Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.26 (
GSK
)
6,788
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
GSK
6068
catenin
944
Mol
743
insulin
538
AKT
524
beta-catenin
498
PI3K
486
Glycogen synthase
478
Sep
434
caspase-3
378
protein kinase B
285
Bcl-2
267
mTOR
260
phosphatidylinositol 3-kinase
256
tau protein
243
cyclin D1
241
glycogen synthase kinase 3
231
ERK
214
ERK1
210
MAPK
206
ATP
195
p38
172
E-cadherin
172
p53
168
threonine
163
TNF
162
TTK
155
glycogen synthase
150
cytokine
144
amyloid precursor protein
143
serine/threonine kinase
141
phosphatase
141
JNK
132
GSK3
132
PKB
124
IRS-1
121
PTEN
120
Axin
112
brain-derived neurotrophic factor
106
axonal
104
collagen
96
phosphoinositide 3-kinase
95
MEK
94
proteasome
94
IL-6
91
TCF
90
insulin receptor
88
c-Myc
88
PKC
87
Nrf2
85
CREB
85
cyclin
83
tumor necrosis factor
83
p65
83
histone
82
c-myc
82
endoplasmic reticulum
81
extracellular signal-regulated kinase
81
cytochrome c
80
glycogen synthase kinase-3 beta
78
lipopolysaccharide
78
caspase-9
77
PI3
74
p21
73
glycogen synthase kinase 3 beta
72
phosphorylating
70
tyrosine kinase
70
adenomatous polyposis coli
70
osteogenic
68
GSH
67
superoxide dismutase
66
ROS
64
PKA
63
c-Jun
62
lymphoid
60
serine/threonine protein kinase
60
N-cadherin
59
calcineurin
58
PARP
57
erythroid
56
more...
Disease
cancer
1004
Alzheimer's disease
961
tumor
643
diabetes
324
ischemia
245
tumorigenesis
199
breast cancer
170
hepatocellular carcinoma
145
cognitive impairment
135
Parkinson's disease
128
carcinogenesis
126
bipolar disorder
123
neuroblastoma
122
tumor growth
121
depression
118
type 2 diabetes
117
colorectal cancer
109
colon cancer
100
dementia
96
schizophrenia
95
stroke
94
carcinoma
93
prostate cancer
88
tumor progression
85
obesity
72
GSH
67
lung cancer
65
cerebral ischemia
63
MCF
61
leukemia
60
glioma
59
myocardial infarction
56
melanoma
56
APC
55
adenocarcinoma
55
gastric cancer
54
pancreatic cancer
52
memory impairment
52
hyperglycemia
48
heart failure
47
myocardial ischemia
45
EMT
39
osteosarcoma
38
osteoporosis
37
HIV
37
metastases
37
glioblastoma
36
squamous cell carcinoma
34
retinoblastoma
33
lymphoma
32
diabetic nephropathy
32
acute myeloid leukemia
31
ovarian cancer
30
hypertension
29
asthma
29
non-small cell lung cancer
28
amyotrophic lateral sclerosis
28
hepatitis B
27
sepsis
27
sepsis
27
chronic obstructive pulmonary disease
26
malaria
26
liver cancer
26
plaque
25
pertussis
24
cardiovascular disease
24
Huntington's disease
24
atherosclerosis
23
hyperinsulinemia
23
B-cell lymphoma
22
cervical cancer
21
epilepsy
21
aggressiveness
20
Blocking
20
mania
19
pheochromocytoma
19
renal cell carcinoma
19
psychosis
19
fatty liver
19
SAR
18
more...
Symptom
pain
36
functional recovery
29
seizures
24
memory loss
19
starvation
15
anesthesia
15
collapse
14
diarrhea
7
acute stress
7
hypothermia
7
fatigue
6
nausea
4
ataxia
4
agitation
4
respiratory distress
4
cachexia
4
despair
4
tremor
3
polyuria
3
exhaustion
2
insomnia
2
abdominal pain
2
chorea
2
apathy
2
Scratch
2
skin damage
2
neurological disability
2
hyperoxia
2
weakness
2
incoordination
2
sleepiness
2
vomiting
2
bradykinesia
2
wheezing
1
decreased appetite
1
hot flushes
1
hypotonia
1
acute pain
1
muscle rigidity
1
adenitis
1
anorexia
1
nasal congestion
1
Mills
1
hunger
1
erythema
1
impaired motor coordination
1
menopausal symptoms
1
Injection site pain
1
cough
1
low back pain
1
abnormal gait
1
dry eye
1
angina
1
Excitable
1
dyspnea
1
analgesia
1
dystonia
1
arthralgia
1
Involuntary Movement
1
paresis
1
postnasal drip
1
headache
1
thinning
1
Neuropathic pain
1
myalgia
1
cerebellar ataxia
1
Ill
1
Drug
ROS
64
lysine
51
MAP
33
Cardiovasc
19
Monit
15
IL-2
13
Dermatol
13
Sorafenib
11
Ethanol
10
ICI
9
CSF
9
Bortezomib
9
CTX
8
caffeine
8
Ezetimibe
8
Donepezil
7
Everolimus
7
Denosumab
6
NVP
6
PCP
6
Pemetrexed disodium
6
Pegasys
6
Sunitinib malate
6
Tocilizumab
6
Gefitinib
6
vitamin E
6
EE2
6
Dasatinib
6
Portal
6
Vorinostat
6
Gleevec
6
Gel
6
CTX
6
Glycyrrhiza
6
CIA
6
Taxol
6
Bevacizumab
6
Lenalidomide
6
CTX
6
Peginterferon alfa-2b
5
Cetuximab
5
Parkin
5
Entecavir
5
Entecavir
5
Darbepoetin alfa
5
Zoledronic acid
5
Angiotensin II
5
Fondaparinux
5
Peginterferon alfa-2b
5
GEO
5
Adalimumab
5
Parkin
5
Epoetin
5
Retinoic acid
5
Activin
5
Rosuvastatin calcium
5
ADR
5
G-CSF
5
Imatinib
5
Asthma
5
Simvastatin
5
TTC
5
Pimecrolimus
5
Zoledronic acid
4
Teriparatide
4
NADH
4
Aliskiren fumarate
4
Salbutamol
4
Heme
4
Liraglutide
4
Pregabalin
4
Escitalopram oxalate
4
Growth hormone
4
Emodin
4
Duloxetine hydrochloride
4
Fulvestrant
4
IFN-gamma
4
ABC
4
PMPA
4
Dutasteride
4
more...
Enzyme
GSK
6788
protein kinase
1908
mitogen-activated protein kinase
642
caspase-3
305
ERK
304
phosphatidylinositol 3-kinase
256
focal adhesion kinase
247
protein kinase C
208
calcineurin
169
MEK
138
cdc2
100
superoxide dismutase
98
luciferase
97
phosphoinositide 3-kinase
95
proteasome
94
AMP-activated protein kinase
91
AMPK
81
caspase-9
63
PARP
62
protein phosphatase 2A
57
APC
55
AMPK
53
lactate dehydrogenase
52
catalase
49
demethylase
45
acetylcholinesterase
44
alkaline phosphatase
44
ACS
38
PDK1
37
glutathione peroxidase
30
alanine aminotransferase
29
MAP
28
creatine kinase
28
CaMKII
28
phosphodiesterase
27
IKK
26
ATPase
25
tyrosine hydroxylase
25
caspase-8
24
aspartate aminotransferase
24
glutathione S-transferase
21
MPP
21
histone demethylase
20
kinesin
19
phosphoenolpyruvate carboxykinase
19
peroxidase
18
NO synthase
16
glucose-6-phosphatase
16
cholinesterase
15
trypsin
15
NQO1
15
phospholipase C
14
adenylate cyclase
14
phosphoenolpyruvate carboxykinase
12
MMP
12
phosphoenolpyruvate carboxykinase
12
NADPH oxidase
12
reverse transcriptase
12
heme oxygenase
12
PKG
12
P-glycoprotein
11
hexokinase
11
tyrosinase
11
phosphorylase
10
NADPH oxidase
10
acetyl-CoA carboxylase
9
phospholipase A2
9
RNA polymerase
9
AST
9
thrombin
9
glucokinase
9
complex I
9
aldehyde dehydrogenase
8
guanylate cyclase
8
choline acetyltransferase
8
polo-like kinase 1
8
thiamine pyrophosphokinase
7
PDE
7
aldehyde dehydrogenase
7
aldehyde dehydrogenase
7
more...
Compound
glucose
489
Glycogen synthase
478
Dec
443
serine
364
DNA
309
threonine
299
oxygen
285
tyrosine
259
ATP
195
water
186
calcium
175
TNF
162
Lithium
138
cAMP
122
Insulin
105
glutamate
98
sodium
97
phosphate
95
Clin
94
MTT
93
MEK
90
MDA
77
nitric oxide
67
GSH
67
GSH
67
alanine
66
lysine
65
hydrogen
64
Glycogen
63
AMP
53
zinc
47
sulfate
46
Cardiol
45
ethanol
44
proline
40
bromide
39
ACS
38
ACS
38
retinoic acid
38
arginine
37
potassium
36
iodine
36
acetate
35
Wortmannin
34
STZ
34
Lithium chloride
33
H2O2
32
leucine
31
nitrogen
30
cysteine
30
MAP
28
Phosphatidylinositol
27
salt
27
COS
26
Curcumin
25
Asp
25
Serine
24
NMDA
24
dUTP
23
galactose
22
urea
22
MPP
21
MPP
21
MPTP
21
Vimentin
20
5-HT
20
pyridine
19
cGMP
19
ADP
19
methionine
19
ADP
19
ADP
19
Valproic acid
18
PGE
18
Neuronal
18
SDS
17
Melatonin
17
Rapamycin
17
Resveratrol
16
Indirubin
15
more...