Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.27 (AMPK)
 6,299 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
AMPK 6226
mTOR 1249
insulin 1082
Mol 637
ATP 582
AMP-activated protein kinase 511
PI3K 410
AKT 401
LKB1 382
PGC 329
adiponectin 309
Sep 305
AMP 304
LC3 298
MAPK 290
SIRT1 290
p53 267
ROS 247
AICAR 235
TNF 233
ACC 214
ULK1 206
caspase-3 205
ERK 203
p62 197
p38 197
JNK 173
endoplasmic reticulum 165
GLUT4 162
leptin 159
IL-6 157
Bcl-2 157
Beclin-1 150
acetyl-CoA carboxylase 149
peroxisome proliferator-activated receptor 138
PPAR 135
Nrf2 135
ERK1 122
cytokine 122
IRS-1 106
eNOS 98
Adiponectin 98
FAS 95
PKA 95
S6K1 90
STAT3 87
superoxide dismutase 87
fatty acid synthase 85
inducible nitric oxide synthase 83
p21 83
lipopolysaccharide 80
LC3B 79
gut 79
ubiquitin 77
TSC2 77
collagen 77
tumor necrosis factor 77
glucagon 75
NAD 74
PDB 70
adipokine 69
SREBP-1 69
PARP 69
LPS 68
PKC 68
CD36 66
proteasome 66
ADP 65
FRAP 65
SREBP-1c 65
glucose transporter 65
PTEN 64
CREB 64
SOD 63
CPT 63
epididymal 62
HO-1 62
GSH 61
catalase 60
phosphatase 60
threonine 60
p65 59
sirtuin 1 59
protein kinase B 58
VEGF 57
NLRP3 56
uncoupling protein 1 54
IGF-1 54
GSK 53
ATG5 53
catenin 53
peroxisome proliferator-activated receptor gamma 53
serine/threonine kinase 50
ATPase 48
TFAM 48
ghrelin 48
GLUT1 48
citrate synthase 48
TOR 47
PKB 47
ATM 47
4E-BP1 46
MEK 45
erythroid 45
cytochrome c 45
lactate dehydrogenase 45
insulin receptor 44
hormone-sensitive lipase 44
c-kit 44
CaMKII 42
CaMKK 42
UCP2 41
CHOP 41
calmodulin 41
4EBP1 40
COX-2 39
adipose triglyceride lipase 39
interleukin-6 39
LDH 39
endothelial nitric oxide synthase 39
TSC1 38
aspartate aminotransferase 38
phosphatidylinositol 3-kinase 38
phosphorylating 38
cyclin D1 37
AST 37
caspase-9 37
glucose transporter 4 37
vascular endothelial growth factor 37
tyrosine kinase 37
P62 36
IL-10 36
muscle protein 36
CPT1 35
rhabdomyosarcoma 35
heme oxygenase-1 35
HDL 35
histone 35
HMG-CoA reductase 34
sirtuin 34
AS160 34
EGFR 34
PERK 34
alanine aminotransferase 33
TLR4 33
NADH 32
IL-1 32
carnitine palmitoyltransferase 32
PEPCK 32
GLP-1 receptor 32
glutathione peroxidase 32
TFEB 31
estrogen receptor 31
nitric oxide synthase 31
microtubule-associated protein 31
14-3-3 30
angiotensin II 30
Ghrelin 30
histone deacetylase 30
osteogenic 30
more...
Disease
cancer 1080
obesity 644
tumor 615
diabetes 593
type 2 diabetes 375
fatty liver 204
breast cancer 173
hyperglycemia 166
tumor growth 162
hepatocellular carcinoma 147
ischemia 141
metabolic syndrome 123
tumorigenesis 123
Alzheimer's disease 111
atherosclerosis 105
FAS 97
hypertension 83
lung cancer 82
prostate cancer 82
cardiovascular disease 81
tumor progression 74
colorectal cancer 74
hyperlipidemia 72
heart failure 71
dyslipidemia 68
glucose intolerance 66
stroke 63
GSH 61
myocardial ischemia 60
alcoholic fatty liver 59
carcinogenesis 58
myocardial infarction 58
carcinoma 55
Parkinson's disease 54
ATM 53
adenocarcinoma 52
pancreatic cancer 45
MCF 45
tuberous sclerosis 43
non-small cell lung cancer 43
colon cancer 42
melanoma 41
diabetic nephropathy 40
glioblastoma 40
leukemia 39
glioma 39
liver disease 38
sepsis 35
cold 35
sepsis 35
liver cancer 33
cerebral ischemia 33
ovarian cancer 32
metabolic disorder 32
liver fibrosis 31
neuroblastoma 31
gastric cancer 29
hypoglycemia 29
NAME 29
liver cancer 28
cognitive impairment 27
acute myeloid leukemia 27
renal cell carcinoma 26
Nonalcoholic fatty liver 26
cardiomyopathy 26
colitis 26
osteoporosis 25
diabetic cardiomyopathy 25
muscular atrophy 25
hyperinsulinemia 24
depression 24
osteosarcoma 23
sickle cell disease 23
Peutz-Jeghers syndrome 23
squamous cell carcinoma 22
dementia 22
Huntington's disease 22
metastases 21
osteoarthritis 21
renal disease 21
plaque 21
SCD 20
cervical cancer 20
polycystic ovary syndrome 19
HIV 19
Blocking 19
heart disease 19
Hepatocellular carcinoma 18
tuberculosis 18
worms 18
malnutrition 17
bladder cancer 16
rheumatoid arthritis 16
Brown 16
INS 16
type 1 diabetes 15
endometrial cancer 15
glioblastoma multiforme 14
chronic myeloid leukemia 14
hypercholesterolemia 14
TEM 14
acute lymphoblastic leukemia 14
EMT 14
TEM 14
cirrhosis 14
lung carcinoma 13
brain tumor 13
aggressiveness 13
chronic disease 13
coronary artery disease 12
lymphoma 12
Mycobacterium 12
NOD 11
hyperphagia 11
Glioblastoma 11
gestational diabetes mellitus 11
lipid disorder 11
acute myocardial infarction 11
polycystic kidney 11
OPA1 11
myopathy 11
lactic acidosis 10
renal cancer 10
tumor angiogenesis 10
B-cell lymphoma 10
multiple myeloma 10
anemia 10
amyotrophic lateral sclerosis 10
HGF 10
inflammatory bowel disease 9
influenza 9
virus infection 9
Evans 9
skin cancer 9
brain cancer 9
macular degeneration 9
diabetic retinopathy 9
Pineal 9
proteinuria 9
SEM 9
Leukemia 8
arthritis 8
insulinoma 8
thyroid cancer 8
Melanoma 8
Endothelial dysfunction 8
LDLR 8
FBS 8
mammary tumor 8
systemic lupus erythematosus 8
chronic obstructive pulmonary disease 8
infectious diseases 8
ulcerative colitis 8
asthma 8
DSS 7
memory impairment 7
subarachnoid hemorrhage 7
ventricular hypertrophy 7
acute promyelocytic leukemia 7
ABL 7
more...
Symptom
starvation 139
fatigue 29
pain 25
functional recovery 21
collapse 21
overweight 20
exhaustion 18
cachexia 14
weakness 10
hunger 10
anesthesia 9
memory loss 8
diarrhea 7
respiratory distress 6
hypothermia 6
hypercapnia 4
seizures 4
anorexia 4
hyperoxia 3
thinning 3
low back pain 3
acute pain 2
hepatomegaly 2
chills 2
angina 2
insomnia 2
Neuropathic pain 2
cough 2
menopausal symptoms 2
ataxia 2
tremor 2
back pain 2
pallor 2
bradykinesia 2
vomiting 1
stigma 1
abdominal pain 1
Anoxia 1
stomach cramps 1
syncope 1
muscle rigidity 1
myalgia 1
spasticity 1
nausea 1
shoulder pain 1
bitter taste 1
ophthalmoplegia 1
cyanosis 1
HSA 1
acidity 1
dyspnea 1
Cushingoid 1
hemoptysis 1
POA 1
rundown 1
headache 1
Scratch 1
Ill 1
skin damage 1
neurological disability 1
Cushingoid 1
Drug
ROS 247
NADH 32
Parkin 28
Parkin 28
lysine 27
Monit 21
Cardiovasc 17
MAP 13
RFP 13
caffeine 12
Ethanol 12
Liraglutide 11
Ginseng 11
Glucagon 10
ascorbate 10
Rosiglitazone 10
Dermatol 9
CSF 8
vitamin E 7
Sorafenib 7
3-Methyladenine 7
EE2 7
ALA 6
citric acid 6
TAK 5
Itraconazole 5
Ara-A 5
Arsenic trioxide 5
Glycyrrhiza 5
Simvastatin 5
Angiotensin II 5
EPA 4
Emodin 4
Portal 4
Adenosine Monophosphate 4
Ezetimibe 4
Troglitazone 4
Docetaxel 4
Emodin 4
Orlistat 4
Bifidobacterium 4
Kenyan 4
Acadesine 4
Salicylate 4
MDS 3
Fructose 3
Glycerol 3
GEO 3
ROC 3
Nitric Oxide 3
Forskolin 3
Methylene blue 3
Artesunate 3
Imatinib 3
balanced salt solution 3
Exenatide 3
niacin 3
DM1 3
TAC 3
Vitamin K2 3
Heme 2
Retinoic acid 2
Luteinizing 2
PTC 2
Bupivacaine 2
Mutagen 2
Dasatinib 2
metformin hydrochloride 2
Triclosan 2
DHT 2
Fidarestat 2
Cilostazol 2
Fidarestat 2
IL-11 2
uPA 2
CAM 2
Pramlintide 2
ADM 2
Asn 2
DHT 2
Clopidogrel 2
Indomethacin 2
ETA 2
Sesamol 2
Ginger 2
CoCl2 2
Gefitinib 2
MRC 2
CoCl2 2
1-Deoxynojirimycin 2
CIA 2
IL-2 2
PFT 2
DEX 2
ATV 2
Donepezil 2
Valsartan 2
TTC 2
PCB 2
Alanine 2
Lovastatin 2
FAD 2
CCL 2
Photofrin 2
Ranolazine 1
Ouabain 1
AMC 1
Ranitidine 1
Taxol 1
Dial 1
-deoxyadenosine 1
Metreleptin 1
Sunitinib malate 1
Artemether 1
Vinpocetine 1
DNase I 1
Histamine 1
TMS 1
NovoSeven 1
Rolipram 1
nitroglycerin 1
Doyle 1
DMAP 1
Leaf 1
FLP 1
Spectrum 1
Orphan 1
Vitamin K 1
Pramipexole 1
Nitazoxanide 1
AGG 1
NBT 1
BLM 1
CPT-11 1
Vinorelbine 1
Esculin 1
Fluorescein 1
Captopril 1
Everolimus 1
CMX 1
CTC 1
Atenolol 1
Rimonabant 1
Spectrum 1
Roflumilast 1
Gel 1
Insulin glargine 1
Rutin 1
Adriamycin 1
Myricetin 1
Limonene 1
Areca 1
Gabapentin 1
Florfenicol 1
Creosote 1
Glutathione 1
TAT 1
Oxaliplatin 1
Vitamin E 1
Pemetrexed 1
more...
Enzyme
AMPK 6299
AMP-activated protein kinase 6228
AMPK 6226
protein kinase 697
mitogen-activated protein kinase 570
ERK 304
focal adhesion kinase 199
acetyl-CoA carboxylase 155
superoxide dismutase 142
caspase-3 140
CPT 94
protein kinase C 86
alanine aminotransferase 82
PARP 79
catalase 74
aspartate aminotransferase 71
proteasome 67
CPT 63
complex I 63
CPT 63
MEK 57
phosphoenolpyruvate carboxykinase 56
GSK 53
ATPase 52
citrate synthase 48
luciferase 47
TOR 47
lactate dehydrogenase 46
calcineurin 46
hormone-sensitive lipase 44
CaMKII 44
phosphatidylinositol 3-kinase 38
AST 37
PDK1 35
glutathione peroxidase 32
NADPH oxidase 31
NADPH oxidase 31
AMP-activated kinase 30
IKK 30
caspase-1 28
peroxidase 27
phosphoenolpyruvate carboxykinase 25
phosphoenolpyruvate carboxykinase 25
creatine kinase 25
alkaline phosphatase 25
STK11 24
ATP synthase 24
NQO1 24
lipase 24
NO synthase 23
NOS 22
caspase-9 22
glyceraldehyde-3-phosphate dehydrogenase 21
glucose-6-phosphatase 21
glutathione S-transferase 19
ACE 19
pyruvate dehydrogenase 18
hexokinase 17
phosphoinositide 3-kinase 17
PKG 17
protein phosphatase 2A 17
phosphofructokinase 16
HK2 15
lipoprotein lipase 15
succinate dehydrogenase 15
heme oxygenase 15
renin 15
pyruvate dehydrogenase 14
glucose-6-phosphate dehydrogenase 14
glucokinase 14
aldehyde dehydrogenase 14
glyceraldehyde-3-phosphate dehydrogenase 14
pyruvate dehydrogenase 14
cytochrome oxidase 13
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
glyceraldehyde-3-phosphate dehydrogenase 12
glyceraldehyde-3-phosphate dehydrogenase 12
glyceraldehyde-3-phosphate dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
pyruvate kinase 11
eEF2 kinase 11
caspase-8 10
phosphodiesterase 10
ACS 10
adenylate cyclase 10
APC 9
cathepsin D 9
LPL 9
phospholipase C 9
MAP 9
cathepsin B 8
MPP 8
guanylate cyclase 8
reverse transcriptase 7
arginase 7
acyl-CoA dehydrogenase 7
adenosine kinase 7
cdc2 7
phosphorylase 7
MMP 6
collagenase 6
nitrate reductase 6
PDH 6
nitrate reductase 6
nitrate reductase 6
acyl-CoA oxidase 6
nitrate reductase 6
nitrate reductase 6
aldolase 6
acetylcholinesterase 6
glutaminase 6
nicotinamide phosphoribosyltransferase 6
nitrate reductase 6
HSD 6
O-GlcNAc transferase 6
3-hydroxy-3-methylglutaryl coenzyme A reductase 5
demethylase 5
glutathione reductase 5
glutamate dehydrogenase 5
glutamate dehydrogenase 5
enolase 5
glutamate dehydrogenase 5
fumarase 5
malate dehydrogenase 5
glucose oxidase 5
thrombin 5
tyrosine hydroxylase 5
adenylate kinase 5
MMP-3 4
malonyl-CoA decarboxylase 4
gamma-glutamyl transpeptidase 4
CD10 4
RNA polymerase 4
Omi/HtrA2 4
PDE 4
isocitrate dehydrogenase 4
aldose reductase 4
TPP 4
ECH 4
isocitrate dehydrogenase 4
GRK2 4
TPP 4
pyruvate carboxylase 4
P-glycoprotein 4
MEKK1 4
glutamate decarboxylase 3
ornithine decarboxylase 3
diacylglycerol acyltransferase 3
PRE 3
acyl-CoA dehydrogenase 3
factor C 3
cathepsin K 3
MAT 3
6-phosphogluconate dehydrogenase 3
6-phosphogluconate dehydrogenase 3
TdT 3
alcohol dehydrogenase 3
acyl-CoA synthetase 3
more...
Compound
glucose 1397
oxygen 588
ATP 582
AMP 373
Dec 355
DNA 315
Metformin 284
Metformin 284
AICAR 249
AICAR 237
TNF 233
calcium 218
threonine 161
water 149
adenylate 142
Clin 129
phosphate 116
cAMP 114
Insulin 110
serine 104
nitric oxide 95
NAD 92
sodium 78
Resveratrol 75
MTT 74
ethanol 74
NAD 74
ADP 72
MDA 72
palmitic acid 70
ADP 65
ADP 65
CPT 63
CPT 63
tyrosine 62
GSH 61
GSH 61
hydrogen 58
methionine 57
galactose 53
CoA 53
palmitic acid 48
cysteine 47
glutamine 47
leucine 46
nitrogen 46
acetate 45
MEK 44
arginine 43
N-acetylcysteine 42
Cardiol 40
Rapamycin 38
urea 38
nicotinamide 37
STZ 37
lysine 34
Berberine 33
cGMP 33
alanine 33
glycerol 33
salt 32
Guo 32
NADH 32
Oil Red O 31
glutamate 31
Oil Red O 31
H2O2 30
THP 29
THP 29
pentose 28
pentose 28
pentose 28
pentose 28
creatinine 27
TSC 25
Curcumin 25
acetyl-CoA 24
sulfate 24
NADPH 24
NADPH 24
TCA 22
iron 21
Melatonin 20
potassium 19
H2S 19
malonyl-CoA 19
FFA 19
pyrimidine 18
ASA 18
pyrimidine 18
bromide 18
CAT 17
Ang II 17
CAT 17
GTP 17
CAT 17
Pac 17
Adriamycin 15
Panam 15
TEM 15
PMA 15
Quercetin 14
ADR 14
proline 14
Sucrose 14
dUTP 14
Leucine 13
COX 13
Serine 13
5-FU 13
kaempferol 12
2-oxoglutarate 12
aldosterone 12
tryptophan 12
zinc 12
Adenosine 12
vitamin D 12
caffeine 12
MPTP 12
Neuronal 12
DPP 12
acridine 11
adenosylmethionine 11
phosphocreatine 11
cadmium 11
ethyl acetate 11
selenium 11
APAP 11
DBI 11
ASC 11
retinoic acid 11
boron 10
Glucagon 10
fluorine 10
GABA 10
GABA 10
PMA 10
MAP 10
butyric acid 10
Estrogen 10
PGE 10
Epigallocatechin gallate 9
Fenofibrate 9
DDP 9
Hematoxylin 9
Estrogen 9
coenzyme Q10 9
Lip 9
ACS 9
Glycogen 9
Phe 9
ACS 9
ALP 9
Asp 9
tryptophan 8
NH2 8
MPP 8
tert-butyl hydroperoxide 8
PEG 8
isoquinoline 8
more...