Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.26 (
GSK
)
6,788
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To identify novel regulators of Wnt signaling, we performed yeast two-hybrid analyses with Dvl-1 and identified
BP75
as a candidate. Here, we demonstrated that
BP75
directly interacts with Dvl-1 in mammalian cells and enhances TCF-dependent gene expression induced by Dvl-1. In support of these results,
BP75
in cooperation with Dvl-1 was found to facilitate dephosphorylation at Tyr216 of
glycogen synthase kinase-3beta
and consequently inhibit its kinase activity. Furthermore, the nuclear translocation and formation of vesicular structures of beta-catenin were induced by
BP75
and Dvl-1 in a synergistic manner. Collectively, these results provided us a novel mechanism in Wnt signaling where
BP75
plays important regulatory roles between
glycogen synthase kinase-3beta
and Dvl.
...
PMID:BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta. 1294 96
