Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.12.2 (MEK)
 18,161 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEK 12715
ERK 6082
MEK1 4168
MAPK 3532
ERK1 3500
p38 2355
Mol 2007
BRAF 1876
extracellular signal-regulated kinase 1837
PI3K 1658
MAP kinase 1470
JNK 1385
mitogen-activated protein 1274
Sep 1250
AKT 1116
RAF 969
mTOR 880
Raf-1 860
c-Jun 840
ERK2 797
tyrosine kinase 779
MKK4 692
cytokine 689
phosphatidylinositol 3-kinase 687
PKC 549
insulin 537
epidermal growth factor 528
KRAS 514
caspase-3 504
EGFR 503
p53 502
epidermal growth factor receptor 492
p42 482
MKK6 442
Bcl-2 436
AP-1 435
MAP 435
p44 426
MEK2 419
phosphatase 417
MEKK 382
threonine 379
MKK7 375
EGF 360
p21 355
ATP 325
MKK3 324
extracellular signal-regulated kinase 1 324
JNK1 323
tumor necrosis factor 316
cyclin D1 293
p38 mitogen-activated protein kinase 285
phosphoinositide 3-kinase 275
STAT3 272
collagen 271
NRAS 271
p38 MAP kinase 269
IL-6 267
PI3 251
TNF 250
ras 247
PKA 245
NS5 241
vascular endothelial growth factor 238
c-fos 230
EGF receptor 230
lipopolysaccharide 223
protein kinase B 216
Rho 215
CREB 205
PTEN 202
GTP 201
nerve growth factor 197
receptor tyrosine kinase 196
STAT 181
platelet-derived growth factor 179
matrix metalloproteinase 179
proteasome 176
p65 174
VEGF 174
MEKK1 174
MAP2K1 168
IL-8 167
fibronectin 165
E-cadherin 163
TNF-alpha 162
catenin 162
estrogen receptor 152
calmodulin 151
cyclooxygenase-2 150
MMP-9 148
PARP 148
chemokine 145
cytochrome c 145
HER2 143
LPS 142
angiotensin II 142
p38MAPK 140
PDGF 139
Mcl-1 139
serine/threonine kinase 138
p27 137
COX-2 133
PP2 133
ROS 133
H-ras 132
AMP 132
GSK 131
interleukin-6 129
cyclin 126
GTPase 126
c-Src 125
JNK2 125
JAK2 125
endoplasmic reticulum 123
Ang II 121
RhoA 121
c-Myc 120
focal adhesion kinase 119
ribosomal S6 kinase 118
brain-derived neurotrophic factor 118
TGF-beta 117
PKB 116
caspase-9 116
phosphorylating 116
nitric oxide synthase 114
inducible nitric oxide synthase 113
MMP-2 112
hepatocyte growth factor 111
ubiquitin 111
THP 109
insulin-like growth factor 109
PLC 108
FGF 107
extracellular signal regulated kinase 107
VEGFR2 106
FAK 104
MAPK/ERK kinase 103
PIK3CA 103
CDK4 102
histone 102
protein phosphatase 102
PI3-kinase 101
Fas 100
IFN 100
MET 100
PP1 99
p90 99
PD-1 98
interferon 98
histone deacetylase 96
B-RAF 94
TLR4 94
caspase-8 94
IKK 93
insulin receptor 91
Cytokine 91
cyclooxygenase 90
ERK5 89
mitogen-activated protein kinase kinase 1 89
more...
Disease
cancer 3808
tumor 2660
melanoma 1296
breast cancer 600
tumor growth 563
tumorigenesis 552
carcinoma 419
hepatocellular carcinoma 360
leukemia 356
lung cancer 349
metastatic melanoma 349
colorectal cancer 332
carcinogenesis 318
tumor progression 305
adenocarcinoma 275
metastases 249
pertussis 243
non-small cell lung cancer 226
Melanoma 224
MCF 213
colon cancer 211
prostate cancer 201
ischemia 191
pancreatic cancer 187
neuroblastoma 173
glioma 168
acute myeloid leukemia 158
ovarian cancer 157
squamous cell carcinoma 145
atherosclerosis 142
diabetes 140
Alzheimer's disease 131
gastric cancer 127
hypertension 118
multiple myeloma 116
Blocking 109
glioblastoma 101
Parkinson's disease 99
obesity 97
skin cancer 96
lymphoma 88
retinoblastoma 87
pheochromocytoma 84
lung carcinoma 83
sarcoma 83
chronic myeloid leukemia 83
GSH 82
Leukemia 80
anthrax 79
thyroid cancer 79
liver cancer 73
ATM 73
cerebral ischemia 73
osteosarcoma 70
stroke 65
heart failure 65
rheumatoid arthritis 63
depression 61
liver cancer 60
epithelial ovarian cancer 60
HIV 59
asthma 59
virus infection 59
cutaneous melanoma 55
infectious diseases 55
acute lymphoblastic leukemia 55
tumor angiogenesis 54
renal cell carcinoma 52
ABL 52
primary tumor 52
astrocytoma 48
neoplastic transformation 47
acute promyelocytic leukemia 46
Infection 46
aggressiveness 45
neurofibromatosis type 1 44
fibrosarcoma 44
type 2 diabetes 42
B-cell lymphoma 42
AGS 42
Hepatocellular carcinoma 42
cold 42
HGF 41
influenza 40
osteoporosis 40
osteoarthritis 40
papillary thyroid cancer 40
NAME 39
hyperglycemia 38
EMT 38
cervical cancer 38
APC 38
plaque 38
bladder cancer 37
Langerhans cell histiocytosis 36
immunodeficiency 36
addiction 34
glioblastoma multiforme 34
mole 33
brain metastases 33
SCID 33
rash 33
brain tumor 33
cardiovascular disease 33
sepsis 33
sepsis 32
colitis 32
SDS 32
myocardial infarction 32
tumor initiation 30
hepatitis C 30
chronic lymphocytic leukemia 30
herpes simplex 29
hematologic malignancies 29
solid tumor 28
arthritis 28
Costello syndrome 28
myeloid leukemia 28
uveal melanoma 27
leukemogenesis 27
anaplastic thyroid cancer 27
myeloproliferative disorders 27
chronic lymphocytic leukemia 27
Mycobacterium 26
chondrosarcoma 26
polycystic kidney 26
endometrial cancer 26
esophageal cancer 26
cholera 25
Osteosarcoma 25
Osteosarcoma 25
Adhesion 25
stage IV melanoma 25
amyotrophic lateral sclerosis 24
diabetic nephropathy 24
mental retardation 24
schizophrenia 24
tuberous sclerosis 24
esophageal cancer 24
Epstein 24
inflammatory bowel disease 23
mental retardation 23
mammary tumor 23
renal cancer 23
neurofibromatosis 22
Adenovirus 22
MIP 22
psoriasis 22
rhabdomyosarcoma 22
myocardial ischemia 21
multiple sclerosis 21
hairy cell leukemia 21
tuberculosis 21
anemia 20
Malignant peripheral nerve sheath tumor 20
vascular disease 20
vaccinia 20
erythroleukemia 20
cognitive impairment 19
coronary artery disease 19
more...
Symptom
pain 108
starvation 62
fatigue 30
seizures 29
diarrhea 29
nausea 24
collapse 17
functional recovery 13
analgesia 9
vomiting 9
headache 8
hypothermia 8
weakness 8
hypotonia 7
arthralgia 6
cachexia 6
hyperoxia 6
exhaustion 6
ataxia 5
splenomegaly 5
respiratory distress 5
skin damage 4
dyspnea 4
anesthesia 4
orofacial pain 4
Neuropathic pain 4
abdominal pain 3
acute stress 3
pelvic pain 3
bone pain 3
memory loss 3
Scratch 3
myalgia 3
erythema 3
dry eye 2
rundown 2
fasciculation 2
cancer pain 2
dry skin 2
acute pain 2
hepatomegaly 2
tremor 2
myoclonus 2
despair 2
angina 2
blurred vision 2
brittle nails 2
chills 2
back pain 2
vertigo 1
dysarthria 1
ENT 1
regurgitation 1
emaciation 1
paresis 1
enuresis 1
thinning 1
cerebellar ataxia 1
Beau's lines 1
onychomadesis 1
asthenia 1
decreased appetite 1
bladder pain 1
knee pain 1
dental pain 1
discomfort 1
bradykinesia 1
urinary frequency 1
Sedation 1
insomnia 1
muscle rigidity 1
twitching 1
distraction 1
spasticity 1
Anoxia 1
scaly skin 1
Organ failure 1
HSA 1
nausea and vomiting 1
neuralgia 1
night sweats 1
numbness 1
muscle stiffness 1
constipation 1
syncope 1
leg pain 1
sore throat 1
abnormal gait 1
general problem 1
Drug
MAP 446
Dermatol 141
ROS 133
Sorafenib 88
CSF 79
IL-2 78
lysine 72
ICI 57
IFN-gamma 56
Angiotensin II 51
ETS 34
Gel 32
Taxol 31
NVP 31
Gefitinib 28
Monit 26
Arsenic trioxide 26
Cardiovasc 24
caffeine 22
p75 22
Forskolin 21
Imatinib 20
TAK 18
Activin 18
vitamin E 18
uPA 18
Ouabain 17
Cetuximab 16
ascorbate 16
Histamine 16
Ipilimumab 16
Retinoic acid 15
ETA 14
Dasatinib 14
Indomethacin 14
Asn 14
Glucagon 13
Nexavar 13
NADH 12
Ethanol 12
EE2 12
Herceptin 12
Growth hormone 11
Gleevec 11
Growth hormone 11
G-CSF 11
Heme 11
Glycyrrhiza 10
RAL 10
PTC 9
PDL 9
Adriamycin 9
IFN-beta 9
CCL 8
Everolimus 8
ABC 8
Simvastatin 8
CTX 8
Leaf 7
Epigallocatechin 7
PCP 7
Erlotinib 7
IL-11 7
K-252a 7
Myricetin 7
Nephron 7
Nitric Oxide 7
lactose 6
Troglitazone 6
CoCl2 6
Rosiglitazone 6
PTH 6
MRC 6
Bortezomib 6
CoCl2 6
Lovastatin 5
Etoposide 5
GEO 5
MDS 5
NBT 5
R1881 5
CTC 4
ADM 4
citric acid 4
Oxaliplatin 4
Tipifarnib 4
Emodin 4
ALA 4
Kenyan 4
G418 4
CTC 4
DNase I 4
Rituximab 4
ADR 4
Gelatin 4
Itraconazole 4
Estrogens 4
Tarceva 4
Doxycycline 4
Bevacizumab 4
CED 4
GHRP 4
Emodin 4
ENT 4
CAM 3
Casodex 3
Kainic acid 3
Flavopiridol 3
Ciglitazone 3
Panitumumab 3
THF 3
Theophylline 3
Fulvestrant 3
KGF 3
TEL 3
Taxotere 3
EPA 3
RFP 3
CPT-11 3
Ginseng 3
Albumin 3
Docetaxel 3
ZnCl2 3
AMC 3
Portal 3
-deoxyadenosine 3
GNA 3
BH4 3
Vorinostat 3
Alanine 3
Verteporfin 3
Lonafarnib 3
ZnCl2 3
TTC 3
2-Methoxyestradiol 3
DEX 3
Rosuvastatin 3
Propofol 3
AraC 3
Tianeptine 2
Rolipram 2
Alliance 2
Magnesium sulfate 2
Azacytidine 2
Cilengitide 2
Fragment 2
Vitamin E 2
PFT 2
Liraglutide 2
Norplant 2
Amiloride 2
Fluorescein 2
CTX 2
Glutathione 2
Urokinase 2
Fraction 2
3-Methyladenine 2
FAD 2
Asthma 2
PFA 2
more...
Enzyme
MEK 18161
mitogen-activated protein kinase 10639
ERK 6869
protein kinase 2472
protein kinase C 1390
phosphatidylinositol 3-kinase 688
focal adhesion kinase 675
MEKK1 574
MAP 435
caspase-3 382
luciferase 370
phosphoinositide 3-kinase 275
calcineurin 229
phospholipase C 208
proteasome 177
PARP 162
cdc2 149
IKK 149
GSK 138
NADPH oxidase 123
NADPH oxidase 107
phospholipase A2 104
AMP-activated protein kinase 101
AMPK 101
ATPase 96
glutathione S-transferase 91
urokinase-type plasminogen activator 90
collagenase 89
catalase 88
NO synthase 88
thrombin 87
caspase-9 85
CaMKII 84
adenylate cyclase 75
protein phosphatase 2A 70
caspase-8 68
superoxide dismutase 66
PDK1 63
alkaline phosphatase 61
MMP 59
AMPK 57
farnesyltransferase 50
farnesyltransferase 49
lactate dehydrogenase 45
reverse transcriptase 43
RNA polymerase 43
phosphodiesterase 38
tyrosinase 38
APC 37
ACS 33
PKG 32
guanylate cyclase 31
tyrosine hydroxylase 30
phospholipase D 29
MMP-3 29
myosin light chain kinase 29
trypsin 29
NOS 28
peroxidase 27
renin 26
P-glycoprotein 25
MIP 22
MPP 22
DNA methyltransferase 20
DCF 20
GRK5 19
lipoxygenase 19
CLK1 17
ornithine decarboxylase 17
inositol 3-kinase 16
matrix metalloproteinase 9 16
polo-like kinase 1 16
alanine aminotransferase 16
choline acetyltransferase 15
CEP 15
matrix metalloproteinase 2 15
xanthine oxidase 15
CEP 15
caspase-7 14
topoisomerase 14
NQO1 14
caspase-7 14
creatine kinase 14
plasmin 13
TOR 13
gamma-glutamylcysteine synthetase 13
RNase 13
RNase 13
caspase-1 13
topoisomerase 12
GRK2 12
complex I 12
CD10 12
transcriptase 12
beta-galactosidase 12
lipase 12
lipoprotein lipase 12
glutathione peroxidase 11
CPT 11
CPT 11
PDE 11
CPT 11
aldose reductase 11
neuraminidase 11
eEF2 kinase 10
acetyl-CoA carboxylase 10
PTPase 10
demethylase 10
histidine kinase 10
acetylcholinesterase 10
aspartate aminotransferase 9
cathepsin B 9
firefly luciferase 9
arginase 9
sphingosine kinase 9
ACE 9
furin 9
histone acetyltransferase 9
interstitial collagenase 9
hormone-sensitive lipase 8
histidine decarboxylase 8
cathepsin D 8
kinesin 8
PI-PLC 8
chloramphenicol acetyltransferase 8
heme oxygenase 8
GAS 8
granzyme B 8
thymidine kinase 8
12-lipoxygenase 8
caspase-2 7
endonuclease 7
caspase-2 7
PCP 7
glyceraldehyde-3-phosphate dehydrogenase 7
tissue plasminogen activator 6
TACE 6
cathepsin K 6
15-hydroxyprostaglandin dehydrogenase 6
neutral sphingomyelinase 6
peroxiredoxin 6
transglutaminase 6
MDR 6
alcohol dehydrogenase 6
factor C 6
Thy1 6
CYP3A4 6
ribonucleotide reductase 6
ribonucleotide reductase 6
elastase 6
soluble epoxide hydrolase 5
malate dehydrogenase 5
triphosphatase 5
isocitrate dehydrogenase 5
chaperonin 5
hexokinase 5
ribonuclease 5
caspase-4 5
pyruvate kinase 5
HCS 5
more...
Compound
MEK 11589
DNA 1440
Dec 1313
tyrosine 1187
calcium 690
oxygen 685
serine 603
threonine 575
acetate 467
cAMP 461
MAP 437
Clin 367
glucose 343
ATP 327
TNF 250
nitric oxide 241
sodium 240
GTP 201
MTT 191
MDA 190
phosphate 173
methionine 169
Insulin 165
NH2 161
cysteine 156
hydrogen 156
alanine 154
glutamate 148
water 147
PMA 137
PMA 136
AMP 136
N-acetylcysteine 118
retinoic acid 117
leucine 114
H2O2 112
THP 109
THP 109
lysine 103
arginine 99
Ang II 95
Wortmannin 84
GSH 83
GSH 83
cGMP 80
PGE 75
boron 74
zinc 73
salt 68
COS 68
Phe 67
Asp 67
iodine 63
Angiotensin II 63
ATF 61
TPA 61
TPA 61
potassium 59
Cardiol 59
BCR 58
ethanol 57
ICI 57
glycerol 56
ADP 55
bromide 54
ABL 53
proline 53
NMDA 52
LY 294002 51
Rapamycin 51
5-HT 49
sulfate 46
ADP 45
ADP 45
nitrogen 44
pyrimidine 43
urea 42
pyrimidine 42
galactose 41
Tyrosine 41
Phosphatidylinositol 40
dUTP 40
PGE2 40
Genistein 38
Thrombin 34
glutamine 34
aldosterone 34
copper 34
iron 33
ACS 33
NAD 33
ACS 33
GF 109203X 32
SDS 32
GDP 32
ASA 32
Gly 31
DDP 31
AMPA 31
vitamin D 31
glutamic acid 31
Neuronal 31
His 30
UTP 30
Curcumin 29
salicylic acid 28
cadmium 28
ADP-ribose 28
Resveratrol 28
DMSO 26
Estrogen 25
Panam 25
Phorbol 25
Estrogen 24
PEG 24
PLA 24
NAD 24
pyrrolidine 24
GAP 23
Vimentin 23
phosphoserine 23
noradrenaline 22
GABA 22
nicotinamide 22
MPP 22
prostacyclin 22
caffeine 22
MPP 22
Serine 22
FK506 22
CAT 21
Thyroid 21
CAT 21
4-chlorophenyl 21
Adriamycin 21
Forskolin 21
pyrrolidine 21
Phorbol 12-myristate 13-acetate 21
4-chlorophenyl 21
CAT 21
uridine 21
GABA 20
acetone 20
kaempferol 20
Melatonin 20
Cycloheximide 20
Cbl 19
Glutamate 19
SCC 19
Pac 18
MIA 18
1H-imidazole 18
creatinine 18
acetic acid 17
Estradiol 17
aspartic acid 17
aspartic acid 17
Ouabain 17
PGJ2 17
NADPH 17
more...