Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.12.2 (
MEK
)
18,161
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BRAF and
MEK
inhibitor combination therapy is the standard treatment for patients with BRAF V600E mutant metastatic melanoma.
Neutrophilic panniculitis
is a known rare complication of BRAF inhibitor therapy and can act as a potential mimic of melanoma metastases on
18
F-FDG PET/CT. In this case series, we present three cases of BRAF inhibitor-induced panniculitis in patients being treated for BRAF-mutant metastatic melanoma and emphasize the use of ultrasound to differentiate between panniculitis lesions, which are typically ill-defined echogenic masses and subcutaneous soft tissue melanoma metastases, which present as hypoechoic vascular masses.
...
PMID:BRAF inhibitor-induced panniculitis in patients treated for stage IV metastatic melanoma: a case series. 3316 13
