Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.27 (
AMPK
)
6,299
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
AMPK
6226
mTOR
1249
insulin
1082
Mol
637
ATP
582
AMP-activated protein kinase
511
PI3K
410
AKT
401
LKB1
382
PGC
329
adiponectin
309
Sep
305
AMP
304
LC3
298
MAPK
290
SIRT1
290
p53
267
ROS
247
AICAR
235
TNF
233
ACC
214
ULK1
206
caspase-3
205
ERK
203
p62
197
p38
197
JNK
173
endoplasmic reticulum
165
GLUT4
162
leptin
159
Bcl-2
157
IL-6
157
Beclin-1
150
acetyl-CoA carboxylase
149
peroxisome proliferator-activated receptor
138
PPAR
135
Nrf2
135
ERK1
122
cytokine
122
IRS-1
106
more...
Disease
cancer
1080
obesity
644
tumor
615
diabetes
593
type 2 diabetes
375
fatty liver
204
breast cancer
173
hyperglycemia
166
tumor growth
162
hepatocellular carcinoma
147
ischemia
141
metabolic syndrome
123
tumorigenesis
123
Alzheimer's disease
111
atherosclerosis
105
FAS
97
hypertension
83
lung cancer
82
prostate cancer
82
cardiovascular disease
81
tumor progression
74
colorectal cancer
74
hyperlipidemia
72
heart failure
71
dyslipidemia
68
glucose intolerance
66
stroke
63
GSH
61
myocardial ischemia
60
alcoholic fatty liver
59
myocardial infarction
58
carcinogenesis
58
carcinoma
55
Parkinson's disease
54
ATM
53
adenocarcinoma
52
MCF
45
pancreatic cancer
45
non-small cell lung cancer
43
tuberous sclerosis
43
more...
Symptom
starvation
139
fatigue
29
pain
25
collapse
21
functional recovery
21
overweight
20
exhaustion
18
cachexia
14
weakness
10
hunger
10
anesthesia
9
memory loss
8
diarrhea
7
hypothermia
6
respiratory distress
6
hypercapnia
4
seizures
4
anorexia
4
hyperoxia
3
thinning
3
low back pain
3
acute pain
2
hepatomegaly
2
bradykinesia
2
angina
2
insomnia
2
chills
2
Neuropathic pain
2
ataxia
2
tremor
2
pallor
2
back pain
2
menopausal symptoms
2
cough
2
vomiting
1
stigma
1
abdominal pain
1
Anoxia
1
stomach cramps
1
syncope
1
more...
Drug
ROS
247
NADH
32
Parkin
28
Parkin
28
lysine
27
Monit
21
Cardiovasc
17
RFP
13
MAP
13
caffeine
12
Ethanol
12
Liraglutide
11
Ginseng
11
Rosiglitazone
10
Glucagon
10
ascorbate
10
Dermatol
9
CSF
8
EE2
7
Sorafenib
7
vitamin E
7
3-Methyladenine
7
ALA
6
citric acid
6
Angiotensin II
5
Ara-A
5
TAK
5
Glycyrrhiza
5
Arsenic trioxide
5
Simvastatin
5
Itraconazole
5
Adenosine Monophosphate
4
EPA
4
Ezetimibe
4
Emodin
4
Emodin
4
Bifidobacterium
4
Troglitazone
4
Acadesine
4
Docetaxel
4
more...
Enzyme
AMPK
6299
AMP-activated protein kinase
6228
AMPK
6226
protein kinase
697
mitogen-activated protein kinase
570
ERK
304
focal adhesion kinase
199
acetyl-CoA carboxylase
155
superoxide dismutase
142
caspase-3
140
CPT
94
protein kinase C
86
alanine aminotransferase
82
PARP
79
catalase
74
aspartate aminotransferase
71
proteasome
67
CPT
63
complex I
63
CPT
63
MEK
57
phosphoenolpyruvate carboxykinase
56
GSK
53
ATPase
52
citrate synthase
48
luciferase
47
TOR
47
calcineurin
46
lactate dehydrogenase
46
CaMKII
44
hormone-sensitive lipase
44
phosphatidylinositol 3-kinase
38
AST
37
PDK1
35
glutathione peroxidase
32
NADPH oxidase
31
NADPH oxidase
31
IKK
30
AMP-activated kinase
30
caspase-1
28
more...
Compound
glucose
1397
oxygen
588
ATP
582
AMP
373
Dec
355
DNA
315
Metformin
284
Metformin
284
AICAR
249
AICAR
237
TNF
233
calcium
218
threonine
161
water
149
adenylate
142
Clin
129
phosphate
116
cAMP
114
Insulin
110
serine
104
nitric oxide
95
NAD
92
sodium
78
Resveratrol
75
ethanol
74
NAD
74
MTT
74
MDA
72
ADP
72
palmitic acid
70
ADP
65
ADP
65
CPT
63
CPT
63
tyrosine
62
GSH
61
GSH
61
hydrogen
58
methionine
57
CoA
53
more...