Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: EC:2.7.12.2 (
MEK
)
18,161
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study we report the activation of c-Jun N-terminal kinase (JNK) in human K562 erythroleukemia cells undergoing hemin-mediated erythroid differentiation, which occurs concomitantly with activation of
heat shock factor 2
(
HSF2
) and leads to a simultaneous in vivo phosphorylation of c-Jun. The activation of JNK occurs through activation of
mitogen-activated protein kinase kinase
(
MKK
) 4 and not by activation of
MKK7
or inhibition of JNK-directed phosphatases. We have previously shown that overexpression of the
HSF2
-beta isoform inhibits the activation of
HSF2
upon hemin-induced erythroid differentiation. Here we demonstrate that
HSF2
-beta overexpression blocks the hemin-induced activation of the
MKK4
-JNK pathway, suggesting an erythroid lineage-specific JNK activation likely to be regulated by
HSF2
.
...
PMID:Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform. 1155 63
