EC:2.7.11.25 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: EC:2.7.11.25 (MEKK1)
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Human Gene/Protein
phosphodiesterase 3B, cGMP-inhibited	14.1
MRPL42	14.1
mitogen-activated protein kinase kinase kinase	14.1
MLTK	14.1
cellular modulator of immune recognition (c-MIR)	14.1
MEKK	14.1
MEKK3	14.0
MEKK2	13.9
MEKK1	13.5
tripartite motif-containing 48	13.1
UEV-3	13.1
TGF-beta activated kinase 1	13.1
MEKK4	13.0
MAP3K15	12.7
MUK-binding inhibitory protein	12.5
MEK kinase 2	12.5
Cerebral cavernous malformation 2	12.5
TAO2	12.4
MAP kinase kinase 4	12.2
MINK	12.2
Mixed lineage kinase	12.1
ZAK	12.1
suppressor of cytokine signaling 7	12.1
proline-rich transcript in brain	12.1
ZPK	12.1
B-3501	12.1
TGF-beta activated kinase	12.1
MEK kinase 4	12.1
TPL2	12.1
MKK5	11.9
MAP4K5	11.9
mixed lineage kinase 3	11.9
TAK1-binding protein 1	11.8
AIR1	11.7
MDS2	11.7
CCDC14	11.7
ASK2	11.7
MLK	11.7
MAP3K2	11.6
Nck-interacting kinase	11.6
MAP3K5	11.6
Glycinamide ribonucleotide formyltransferase	11.5
RalGDS-like factor	11.5
TNF receptor-associated factor 4	11.5
MAPKBP1	11.5
Cardiotrophin 1	11.5
LZK	11.5
COP9 signalosome subunit 6	11.5
MAD protein	11.5
MEK5	11.4
transforming growth factor-beta-activated kinase 1	11.4
TPL-2	11.4
MKK7	11.3
apoptosis signal-regulating kinase 1	11.3
MAP3K3	11.3
MYLK3	11.3
mitogen-activated protein kinase kinase kinase 3	11.3
PPEF-2	11.3
SSR3	11.3
MKK4	11.2
MAP4K1	11.2
ICAP-1	11.2
STX5	11.1
germinal center kinase-like kinase	11.1
PSK1	11.1
DLK	11.0
MyD118	11.0
HPK1	11.0
ECSIT	11.0
SPRK	10.9
MAPKK6	10.9
Protocadherin-8	10.9
kinase suppressor of ras	10.9
Mak3p	10.9
retinitis pigmentosa GTPase regulator interacting protein 1	10.9
HSF2BP	10.9
CENTG1	10.9
TAB1	10.9
ASK1	10.9
TAK1-binding protein 2	10.8

Disease
SPH1	10.3
CCM2	9.5
CCM3	8.6
Eosinophilic meningitis	8.6
Reovirus infection	8.6
Persistent hyperinsulinemic hypoglycemia of infancy	8.4
Bladder outlet obstruction	7.9
Brachydactyly	7.8
PARK8	7.8
cardiofaciocutaneous syndrome	7.7
amphetamine abuse	7.0
JIP	6.8
salivary gland cancer	6.8
Aeromonas hydrophila infection	6.7
EDS1	6.7
OCM	6.6
Simpson-Golabi-Behmel syndrome	6.2
ACS1	5.9
CEP	5.9
leukoderma	5.7
chondrodysplasia	5.6
pachygyria	5.6
Wolfram syndrome	5.5
renal clear cell carcinoma	5.4
Buerger's disease	5.3
familial dysautonomia	5.3
RGS	5.2
MEN 2B	5.2
benign nevi	5.2
olivopontocerebellar atrophy	5.1
SM1	5.1
plant disease	5.0
DVD	5.0
Chronic heart failure	5.0
DVD	5.0
juvenile myelomonocytic leukemia	5.0
Optic nerve	4.9
FBS	4.9
kidney tumor	4.8
Ovarian Cancer	4.7
Angiostrongylus cantonensis	4.7
infectious endocarditis	4.6
Osteosarcoma	4.5
Osteosarcoma	4.5
Apert syndrome	4.5
AGS	4.5
Still's disease	4.5
osteopetrosis	4.4
dysplastic nevi	4.4
CLN3	4.4
Dementia with Lewy bodies	4.4
embryonal carcinoma	4.3
Bardet-Biedl syndrome	4.3
malignant ascites	4.3
metastatic melanoma	4.3
hyperosmolality	4.3
MEC	4.2
pituitary tumor	4.2
Tumour necrosis	4.2
adenocarcinoma of the pancreas	4.1
MIP	4.1
Testis	4.1
Testis	4.1
Menkes	4.0
LDLR	3.9
HOS	3.9
SMC	3.9
neurofibromatosis	3.9
PPP	3.9
tumor initiation	3.9
neoplastic transformation	3.8
myelofibrosis	3.8
renal ischemia	3.8
gonadal dysgenesis	3.8
Beckwith-Wiedemann syndrome	3.7
NF2	3.7
HGF	3.7
Esophageal squamous cell carcinoma	3.7
chemical carcinogenesis	3.6
Ischemic stroke	3.6

Enzyme
MEKK1	14.1
NSY	11.0
MEK	9.1
IKK	8.1
CLK1	8.1
retinyl ester hydrolase	7.7
mitogen-activated protein kinase	7.7
stilbene synthase	7.3
ceramide kinase	7.3
MAP	7.3
stilbene synthase	7.2
isochorismate synthase	6.9
UDP-glucosyltransferase	6.8
lecithin:retinol acyltransferase	6.7
PHD	6.6
phosphatidylserine synthase	6.5
PIP kinase	6.4
alpha-sarcin	6.3
CEP	6.1
protein kinase	6.0
GRK2	5.9
6-phosphofructo-2-kinase	5.7
caspase-11	5.6
caspase-11	5.6
CEP	5.5
histidine kinase	5.4
xylose isomerase	5.4
caspase-2	5.4
ERK	5.3
p100	5.3
phosphoinositide 3-kinase	5.2
kinesin	5.2
GAS	5.2
protein kinase C	5.1
CaMKII	5.1
protein phosphatase 2A	5.1
phosphoribulokinase	5.0
isopeptidase	4.9
calcineurin	4.8
GTP cyclohydrolase I	4.7
myosin light chain kinase	4.7
phosphatidylinositol 3-kinase	4.6
PGM	4.6
triphosphatase	4.5
polo-like kinase 1	4.5
caspase-2	4.5
peptidyl-prolyl cis-trans isomerase	4.5
TMT	4.4
luciferase	4.3
beta-secretase	4.3
caspase-7	4.3
caspase-7	4.2
MPP	4.2
caspase-9	4.2
urokinase-type plasminogen activator	4.1
DCF	4.1
MIP	4.1
CYP7A1	4.1
caspase-3	4.1
PTPase	4.1
ADP-ribosyltransferase	4.1
cdc2	4.0
ADP-ribosyltransferase	4.0
CPT	4.0
chaperonin	4.0
PDK1	3.9
GRK5	3.9
NADPH oxidase	3.9
GSK	3.9
NADPH oxidase	3.9
proteasome	3.9
CPT	3.9
matrix metalloproteinase 2	3.9
glutathione S-transferase	3.9
uricase	3.8
transglutaminase	3.8
xanthine dehydrogenase	3.8
AMPK	3.8
PKG	3.8
cellulose synthase	3.8