EC:2.7.11.25 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: EC:2.7.11.25 (MEKK1)
1,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein
MEKK	1063
MEKK1	465
MAPK	423
MEK	357
p38	343
JNK	335
mitogen-activated protein kinase kinase kinase	285
Mol	273
MAP kinase	222
c-Jun	197
ERK	188
mitogen-activated protein	155
ERK1	144
MEKK3	138
MKK4	129
Sep	127
extracellular signal-regulated kinase	105
cytokine	102
TAK1	101
MEKK2	94
MEK1	93
threonine	93
AP-1	92
apoptosis signal-regulating kinase 1	84
JNK1	80
NS5	79
tumor necrosis factor	76
ASK1	73
MAP	67
Raf-1	65
MKK3	61
MKK7	61
ERK2	59
TNF	52
BRAF	50
IkappaB kinase	49
lipopolysaccharide	48
caspase-3	47
MKK6	46
p38 mitogen-activated protein kinase	44
IKK	44
phosphatase	40
ERK5	39
MAP2K1	39
tyrosine kinase	39
MEKK4	38
ubiquitin	37
p38 MAP kinase	37
PI3K	37
GTP	36
ATP	36
MEK5	36
insulin	35
serine/threonine kinase	35
Rho	34
epidermal growth factor	34
IL-1	34
p65	32
PKC	32
TNF-alpha	31
RhoA	31
MEK2	30
p53	30
TRAF2	30
TRAF6	30
JNK2	28
IL-6	26
p21	26
TPL-2	25
leucine zipper	25
GTPase	25
phosphorylating	25
proteasome	25
tumor necrosis factor alpha	24
AKT	24
SEK	23
TNF receptor	23
Bcl-2	22
mixed lineage kinase 3	22
ras	22

Disease
cancer	182
tumor	98
tumorigenesis	36
breast cancer	33
melanoma	24
Parkinson's disease	22
ischemia	20
leukemia	19
cold	19
tumor growth	18
tumor progression	15
carcinogenesis	15
Alzheimer's disease	15
atherosclerosis	13
diabetes	13
metastases	13
neuroblastoma	11
lung cancer	11
carcinoma	11
virus infection	11
heart failure	11
prostate cancer	11
ovarian cancer	10
rheumatoid arthritis	10
lymphoma	10
obesity	10
pertussis	9
ATM	8
squamous cell carcinoma	8
CCM2	8
stroke	8
hepatocellular carcinoma	8
colon cancer	7
metastatic melanoma	7
MCF	7
adenocarcinoma	7
cerebral ischemia	7
bacterial infection	6
osteosarcoma	6
dehydration	6
worms	6
Blocking	6
hepatitis B	6
non-small cell lung cancer	5
MIP	5
immunodeficiency	5
glioblastoma	5
osteoarthritis	5
gastric cancer	5
pancreatic cancer	5
hepatitis C	5
hypertension	5
hypercalcemia	5
influenza	5
Epstein	5
Infection	4
acute myeloid leukemia	4
infectious diseases	4
multiple sclerosis	4
multiple myeloma	4
CCM3	4
APC	4
colorectal cancer	4
pheochromocytoma	4
HIV	4
amyotrophic lateral sclerosis	4
neoplastic transformation	4
SDS	4
myocardial infarction	4
neurofibromatosis	4
asthma	4
arthritis	4
embryonal carcinoma	4
GSH	4
FBS	3
sarcoma	3
plant disease	3
tumor initiation	3
oral cancer	3
psoriasis	3

Enzyme
MEKK1	1856
mitogen-activated protein kinase	1152
MEK	574
protein kinase	300
ERK	224
protein kinase C	98
IKK	81
MAP	67
luciferase	45
caspase-3	36
focal adhesion kinase	32
calcineurin	27
proteasome	25
glutathione S-transferase	19
phosphatidylinositol 3-kinase	16
thrombin	15
phosphoinositide 3-kinase	13
collagenase	11
kinesin	11
ATPase	11
urokinase-type plasminogen activator	11
NADPH oxidase	10
phospholipase C	10
AMPK	10
NADPH oxidase	9
CaMKII	8
cdc2	8
catalase	8
caspase-9	8
superoxide dismutase	8
PARP	7
NSY	7
AMP-activated protein kinase	7
GSK	6
protein phosphatase 2A	6
histidine kinase	6
MIP	5
NO synthase	5
PHD	5
caspase-8	5
myosin light chain kinase	4
AMPK	4
peroxidase	4
transglutaminase	4
complex I	3
lactate dehydrogenase	3
CPT	3
CPT	3
CEP	3
CEP	3
ACS	3
RNA polymerase	3
chloramphenicol acetyltransferase	3
CPT	3
CLK1	3
APC	3
GRK2	3
thymidine kinase	2
MPP	2
GAS	2
reverse transcriptase	2
stilbene synthase	2
heme oxygenase	2
PDK1	2
NOS	2
polo-like kinase 1	2
peroxiredoxin	2
stilbene synthase	2
matrix metalloproteinase 2	2
DCF	2
phospholipase A2	2
p100	2
triphosphatase	2
chaperonin	2
caspase-2	2
tissue plasminogen activator	2
topoisomerase	2
adenylate cyclase	2
PKG	2
topoisomerase	2