Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.8 (
FAST
)
758
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The replicate lines of selectively bred
FAST
and SLOW mice differ in locomotor response to 2 g/kg ethanol (EtOH).
FAST
mice show enhanced locomotion; SLOW mice exhibit no change or locomotor depression. Little is known about the responses of
FAST
and SLOW mice to EtOH during development. We assessed the locomotor responses of
FAST
and SLOW mice at postnatal days (P) 10, 15, 30, and 60. A genetically correlated response, EtOH-induced hypothermia, was also investigated. Although all animals demonstrated their respective selection phenotypes in adulthood, developing
FAST
mice exhibited ethanol stimulation by
P15
(replicate 1) or P30 (replicate 2). At these ages, responses of
FAST
mice differed from those of SLOW. The stimulant response in
FAST
mice was adult-like at P30. EtOH-induced hypothermia was seen in SLOW mice by
P15
. These data suggest that sensitivity to the locomotor stimulant effects of EtOH changes during postnatal development, and may mirror developmental profiles for certain neurotransmitter systems.
...
PMID:Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice. 997 2
