Gene/Protein
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Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Drug
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Target Concepts:
Gene/Protein
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Query: EC:2.7.11.31 (
AMP-activated protein kinase
)
13,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
AMP-activated protein kinase
(
AMPK
) is a metabolite sensing serine/threonine kinase that has been termed the master regulator of cellular energy metabolism due to its numerous roles in the regulation of glucose, lipid, and protein metabolism. In this review, we first summarize the current literature on a number of important aspects of
AMPK
in skeletal muscle. These include the following: (1) the structural components of the three
AMPK
subunits (i.e. AMPKalpha, beta, and gamma), and their differential localization in response to stimulation in muscle; (2) the biochemical regulation of
AMPK
by AMP, protein phosphatases, and its three known upstream kinases, LKB1, Ca2+/calmodulin-dependent protein kinase kinase (CaMKK), and
transforming growth factor-beta-activated kinase 1
(
TAK1
); (3) the pharmacological agents that are currently available for the activation and inhibition of
AMPK
; (4) the physiological stimuli that activate
AMPK
in muscle; and (5) the metabolic processes that
AMPK
regulates in skeletal muscle.
...
PMID:AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism. 1881 Mar 25
