Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.12.2 (MEK)
18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein MEK 0.700 MEK1 0.229 ERK 0.078 ERK1 0.030 MKK4 0.029 RAF 0.027 MEK2 0.023 MKK6 0.023 MAPK 0.022 BRAF 0.020 MKK7 0.019 extracellular signal-regulated kinase 0.015 MAP kinase 0.014 p38 0.010 ERK2 0.010 MKK3 0.009 Raf-1 0.009 mitogen-activated protein 0.008 MEKK 0.008 PI3K 0.006 JNK 0.006 p42 0.004 p44 0.004 c-Jun 0.003 MAP2K1 0.003 AKT 0.003 JNK1 0.002 MEKK1 0.002 phosphatidylinositol 3-kinase 0.002 KRAS 0.002 NRAS 0.002 NS5 0.002 mitogen-activated protein kinase kinase 1 0.002 extracellular signal-regulated kinase 1 0.002 mTOR 0.002 p38 MAP kinase 0.002 MAPK/ERK kinase 0.002 MAP 0.001 B-RAF 0.001 MKK5 0.001 PKC 0.001 PI3 0.001 MEK5 0.001 EGFR 0.001 RSK 0.001 AP-1 0.001 tyrosine kinase 0.001 ribosomal S6 kinase 0.001 JNK2 0.001 KSR1 0.001 ERK5 0.001 p90 0.001 p38 mitogen-activated protein kinase 0.001 MyD118 0.001 MLK3 0.001 extracellular signal regulated kinase 0.001 C-RAF 0.001 phosphoinositide 3-kinase 0.001 epidermal growth factor 0.001 kinase suppressor of Ras 0.001 MAP kinase kinase 1 0.001 ASK1 0.001 EGF 0.001 Elk1 0.001 MAP kinase kinase 4 0.001 PP2 0.001 epidermal growth factor receptor 0.001 p38MAPK 0.001 MKP-1 0.001 KSR 0.001 MKP-3 0.001 MEKK2 0.000 EGF receptor 0.000 Ras inhibitor 0.000 PKA 0.000 PI3-kinase 0.000 MAP2K2 0.000 mitogen-activated protein kinase kinase kinase 0.000 SEK 0.000 RSK1 0.000 MEKK4 0.000 HRAS 0.000 JNK3 0.000 cyclin D1 0.000 protein kinase B 0.000 CREB 0.000 Mol 0.000 phosphatase 0.000 TAK1 0.000 STAT3 0.000 p21 0.000 MEKK3 0.000 ARAF 0.000 threonine 0.000 Bcl-2 0.000 Mcl-1 0.000 caspase-3 0.000 RAF-1 0.000 H-ras 0.000 PI-3 kinase 0.000 PKB 0.000 TPL2 0.000 protein kinase 2 0.000 Kinase suppressor of Ras 1 0.000 c-Src 0.000 c-fos 0.000 PP1 0.000 PTEN 0.000 B-raf 0.000 MAP3K8 0.000 v-raf murine sarcoma viral oncogene homolog B1 0.000 p70 S6 kinase 0.000 ras 0.000 SHOC2 0.000 MSK1 0.000 receptor tyrosine kinase 0.000 PTPN11 0.000 S6K1 0.000 ELK1 0.000 TPL-2 0.000 PIK3CA 0.000 STAT 0.000 FAK 0.000 serine/threonine kinase 0.000 RalGDS 0.000 MAPK3 0.000 GRB2 0.000 RSK2 0.000 IKK 0.000 protein kinase C inhibitor 0.000 JIP1 0.000 ATF2 0.000 GNAQ 0.000 cytokine 0.000 SOS1 0.000 p53 0.000 platelet-derived growth factor 0.000 nerve growth factor 0.000 PDGF 0.000 JUN N-terminal kinase 0.000 Mitogen-activated protein kinase kinase 1 0.000 apoptosis signal-regulating kinase 1 0.000 MLK 0.000 GSK3 0.000 p38gamma 0.000 focal adhesion kinase 0.000 Rho 0.000 JAK2 0.000 Raf kinase inhibitor protein 0.000 GSK 0.000 CDK4 0.000 B-Raf protein 0.000 mitogen-activated protein kinase 4 0.000 PAQR3 0.000 Mixed lineage kinase 0.000 p27 0.000 DUSP6 0.000 MET 0.000 MAPK1 0.000 IkappaBalpha 0.000 more...

Disease melanoma 0.001 metastatic melanoma 0.001 cancer 0.001 tumor 0.001 Melanoma 0.000 tumor growth 0.000 tumorigenesis 0.000 pertussis 0.000 Costello syndrome 0.000 cardiofaciocutaneous syndrome 0.000 tumor progression 0.000 non-small cell lung cancer 0.000 breast cancer 0.000 colorectal cancer 0.000 hepatocellular carcinoma 0.000 RP27 0.000 stage IV melanoma 0.000 pancreatic cancer 0.000 lung cancer 0.000 MCF 0.000 carcinogenesis 0.000 colon cancer 0.000 anthrax 0.000 leukemia 0.000 Blocking 0.000 carcinoma 0.000 NRC1 0.000 adenocarcinoma 0.000 neuroblastoma 0.000 Papillary craniopharyngioma 0.000 anaplastic thyroid cancer 0.000 Malignant peripheral nerve sheath tumor 0.000 glioma 0.000 ovarian cancer 0.000 cutaneous melanoma 0.000 Congenital melanocytic nevus 0.000 AGS 0.000 skin cancer 0.000 thyroid cancer 0.000 acute myeloid leukemia 0.000 retinoblastoma 0.000 prostate cancer 0.000 HGF 0.000 HPC3 0.000 Histiocytic neoplasms 0.000 Precursor T-cell lymphoblastic lymphoma 0.000 Malignant peripheral nerve sheath tumor 0.000 ABL 0.000 Conjunctival melanoma 0.000 metastases 0.000 Opsismodysplasia 0.000 glioblastoma 0.000 Pilocytic astrocytoma 0.000 EMT 0.000 Erdheim-Chester disease 0.000 uveal melanoma 0.000 tumor angiogenesis 0.000 neurofibromatosis type 1 0.000 pheochromocytoma 0.000 squamous cell carcinoma 0.000 FDC 0.000 neoplastic transformation 0.000 gastric cancer 0.000 adult pilocytic astrocytoma 0.000 Mucinous Neoplasm 0.000 Leukemia 0.000 papillary thyroid cancer 0.000 ATM 0.000 Langerhans cell histiocytosis 0.000 juvenile myelomonocytic leukemia 0.000 Jaagsiekte 0.000 ischemia 0.000 JIP 0.000 Gastrointestinal anthrax 0.000 multiple myeloma 0.000 chronic myeloid leukemia 0.000 Pleomorphic xanthoastrocytoma 0.000 phakoma 0.000 liver cancer 0.000 astrocytoma 0.000 Malignant Peripheral Nerve Sheath Tumor 0.000 liver cancer 0.000 epithelial ovarian cancer 0.000 cerebral ischemia 0.000 Osteosarcoma 0.000 Osteosarcoma 0.000 osteosarcoma 0.000 lung carcinoma 0.000 Hepatocellular carcinoma 0.000 CEP 0.000 DSCR 0.000 acute promyelocytic leukemia 0.000 fibrosarcoma 0.000 sarcoma 0.000 tumor initiation 0.000 atherosclerosis 0.000 brain metastases 0.000 paronychia 0.000 Gastrointestinal mucositis 0.000 Neutrophilic panniculitis 0.000 monocytic leukemia 0.000 grade II meningioma 0.000 Invasive bladder cancer 0.000 stage III melanoma 0.000 myeloid leukemia 0.000 WWS 0.000 Eosinophilic meningitis 0.000 leukemogenesis 0.000 PGL2 0.000 onychorrhexis 0.000 Tumour necrosis 0.000 LEOPARD syndrome 0.000 Myelokathexis 0.000 FBS 0.000 hairy cell leukemia 0.000 GSH 0.000 Ph-positive acute lymphoblastic leukemia 0.000 aggressiveness 0.000 Adenovirus 0.000 keratoacanthoma 0.000 Multiple cancer 0.000 chondrosarcoma 0.000 Leydig cell hypoplasia 0.000 Neuroblastoma 0.000 Neuroblastoma 0.000 Parkinson's disease 0.000 Alzheimer's disease 0.000 myeloproliferative disorders 0.000 polycystic kidney 0.000 Congenital myotonic dystrophy 0.000 APC 0.000 acute lymphoblastic leukemia 0.000 EDS1 0.000 pancreatic fibrosis 0.000 primary tumor 0.000 EDS5 0.000 glioblastoma multiforme 0.000 Gastric infection 0.000 Anaplastic Lymphoma 0.000 Thyroid cancer 0.000 renal cell carcinoma 0.000 SCCD 0.000 Rhabdoid meningioma 0.000 embryonal rhabdomyosarcoma 0.000 NAME 0.000 biliary tract cancer 0.000 LIN 0.000 Philadelphia chromosome positive chronic myelogenous leukemia 0.000 HRA 0.000 Histiocytic sarcoma 0.000 renal cancer 0.000 PCH2 0.000 Adhesion 0.000 neurofibromatosis 0.000 B-cell lymphoma 0.000 solid tumor 0.000 Glioblastoma 0.000 RGS 0.000 tuberous sclerosis 0.000 lymphoma 0.000 more...

Symptom starvation 0.000 brittle nails 0.000 Beau's lines 0.000 Organ failure 0.000 pain 0.000 onychomadesis 0.000 Scratch 0.000 nausea 0.000 orofacial pain 0.000 scaly skin 0.000 fatigue 0.000 rundown 0.000 Neuropathic pain 0.000 skin damage 0.000 diarrhea 0.000 functional recovery 0.000 collapse 0.000 seizures 0.000 hypotonia 0.000 bladder pain 0.000 hyperoxia 0.000 dry skin 0.000 cachexia 0.000 Anoxia 0.000 fasciculation 0.000 arthralgia 0.000 despair 0.000 bone pain 0.000 hypothermia 0.000 general problem 0.000 memory loss 0.000 blurred vision 0.000 pelvic pain 0.000 emaciation 0.000 muscle rigidity 0.000 splenomegaly 0.000 exhaustion 0.000 urinary frequency 0.000 analgesia 0.000 abnormal gait 0.000 acute stress 0.000 dry eye 0.000 decreased appetite 0.000 night sweats 0.000 dental pain 0.000 muscle stiffness 0.000 vomiting 0.000 Sedation 0.000 cancer pain 0.000 myalgia 0.000 enuresis 0.000 neuralgia 0.000 acute pain 0.000 ataxia 0.000 weakness 0.000 chills 0.000 myoclonus 0.000 leg pain 0.000 twitching 0.000 respiratory distress 0.000 bradykinesia 0.000 hepatomegaly 0.000 asthenia 0.000 sore throat 0.000 headache 0.000 knee pain 0.000 HSA 0.000 erythema 0.000 cerebellar ataxia 0.000 dysarthria 0.000 dyspnea 0.000 numbness 0.000 ENT 0.000 back pain 0.000 paresis 0.000 spasticity 0.000 vertigo 0.000 abdominal pain 0.000 tremor 0.000 regurgitation 0.000 syncope 0.000 distraction 0.000 angina 0.000 nausea and vomiting 0.000 constipation 0.000 insomnia 0.000 thinning 0.000 anesthesia 0.000 discomfort 0.000

Drug MAP 0.001 Sorafenib 0.000 Nexavar 0.000 Xaliproden 0.000 NVP 0.000 ROS 0.000 Ipilimumab 0.000 Gefitinib 0.000 Quazinone 0.000 ICI 0.000 Arsenic trioxide 0.000 Angiotensin II 0.000 RAL 0.000 Sulfamide 0.000 ETS 0.000 Lonafarnib 0.000 Dasatinib 0.000 TAK 0.000 Tipifarnib 0.000 Taxol 0.000 2-Butanol 0.000 Cetuximab 0.000 Ilomastat 0.000 IL-2 0.000 Activin 0.000 CSF 0.000 Myricetin 0.000 Ciglitazone 0.000 K-252a 0.000 Forskolin 0.000 Imatinib 0.000 Scutellaria root 0.000 uPA 0.000 PDL 0.000 Epigallocatechin 0.000 p75 0.000 Ouabain 0.000 Cilengitide 0.000 Everolimus 0.000 Tarceva 0.000 IFN-gamma 0.000 Gleevec 0.000 Panitumumab 0.000 2-Methoxyestradiol 0.000 Azacytidine 0.000 Troglitazone 0.000 lysine 0.000 Mevastatin 0.000 Erlotinib 0.000 Glycyrrhiza 0.000 Temodal 0.000 Casodex 0.000 ETA 0.000 Romidepsin 0.000 Flavopiridol 0.000 Dermatol 0.000 Retinoic acid 0.000 Herceptin 0.000 Verteporfin 0.000 Gel 0.000 Tykerb 0.000 Lercanidipine 0.000 CCL 0.000 Butaprost 0.000 Midostaurin 0.000 Rosiglitazone 0.000 GNA 0.000 IL-11 0.000 PTC 0.000 R1881 0.000 Tianeptine 0.000 3-Methyladenine 0.000 Emodin 0.000 Glucagon 0.000 Histamine 0.000 Vesnarinone 0.000 Simvastatin 0.000 Growth hormone 0.000 Growth hormone 0.000 Heme 0.000 Fulvestrant 0.000 Vorinostat 0.000 GHRP 0.000 CED 0.000 Emodin 0.000 Bimatoprost 0.000 Batimastat 0.000 Batimastat 0.000 CMZ 0.000 Bosutinib 0.000 CoCl2 0.000 CoCl2 0.000 Perphenazine 0.000 Onconase 0.000 Indomethacin 0.000 Rosuvastatin 0.000 Magnesium sulfate 0.000 Fluticasone propionate 0.000 Ulinastatin 0.000 Aliskiren 0.000 Sodium citrate 0.000 Morphine sulfate 0.000 Sodium citrate 0.000 Red ginseng 0.000 IFN-beta 0.000 KGF 0.000 Bortezomib 0.000 Idebenone 0.000 Celebrex 0.000 Etoposide 0.000 FSH-beta 0.000 FSH-beta 0.000 Pertuzumab 0.000 Hyperforin 0.000 Vandetanib 0.000 Clofarabine 0.000 KAN 0.000 Rhamnose 0.000 Sunitinib malate 0.000 G-CSF 0.000 NBT 0.000 Oxaliplatin 0.000 Lovastatin 0.000 FSH-beta 0.000 Taxotere 0.000 Latanoprost 0.000 NLF 0.000 Kainic acid 0.000 Nitric Oxide 0.000 caffeine 0.000 CTC 0.000 GEO 0.000 EML 0.000 Doxycycline 0.000 Bromelain 0.000 PDGF B-chain 0.000 EE2 0.000 Dihydrotestosterone 0.000 Adriamycin 0.000 Rolipram 0.000 Monit 0.000 Liraglutide 0.000 vitamin E 0.000 Finasteride 0.000 TEL 0.000 Ezetimibe 0.000 R-gene 0.000 CTC 0.000 Asn 0.000 Idarubicin 0.000 Ethane 0.000 Papaverine 0.000 PFT 0.000 Zoledronic acid 0.000 PE2 0.000 DEX 0.000 PCP 0.000 Ethanol 0.000 SnF2 0.000 Indinavir 0.000 more...

Enzyme MEK 1.000 mitogen-activated protein kinase 0.065 ERK 0.027 MEKK1 0.010 protein kinase 0.004 phosphatidylinositol 3-kinase 0.002 protein kinase C 0.002 MAP 0.001 phosphoinositide 3-kinase 0.001 focal adhesion kinase 0.001 IKK 0.000 caspase-3 0.000 luciferase 0.000 calcineurin 0.000 GSK 0.000 cdc2 0.000 farnesyltransferase 0.000 phospholipase C 0.000 PARP 0.000 PDK1 0.000 CaMKII 0.000 CLK1 0.000 farnesyltransferase 0.000 protein phosphatase 2A 0.000 NADPH oxidase 0.000 inositol 3-kinase 0.000 NADPH oxidase 0.000 proteasome 0.000 caspase-9 0.000 MMP 0.000 AMPK 0.000 AMP-activated protein kinase 0.000 urokinase-type plasminogen activator 0.000 phospholipase A2 0.000 caspase-8 0.000 AMPK 0.000 eEF2 kinase 0.000 NO synthase 0.000 collagenase 0.000 PKG 0.000 NSY 0.000 glutathione S-transferase 0.000 GRK5 0.000 CEP 0.000 glucuronosyltransferase I 0.000 myosin light chain kinase 0.000 adenylate cyclase 0.000 MPP 0.000 MMP-3 0.000 caspase-7 0.000 caspase-7 0.000 phospholipase D 0.000 thrombin 0.000 CEP 0.000 DCF 0.000 prenylated protein methyltransferase 0.000 small monomeric GTPase 0.000 GRK2 0.000 polo-like kinase 1 0.000 phosphatidylinositol-4,5-bisphosphate 3-kinase 0.000 tyrosinase 0.000 duodenase 0.000 ATPase 0.000 catalase 0.000 PI-PLC 0.000 gamma-glutamylcysteine synthetase 0.000 sphingosine kinase 0.000 TOR 0.000 matrix metalloproteinase 9 0.000 biliverdin reductase 0.000 guanylate cyclase 0.000 PTPase 0.000 NOS 0.000 3-hydroxy-3-methylglutaryl-CoA lyase 0.000 protein L-isoaspartyl methyltransferase 0.000 matrix metalloproteinase 2 0.000 MIP 0.000 interstitial collagenase 0.000 matrix metalloproteinase 14 0.000 12-lipoxygenase 0.000 DNA methyltransferase 0.000 APC 0.000 HCS 0.000 caspase-4 0.000 GAS 0.000 caspase-2 0.000 phosphodiesterase 0.000 alkaline phosphatase 0.000 caspase-2 0.000 15-hydroxyprostaglandin dehydrogenase 0.000 factor C 0.000 superoxide dismutase 0.000 neutral sphingomyelinase 0.000 Omi/HtrA2 0.000 lactate dehydrogenase 0.000 caspase-4 0.000 tyrosine hydroxylase 0.000 isochorismate synthase 0.000 collagenase 3 0.000 cathepsin V 0.000 TACE 0.000 reverse transcriptase 0.000 phosphoenolpyruvate synthase 0.000 RNA polymerase 0.000 histidine decarboxylase 0.000 STK11 0.000 ornithine decarboxylase 0.000 P-glycoprotein 0.000 histidine kinase 0.000 caspase-10 0.000 caspase-10 0.000 ceramidase 0.000 lipoxygenase 0.000 deoxycytidine deaminase 0.000 CPT 0.000 aldose reductase 0.000 CYP8B1 0.000 acetyl-CoA carboxylase 0.000 CPT 0.000 choline acetyltransferase 0.000 Thy1 0.000 PDE 0.000 hormone-sensitive lipase 0.000 histone acetyltransferase 0.000 NQO1 0.000 ceramide kinase 0.000 firefly luciferase 0.000 caspase-6 0.000 prolidase 0.000 LTC4 synthase 0.000 caspase-6 0.000 peptidyl-prolyl cis-trans isomerase 0.000 CPT 0.000 furin 0.000 caspase-1 0.000 xanthine oxidase 0.000 hatching enzyme 0.000 p80 0.000 endodeoxyribonuclease 0.000 phosphoglycerate dehydrogenase 0.000 ALDH 0.000 arginase 0.000 MTD 0.000 STK 0.000 cathepsin K 0.000 calpain 3 0.000 fatty-acid synthase 0.000 peptidylarginine deiminase 0.000 N-acetylglucosaminyltransferase V 0.000 granzyme B 0.000 BBE 0.000 lipoprotein lipase 0.000 cathepsin B 0.000 type 1 protein phosphatase 0.000 triphosphatase 0.000 apyrase 0.000 VIP1 0.000 topoisomerase 0.000 CYP46A1 0.000 ACC synthase 0.000 more...

Compound MEK 0.576 MAP 0.001 tyrosine 0.001 LY 294002 0.001 threonine 0.000 Wortmannin 0.000 serine 0.000 cAMP 0.000 GF 109203X 0.000 DNA 0.000 PMA 0.000 ATF 0.000 acetate 0.000 PMA 0.000 MDA 0.000 calcium 0.000 GTP 0.000 Ang II 0.000 Catenarin 0.000 N-acetylcysteine 0.000 oxygen 0.000 THP 0.000 THP 0.000 MTT 0.000 TNF 0.000 Cajanin 0.000 Insulin 0.000 ATP 0.000 Dec 0.000 TPA 0.000 4-(4-chlorophenyl)-4-piperidinol 0.000 N-(2-pyridinyl)benzamide 0.000 Xanthoxyletin 0.000 Rapamycin 0.000 Genistein 0.000 Phorbol 12-myristate 13-acetate 0.000 TPA 0.000 Telocinobufagin 0.000 PGE 0.000 3-quinolinecarbonitrile 0.000 Phosphatidylinositol 0.000 nitric oxide 0.000 retinoic acid 0.000 Rocaglamide 0.000 3,4-D 0.000 NH2 0.000 PGJ2 0.000 BCR 0.000 ICI 0.000 Anisomycin 0.000 Dracorhodin 0.000 ABL 0.000 methionine 0.000 Angiotensin II 0.000 Rottlerin 0.000 Tyrosine 0.000 AMP 0.000 DG 2 0.000 2-butanone 0.000 2-butanone 0.000 H2O2 0.000 Rottlerin 0.000 2,4,5-trimethoxybenzaldehyde 0.000 1,2,4-trimethylcyclohexane 0.000 Ginkgolide C 0.000 1,2,4-trimethylcyclohexane 0.000 glucose 0.000 TPCK 0.000 Rottlerin 0.000 1H-imidazole 0.000 COS 0.000 HOG 0.000 Nobiletin 0.000 alanine 0.000 Tanshinone 0.000 Cyclovirobuxine D 0.000 Malabaricone C 0.000 Senegenin 0.000 Ethyl ferulate 0.000 Phorbol 0.000 prostaglandin J2 0.000 cysteine 0.000 cGMP 0.000 Euxanthone 0.000 Gossypin 0.000 Tectoridin 0.000 MPP 0.000 boron 0.000 glutamate 0.000 Magnolol 0.000 1-piperidinecarboxamide 0.000 MPP 0.000 Butin 0.000 Thrombin 0.000 2-butanone 0.000 12(S)-HETE 0.000 Chelerythrine 0.000 Chelerythrine 0.000 GAP 0.000 15(S)-HETE 0.000 MAK 0.000 NOXA 0.000 Benzo[a]pyrene-7,8-diol 0.000 Eupatilin 0.000 2,4-pyrimidinediamine 0.000 ASK 0.000 Delphinidin 0.000 RBA 0.000 Geldanamycin 0.000 BzATP 0.000 2-hexanol 0.000 Bisdemethoxycurcumin 0.000 S152 0.000 delta12,14-PGJ2 0.000 Tylophorine 0.000 Ginkgolide C 0.000 Sangivamycin 0.000 3,4-dichloro-5-hydroxy-2(5H)-furanone 0.000 Arsenite 0.000 BON 0.000 Bufalin 0.000 Wogonin 0.000 Vimentin 0.000 DETA 0.000 phosphoserine 0.000 Pentalenolactone 0.000 Cbl 0.000 dUTP 0.000 leucine 0.000 Glycogen synthase 0.000 Luteolin 0.000 [6]-Shogaol 0.000 Ailanthone 0.000 Purpurogallin 0.000 Gallein 0.000 sodium 0.000 Baicalein 0.000 Glycyrrhetinic acid 0.000 Manumycin 0.000 UTP 0.000 2-aminoethyl diphenylborinate 0.000 2-aminoethyl diphenylborinate 0.000 1H-imidazole 0.000 Gallein 0.000 4-methoxybenzenesulfonamide 0.000 Propyl gallate 0.000 Sphingosine 1-phosphate 0.000 butylcyclohexane 0.000 Taurodeoxycholic acid 0.000 Resveratrol 0.000 Cycloheximide 0.000 Forskolin 0.000 Trimethyltin chloride 0.000 Atropine sulfate 0.000 NMDA 0.000 Staurosporine 0.000 Santonin 0.000 Ailanthone 0.000 4-chlorophenyl 0.000 4-chlorophenyl 0.000 more...

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