Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.27 (AMPK)
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Human Gene/Protein
phosphodiesterase 3B, cGMP-inhibited 12.3
peroxisomal biogenesis factor 3 12.3
DNM1L protein 12.3
proline rich 5 12.3
GRIK2 protein 12.3
C12orf73 12.3
AMPK 12.3
LONP 12.3
AMPK beta 1 12.3
Rab40A 11.3
BR serine/threonine kinase 1 11.3
WD repeat and FYVE domain containing 3 11.3
GLB1L 11.3
6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase 11.3
mitogen-activated protein kinase associated protein 1 11.3
TBC1D7 protein 11.3
plakophilin 4 11.3
TBC1D1 protein 11.3
CAMKK 11.3
SSTK 11.3
NSPL1 11.3
ubiquitin specific peptidase 10 11.3
WD repeat domain, phosphoinositide interacting 1 11.0
NUAK2 10.8
ARMCX3 10.7
Erbb2 interacting protein 10.7
CAB39 10.7
neighbor of BRCA1 gene 2 10.7
ITGB4 protein 10.7
DEFB125 10.7
TBC1 domain family member 7 10.7
LC27 10.7
RAB2A, member RAS oncogene family 10.7
DEFB109 10.7
LTBP1 protein 10.7
transmembrane protein 26 10.7
ATP6V0E2 10.7
AP2 associated kinase 1 10.7
AICAR 10.6
PRKAA 10.6
LKB1 10.6
sestrin 3 10.5
FNIP1 10.3
ANAPC4 10.3
ZFYVE21 10.3
Raptor protein 10.3
phosphofructokinase, platelet 10.3
WIPI3 10.3
tetratricopeptide repeat domain 3 10.3
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 10.3
ZIM3 10.3
apolipoprotein O 10.3
PAXILLIN 10.3
TIMM44 10.3
KLEIP 10.3
RAB9B 10.3
DUPD1 10.3
SHMT2 protein 10.3
CaMKK 10.3
TBC1D1 10.2
NUAK1 10.2
STRAD 10.1
sestrin 1 10.1
ARK5 10.1
ALCAT1 10.1
CAMKK2 10.1
MO25 10.1
ULK1 10.0
PRKAA1 10.0
transmembrane protein 59 10.0
nephronophthisis 4 10.0
MTHFD2L 10.0
raptor protein 10.0
transcription factor binding to IGHM enhancer 3 10.0
PLEKHA2 10.0
CREB regulated transcription coactivator 2 10.0
conserved helix-loop-helix ubiquitous kinase 10.0
calcium binding protein 39 10.0
CCDC14 10.0
TIM50 10.0
more...
Disease
Female hypogonadism 11.3
CCAL1 10.7
Infantile diarrhea 9.1
ATP synthase deficiency 8.6
EBSS 8.3
muscle cancer 8.3
IMD1 8.1
female subfertility 7.9
Multiple cancer 7.8
SAMS 7.7
Diabetic encephalopathy 7.6
Secretory diarrhea 7.5
BHD 7.2
BHD 7.1
Hypoxic-ischemic encephalopathy (HIE) 6.9
WTS 6.9
FAS 6.9
Peutz-Jeghers syndrome 6.9
NEK1 6.8
Sepsis-associated encephalopathy 6.8
adult brain tumor 6.8
Congenital nephrogenic diabetes insipidus 6.7
Cancer cachexia 6.6
EPM2B 6.6
Conduction disorders 6.5
Leukemia stem cell 6.5
SCD 6.5
AML progression 6.4
OPA1 6.4
alcoholic fatty liver 6.4
Hypoxic-ischemic brain injury 6.3
Biotin deficiency 6.3
TD2 6.3
diabetic cardiomyopathy 6.3
fatty liver 6.2
lipid disorder 6.1
Epididymis 6.1
Epididymis 6.1
Diastolic heart failure 5.9
Placental insufficiency 5.9
MIN 5.8
MIN 5.8
INS 5.8
extrahepatic bile duct cancer 5.8
CSE 5.8
Subclinical hypothyroidism 5.8
Hajdu-Cheney syndrome 5.7
OFD1 5.7
Lewis Lung Carcinoma 5.7
Acute myocardial ischemia 5.6
FED 5.6
alcoholic myopathy 5.6
Estrogen deficiency 5.5
KCS 5.5
lung cyst 5.5
Necrotic enteritis 5.5
Simpson-Golabi-Behmel syndrome 5.4
colorectal neoplasm 5.4
Glomerular diseases 5.4
viral carcinogenesis 5.3
PanIN 5.3
adrenal cancer 5.3
Nonalcoholic fatty liver 5.3
tuberous sclerosis 5.3
PARK7 5.3
Digestive Diseases 5.2
Oculopharyngeal muscular dystrophy 5.2
Renal fibrosis 5.2
LDLR 5.2
Photosensitization 5.2
ovarian dysfunction 5.2
neurothekeoma 5.1
overnutrition 5.0
type 2 diabetes 5.0
metabolic disorder 5.0
Autosomal dominant polycystic kidney disease 5.0
Diabetes and Pregnancy 5.0
Cardiac rupture 5.0
Spinal cord ischemia 4.9
Diabetic peripheral neuropathy 4.9
more...
Symptom
stomach cramps 6.7
starvation 4.8
Cushingoid 4.6
Cushingoid 4.5
Scratch 3.7
cachexia 3.6
memory loss 3.5
rundown 3.3
POA 3.2
Anoxia 3.2
hunger 3.2
functional recovery 3.0
Neuropathic pain 2.8
exhaustion 2.7
menopausal symptoms 2.6
neurological disability 2.4
muscle rigidity 2.2
bradykinesia 2.1
pallor 2.0
overweight 1.9
collapse 1.9
bitter taste 1.8
skin damage 1.7
hyperoxia 1.5
fatigue 1.5
acute pain 1.4
hypercapnia 1.3
chills 1.2
shoulder pain 0.9
hypothermia 0.8
hepatomegaly 0.8
HSA 0.8
respiratory distress 0.6
low back pain 0.6
ophthalmoplegia 0.6
anorexia 0.6
thinning 0.4
cyanosis 0.4
weakness 0.4
insomnia -0.1
back pain -0.3
hemoptysis -0.3
spasticity -0.4
myalgia -0.4
ataxia -0.7
diarrhea -0.7
tremor -0.9
syncope -0.9
pain -1.0
angina -1.1
Ill -1.1
cough -1.2
anesthesia -1.3
stigma -1.4
acidity -1.6
seizures -2.0
nausea -2.2
dyspnea -2.5
abdominal pain -2.6
vomiting -2.7
headache -3.5
Drug
Benproperine phosphate 12.3
Adenosine Monophosphate 9.4
Acadesine 9.3
Fidarestat 8.5
Fidarestat 8.5
Safingol 8.1
Metreleptin 7.9
Ara-A 7.8
3-Methyladenine 7.7
1-Deoxynojirimycin 7.7
Nelarabine 7.3
Pramlintide 7.2
Aescin 7.2
Liraglutide 7.0
Adamantane 6.7
Vitamin K2 6.7
Penfluridol 6.7
Creosote 6.6
Sesamol 6.5
Esculin 6.3
Parkin 6.2
Parkin 6.2
Virginiamycin 6.2
Omapatrilat 6.1
ROS 6.0
Ramelteon 6.0
Telbivudine 6.0
Rosiglitazone 6.0
RFP 5.8
AMK 5.7
Insulin glargine 5.7
Orlistat 5.7
Coconut oil 5.6
Nexavar 5.6
Exenatide 5.6
CMX 5.5
Ezetimibe 5.5
Artesunate 5.5
Red ginseng 5.4
Emodin 5.4
Safflower 5.4
Celebrex 5.3
metformin hydrochloride 5.3
Rhubarb 5.3
Roflumilast 5.3
Roflumilast 5.3
Troglitazone 5.2
Cilazapril 5.2
Salicylate 5.2
Sunitinib malate 5.1
Emodin 5.1
Florfenicol 5.1
Vinpocetine 5.1
Ginseng 5.1
Nitazoxanide 5.0
Atovaquone 4.9
Bromelain 4.9
Artemether 4.8
ATV 4.7
TAK 4.7
Pramipexole 4.6
Cilostazol 4.6
Cinacalcet 4.6
Verteporfin 4.6
Pramipexole 4.6
Sorafenib 4.5
Atovaquone 4.5
Valsartan 4.4
Ginger 4.4
Loratadine 4.4
Indinavir 4.4
Thioridazine 4.4
PFT 4.4
Ranolazine 4.3
Ranolazine 4.3
Compound 9 4.3
Arsenic trioxide 4.3
Areca 4.2
Donepezil 4.2
Glycyrrhiza 4.2
more...
Enzyme
AMPK 12.3
calpain C 12.3
AMPK 11.3
AMP-activated protein kinase 11.2
phosphatidylinositol 3-phosphate 5-kinase 9.3
YeiK 8.5
AMP-activated kinase 8.3
acetyl-CoA carboxylase 8.1
STK11 8.0
eEF2 kinase 7.9
TOR 7.3
malonyl-CoA decarboxylase 7.1
HK2 7.1
isochorismatase 7.1
acetoacetyl-CoA synthetase 7.0
DHOdehase 6.9
GK2 6.8
proprotein convertase 1 6.8
6-pyruvoyltetrahydropterin synthase 6.7
CPT 6.7
hormone-sensitive lipase 6.7
CPT 6.6
CPT 6.5
nicotinamide phosphoribosyltransferase 6.4
PDK1 6.3
Tpt1 6.3
cathepsin F 6.3
D-alanine:D-alanine ligase 6.3
D-dopachrome tautomerase 6.3
palmitoyl-protein thioesterase 6.3
phosphatidate phosphatase 6.2
nicotinic acid phosphoribosyltransferase 6.1
choline dehydrogenase 6.0
glycine N-methyltransferase 6.0
phosphoenolpyruvate carboxykinase 5.9
O-GlcNAc transferase 5.9
Omi/HtrA2 5.9
6-phosphogluconolactonase 5.8
pyruvate dehydrogenase phosphatase 5.8
fructose-2,6-bisphosphatase 5.8
CaMKII 5.8
STK2 5.8
citrate synthase 5.8
3-oxoacid CoA-transferase 5.7
glycerol-3-phosphate oxidase 5.6
nicotinamidase 5.5
PDH 5.5
phosphofructokinase 1 5.5
FPS 5.5
protein kinase 5.4
aminopeptidase I 5.4
GSK 5.3
PWD 5.3
adenosine kinase 5.2
guanidinoacetate methyltransferase 5.2
complex I 5.2
deoxyguanosine kinase 5.1
glycogenin 5.1
glucose-6-phosphatase 5.1
PKG 5.1
LPL 5.1
betaine-homocysteine methyltransferase 5.0
nucleoside diphosphokinase 5.0
acyl-CoA oxidase 5.0
IKK 5.0
AST 4.9
6-phosphofructo-2-kinase 4.9
ceramidase 4.9
mitogen-activated protein kinase 4.9
phosphoenolpyruvate carboxykinase 4.9
phosphoenolpyruvate carboxykinase 4.9
PARP 4.9
protein phosphatase 2A 4.8
lysine acetyltransferase 4.8
sepiapterin reductase 4.8
squalene epoxidase 4.8
phosphoglyceromutase 4.7
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.7
acyl-CoA dehydrogenase 4.6
glucokinase 4.6
more...
Compound
Evoxine 12.3
4-Bromodiphenyl ether 11.3
4-Bromodiphenyl ether 11.3
Hernandezine 11.0
Scirpusin A 10.7
AICAR 10.5
Batatasin I 10.0
AICAR 9.7
Wuweizisu C 9.7
Jervine 9.5
Hispidulin 9.5
Panaxatriol 9.3
Saponarin 9.1
Aminoimidazole 9.1
Tubeimoside I 9.0
Taraxerol 8.8
Taraxerol 8.8
Metformin 8.7
5-Iodotubercidin 8.7
5-Iodotubercidin 8.7
5-Iodotubercidin 8.7
Metformin 8.7
Tuberin 8.7
5-Iodotubercidin 8.6
Fagomine 8.6
Soraphen A 8.6
Sinensetin 8.5
p-Synephrine 8.4
Isoorientin 8.3
Wedelolactone 8.3
Endothall 8.2
Prunetin 8.1
Buformin 8.1
Capsanthin 8.1
Isoquercitrin 8.1
Isovitexin 8.0
Rutaecarpine 7.9
Rutaecarpine 7.9
Vicenin-2 7.9
Thioflavine S 7.9
Pinosylvin 7.9
Pinosylvin 7.9
DBI 7.9
Chelidonine 7.8
1,3-dichloro-2-propanol 7.8
Dihydromyricetin 7.8
Benzo[b]fluoranthene 7.8
Saikosaponin A 7.8
N-phenylbenzamide 7.8
3-Methyladenine 7.7
Farrerol 7.7
TSC 7.6
Aloperine 7.6
NIX 7.5
Glycochenodeoxycholic acid 7.5
4-ethyl-2-methoxyphenol 7.5
Salina 7.5
Acetylshikonin 7.4
6-phosphogluconolactone 7.4
Morusin 7.4
Ginsenoside Rg1 7.4
Medicarpin 7.3
Alliin 7.3
Swertiamarin 7.3
Catalpol 7.3
Physcion 7.3
Simeon 7.2
Fucosterol 7.2
Fucosterol 7.1
Berberine 7.1
Cobaltous chloride 7.1
Calycosin 7.0
Oil Red O 7.0
Deguelin 7.0
10-hydroxy-2-decenoic acid 7.0
Aucubin 6.9
Paeonol 6.9
Tauroursodeoxycholic acid 6.9
Dibenzoylmethane 6.9
Nitidine 6.9
more...