Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.26 (GSK)
 6,788 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
GSK 6068
catenin 944
Mol 743
insulin 538
AKT 524
beta-catenin 498
PI3K 486
Glycogen synthase 478
Sep 434
caspase-3 378
protein kinase B 285
Bcl-2 267
mTOR 260
phosphatidylinositol 3-kinase 256
tau protein 243
cyclin D1 241
glycogen synthase kinase 3 231
ERK 214
ERK1 210
MAPK 206
ATP 195
E-cadherin 172
p38 172
p53 168
threonine 163
TNF 162
TTK 155
glycogen synthase 150
cytokine 144
amyloid precursor protein 143
phosphatase 141
serine/threonine kinase 141
JNK 132
GSK3 132
PKB 124
IRS-1 121
PTEN 120
Axin 112
brain-derived neurotrophic factor 106
axonal 104
collagen 96
phosphoinositide 3-kinase 95
MEK 94
proteasome 94
IL-6 91
TCF 90
c-Myc 88
insulin receptor 88
PKC 87
CREB 85
Nrf2 85
tumor necrosis factor 83
p65 83
cyclin 83
histone 82
c-myc 82
extracellular signal-regulated kinase 81
endoplasmic reticulum 81
cytochrome c 80
glycogen synthase kinase-3 beta 78
lipopolysaccharide 78
caspase-9 77
PI3 74
p21 73
glycogen synthase kinase 3 beta 72
adenomatous polyposis coli 70
phosphorylating 70
tyrosine kinase 70
osteogenic 68
GSH 67
superoxide dismutase 66
ROS 64
PKA 63
c-Jun 62
serine/threonine protein kinase 60
lymphoid 60
N-cadherin 59
calcineurin 58
PARP 57
erythroid 56
APC 55
vascular endothelial growth factor 55
vimentin 55
p27 54
insulin-like growth factor 52
ubiquitin 52
AMPK 52
inducible nitric oxide synthase 51
lactate dehydrogenase 51
APP 51
CDK5 49
AMP 48
protein phosphatase 48
cyclin-dependent kinase 48
mitogen-activated protein 47
calmodulin 47
fibronectin 46
p25 45
IL-10 45
IGF-1 45
amyloid beta 45
rhabdomyosarcoma 44
cyclooxygenase-2 44
alkaline phosphatase 44
PP2A 43
calpain 43
Dickkopf-1 42
microtubule-associated protein 41
catalase 41
AMP-activated protein kinase 41
CDK1 41
MEK1 40
LPS 40
NMDA receptor 40
COX-2 40
heme oxygenase-1 40
Cyclin D1 40
EMT 39
CA1 39
ACS 38
survivin 38
acetylcholinesterase 38
VEGF 37
interleukin-6 37
estrogen receptor 36
p85 36
SOD 36
AP-1 36
MMP-9 36
Rho 36
cyclin-dependent kinase 5 35
Aurora-A 35
Mcl-1 35
histone deacetylase 35
integrin-linked kinase 34
phosphatase and tensin homolog 34
JMJD3 33
epidermal growth factor receptor 33
STAT3 33
EGFR 33
osteosarcoma 33
p38 mitogen-activated protein kinase 33
SMA 32
epidermal growth factor 32
androgen receptor 32
synaptophysin 32
nerve growth factor 32
p70 31
LDH 31
erythropoietin 31
PI3-kinase 31
EGF 30
glutathione peroxidase 30
LC3 30
MAP kinase 30
PSD-95 30
Dictyostelium 29
cAMP-dependent protein kinase 29
S6K1 29
glucose transporter 29
more...
Disease
cancer 1004
Alzheimer's disease 961
tumor 643
diabetes 324
ischemia 245
tumorigenesis 199
breast cancer 170
hepatocellular carcinoma 145
cognitive impairment 135
Parkinson's disease 128
carcinogenesis 126
bipolar disorder 123
neuroblastoma 122
tumor growth 121
depression 118
type 2 diabetes 117
colorectal cancer 109
colon cancer 100
dementia 96
schizophrenia 95
stroke 94
carcinoma 93
prostate cancer 88
tumor progression 85
obesity 72
GSH 67
lung cancer 65
cerebral ischemia 63
MCF 61
leukemia 60
glioma 59
myocardial infarction 56
melanoma 56
APC 55
adenocarcinoma 55
gastric cancer 54
memory impairment 52
pancreatic cancer 52
hyperglycemia 48
heart failure 47
myocardial ischemia 45
EMT 39
osteosarcoma 38
HIV 37
metastases 37
osteoporosis 37
glioblastoma 36
squamous cell carcinoma 34
retinoblastoma 33
lymphoma 32
diabetic nephropathy 32
acute myeloid leukemia 31
ovarian cancer 30
hypertension 29
asthma 29
non-small cell lung cancer 28
amyotrophic lateral sclerosis 28
sepsis 27
sepsis 27
hepatitis B 27
liver cancer 26
malaria 26
chronic obstructive pulmonary disease 26
plaque 25
Huntington's disease 24
pertussis 24
cardiovascular disease 24
atherosclerosis 23
hyperinsulinemia 23
B-cell lymphoma 22
cervical cancer 21
epilepsy 21
aggressiveness 20
Blocking 20
mania 19
psychosis 19
fatty liver 19
pheochromocytoma 19
renal cell carcinoma 19
SAR 18
glucose intolerance 18
epithelial ovarian cancer 18
major depressive disorder 18
liver cancer 18
glioblastoma multiforme 18
SDS 17
cold 17
tetanus 16
acute myocardial infarction 16
influenza 16
metabolic syndrome 16
bladder cancer 16
brain edema 15
renal disease 15
multiple sclerosis 15
cardiomyopathy 15
progressive supranuclear palsy 15
endometrial cancer 15
muscular atrophy 15
Hepatocellular carcinoma 15
AGS 14
medulloblastoma 14
Down syndrome 14
diphtheria 14
colitis 14
familial adenomatous polyposis 14
virus infection 14
parkinsonism 13
Kaposi's sarcoma 13
infectious diseases 13
diabetic cardiomyopathy 13
immunodeficiency 13
varicella 12
hyperlipidemia 12
mental illness 12
rheumatoid arthritis 12
sarcoma 11
chronic myeloid leukemia 11
herpes zoster 11
FAS 11
multiple myeloma 11
dyslipidemia 11
affective disorder 11
lung carcinoma 11
IPV 11
arthritis 10
Evans 10
tumor angiogenesis 10
DDP 10
dysplasia 10
Osteosarcoma 10
Osteosarcoma 10
primary tumor 10
cognitive deficit 10
tuberculosis 10
liver disease 10
SCID 10
Haemophilus 10
measles 10
ATM 10
tuberous sclerosis 9
osteoarthritis 9
chronic lymphocytic leukemia 9
Mycobacterium 9
hepatitis C 9
Tauopathies 9
brain tumor 9
Pineal 9
heart disease 9
HCC 8
proteinuria 8
mantle cell lymphoma 8
PSA 8
CNS diseases 8
neoplastic transformation 8
idiopathic pulmonary fibrosis 8
hypercholesterolemia 8
aggression 8
NAME 8
adenoma 8
more...
Symptom
pain 36
functional recovery 29
seizures 24
memory loss 19
starvation 15
anesthesia 15
collapse 14
diarrhea 7
acute stress 7
hypothermia 7
fatigue 6
nausea 4
ataxia 4
agitation 4
respiratory distress 4
cachexia 4
despair 4
tremor 3
polyuria 3
exhaustion 2
insomnia 2
abdominal pain 2
chorea 2
apathy 2
Scratch 2
skin damage 2
neurological disability 2
hyperoxia 2
weakness 2
incoordination 2
sleepiness 2
vomiting 2
bradykinesia 2
wheezing 1
decreased appetite 1
hot flushes 1
hypotonia 1
acute pain 1
muscle rigidity 1
adenitis 1
anorexia 1
nasal congestion 1
Mills 1
hunger 1
erythema 1
impaired motor coordination 1
menopausal symptoms 1
Injection site pain 1
cough 1
low back pain 1
abnormal gait 1
dry eye 1
angina 1
Excitable 1
dyspnea 1
analgesia 1
dystonia 1
arthralgia 1
Involuntary Movement 1
paresis 1
postnasal drip 1
headache 1
thinning 1
Neuropathic pain 1
myalgia 1
cerebellar ataxia 1
Ill 1
Drug
ROS 64
lysine 51
MAP 33
Cardiovasc 19
Monit 15
Dermatol 13
IL-2 13
Sorafenib 11
Ethanol 10
Bortezomib 9
ICI 9
CSF 9
caffeine 8
Ezetimibe 8
CTX 8
Donepezil 7
Everolimus 7
Lenalidomide 6
Gleevec 6
Sunitinib malate 6
PCP 6
CTX 6
vitamin E 6
Taxol 6
Vorinostat 6
Tocilizumab 6
CTX 6
CIA 6
Portal 6
Dasatinib 6
Pegasys 6
Gel 6
Glycyrrhiza 6
Denosumab 6
Gefitinib 6
Pemetrexed disodium 6
EE2 6
Bevacizumab 6
NVP 6
Asthma 5
Parkin 5
TTC 5
Activin 5
Angiotensin II 5
Cetuximab 5
GEO 5
ADR 5
Simvastatin 5
Parkin 5
Entecavir 5
Entecavir 5
Darbepoetin alfa 5
Zoledronic acid 5
Retinoic acid 5
Imatinib 5
Rosuvastatin calcium 5
G-CSF 5
Peginterferon alfa-2b 5
Adalimumab 5
Fondaparinux 5
Epoetin 5
Pimecrolimus 5
Peginterferon alfa-2b 5
Zoledronic acid 4
Bayer 4
Emodin 4
NADH 4
Pitavastatin calcium 4
Pregabalin 4
Salbutamol 4
Tenofovir disoproxil fumarate 4
Teriparatide 4
Heme 4
Mycophenolic acid 4
Raltegravir 4
Aliskiren fumarate 4
Liraglutide 4
ABC 4
PMPA 4
IFN-gamma 4
Glucagon 4
Rosiglitazone 4
Emodin 4
Dutasteride 4
Fulvestrant 4
Duloxetine hydrochloride 4
Escitalopram oxalate 4
Growth hormone 4
IL-1ra 3
Caspofungin 3
Paliperidone 3
DEX 3
Cilostazol 3
ROC 3
Nitric Oxide 3
TAK 3
Vitamin E 3
Tarceva 3
Valsartan 3
Epigallocatechin 3
Tykerb 3
Arsenic trioxide 3
Histamine 3
TAC 3
Spectrum 3
lactose 3
Vernakalant hydrochloride 3
Leaf 3
MDM 3
CAM 3
Ixabepilone 3
TAT 3
Campath 3
Flixotide 3
Posaconazole 3
Levitra 3
Alsterpaullone 3
ADM 3
Abatacept 3
Axitinib 3
CPT-11 3
Ventolin 3
Olmesartan medoxomil 3
FAD 3
Ciclesonide 3
Adefovir dipivoxil 3
Bosentan 3
Fluticasone furoate 3
Enfuvirtide 3
Ginseng 3
Solifenacin succinate 3
uPA 3
Indomethacin 3
Chantix 3
Bosentan 3
Cinacalcet hydrochloride 3
Natalizumab 3
GHRP 3
Campath 3
p75 2
Certolizumab pegol 2
Alefacept 2
Loratadine 2
PCB 2
Succinobucol 2
Vardenafil 2
Dronedarone hydrochloride 2
Tirapazamine 2
ZnCl2 2
Belimumab 2
KCL 2
EPA 2
Mepolizumab 2
MDS 2
Enzastaurin hydrochloride 2
Rasburicase 2
Flavopiridol 2
Genasense 2
CCL 2
Bupivacaine 2
more...
Enzyme
GSK 6788
protein kinase 1908
mitogen-activated protein kinase 642
caspase-3 305
ERK 304
phosphatidylinositol 3-kinase 256
focal adhesion kinase 247
protein kinase C 208
calcineurin 169
MEK 138
cdc2 100
superoxide dismutase 98
luciferase 97
phosphoinositide 3-kinase 95
proteasome 94
AMP-activated protein kinase 91
AMPK 81
caspase-9 63
PARP 62
protein phosphatase 2A 57
APC 55
AMPK 53
lactate dehydrogenase 52
catalase 49
demethylase 45
acetylcholinesterase 44
alkaline phosphatase 44
ACS 38
PDK1 37
glutathione peroxidase 30
alanine aminotransferase 29
creatine kinase 28
CaMKII 28
MAP 28
phosphodiesterase 27
IKK 26
ATPase 25
tyrosine hydroxylase 25
caspase-8 24
aspartate aminotransferase 24
MPP 21
glutathione S-transferase 21
histone demethylase 20
phosphoenolpyruvate carboxykinase 19
kinesin 19
peroxidase 18
glucose-6-phosphatase 16
NO synthase 16
cholinesterase 15
trypsin 15
NQO1 15
phospholipase C 14
adenylate cyclase 14
NADPH oxidase 12
PKG 12
MMP 12
phosphoenolpyruvate carboxykinase 12
reverse transcriptase 12
phosphoenolpyruvate carboxykinase 12
heme oxygenase 12
hexokinase 11
P-glycoprotein 11
tyrosinase 11
NADPH oxidase 10
phosphorylase 10
complex I 9
AST 9
acetyl-CoA carboxylase 9
phospholipase A2 9
RNA polymerase 9
thrombin 9
glucokinase 9
choline acetyltransferase 8
guanylate cyclase 8
aldehyde dehydrogenase 8
polo-like kinase 1 8
aldehyde dehydrogenase 7
TOR 7
aldehyde dehydrogenase 7
PDE 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
NOS 7
caspase-1 7
thiamine pyrophosphokinase 7
pyruvate kinase 7
urokinase-type plasminogen activator 6
prostate-specific antigen 6
renin 6
phosphatidylinositol-4,5-bisphosphate 3-kinase 6
alcohol dehydrogenase 6
O-GlcNAc transferase 6
prolyl endopeptidase 6
pyruvate dehydrogenase 6
collagenase 6
phosphorylase kinase 6
PCP 6
MEKK1 6
monoamine oxidase 6
pyruvate dehydrogenase 6
CD10 6
tissue plasminogen activator 6
CLK1 6
pyruvate dehydrogenase 6
CPT 5
type 1 protein phosphatase 5
caspase-2 5
phosphofructokinase 5
caspase-7 5
DCF 5
glyceraldehyde-3-phosphate dehydrogenase 5
CPT 5
CPT 5
insulin-degrading enzyme 5
caspase-7 5
chloramphenicol acetyltransferase 5
glutamine synthetase 5
RNase 5
caspase-2 5
cathepsin K 5
RNase 5
beta-galactosidase 4
ECH 4
trehalase 4
TAT 4
lipoprotein lipase 4
ACE 4
inositol 3-kinase 4
matrix metalloproteinase 9 4
AMP-activated kinase 4
cathepsin D 4
TGT 4
beta-secretase 4
CFI 4
Omi/HtrA2 3
proteinase-3 3
topoisomerase 3
topoisomerase 3
succinate dehydrogenase 3
kallikrein 3
DNA methyltransferase 3
DNA polymerase 3
ADH 3
ribonucleotide reductase 3
ribonucleotide reductase 3
matrix metalloproteinase 2 3
citrate synthase 3
thioredoxin reductase 3
glutathione reductase 3
gamma-glutamylcysteine synthetase 3
3-hydroxy-3-methylglutaryl-CoA reductase 2
prolyl hydroxylase 2
15-hydroxyprostaglandin dehydrogenase 2
BAT 2
granzyme B 2
acid phosphatase 2
endonuclease 2
enolase 2
thymidine kinase 2
histone acetyltransferase 2
more...
Compound
glucose 489
Glycogen synthase 478
Dec 443
serine 364
DNA 309
threonine 299
oxygen 285
tyrosine 259
ATP 195
water 186
calcium 175
TNF 162
Lithium 138
cAMP 122
Insulin 105
glutamate 98
sodium 97
phosphate 95
Clin 94
MTT 93
MEK 90
MDA 77
nitric oxide 67
GSH 67
GSH 67
alanine 66
lysine 65
hydrogen 64
Glycogen 63
AMP 53
zinc 47
sulfate 46
Cardiol 45
ethanol 44
proline 40
bromide 39
ACS 38
retinoic acid 38
ACS 38
arginine 37
iodine 36
potassium 36
acetate 35
Wortmannin 34
STZ 34
Lithium chloride 33
H2O2 32
leucine 31
nitrogen 30
cysteine 30
MAP 28
salt 27
Phosphatidylinositol 27
COS 26
Asp 25
Curcumin 25
Serine 24
NMDA 24
dUTP 23
urea 22
galactose 22
MPTP 21
MPP 21
MPP 21
Vimentin 20
5-HT 20
ADP 19
ADP 19
methionine 19
pyridine 19
cGMP 19
ADP 19
Valproic acid 18
PGE 18
Neuronal 18
Rapamycin 17
SDS 17
Melatonin 17
Resveratrol 16
Indirubin 15
NH2 15
His 15
Casein 14
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 14
Phe 14
iron 14
Gly 14
Histone 14
AMPA 14
N-acetylcysteine 13
copper 13
PEG 13
ALP 13
NAD 13
creatinine 13
GlcNAc 13
Valproic acid 12
Ang II 12
THP 12
Estrogen 12
THP 12
GABA 12
GABA 12
PGE2 12
Ketamine 12
glutamic acid 11
H2S 11
ASA 11
GTP 11
pyrimidine 11
Hoechst 33342 11
NAD 11
Pac 11
Estrogen 11
Aripiprazole 10
adenylate 10
L-threonine 10
aldehyde 10
pyrimidine 10
selenium 10
aspartic acid 10
phosphoserine 10
Mg2+ 10
tryptophan 10
aluminum 9
Metformin 9
cadmium 9
quinoline 9
isopropanol 9
aldosterone 9
quinoline 9
DMSO 9
Morphine 9
ICI 9
ADR 9
Hearts 9
Hearts 9
Metformin 9
nicotinamide 9
ADP-ribose 9
TNM 9
CAT 9
Collagen 9
glutamine 8
CAT 8
aspartic acid 8
1,2-dimethylhydrazine 8
PEG 8
CAT 8
caffeine 8
aspartic acid 8
DDP 8
DEAE 8
aspartic acid 8
APAP 8
CTX 8
manganese 8
Emodin 7
TOF 7
Puerarin 7
more...