Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.12.2 (
MEK
)
18,161
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
PTPRS
is the most commonly mutated receptor tyrosine phosphatase in colorectal cancer (CRC).
PTPRS
has been shown to directly affect ERK and regulate its activation and nuclear localization. Here we identify that
PTPRS
may play a significant role in developing adaptive resistance to
MEK
/ERK inhibitors (MEKi/ERKi) through SRC activation. Moreover, we demonstrate a new clinical approach to averting adaptive resistance through the use of the SRC inhibitor, dasatinib. Our data suggest the potential for dasatinib to enhance the efficacy of MEKi and ERKi by preventing adaptive resistance pathways operating through SRC.
...
PMID:PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC. 3182 20
