tiludronate 5.9
Magnolol 5.9
4-(methylsulfonyl)phenyl 5.8
Bufalin 5.8
more...