Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.11.8 (FAST)
 758 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 79 males aged 19-21 years with acute and chronic urticaria living under similar conditions the levels were determined of total IgE (FIST test) and specific IgE (FAST test) against the most frequent inhaled and food allergens. Statistically significant rise of the mean value of total IgE was noted in both groups of patients. In acute urticaria increased concentration of specific IgE against inhaled allergens was significantly more common.
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PMID:[IgE levels and hypersensitivity to certain inhaled and food allergens in acute and chronic urticaria]. 228 42

In 67 patients with allergic dermatitis the levels of total IgE and specific IgEs against 14 allergens were determined by the FAST-test method. The most frequently raised levels of specific IgE were found against the following allergens: dog epidermis, timothy grass, Candida albicans, beef. Test by FAST method confirmed increased levels of total and specific IgEs in most cases of atopic dermatitis.
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PMID:[The usefulness of determining specific immunoglobulins E in atopic dermatitis in light of personal investigations]. 228 43

The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positive RAST to a food allergen). The within-run variation coefficient of class 0-2 sera was 9% for the Phadebas RAST, and higher than 20% for the Phadezym and the FAST. It was in order of 8.7%, 9.4% and of 17.6% respectively for Phadebas RAST, Phadezym and FAST when estimated with class 3-4 sera. The specificity was higher than 95% for the three techniques. The sensitivity was 75% for Phadebas and 43% for Phadezym and FAST. The FAST test is much less sensitive with allergens of vegetal origin than those of animal origin (P less than 0.01). This work indicates the high percentage of false negative results of immunoenzymatic techniques when food extracts are tested. This could be explained either by an enzyme-substrate reaction or by a non-specific inhibition of the enzyme linked to the anti-IgE IgG.
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PMID:Comparative evaluation between two immunoenzymatic techniques (FAST and Phadezym) and the Phadebas RAST in food allergy. 231 20

According to results available to date, skin tests are of limited value in determining the risk of anaphylactic shock. By identifying specific IgE antibodies, e.g. via the Chymo-FAST test or the corresponding RAST, the risk of anaphylactic shock of 0.2%-1% in the total group of patients can be reduced to 0.05% in patients in whom the test was negative, whereas in test-positive patients the risk is above 60%. Previous intolerance reactions among the remaining 0.05% are probably due to a non-testable pseudoallergic reaction, just like the 6% mild late reactions after the injection. For the remaining risk of 0.05% in IgE-negative patients drug prophylaxis with antihistamines or if necessary even steroids will continue to be mandatory. Examination of histamine release from leucocytes, which can be conducted in very few centres only, may possibly be able to clarify in future to what extent reinjection is permissible if a disc on a different level is affected, besides other scientific problems.
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PMID:[Immunologic methods of study for evaluating the risk of anaphylactic reactions in intradisk chymopapain injections]. 243 31

Seventy-two consecutive adult asthmatic patients seen in the Pulmonary Clinic at Rhode Island Hospital were tested for atopy by prick test with 14 standard aeroallergens and by in vitro total and specific IgE determinations (FAST). A total of 58.3 percent of patients were found to be atopic by these tests. There was a significant difference between the mean total serum IgE in atopic and nonatopic asthma and in atopic asthma and control subjects. The age onset was lower in atopic asthmatic patients, and they were more likely to have a history of chronic rhinitis than nonatopic subjects. Family history of rhinitis or asthma and severity of asthma was not different between the two groups. Since our outpatient facility has a large allergy clinic in proximity to the pulmonary clinic, which was the source of our patient population, this investigation has a negative bias toward allergy. Nevertheless, this study reveals that atopy is common in adult asthmatic patients, and a battery of allergy tests (skin tests or in vitro tests) together with total serum IgE is able to differentiate between atopic and nonatopic asthma.
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PMID:High frequency of atopic asthma in a pulmonary clinic population. 258 23

The specific IgE levels for 11 allergens were compared in 288 patients by means of the Phadebas RAST and the IgE-FAST. Agreement (less than 1 class difference) was observed in 78.7% of the cases. The best agreement was observed with Phleum pratense, egg white, corn, Betula verrucosa and cat epithelium. In 91 cases the results were retrospectively compared with clinical data and skin tests. When RAST and FAST differed (n = 31) 93.5% and 51.6% of the respective results were in agreement with the skin test. When RAST and FAST were similar (n = 60) 81.7% and 80.0% of the respective results were in agreement with the skin test. It was concluded that the RAST and the FAST gave similar results in most cases but that the RAST was more sensitive than the FAST, especially when the results obtained with both methods differed.
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PMID:Comparative evaluation of RAST and FAST for 11 allergens in 288 patients. 271 56

A case of allergic bronchopulmonary aspergillosis is presented. The patient had corticosteroid-dependent asthma, recurrent pulmonary infiltrates clearing with oral prednisone bursts, positive dual (immediate and late) skin test (prick and intradermal) reactivity to Aspergillus fumigatus, 11% blood eosinophilia, elevated total serum IgE, positive precipitating antibody against Aspergillus fumigatus, and elevated specific serum antibodies to Aspergillus fumigatus (positive IgE and IgG antibody indices, and elevated IgE levels by both RAST and FAST). To our knowledge this is the first immunologically documented case of allergic bronchopulmonary aspergillosis in Brazil. Future survey studies are required.
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PMID:Allergic bronchopulmonary aspergillosis does exist in Brazil. 280 69

Specific IgE antibodies to common inhalant allergen were measured in ten healthy and 82 rhinitic or asthmatic subjects by both FAST and RAST. Significant correlations were found between FAST and RAST results for grass, Parietaria, Dermatophagoides, and cat dandruff. For these allergens the agreement between FAST and prick test was similar to that between RAST and prick test. In contrast to RAST and/or prick test, for Tag alder and birch allergens, the FAST apparently gave false negative results. In conclusion, FAST seems to be a promising technique for in vitro measurement of specific IgE against most inhalant allergens but some improvement is still necessary in standardizing allergens for this assay.
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PMID:The fluoroallergosorbent test: a comparison with rast and skin test in respiratory allergy. 305 25

We have studied the IgE content of different lots of commercial intravenous IgG preparations used in our day hospital as replacement therapy for patients with agammaglobulinemia. Two enzymatic methods were used: Phadezym and FAST. The average amounts of IgE detected in Endobulin and Sandoglobulin lots were very high with respect to serum values in the general population. In some lots we found low titers of specific IgE (RAST class 1) to house dust mite, rye grass and cow's milk. We also found in most preparations the presence of IgG anti-IgE which are usually present in sera from atopic patients. Despite a low post-infusion increase of serum IgE and the absence of sensitization or adverse reactions observed, a careful selection of donors with normal IgE levels may need to be recommended to manufacturers in the future.
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PMID:A study of IgE in immunoglobulin preparations for intravenous administration. I. IgE in intravenous IgG. 309 90

A small panel of local individual regional allergens (miniscreen) tested in vitro by FAST was developed to evaluate the utility of screening for IgE-mediated airborne allergy. Using this miniscreen in a population of 125 subjects referred for evaluation of possible allergic respiratory disorders would have increased the accuracy of referral from 74.4% to 95.6%. The miniscreen correctly classified 119 of the 125 subjects. The miniscreen appears to be a potentially useful tool for the allergy specialist in the present medical climate.
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PMID:Regional individual allergen based miniscreen to predict IgE-mediated airborne allergy. 317 66


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