Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.12.2 (
MEK
)
18,161
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify
MAST1
as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of
MEK1
and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.
...
PMID:Pulling a MAST1 on Cisplatin Resistance. 3003 91
