Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.11.8 (FAST)
 758 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of two new quinolones, ofloxacin and ciprofloxacin and nalidixic acid on serum theophylline level in 17 asthma patients treated with methylxanthines was evaluated. Each quinolone was administered one tablet twice daily to all patients for three days. Blood samples were taken before quinolone administration and 1 h, 3h and 5 h after taking the drug on the first day. Last sample was taken 5 h after quinolone administration on the third day of therapy. The serum theophylline concentration was determined by 3 M Theo FAST test. It was found that in the patients treated with ciprofloxacin serum theophylline level in all samples was significantly higher as compared with the control sample. In the patients receiving ofloxacin the theophylline level only 1 h after receiving the drug the increase was statistical significant. Nalidixic acid had no influence on serum theophylline concentration. As these studies show, the new quinolones should be applied with great caution in patients treated with high doses of methylxanthines or in patients with decreased methylxanthines clearance. In patients with chronic obturative diseases and pulmonary infections the safer drug would appear to be ofloxacin.
Pneumonol Alergol Pol 1992
PMID:[Effect of ofloxacin, ciprofloxacin and nalidixic acid on serum theophylline level in patients treated with methylxanthine preparations]. 129 Sep 77

In 25 subjects with pollinosis the following parameters were assessed three times annually (early spring, pollen seasons, autumn): serum IgE levels and allergen specific IgE (asIgE), T lymphocyte subpopulation in peripheral blood. In selected patients allergen specific IgG-4 levels were calculated. All serum parameters were assessed using the FAST enzymatic methods (3M Diagnostic Systems). Lymphocyte subpopulations were assessed using the monoclonal antibodies (Ortho Diagnostic System). During the pollen seasons a statistically significant increase of serum IgE, asIgE and T suppressor cells was found. The CD4/CD8 ratio during this period was decreased, caused by stable level of T helper cells. In the 4 patients the levels of asIgG-4 did not change although the initial levels were elevated.
Pneumonol Alergol Pol 1991
PMID:[Seasonal changes in various immunological parameters in patients with hay fever]. 184 5

The study involved 117 adults and 535 children with atopic dermatitis. Immunoglobulins E against D. pteronyssinus--main allergen of the home dust--were assayed with RAST technique in children and FAST technique in adult patients. It was found that the blood serum IgE levels increase with patients' age and is the highest in patients with coexisting allergic respiratory diseases (difference statistically significant). RAST precision was compared with that of "prick" skin tests in the detection of allergy to home dust mites. Desensitization of 15 patients with home mite allergen produced satisfactory effects.
Pol Tyg Lek
PMID:[Sensitivity to the primary house dust allergen--dermatophagoides pteronyssinus--in patients with atopic dermatitis]. 209 37

The study compares results of skin test and assessments of venom specific IgE levels (FAST) in patients with Hymenoptera sting allergic reactions. Results of the two diagnostic methods show considerable correlation. Positive correlation occurred in 90% of the patients (92.4% bee venom sensitive allergic patients and 80% wasp venom sensitive patients). Negative correlation occurred in 2% of the patients. In the remaining 8% of the group the results did not correlate. Basophil histamine release test was performed in 13 patients with allergic reactions after stinging. 77% of the basophil histamine release test results showed positive correlation with the other two tests. No correlation was found between the size skin test, the class of the FAST test, and the result of basophil histamine release test. No relationship was found either, between results of the described test and the severity of sting reaction classified to Mueller scale.
Pneumonol Alergol Pol 1993
PMID:[Evaluation of diagnostic value of skin test, venom specific antibodies against EgE and basophil histamine release test in hymenoptera allergy]. 769 38

The study comprised of 50 patients with the diagnosis of pollinosis based on characteristic history data, positive results of skin test and positive IgE FAST test with grass pollen allergens. 20 ml of blood was taken from all patients and total E rosette test was carried. Antihistamine was added to rosette test in the concentration of 10(-3) mg/ml in the following doses: 0.1 ml, 0.2 ml, 0.3 ml. Histamine caused stat. sig. (P < 0.001) decrease in the percentage of lymphocytes forming E rosettes. We think that lymphocyte may be injured by histamine under exposition to grass pollens.
Pneumonol Alergol Pol 1994
PMID:[Effect of histamine on behavior of the rosette test in patients with pollinosis]. 795 Oct 80

Described are two scales for the diagnosis of dementia of the Alzheimer type and for identifying its following stages solely on the basis of social functioning and on daily activity level of the patient. The authors of the scale, Resiberg et al. based their findings on the conclusion that dementia of the Alzheimer type is a rare clinical syndrome with a characteristic onset and development which are identical in over 90% of patients. The GDS (Global Deterioration Scale) separates the course of dementia into 6 stages. The FAST (Functional Assessment Scale) separates deterioration into 16 stages. Both scales, especially allow for the systematic tracking of course of the uncomplicated Alzheimer's case. They also show the appearance of any additional somatic and psychopathological factors which cause the state of the patient to appear worst than could result from the current stage the patient is in. They ease the differentiation between dementia of the Alzheimer type and dementia of other aetiology. Apart from these scales, especially the FAST, allow to the estimation with significant accuracy how long the current stage, as well as the whole illness will last in a given patient. Similarly, predictions may be made as to the time and in what order particular life functions will be diminishing in specific patients until the terminal state.
Psychiatr Pol
PMID:[The Global Deterioration Scale (GDS) and Functional Assessment Staging (FAST) in the diagnosis of Alzheimer type dementia]. 837 66

In 14 occupationally active bee-keepers, who tolerated stinging well, two diagnostic tests have been performed: 1. skin test at the venom concentration of 10(-3) g/l, 2. both total and venom specific IgE and IgG4 assessments. The study group consisted of 13 male and 1 female aged 34-56 (mean age 44.3). 7 out of 14 bee-keepers (50%) had positive skin tests; mean size being mean = 3.57 +/- 4.07 mm. None of the subjects showed increased total IgE levels, but 71.4% showed bee venom specific IgE (mean mean 1.64 +/- 1.34 FAST). Specific bee venom IgG4 occurred in 13 out 14 individuals (92.8%). Their average serum level was mean 21.74 +/- 17.16 IU/ml.
Pneumonol Alergol Pol 1993
PMID:[Skin tests, total IgE and venom specific IgE and IgG4 in serum of bee-keepers]. 840 38

The aim was to study the value of the CAP system (Pharmacia) in comparison with the FAST method (Bio Whittaker) in determination of total IgE, specific IgE and IgG4 during specific immunotherapy (sIT). The studies were carried out on a group of 67 patients with pollinosis treated with various pollen allergen extracts. The immunological studies were performed before and after several courses of sIT. A higher reproducibility and sensitivity of the CAP System was shown. The values of specific IgE were somewhat higher on using the CAP system than using the FAST method. The CAP system seems to be of great value in diagnostics and monitoring sIT, especially in birch pollen allergy.
Pneumonol Alergol Pol 1995
PMID:[CAP system methods versus FAST methods in immunologic monitoring of specific immunotherapy in pollen allergy]. 864 Jan 48

We examined 83 infants suffering from spastic bronchitis and cow milk protein allergy and analyzed the diagnostic value of two allergic tests (Mancini, FAST) commonly used for measuring total IgE (t-IgE) level in serum. The aim of the study was to establish the sensitivity of these two methods. Our statistical analysis proved FAST test to be more sensitive than Mancini one (p < 0.01).
Pneumonol Alergol Pol 1996
PMID:[Diagnostic value of immunoglobulin E in serum of infants with spastic bronchitis and cow milk protein allergy depending on the method of examination]. 875 62

The possibility of forecasting of atopic dermatitis (AD) course is limited. The aim of the study was to determine the prognostic usefulness of determination of total and specific IgE concentrations and the results of immediate skin tests in AD patients. The study included 480 adult patients with AD. Immediate skin tests with extracts of 18 aeroallergens and 10 food allergens were performed by PRICK method. Total IgE concentration and concentration of specific IgE (sIgE) against 13 aeroallergens and 12 food allergens were determined by the FAST method. For the assessment of the degree of pathologic process intensity the occurrence was determined of selected AD features according to Hanifin and Rajka exerting direct effect on the severity of the disease, urticaria, extensive cutaneous lesions and remission of the disease. The results were subjected to statistical analysis. In patients in whom total IgE concentration was significantly increased and/or hypersensitivity was found to aeroallergens, coexistence of atopic diseases of the airways, ectodermal defect, urticaria and extensive skin lesions was more frequently observed. Extensive skin lesions were also more frequent in patients with hypersensitivity to food allergens. The studies performed demonstrated that the diagnostic tests discussed are useful for prognostication of AD course. The presence of SIgE, positive results of immediate skin tests and high total IgE concentration prognosticate a more severe course of the disease.
Pol Merkur Lekarski 2004 Feb
PMID:[Total and specific IgE and immediate skin tests in the prognosis of atopic dermatitis]. 1517 98


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