Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.12.2 (MEK)
18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein MEK 12715 ERK 6082 MEK1 4168 MAPK 3532 ERK1 3500 p38 2355 Mol 2007 BRAF 1876 extracellular signal-regulated kinase 1837 PI3K 1658 MAP kinase 1470 JNK 1385 mitogen-activated protein 1274 Sep 1250 AKT 1116 RAF 969 mTOR 880 Raf-1 860 c-Jun 840 ERK2 797 tyrosine kinase 779 MKK4 692 cytokine 689 phosphatidylinositol 3-kinase 687 PKC 549 insulin 537 epidermal growth factor 528 KRAS 514 caspase-3 504 EGFR 503 p53 502 epidermal growth factor receptor 492 p42 482 MKK6 442 Bcl-2 436 AP-1 435 MAP 435 p44 426 MEK2 419 phosphatase 417 more...

Disease cancer 3808 tumor 2660 melanoma 1296 breast cancer 600 tumor growth 563 tumorigenesis 552 carcinoma 419 hepatocellular carcinoma 360 leukemia 356 lung cancer 349 metastatic melanoma 349 colorectal cancer 332 carcinogenesis 318 tumor progression 305 adenocarcinoma 275 metastases 249 pertussis 243 non-small cell lung cancer 226 Melanoma 224 MCF 213 colon cancer 211 prostate cancer 201 ischemia 191 pancreatic cancer 187 neuroblastoma 173 glioma 168 acute myeloid leukemia 158 ovarian cancer 157 squamous cell carcinoma 145 atherosclerosis 142 diabetes 140 Alzheimer's disease 131 gastric cancer 127 hypertension 118 multiple myeloma 116 Blocking 109 glioblastoma 101 Parkinson's disease 99 obesity 97 skin cancer 96 more...

Symptom pain 108 starvation 62 fatigue 30 diarrhea 29 seizures 29 nausea 24 collapse 17 functional recovery 13 vomiting 9 analgesia 9 weakness 8 hypothermia 8 headache 8 hypotonia 7 exhaustion 6 cachexia 6 hyperoxia 6 arthralgia 6 ataxia 5 respiratory distress 5 splenomegaly 5 skin damage 4 Neuropathic pain 4 anesthesia 4 orofacial pain 4 dyspnea 4 acute stress 3 pelvic pain 3 memory loss 3 abdominal pain 3 bone pain 3 Scratch 3 myalgia 3 erythema 3 dry eye 2 dry skin 2 hepatomegaly 2 back pain 2 tremor 2 acute pain 2 more...

Drug MAP 446 Dermatol 141 ROS 133 Sorafenib 88 CSF 79 IL-2 78 lysine 72 ICI 57 IFN-gamma 56 Angiotensin II 51 ETS 34 Gel 32 NVP 31 Taxol 31 Gefitinib 28 Arsenic trioxide 26 Monit 26 Cardiovasc 24 caffeine 22 p75 22 Forskolin 21 Imatinib 20 uPA 18 vitamin E 18 Activin 18 TAK 18 Ouabain 17 Histamine 16 Cetuximab 16 Ipilimumab 16 ascorbate 16 Retinoic acid 15 Asn 14 ETA 14 Indomethacin 14 Dasatinib 14 Nexavar 13 Glucagon 13 Herceptin 12 Ethanol 12 more...

Enzyme MEK 18161 mitogen-activated protein kinase 10639 ERK 6869 protein kinase 2472 protein kinase C 1390 phosphatidylinositol 3-kinase 688 focal adhesion kinase 675 MEKK1 574 MAP 435 caspase-3 382 luciferase 370 phosphoinositide 3-kinase 275 calcineurin 229 phospholipase C 208 proteasome 177 PARP 162 cdc2 149 IKK 149 GSK 138 NADPH oxidase 123 NADPH oxidase 107 phospholipase A2 104 AMP-activated protein kinase 101 AMPK 101 ATPase 96 glutathione S-transferase 91 urokinase-type plasminogen activator 90 collagenase 89 NO synthase 88 catalase 88 thrombin 87 caspase-9 85 CaMKII 84 adenylate cyclase 75 protein phosphatase 2A 70 caspase-8 68 superoxide dismutase 66 PDK1 63 alkaline phosphatase 61 MMP 59 more...

Compound MEK 11589 DNA 1440 Dec 1313 tyrosine 1187 calcium 690 oxygen 685 serine 603 threonine 575 acetate 467 cAMP 461 MAP 437 Clin 367 glucose 343 ATP 327 TNF 250 nitric oxide 241 sodium 240 GTP 201 MTT 191 MDA 190 phosphate 173 methionine 169 Insulin 165 NH2 161 cysteine 156 hydrogen 156 alanine 154 glutamate 148 water 147 PMA 137 PMA 136 AMP 136 N-acetylcysteine 118 retinoic acid 117 leucine 114 H2O2 112 THP 109 THP 109 lysine 103 arginine 99 more...

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