Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.31 (
AMP-activated protein kinase
)
13,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tributyltin chloride
(
TBT
) is a neurotoxic environmental pollutant that inhibits mitochondrial adenosine triphosphate (ATP) synthase. Autophagy is one of the major protein degradation systems induced by a decrease of intracellular ATP following activation of
AMP-activated protein kinase
(
AMPK
). Because we previously found that
TBT
induces activation of
AMPK
, here we examined whether
TBT
induces autophagic neuronal death. Exposure of cortical neurons to 500 nM
TBT
reduced the phosphorylation of mammalian target of rapamycin (mTOR), a regulator of autophagy. An autophagy inhibitor, 3-methyladenine (3-MA), markedly decreased
TBT
-induced neuronal death.
TBT
also induced the formation of LC3-II, an autophagy marker. These results suggest that
TBT
-induced neuronal death is at least partly autophagic.
...
PMID:Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death. 2037 77
