Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.12.2 (MEK)
18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein MEK 12715 ERK 6082 MEK1 4168 MAPK 3532 ERK1 3500 p38 2355 Mol 2007 BRAF 1876 extracellular signal-regulated kinase 1837 PI3K 1658 MAP kinase 1470 JNK 1385 mitogen-activated protein 1274 Sep 1250 AKT 1116 RAF 969 mTOR 880 Raf-1 860 c-Jun 840 ERK2 797 tyrosine kinase 779 MKK4 692 cytokine 689 phosphatidylinositol 3-kinase 687 PKC 549 insulin 537 epidermal growth factor 528 KRAS 514 caspase-3 504 EGFR 503 p53 502 epidermal growth factor receptor 492 p42 482 MKK6 442 Bcl-2 436 AP-1 435 MAP 435 p44 426 MEK2 419 phosphatase 417 MEKK 382 threonine 379 MKK7 375 EGF 360 p21 355 ATP 325 extracellular signal-regulated kinase 1 324 MKK3 324 JNK1 323 tumor necrosis factor 316 cyclin D1 293 p38 mitogen-activated protein kinase 285 phosphoinositide 3-kinase 275 STAT3 272 collagen 271 NRAS 271 p38 MAP kinase 269 IL-6 267 PI3 251 TNF 250 ras 247 PKA 245 NS5 241 vascular endothelial growth factor 238 EGF receptor 230 c-fos 230 lipopolysaccharide 223 protein kinase B 216 Rho 215 CREB 205 PTEN 202 GTP 201 nerve growth factor 197 receptor tyrosine kinase 196 STAT 181 platelet-derived growth factor 179 matrix metalloproteinase 179 proteasome 176 p65 174 VEGF 174 more...

Disease cancer 3808 tumor 2660 melanoma 1296 breast cancer 600 tumor growth 563 tumorigenesis 552 carcinoma 419 hepatocellular carcinoma 360 leukemia 356 metastatic melanoma 349 lung cancer 349 colorectal cancer 332 carcinogenesis 318 tumor progression 305 adenocarcinoma 275 metastases 249 pertussis 243 non-small cell lung cancer 226 Melanoma 224 MCF 213 colon cancer 211 prostate cancer 201 ischemia 191 pancreatic cancer 187 neuroblastoma 173 glioma 168 acute myeloid leukemia 158 ovarian cancer 157 squamous cell carcinoma 145 atherosclerosis 142 diabetes 140 Alzheimer's disease 131 gastric cancer 127 hypertension 118 multiple myeloma 116 Blocking 109 glioblastoma 101 Parkinson's disease 99 obesity 97 skin cancer 96 lymphoma 88 retinoblastoma 87 pheochromocytoma 84 sarcoma 83 lung carcinoma 83 chronic myeloid leukemia 83 GSH 82 Leukemia 80 anthrax 79 thyroid cancer 79 ATM 73 liver cancer 73 cerebral ischemia 73 osteosarcoma 70 heart failure 65 stroke 65 rheumatoid arthritis 63 depression 61 liver cancer 60 epithelial ovarian cancer 60 HIV 59 virus infection 59 asthma 59 infectious diseases 55 cutaneous melanoma 55 acute lymphoblastic leukemia 55 tumor angiogenesis 54 renal cell carcinoma 52 primary tumor 52 ABL 52 astrocytoma 48 neoplastic transformation 47 acute promyelocytic leukemia 46 Infection 46 aggressiveness 45 neurofibromatosis type 1 44 fibrosarcoma 44 AGS 42 Hepatocellular carcinoma 42 type 2 diabetes 42 more...

Symptom pain 108 starvation 62 fatigue 30 seizures 29 diarrhea 29 nausea 24 collapse 17 functional recovery 13 analgesia 9 vomiting 9 weakness 8 headache 8 hypothermia 8 hypotonia 7 arthralgia 6 cachexia 6 hyperoxia 6 exhaustion 6 splenomegaly 5 ataxia 5 respiratory distress 5 dyspnea 4 orofacial pain 4 skin damage 4 anesthesia 4 Neuropathic pain 4 abdominal pain 3 acute stress 3 memory loss 3 pelvic pain 3 bone pain 3 Scratch 3 myalgia 3 erythema 3 dry eye 2 rundown 2 fasciculation 2 chills 2 back pain 2 acute pain 2 dry skin 2 hepatomegaly 2 tremor 2 myoclonus 2 angina 2 blurred vision 2 brittle nails 2 despair 2 cancer pain 2 vertigo 1 dysarthria 1 ENT 1 regurgitation 1 emaciation 1 paresis 1 enuresis 1 thinning 1 cerebellar ataxia 1 Beau's lines 1 onychomadesis 1 asthenia 1 decreased appetite 1 dental pain 1 discomfort 1 urinary frequency 1 insomnia 1 muscle rigidity 1 twitching 1 distraction 1 spasticity 1 Anoxia 1 scaly skin 1 Organ failure 1 HSA 1 nausea and vomiting 1 neuralgia 1 night sweats 1 numbness 1 muscle stiffness 1 constipation 1 more...

Drug MAP 446 Dermatol 141 ROS 133 Sorafenib 88 CSF 79 IL-2 78 lysine 72 ICI 57 IFN-gamma 56 Angiotensin II 51 ETS 34 Gel 32 Taxol 31 NVP 31 Gefitinib 28 Arsenic trioxide 26 Monit 26 Cardiovasc 24 p75 22 caffeine 22 Forskolin 21 Imatinib 20 TAK 18 uPA 18 vitamin E 18 Activin 18 Ouabain 17 Cetuximab 16 ascorbate 16 Ipilimumab 16 Histamine 16 Retinoic acid 15 Indomethacin 14 ETA 14 Asn 14 Dasatinib 14 Glucagon 13 Nexavar 13 NADH 12 EE2 12 Herceptin 12 Ethanol 12 Growth hormone 11 G-CSF 11 Gleevec 11 Heme 11 Growth hormone 11 RAL 10 Glycyrrhiza 10 PTC 9 Adriamycin 9 PDL 9 IFN-beta 9 CTX 8 CCL 8 Simvastatin 8 Everolimus 8 ABC 8 Myricetin 7 Erlotinib 7 K-252a 7 PCP 7 Nitric Oxide 7 Epigallocatechin 7 IL-11 7 Leaf 7 Nephron 7 Rosiglitazone 6 CoCl2 6 CoCl2 6 lactose 6 MRC 6 Troglitazone 6 Bortezomib 6 PTH 6 Lovastatin 5 Etoposide 5 NBT 5 R1881 5 MDS 5 more...

Enzyme MEK 18161 mitogen-activated protein kinase 10639 ERK 6869 protein kinase 2472 protein kinase C 1390 phosphatidylinositol 3-kinase 688 focal adhesion kinase 675 MEKK1 574 MAP 435 caspase-3 382 luciferase 370 phosphoinositide 3-kinase 275 calcineurin 229 phospholipase C 208 proteasome 177 PARP 162 cdc2 149 IKK 149 GSK 138 NADPH oxidase 123 NADPH oxidase 107 phospholipase A2 104 AMPK 101 AMP-activated protein kinase 101 ATPase 96 glutathione S-transferase 91 urokinase-type plasminogen activator 90 collagenase 89 NO synthase 88 catalase 88 thrombin 87 caspase-9 85 CaMKII 84 adenylate cyclase 75 protein phosphatase 2A 70 caspase-8 68 superoxide dismutase 66 PDK1 63 alkaline phosphatase 61 MMP 59 AMPK 57 farnesyltransferase 50 farnesyltransferase 49 lactate dehydrogenase 45 RNA polymerase 43 reverse transcriptase 43 tyrosinase 38 phosphodiesterase 38 APC 37 ACS 33 PKG 32 guanylate cyclase 31 tyrosine hydroxylase 30 phospholipase D 29 trypsin 29 myosin light chain kinase 29 MMP-3 29 NOS 28 peroxidase 27 renin 26 P-glycoprotein 25 MPP 22 MIP 22 DNA methyltransferase 20 DCF 20 GRK5 19 lipoxygenase 19 CLK1 17 ornithine decarboxylase 17 inositol 3-kinase 16 alanine aminotransferase 16 matrix metalloproteinase 9 16 polo-like kinase 1 16 CEP 15 choline acetyltransferase 15 xanthine oxidase 15 matrix metalloproteinase 2 15 CEP 15 caspase-7 14 NQO1 14 more...

Compound MEK 11589 DNA 1440 Dec 1313 tyrosine 1187 calcium 690 oxygen 685 serine 603 threonine 575 acetate 467 cAMP 461 MAP 437 Clin 367 glucose 343 ATP 327 TNF 250 nitric oxide 241 sodium 240 GTP 201 MTT 191 MDA 190 phosphate 173 methionine 169 Insulin 165 NH2 161 hydrogen 156 cysteine 156 alanine 154 glutamate 148 water 147 PMA 137 PMA 136 AMP 136 N-acetylcysteine 118 retinoic acid 117 leucine 114 H2O2 112 THP 109 THP 109 lysine 103 arginine 99 Ang II 95 Wortmannin 84 GSH 83 GSH 83 cGMP 80 PGE 75 boron 74 zinc 73 COS 68 salt 68 Asp 67 Phe 67 Angiotensin II 63 iodine 63 TPA 61 ATF 61 TPA 61 Cardiol 59 potassium 59 BCR 58 ethanol 57 ICI 57 glycerol 56 ADP 55 bromide 54 proline 53 ABL 53 NMDA 52 LY 294002 51 Rapamycin 51 5-HT 49 sulfate 46 ADP 45 ADP 45 nitrogen 44 pyrimidine 43 urea 42 pyrimidine 42 galactose 41 Tyrosine 41 more...

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