Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.11.8 (FAST)
 758 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six subjects (4 female, 2 male), aged from 16 to 25 years, presented with allergic rhinitis to Dermatophagoides mites and received SIT by the sub-cutaneous route with delayed-release alpha fraction Bayropharm at the standard doses. Diagnosis was based on clinical history, skin tests and measurement of specific IgE at 0, 3, 9, and 12 months, by the fluoro-enzymatic technique (FAST). For comparison, in a reference group (n = 20) the IgE varied between 0.32 and 0.11 IU/ml for D1 and 0.31 to 0.09 IU/ml for D2. The eight patients had specific IgE titres of D1 = 0.96, D2 = 0.99. For these authors, the FAST technique used for the measurement of specific IgE, although less sensitive than the RIA technique of RAST, gives a good evaluation of SIT.
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PMID:IgE modification of the specific antidermatophagoides during the first year of specific immunotherapy (SIT). 128 44

Not much data is available on the reliability diagnosis of IgE FAST, in comparison with other "in vitro" and "in vivo" techniques. The motive of this study was to evaluate FAST sensitivity in patients with rhinitic allergies, comparing it with RAST and the prick test. Thirty-four patients, monosensitized in 11 cases for pollen, in 16 for mites and in 7 for moulds were studied. Ten patients with negative nasal provocation were used for the control group. In a total of 133 sera, there was class concordance between FAST and prick test in 59.39% of the cases, with a r = +0.41 and p less than 0.001 correlation coefficient. Corcordance of FAST and RAST for a total of 135 sera was 65.18%. Concordance in those who had nasal positive provocation was 87.65% for FAST, 75.04% for RAST and 92.85% for prick. From our experience with FAST, in patients with allergic rhinitis for the pneumoallergens evaluated, we conclude that this test constitutes an alternative "in vitro" diagnosis in the cases indicated. We found that its advantages were its low cost in the way of human and economical resources, its greater reliability in comparison with RAST, its simple administration and it being harmiess.
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PMID:Reliability diagnosis of FAST in allergic rhinitis. Correlation with RAST, nasal provocation and prick test. 328 32

The purpose of this study is to assess the frequency of clinical sensitivity to Eastern White Pine Pollen, 100 consecutive patients with the seasonal (SAR) or perennial (PAR) allergic rhinitis seen in the allergy clinic were prick tested with pine pollen extract, 8-tree mixture, histamine and negative control. Positive skin test (ST) was defined as a wheal greater than 3 mm larger than control, plus flare. Patients with a positive ST were then asked to stop antihistamine and other related drug, for 48 hours and challenged in a double blind manner with increasing concentrations of intranasal pine extract, starting at 1/100,000 w/v, followed by 1/10,000, 1/1000 and 1/100 at 20 minute intervals. The dose given was 0.15 cc by metered dose spray; one nostril received pine extract diluted in saline, the other received plain saline,. Rhinometric measurements were obtained before and 20 minutes after each challenge. Positive challenges were defined as 1) subjective feeling of increased stuffiness or rhinorrhea and 2) greater than 25% decrease in nasal airflow. Six patients (6%) had a positive ST to pine pollen extract and two of four patients with positive pine skin test had a positive FAST. Four of these were challenged intranasally, 2 had a positive challenge. All six patients had a history of spring SAR and positive reaction to 8-tree mix. Out of the 100 patients skin tested, 61 had spring SAR; therefore, the incidence of positive ST to pine in patients with spring SAR was 6/61 (10%). We conclude that pine pollen can be a cause of spring SAR in the New England area.
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PMID:Eastern pine sensitivity in New England. 341 92

The aim of this study was to determine the allergen skin test positivity and total serum IgE of adult patients in Singapore with clinical features suggestive of allergic rhinitis. The study was carried out prospectively from January to August 1990. All patients had one or more of three symptoms (1) rhinorrhoea or nasal congestion, (2) itching nose or throat and (3) sneezing, as well as pale edematous nasal mucosa. Twenty inhalant allergens (Greers Laboratory, USA) were used for skin prick test (SPT). Serum total IgE was measured using 3M FAST test. Eighty-five consecutive patients, 54 males and 31 females, were studied. Their mean age (SD) was 26.8 (6.1) years. More than half (55.3%) had severe symptoms affecting work. Twenty percent did not have any positive skin reaction compared with 44.9% of age-matched healthy controls; 62.4% had 2 or more positive reactions compared to only 37.2% of controls. These differences were statistically significant (p < 0.002). The two most commonly, positive allergens were Dermatophagoides farinae (76.5%) and house dust (61.2%). No significant difference was found in the skin test positivity between males and females. Forty-three patients also had serum total IgE measurement and their geometric mean IgE was 240 IU/I which was significantly higher than the geometric mean IgE of healthy controls (88 IU/I, P = 0.0005).
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PMID:Allergen skin test and total IgE in adults with rhinitis in Singapore. 898 Jul 94

Two groups of 20 patients having an allergic rhinitis due to the pollen of Parietaria judaica were studied, one received a treatment of specific hyposensitization, the other one a placebo. All of them were monosensitized. The study was carried out using double blind methodology and was conducted for one year. Each case was assessed by clinical tests: case history, skin tests, score symptoms, drug consumption, nasal provocation test and by in vitro tests (FAST technique): total and specific IgGE, specific IgG4. The clinical tests revealed a statistically significant improvement in the treated group as compared to those receiving the placebo. We found a statistically significant regular and important increase of specific IgG4 values in the treated group. In this case, the specific IgG4 antibodies most likely play a protective role and act as blocking antibodies.
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PMID:Monitoring of specific IgG4 antibodies in respiratory allergy due to the pollen of Parietaria judaica. Evidence for a protective role. 901 May 62