Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.31 (AMP-activated protein kinase)
 13,065 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
AMP-activated protein kinase 7316
AMPK 6226
insulin 2471
mTOR 1962
ATP 1507
Mol 1347
AMP 866
Sep 711
LKB1 683
acetyl-CoA carboxylase 678
adiponectin 647
AKT 559
PGC 534
AICAR 532
PI3K 500
peroxisome proliferator-activated receptor 485
p53 432
LC3 413
MAPK 412
SIRT1 392
leptin 391
p38 391
caspase-3 347
TNF 347
endoplasmic reticulum 337
ROS 308
GLUT4 305
p62 295
ERK 284
fatty acid synthase 282
ACC 281
ULK1 271
cytokine 257
JNK 256
IL-6 243
Adiponectin 241
ERK1 238
Bcl-2 234
protein kinase B 233
IRS-1 218
glucose transporter 212
calmodulin 211
tumor necrosis factor 210
Beclin-1 208
peroxisome proliferator-activated receptor gamma 199
PPAR 196
lipopolysaccharide 183
ADP 174
glucagon 172
threonine 168
sirtuin 1 168
superoxide dismutase 163
Nrf2 161
p21 156
phosphatase 149
NAD 149
serine/threonine kinase 147
S6K1 143
inducible nitric oxide synthase 142
phosphatidylinositol 3-kinase 141
collagen 139
PKA 137
adipokine 134
endothelial nitric oxide synthase 133
ubiquitin 128
gut 127
eNOS 126
glucose transporter 4 123
sterol regulatory element-binding protein 123
epididymal 122
STAT3 120
CaMKII 119
uncoupling protein 1 118
CD36 117
LPS 117
catalase 115
insulin receptor 113
LC3B 111
erythroid 110
FAS 109
ATPase 108
proteasome 108
ghrelin 107
interleukin-6 106
4E-BP1 106
HMG-CoA reductase 105
TSC2 105
p65 103
phosphorylating 103
CaMKK 102
nitric oxide synthase 101
carnitine palmitoyltransferase 100
PKC 100
CREB 99
p38 mitogen-activated protein kinase 99
PARP 99
heme oxygenase-1 97
CPT 97
GSH 97
hormone-sensitive lipase 95
vascular endothelial growth factor 95
histone 95
SREBP-1 93
PKB 93
SREBP-1c 91
catenin 91
lactate dehydrogenase 89
PDB 89
GLUT1 89
citrate synthase 88
ribosomal protein S6 86
STO 86
aspartate aminotransferase 85
cytochrome c 84
GSK 84
FRAP 83
PTEN 83
sirtuin 83
IGF-1 82
UCP2 82
extracellular signal-regulated kinase 82
adipose triglyceride lipase 80
HO-1 80
Leptin 78
reductase 78
AS160 77
glucose-6-phosphatase 76
phosphoinositide 3-kinase 76
glycogen synthase 76
SOD 76
VEGF 75
NLRP3 74
MEK 73
protein phosphatase 73
microtubule-associated protein 72
cyclin D1 72
c-Jun 70
rhabdomyosarcoma 70
ATG5 69
phosphoenolpyruvate carboxykinase 69
alanine aminotransferase 68
angiotensin II 67
NADH 67
insulin-like growth factor 66
TFAM 66
muscle protein 64
neuropeptide Y 62
caspase-9 61
COX-2 61
mitogen-activated protein 60
lipoprotein lipase 59
serine/threonine protein kinase 59
estrogen receptor 59
resistin 58
THP 58
tyrosine kinase 57
TLR4 57
4EBP1 57
p70 56
Ang II 56
more...
Disease
cancer 1860
obesity 1475
diabetes 1310
tumor 1077
type 2 diabetes 927
fatty liver 434
hyperglycemia 353
ischemia 334
metabolic syndrome 306
breast cancer 283
hepatocellular carcinoma 281
tumor growth 264
atherosclerosis 215
Alzheimer's disease 198
tumorigenesis 194
hypertension 181
cardiovascular disease 174
heart failure 155
hyperlipidemia 148
dyslipidemia 142
prostate cancer 136
myocardial ischemia 129
glucose intolerance 126
lung cancer 126
tumor progression 122
stroke 121
colorectal cancer 120
carcinogenesis 113
FAS 111
alcoholic fatty liver 110
Parkinson's disease 105
myocardial infarction 104
GSH 97
carcinoma 96
tuberous sclerosis 92
colon cancer 91
diabetic nephropathy 81
liver disease 80
MCF 80
sepsis 77
sepsis 77
adenocarcinoma 76
neuroblastoma 75
hypoglycemia 74
Nonalcoholic fatty liver 73
cold 72
pancreatic cancer 72
leukemia 70
melanoma 70
hyperinsulinemia 69
ATM 68
non-small cell lung cancer 66
glioma 65
depression 65
cardiomyopathy 64
glioblastoma 62
cerebral ischemia 60
metabolic disorder 57
ovarian cancer 56
cognitive impairment 55
liver cancer 51
gastric cancer 50
diabetic cardiomyopathy 49
NAME 47
type 1 diabetes 44
Blocking 43
muscular atrophy 43
plaque 43
metastases 42
colitis 42
liver fibrosis 42
osteoporosis 42
liver cancer 42
osteoarthritis 42
acute myeloid leukemia 42
squamous cell carcinoma 41
dementia 40
heart disease 39
Peutz-Jeghers syndrome 38
Huntington's disease 38
polycystic ovary syndrome 38
renal cell carcinoma 37
renal disease 36
hyperphagia 35
malnutrition 32
cirrhosis 32
bladder cancer 31
Hepatocellular carcinoma 31
tuberculosis 31
osteosarcoma 31
B-cell lymphoma 30
Brown 30
cervical cancer 30
worms 29
rheumatoid arthritis 28
sickle cell disease 28
HIV 27
hypercholesterolemia 27
hypertrophic cardiomyopathy 25
SCD 25
Mycobacterium 25
asthma 25
coronary artery disease 25
endometrial cancer 24
polycystic kidney 24
lymphoma 24
virus infection 23
infectious diseases 23
NOD 23
chronic liver disease 23
lung carcinoma 23
amyotrophic lateral sclerosis 22
aggressiveness 22
INS 22
myopathy 22
ventricular hypertrophy 22
insulinoma 22
multiple myeloma 21
glioblastoma multiforme 21
acute myocardial infarction 21
Wolff-Parkinson-White syndrome 21
chronic disease 20
inflammatory bowel disease 20
skin cancer 20
Evans 20
proteinuria 19
multiple sclerosis 19
chronic myeloid leukemia 19
Adenovirus 19
brain tumor 19
chronic obstructive pulmonary disease 18
anemia 18
hepatitis 18
diabetic retinopathy 18
vascular disease 18
SDS 17
schizophrenia 17
lactic acidosis 17
gestational diabetes mellitus 17
retinoblastoma 17
acute lymphoblastic leukemia 17
thyroid cancer 17
dilated cardiomyopathy 16
TEM 16
renal cancer 16
macular degeneration 16
renal ischemia 16
arthritis 16
TEM 16
mitochondrial disease 15
glomerulosclerosis 15
lipid disorder 15
EMT 15
memory impairment 15
pulmonary hypertension 15
systemic lupus erythematosus 14
Duchenne muscular dystrophy 14
OPA1 14
encephalomyelitis 14
epilepsy 14
more...
Symptom
starvation 285
fatigue 64
pain 45
exhaustion 35
functional recovery 31
overweight 30
collapse 29
cachexia 27
weakness 20
anesthesia 18
anorexia 16
hunger 14
seizures 14
diarrhea 13
respiratory distress 13
hypothermia 12
hypercapnia 9
memory loss 9
angina 5
splenomegaly 5
hyperoxia 5
menopausal symptoms 4
ataxia 4
acute stress 3
rundown 3
thinning 3
hepatomegaly 3
acute pain 3
low back pain 3
myalgia 3
tremor 3
headache 3
pallor 2
Ill 2
bradykinesia 2
Anoxia 2
chills 2
insomnia 2
Neuropathic pain 2
back pain 2
HSA 2
cough 2
abdominal pain 2
acidity 2
Scratch 1
skin damage 1
incoordination 1
dyspnea 1
Hudson 1
Cushingoid 1
Cushingoid 1
vomiting 1
analgesia 1
stigma 1
spasm 1
stomach cramps 1
decreased appetite 1
shoulder pain 1
bitter taste 1
arthralgia 1
hypotonia 1
syncope 1
dry eye 1
discomfort 1
discomfort 1
muscle rigidity 1
spasticity 1
polydipsia 1
hemoptysis 1
myoclonus 1
nausea 1
agitation 1
Cold intolerance 1
ophthalmoplegia 1
aphagia 1
stomach pain 1
neurological disability 1
Decreased activity 1
POA 1
cyanosis 1
Drug
ROS 308
NADH 67
lysine 54
Cardiovasc 45
Parkin 44
Parkin 44
caffeine 39
Ethanol 33
Glucagon 29
Monit 26
RFP 18
Rosiglitazone 18
Angiotensin II 17
Ginseng 17
Liraglutide 16
MAP 16
citric acid 15
ascorbate 14
Sorafenib 14
Fructose 13
vitamin E 13
EE2 11
Kenyan 11
Simvastatin 10
Emodin 10
3-Methyladenine 10
Emodin 10
Glycyrrhiza 10
CSF 10
Troglitazone 9
EPA 9
Dermatol 9
IL-2 9
Bifidobacterium 8
Ara-A 8
CAM 8
Forskolin 7
Salicylate 7
Lovastatin 7
ALA 7
TAK 7
Orlistat 6
Nephron 6
Leaf 6
Cilostazol 6
Acadesine 6
Itraconazole 6
DM1 5
balanced salt solution 5
-deoxyadenosine 5
GEO 5
AIC 5
Ezetimibe 5
IFN-gamma 5
MRC 5
Pravastatin 5
ROC 5
Arsenic trioxide 5
Nitric Oxide 5
Methylene blue 5
Adriamycin 5
Epigallocatechin 5
Docetaxel 4
Growth hormone 4
lactose 4
Bupivacaine 4
Retinoic acid 4
metformin hydrochloride 4
Growth hormone 4
Gefitinib 4
CoCl2 4
Portal 4
niacin 4
Gel 4
ADM 4
CoCl2 4
Indomethacin 4
Adenosine Monophosphate 4
Adenosine triphosphate 4
MDS 3
Alanine 3
DEX 3
CIA 3
CCL 3
Ginger 3
Donepezil 3
Ouabain 3
Glycerol 3
Heme 3
Ringer's solution 3
FAD 3
Triclosan 3
nitroglycerin 3
PTC 3
ETA 3
uPA 3
Exenatide 3
Rutin 3
Rimonabant 3
Erlotinib 3
Taxol 3
Vitamin K2 3
BH4 3
TAC 3
Artesunate 3
Pemetrexed 3
1-Deoxynojirimycin 2
Cinacalcet 2
AZT 2
HCH 2
Crotonaldehyde 2
Amiloride 2
Cassia seed 2
linolenate 2
ABC 2
PFT 2
Bortezomib 2
CDP 2
TTC 2
PTH 2
R1881 2
ICI 2
Activin 2
Ranolazine 2
AZT 2
Ciglitazone 2
IL-1ra 2
Photofrin 2
p75 2
DHT 2
Kainic acid 2
Pramlintide 2
Amiloride 2
Dasatinib 2
Fidarestat 2
Sesamol 2
Areca 2
Aicar 2
FLP 2
Histamine 2
NovoSeven 2
Rolipram 2
Captopril 2
Valsartan 2
Fidarestat 2
DNase I 2
Luteinizing 2
Imatinib 2
PCB 2
GHRP 2
ATV 2
Alliance 2
Mutagen 2
Myricetin 2
Everolimus 2
Vitamin E 2
CFS 2
Glutathione 2
Etoposide 2
Dihydro 2
more...
Enzyme
AMP-activated protein kinase 13065
AMPK 6254
AMPK 6228
protein kinase 1285
mitogen-activated protein kinase 1050
acetyl-CoA carboxylase 709
ERK 407
caspase-3 243
superoxide dismutase 230
focal adhesion kinase 213
CPT 198
protein kinase C 195
calcineurin 155
phosphatidylinositol 3-kinase 141
alanine aminotransferase 141
aspartate aminotransferase 128
catalase 128
complex I 127
PARP 115
ATPase 114
CaMKII 114
proteasome 109
phosphoenolpyruvate carboxykinase 109
MEK 101
CPT 97
CPT 97
hormone-sensitive lipase 95
lactate dehydrogenase 92
luciferase 92
NO synthase 91
GSK 91
citrate synthase 88
glucose-6-phosphatase 76
phosphoinositide 3-kinase 76
NADPH oxidase 71
AMP-activated kinase 69
phosphoenolpyruvate carboxykinase 68
phosphoenolpyruvate carboxykinase 68
NADPH oxidase 66
PDK1 60
lipoprotein lipase 60
protein phosphatase 2A 59
lipase 57
TOR 54
glutathione peroxidase 52
IKK 50
creatine kinase 48
AST 48
peroxidase 47
STK11 43
caspase-9 43
hexokinase 43
alkaline phosphatase 42
glucokinase 42
pyruvate kinase 41
pyruvate dehydrogenase 41
caspase-1 41
glutathione S-transferase 40
ATP synthase 40
heme oxygenase 38
NOS 38
NQO1 36
phosphorylase 36
renin 35
pyruvate dehydrogenase 33
3-hydroxy-3-methylglutaryl-CoA reductase 33
succinate dehydrogenase 33
pyruvate dehydrogenase 33
phosphofructokinase 32
glyceraldehyde-3-phosphate dehydrogenase 30
phospholipase C 27
phosphodiesterase 27
cytochrome oxidase 26
adenosine kinase 25
eEF2 kinase 25
adenylate cyclase 24
PKG 24
acyl-CoA oxidase 22
aldehyde dehydrogenase 22
3-hydroxy-3-methylglutaryl coenzyme A reductase 22
ACE 22
malonyl-CoA decarboxylase 21
glyceraldehyde-3-phosphate dehydrogenase 21
thrombin 21
caspase-8 21
ACS 21
guanylate cyclase 19
HK2 19
glucose-6-phosphate dehydrogenase 19
aldehyde dehydrogenase 18
aldehyde dehydrogenase 18
glyceraldehyde-3-phosphate dehydrogenase 18
aldehyde dehydrogenase 18
aldehyde dehydrogenase 18
acyl-CoA dehydrogenase 17
MPP 17
glyceraldehyde-3-phosphate dehydrogenase 16
RNA polymerase 16
adenylate kinase 16
reverse transcriptase 16
glyceraldehyde-3-phosphate dehydrogenase 16
APC 15
tyrosine hydroxylase 15
nicotinamide phosphoribosyltransferase 14
cathepsin D 13
MAP 13
O-GlcNAc transferase 13
LPL 12
demethylase 12
cdc2 11
myosin light chain kinase 11
MMP 11
cathepsin B 11
nitrate reductase 10
malate dehydrogenase 10
nitrate reductase 10
glutaminase 10
glutamate dehydrogenase 10
nitrate reductase 10
HSD 10
diacylglycerol acyltransferase 10
glutamate dehydrogenase 10
nitrate reductase 10
phosphorylase kinase 10
pyruvate carboxylase 10
P-glycoprotein 10
trypsin 10
arginase 10
nitrate reductase 10
ECH 10
glutamate dehydrogenase 10
nitrate reductase 10
aldolase 9
MMP-3 9
6-phosphofructo-2-kinase 9
glycerol-3-phosphate dehydrogenase 9
glycerol-3-phosphate dehydrogenase 9
CYP7A1 9
isocitrate dehydrogenase 8
collagenase 8
isocitrate dehydrogenase 8
xanthine oxidase 8
MIP 8
prolyl hydroxylase 8
cystathionine beta-synthase 8
fumarase 8
MEKK1 7
peroxiredoxin 7
PDH 7
acetylcholinesterase 7
aldose reductase 7
BAT 6
D-dopachrome tautomerase 6
adenosine deaminase 6
glucose oxidase 6
adenosine deaminase 6
cathepsin K 6
PDE 6
soluble epoxide hydrolase 6
TdT 6
more...
Compound
glucose 3341
ATP 1507
oxygen 1215
AMP 949
Dec 808
AICAR 600
Metformin 584
Metformin 583
DNA 568
AICAR 547
threonine 474
calcium 446
TNF 347
water 277
serine 272
nitric oxide 270
phosphate 265
Clin 254
Insulin 251
cAMP 222
CoA 215
ADP 186
ethanol 183
NAD 183
adenylate 179
ADP 174
ADP 174
sodium 163
Guo 152
NAD 149
Resveratrol 146
palmitic acid 138
galactose 129
tyrosine 121
malonyl-CoA 113
arginine 112
hydrogen 111
MTT 111
cysteine 109
leucine 108
MDA 105
CPT 97
GSH 97
CPT 97
GSH 97
palmitic acid 94
nicotinamide 91
acetate 91
alanine 84
glutamate 83
nitrogen 83
methionine 83
glutamine 83
glycerol 79
Cardiol 78
N-acetylcysteine 74
lysine 74
MEK 71
acetyl-CoA 69
salt 68
NADH 67
Berberine 66
urea 60
cGMP 59
Rapamycin 59
Oil Red O 58
THP 58
THP 58
NADPH 55
STZ 55
Oil Red O 55
NADPH 55
H2O2 54
pentose 53
pentose 53
pentose 53
pentose 53
iron 50
potassium 47
Curcumin 47
Ang II 47
creatinine 46
sulfate 46
GTP 43
phosphocreatine 42
caffeine 39
Glycogen 37
H2S 35
pyrimidine 34
Quercetin 33
pyrimidine 33
TSC 32
Adriamycin 31
TCA 31
Melatonin 30
zinc 30
HMG-CoA 30
bromide 30
Serine 29
Glucagon 29
Hearts 28
FFA 28
Hearts 28
ASA 27
PMA 27
ADR 27
Adenosine 26
Leucine 26
proline 26
Neuronal 26
dUTP 26
Pac 25
ethyl acetate 24
CO2 23
acetic acid 23
Sucrose 23
retinoic acid 22
NH2 22
AICA-riboside 22
Panam 21
MPTP 21
acridine 21
iodine 21
COX 21
Angiotensin II 21
adenosylmethionine 20
tryptophan 20
vitamin D 20
2-oxoglutarate 20
GlcNAc 20
Phe 20
kaempferol 19
Salt 19
isoquinoline 19
aldehyde 19
cadmium 19
aldosterone 19
cyanide 19
Fenofibrate 19
TEM 18
GSSG 18
DPP 18
His 17
SDS 17
ADP-ribose 17
selenium 17
MPP 17
Sodium 17
MPP 17
boron 17
Asp 17
Thyroid 16
APAP 16
copper 16
DDP 16
5-FU 16
CBS 16
ACS 16
Estrogen 16
PMA 16
more...