Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.26 (
GSK
)
6,788
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of glycogen synthase kinase-3 (GSK-3) in the nitric oxide-guanosine 3',5'-cyclic monophosphate (NO-cGMP)-induced isoflavone production in soybean sprouts was examined. Inhibitors and donors of NO, cGMP, and
GSK
-3 inhibitor were added to UV-B irradiated sprouts. Results showed that NO, with cGMP, induced the expression of
GSK
-3 under UV-B radiation. Protein kinase G (PKG) was shown to be involved in NO-cGMP-induced
GSK
-3 activation.
GSK
-3 elevated activity and expression levels of
chalcone synthase
(
CHS
) and isoflavone synthase (IFS), and increased isoflavone accumulation.
...
PMID:GSK-3 mediates NO-cGMP-induced isoflavone production in soybean sprouts. 2894 85
