Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.11.8 (FAST)
 758 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of 24 hours of food deprivation on the subjective response to 10 mg oral d-amphetamine were studied in 12 healthy normal volunteers. A within-subjects design was used in which subjects ingested amphetamine and placebo capsules in both a fed and a fasting state. Each of the four experimental conditions-FED/DRUG, FED/PLACEBO, FAST/DRUG, FAST/PLACEBO--was enacted twice according to a randomized block design. Three subjective effects questionnaires, the Profile of Mood States, the Addiction Research Center Inventory, and the Visual Analogue Scale, were completed prior to and 1, 3 and 6 hr after the early morning capsule ingestion. Typical elevations in such subjective effects as elation and vigor were obtained after amphetamine ingestion in both feeding conditions, but fasting neither potentiated nor attenuated the drug response. Subjects at the end of the session, however, were more likely in the FAST/DRUG condition than in the FED/DRUG condition to label the capsule they had ingested at the beginning of the session as a stimulant.
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PMID:Effects of food deprivation on subjective responses to d-amphetamine in humans. 262 32

"Diffusion-weighted"MRI in the normal human brain and in a patient with a cerebral metastasis is demonstrated. The method employed was a modified CE-FAST sequence with imaging times of only 6-10 s using a conventional 1.5-T whole-body MRI system (Siemens Magnetom). As with previous phantom and animal studies, the use of strong gradients together with macroscopic motions in vivo causes unavoidable artifacts in diffusion-weighted images of the human brain. While these artifacts are shown to be considerably reduced by averaging of 8-16 images, the resulting diffusion contrast is compromised by unknown signal losses due to motion.
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PMID:MRI of "diffusion" in the human brain: new results using a modified CE-FAST sequence. 271 8

The specific IgE levels for 11 allergens were compared in 288 patients by means of the Phadebas RAST and the IgE-FAST. Agreement (less than 1 class difference) was observed in 78.7% of the cases. The best agreement was observed with Phleum pratense, egg white, corn, Betula verrucosa and cat epithelium. In 91 cases the results were retrospectively compared with clinical data and skin tests. When RAST and FAST differed (n = 31) 93.5% and 51.6% of the respective results were in agreement with the skin test. When RAST and FAST were similar (n = 60) 81.7% and 80.0% of the respective results were in agreement with the skin test. It was concluded that the RAST and the FAST gave similar results in most cases but that the RAST was more sensitive than the FAST, especially when the results obtained with both methods differed.
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PMID:Comparative evaluation of RAST and FAST for 11 allergens in 288 patients. 271 56

We examined two ELISA methods for measuring antibodies to Streptococcus pneumoniae using tyraminated S. pneumoniae polysaccharide types 3, 7N, 9F and 14 as antigens. The ELISA has the usual format with a relatively long incubation time whereas the FAST-ELISA has a short incubation time and employs a different solid-phase configuration. We showed that both techniques can be used for the detection of antibodies to S. pneumoniae polysaccharides. Although its analytical sensitivity is about 1/10 of that of the ELISA, the FAST-ELISA is sufficiently sensitive to distinguish protective from unprotective levels of antibodies to the types of S. pneumoniae studied. In studying pre- and post-immunization response, we showed that type 3 is the most immunogenic.
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PMID:Quantitation of IgG antibody to Streptococcus pneumoniae vaccine by ELISA and FAST-ELISA using tyraminated antigen. 273 10

To compare respiratory workloads, inspiratory efforts were evaluated in 11 children anesthetized with halothane while breathing through a pediatric circle or a Jackson-Rees system. All underwent urogenital surgery and received caudal analgesia after tracheal intubation. Anesthesia was maintained with O2/air at an end-tidal halothane concentration of 0.8%. A pediatric circle system at a fresh gas flow (FGF) of 0.5 and 1.5 x min ventilation (VE) (C0.5 and C1.5, respectively) and a Jackson-Rees system at FGF of 1.5 and 3.0 x VE (JR1.5 and JR3.0, respectively) were used in each patient in a random order. Tidal volume (VT), mean inspiratory flow (VT divided by the duration of inspiration TI, VT/TI), and the initial fast slopes of the airway occlusion pressure phase (delta P degrees/delta t FAST) were significantly lower (P less than 0.05) with the Jackson-Rees than with the circle system, indicating greater impedence to spontaneous breathing with the Jackson-Rees system. The Jackson-Rees system also required a greater peak transpulmonary pressure (PtpMAXe) than did the circle system to achieve the same peak expiratory flows (VMAXe, P less than 0.05), again suggesting an increased resistance with the Jackson-Rees system. These results are most likely explained by the difference in elastic loads (two to three times more with the Jackson-Rees systems) between the two systems. The pediatric circle system appears to be a reliable alternative to the Jackson-Rees system.
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PMID:Assessment of spontaneous ventilation in anesthetized children with use of a pediatric circle or a Jackson-Rees system. 278 48

A case of allergic bronchopulmonary aspergillosis is presented. The patient had corticosteroid-dependent asthma, recurrent pulmonary infiltrates clearing with oral prednisone bursts, positive dual (immediate and late) skin test (prick and intradermal) reactivity to Aspergillus fumigatus, 11% blood eosinophilia, elevated total serum IgE, positive precipitating antibody against Aspergillus fumigatus, and elevated specific serum antibodies to Aspergillus fumigatus (positive IgE and IgG antibody indices, and elevated IgE levels by both RAST and FAST). To our knowledge this is the first immunologically documented case of allergic bronchopulmonary aspergillosis in Brazil. Future survey studies are required.
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PMID:Allergic bronchopulmonary aspergillosis does exist in Brazil. 280 69

The electrophoresis of serum isoenzymes in cancer pathology at different stages has enabled us to recognise for LDH4 and LDH5, characteristics of sensitivity in all stages, with positivity greater than 60% in the advanced and multiply metastasized stages or with interference from other pathologies; to reveal portions pathologically heavy like FAST (46%); to reveal atypical bands (BB and MIT), as well as the values for normal or really low enzymatic activity. Through the elevated sensitivity and the high percentage of positivity, the isoenzymes LDH4 and LDH5 can be considered tumour markers and superior in validity to the conventional markers.
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PMID:[Isoenzymes of lactate dehydrogenase, alkaline phosphatase, creatine kinase. Possible use as tumor markers]. 280 40

A flexible package designed to study protein structure is described. The package is devoted to the analysis of protein sequences by drawing structural profiles of specific structure-related amino acid parameters. An Aminoacidic Parameters Data Bank (CHAMP) containing 32 different series of physico-chemical parameters of amino acids is available. Sequences can be loaded from any ASCII format data bank or from keyboard. The program possesses a routine which enables easy updating of the protein data bank and CHAMP Data Bank. FAST reads statistical correlations between two plots in order to identify structural similarities. Plots can be printed, saved or used for correlation, comparison or graph overlap by using common spreadsheets (e.g. Lotus 123). Plots can be smoothed by a running mean or a running median. The program also has a special feature--a global flexibility analysis of proteins. The package runs on IBM or compatibles and requires DOS 3.0 or later.
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PMID:FAST (Flexible Analysis by Software Tool) and CHAMP (CHemico-physical AMinoacidic Parameter data bank): a new tool to investigate protein structure. 281 15

Specific IgE antibodies to common inhalant allergen were measured in ten healthy and 82 rhinitic or asthmatic subjects by both FAST and RAST. Significant correlations were found between FAST and RAST results for grass, Parietaria, Dermatophagoides, and cat dandruff. For these allergens the agreement between FAST and prick test was similar to that between RAST and prick test. In contrast to RAST and/or prick test, for Tag alder and birch allergens, the FAST apparently gave false negative results. In conclusion, FAST seems to be a promising technique for in vitro measurement of specific IgE against most inhalant allergens but some improvement is still necessary in standardizing allergens for this assay.
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PMID:The fluoroallergosorbent test: a comparison with rast and skin test in respiratory allergy. 305 25

We have studied the IgE content of different lots of commercial intravenous IgG preparations used in our day hospital as replacement therapy for patients with agammaglobulinemia. Two enzymatic methods were used: Phadezym and FAST. The average amounts of IgE detected in Endobulin and Sandoglobulin lots were very high with respect to serum values in the general population. In some lots we found low titers of specific IgE (RAST class 1) to house dust mite, rye grass and cow's milk. We also found in most preparations the presence of IgG anti-IgE which are usually present in sera from atopic patients. Despite a low post-infusion increase of serum IgE and the absence of sensitization or adverse reactions observed, a careful selection of donors with normal IgE levels may need to be recommended to manufacturers in the future.
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PMID:A study of IgE in immunoglobulin preparations for intravenous administration. I. IgE in intravenous IgG. 309 90


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