Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.12.2 (
MEK
)
18,161
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Publicly available microarray data suggests that the expression of
FAM83D
(Family with sequence similarity 83, member D) is elevated in a wide variety of tumor types, including hepatocellular carcinoma (HCC). However, its role in the pathogenesis of HCC has not been elucidated. Here, we showed that
FAM83D
was frequently up-regulated in HCC samples. Forced
FAM83D
expression in HCC cell lines significantly promoted their proliferation and colony formation while
FAM83D
knockdown resulted in the opposite effects. Mechanistic analyses indicated that
FAM83D
was able to activate the
MEK
/ERK signaling pathway and promote the entry into S phase of cell cycle progression. Taken together, these results demonstrate that
FAM83D
is a novel oncogene in HCC development and may constitute a potential therapeutic target in HCC.
...
PMID:FAM83D activates the MEK/ERK signaling pathway and promotes cell proliferation in hepatocellular carcinoma. 2564 92
