Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.12.2 (MEK)
 18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEK 12715
ERK 6082
MEK1 4168
MAPK 3532
ERK1 3500
p38 2355
Mol 2007
BRAF 1876
extracellular signal-regulated kinase 1837
PI3K 1658
MAP kinase 1470
JNK 1385
mitogen-activated protein 1274
Sep 1250
AKT 1116
RAF 969
mTOR 880
Raf-1 860
c-Jun 840
ERK2 797
more...
Disease
cancer 3808
tumor 2660
melanoma 1296
breast cancer 600
tumor growth 563
tumorigenesis 552
carcinoma 419
hepatocellular carcinoma 360
leukemia 356
lung cancer 349
metastatic melanoma 349
colorectal cancer 332
carcinogenesis 318
tumor progression 305
adenocarcinoma 275
metastases 249
pertussis 243
non-small cell lung cancer 226
Melanoma 224
MCF 213
more...
Symptom
pain 108
starvation 62
fatigue 30
seizures 29
diarrhea 29
nausea 24
collapse 17
functional recovery 13
vomiting 9
analgesia 9
hypothermia 8
weakness 8
headache 8
hypotonia 7
cachexia 6
exhaustion 6
hyperoxia 6
arthralgia 6
respiratory distress 5
ataxia 5
more...
Drug
MAP 446
Dermatol 141
ROS 133
Sorafenib 88
CSF 79
IL-2 78
lysine 72
ICI 57
IFN-gamma 56
Angiotensin II 51
ETS 34
Gel 32
Taxol 31
NVP 31
Gefitinib 28
Arsenic trioxide 26
Monit 26
Cardiovasc 24
p75 22
caffeine 22
more...
Enzyme
MEK 18161
mitogen-activated protein kinase 10639
ERK 6869
protein kinase 2472
protein kinase C 1390
phosphatidylinositol 3-kinase 688
focal adhesion kinase 675
MEKK1 574
MAP 435
caspase-3 382
luciferase 370
phosphoinositide 3-kinase 275
calcineurin 229
phospholipase C 208
proteasome 177
PARP 162
cdc2 149
IKK 149
GSK 138
NADPH oxidase 123
more...
Compound
MEK 11589
DNA 1440
Dec 1313
tyrosine 1187
calcium 690
oxygen 685
serine 603
threonine 575
acetate 467
cAMP 461
MAP 437
Clin 367
glucose 343
ATP 327
TNF 250
nitric oxide 241
sodium 240
GTP 201
MTT 191
MDA 190
more...