Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.12.2 (MEK)
18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

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Human Gene/Protein
G6f protein 10.8
topoisomerase III beta 10.8
FAM73A 10.8
MEK1 10.8
MEK 10.8
PLA2G16 protein 10.8
SNAP25-interacting protein 10.8
CNN2 protein 10.8
RIT1 protein 10.8
TCF2 protein 10.8
MRIP-1 10.8
HMGCL protein 10.8
Signal protein 10.8
TMEM55A 10.8
guanine nucleotide-releasing factor 2 10.8
jumonji C domain containing histone demethylase 1 homolog D 10.8
PTPN5 protein 10.8
MAP3K8 protein 10.8
MEK2 10.7
MKK6 10.7
MKK7 10.6
MKK4 10.4
MKK5 10.3
Mitogen-activated protein kinase kinase 1 10.2
erythrocyte membrane glycopeptide 10.2
Kinase suppressor of Ras 1 10.1
MAP kinase kinase 4 10.1
MKK3 9.8
RAF 9.8
TBC1D7 protein 9.8
G5c 9.8
RNF149 9.8
HDJ2 protein 9.8
C1QL4 9.8
opsin 4 9.8
TANK protein 9.8
zinc finger protein 32 9.8
KLB protein 9.8
CEBPB protein 9.8
RNF157 9.8
more...
Disease
RP27 10.2
Papillary craniopharyngioma 9.8
NRC1 8.8
Histiocytic neoplasms 8.8
Precursor T-cell lymphoblastic lymphoma 8.8
HPC3 8.8
Opsismodysplasia 8.5
Congenital melanocytic nevus 8.3
cardiofaciocutaneous syndrome 8.1
adult pilocytic astrocytoma 8.0
Mucinous Neoplasm 8.0
Gastrointestinal anthrax 7.8
phakoma 7.6
Conjunctival melanoma 7.5
Malignant Peripheral Nerve Sheath Tumor 7.5
Costello syndrome 7.4
DSCR 7.2
Pilocytic astrocytoma 6.9
Gastrointestinal mucositis 6.9
Neutrophilic panniculitis 6.9
stage IV melanoma 6.8
grade II meningioma 6.8
Invasive bladder cancer 6.7
metastatic melanoma 6.6
WWS 6.6
PGL2 6.5
onychorrhexis 6.5
Pleomorphic xanthoastrocytoma 6.5
Myelokathexis 6.5
Malignant peripheral nerve sheath tumor 6.4
Ph-positive acute lymphoblastic leukemia 6.4
Eosinophilic meningitis 6.3
Multiple cancer 6.3
Jaagsiekte 6.3
Malignant peripheral nerve sheath tumor 6.3
Congenital myotonic dystrophy 6.2
Leydig cell hypoplasia 6.0
EDS5 6.0
Gastric infection 6.0
anaplastic thyroid cancer 5.9
more...
Symptom
brittle nails 5.8
Beau's lines 5.0
Organ failure 4.8
onychomadesis 4.3
Scratch 3.7
scaly skin 3.3
orofacial pain 2.9
rundown 2.8
Neuropathic pain 2.3
skin damage 2.2
bladder pain 2.2
starvation 2.1
dry skin 1.8
Anoxia 1.7
fasciculation 1.4
despair 1.1
hypotonia 1.1
general problem 1.0
hyperoxia 1.0
cachexia 0.9
nausea 0.8
functional recovery 0.8
blurred vision 0.8
bone pain 0.8
emaciation 0.7
muscle rigidity 0.7
urinary frequency 0.6
abnormal gait 0.6
decreased appetite 0.6
night sweats 0.6
arthralgia 0.5
dental pain 0.5
memory loss 0.5
muscle stiffness 0.5
dry eye 0.4
Sedation 0.4
pelvic pain 0.4
cancer pain 0.2
acute stress 0.2
enuresis 0.1
more...
Drug
Xaliproden 9.2
Quazinone 8.8
Nexavar 7.7
Sulfamide 7.7
2-Butanol 7.3
Lonafarnib 7.2
Sorafenib 6.7
Tipifarnib 6.6
Ilomastat 6.5
Scutellaria root 6.4
RAL 6.1
Ipilimumab 6.1
Ciglitazone 6.1
NVP 5.8
MAP 5.6
Cilengitide 5.6
Gefitinib 5.4
Mevastatin 5.3
Dasatinib 5.3
Myricetin 5.3
Temodal 5.3
Azacytidine 5.2
K-252a 5.2
Arsenic trioxide 5.2
Tarceva 5.0
Panitumumab 5.0
Tykerb 5.0
TAK 5.0
2-Methoxyestradiol 5.0
Romidepsin 4.9
Cetuximab 4.9
Lercanidipine 4.9
Butaprost 4.8
Midostaurin 4.8
Casodex 4.8
Epigallocatechin 4.8
Flavopiridol 4.7
Verteporfin 4.6
PDL 4.6
Vesnarinone 4.5
more...
Enzyme
MEK 10.8
MEKK1 9.1
mitogen-activated protein kinase 7.6
glucuronosyltransferase I 7.5
CLK1 7.3
ERK 7.0
inositol 3-kinase 6.9
NSY 6.9
prenylated protein methyltransferase 6.8
phosphatidylinositol 3-kinase 6.8
MAP 6.7
small monomeric GTPase 6.6
farnesyltransferase 6.4
phosphoinositide 3-kinase 6.4
eEF2 kinase 6.2
duodenase 6.1
farnesyltransferase 5.9
protein kinase 5.7
IKK 5.7
protein kinase C 5.6
PDK1 5.6
3-hydroxy-3-methylglutaryl-CoA lyase 5.5
protein L-isoaspartyl methyltransferase 5.5
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.5
protein phosphatase 2A 5.3
matrix metalloproteinase 14 5.3
CaMKII 5.2
GSK 5.2
CEP 5.1
biliverdin reductase 5.0
cdc2 5.0
GRK5 4.9
cathepsin V 4.8
collagenase 3 4.8
caspase-7 4.8
focal adhesion kinase 4.7
caspase-7 4.7
phosphoenolpyruvate synthase 4.7
isochorismate synthase 4.6
PI-PLC 4.6
more...
Compound
Catenarin 10.8
MEK 10.6
Cajanin 9.8
4-(4-chlorophenyl)-4-piperidinol 9.2
N-(2-pyridinyl)benzamide 9.2
Xanthoxyletin 9.2
Telocinobufagin 8.8
LY 294002 8.3
DG 2 8.0
3-quinolinecarbonitrile 7.8
Dracorhodin 7.8
1,2,4-trimethylcyclohexane 7.8
Ginkgolide C 7.8
1,2,4-trimethylcyclohexane 7.8
3,4-D 7.7
Rocaglamide 7.7
Malabaricone C 7.5
Senegenin 7.5
Cyclovirobuxine D 7.5
2,4,5-trimethoxybenzaldehyde 7.5
Ethyl ferulate 7.5
Tectoridin 7.3
Euxanthone 7.3
Gossypin 7.3
Butin 7.2
Benzo[a]pyrene-7,8-diol 7.1
2,4-pyrimidinediamine 7.1
GF 109203X 7.1
Wortmannin 7.0
1-piperidinecarboxamide 7.0
3,4-dichloro-5-hydroxy-2(5H)-furanone 6.9
S152 6.9
delta12,14-PGJ2 6.9
Sangivamycin 6.9
Ginkgolide C 6.9
Tylophorine 6.9
Pentalenolactone 6.8
Gallein 6.7
Ailanthone 6.7
Purpurogallin 6.7
more...