Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.12.2 (
MEK
)
18,161
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
FBXO25
mediates degradation of ELK-1 and thus inhibits transcriptional activation of immediate early genes (iEG). Here we show that
FBXO25
regulates yet another node of this signaling pathway, by decreasing MAPK/ERK activity. We show that induction of
FBXO25
reduced ERK1/2 phosphorylation independently of
MEK1
/2. Accordingly, in HAP1
FBXO25
knockout cells (
FBXO25
KO
), we observed that upon PMA treatment ERK1/2 was more active than in parental cells. An increase in cell proliferation under receptor mediated activation of the ERK signaling pathway in
FBXO25
KO
cells was also observed. Taken together we show that
FBXO25
functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.
...
PMID:FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation. 2838 97
