Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.25 (MEKK1)
1,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEKK 1063
MEKK1 465
MAPK 423
MEK 357
p38 343
JNK 335
mitogen-activated protein kinase kinase kinase 285
Mol 273
MAP kinase 222
c-Jun 197
ERK 188
mitogen-activated protein 155
ERK1 144
MEKK3 138
MKK4 129
Sep 127
extracellular signal-regulated kinase 105
cytokine 102
TAK1 101
MEKK2 94
threonine 93
MEK1 93
AP-1 92
apoptosis signal-regulating kinase 1 84
JNK1 80
NS5 79
tumor necrosis factor 76
ASK1 73
MAP 67
Raf-1 65
MKK3 61
MKK7 61
ERK2 59
TNF 52
BRAF 50
IkappaB kinase 49
lipopolysaccharide 48
caspase-3 47
MKK6 46
IKK 44
more...
Disease
cancer 182
tumor 98
tumorigenesis 36
breast cancer 33
melanoma 24
Parkinson's disease 22
ischemia 20
leukemia 19
cold 19
tumor growth 18
tumor progression 15
carcinogenesis 15
Alzheimer's disease 15
atherosclerosis 13
metastases 13
diabetes 13
heart failure 11
carcinoma 11
lung cancer 11
prostate cancer 11
neuroblastoma 11
virus infection 11
ovarian cancer 10
rheumatoid arthritis 10
lymphoma 10
obesity 10
pertussis 9
ATM 8
stroke 8
CCM2 8
hepatocellular carcinoma 8
squamous cell carcinoma 8
MCF 7
cerebral ischemia 7
metastatic melanoma 7
colon cancer 7
adenocarcinoma 7
osteosarcoma 6
worms 6
dehydration 6
more...
Symptom
starvation 12
seizures 5
tremor 2
splenomegaly 2
hyperoxia 2
pain 2
collapse 2
acute stress 2
memory loss 1
bradykinesia 1
motor symptom 1
ataxia 1
hypotonia 1
anorexia 1
HSA 1
anesthesia 1
lethargy 1
dyspnea 1
Drug
MAP 68
lysine 22
ROS 11
Gel 7
TAK 6
CSF 5
caffeine 5
p75 5
Angiotensin II 4
IFN-gamma 4
Dermatol 3
Asn 3
uPA 3
IL-2 3
ETS 3
Magnesium sulfate 2
Indomethacin 2
Capsicum 2
IFN-beta 2
Activin 2
Nitric Oxide 2
Fluorescein 1
ascorbate 1
RFP 1
Emodin 1
MgSO4 1
Leaf 1
CED 1
Nexavar 1
NADH 1
CMZ 1
CaCl2 1
CaCl2 1
citric acid 1
Arsenic trioxide 1
Aprotinin 1
Parkin 1
DNase I 1
Vitamin A 1
AraC 1
more...
Enzyme
MEKK1 1856
mitogen-activated protein kinase 1152
MEK 574
protein kinase 300
ERK 224
protein kinase C 98
IKK 81
MAP 67
luciferase 45
caspase-3 36
focal adhesion kinase 32
calcineurin 27
proteasome 25
glutathione S-transferase 19
phosphatidylinositol 3-kinase 16
thrombin 15
phosphoinositide 3-kinase 13
kinesin 11
collagenase 11
ATPase 11
urokinase-type plasminogen activator 11
NADPH oxidase 10
phospholipase C 10
AMPK 10
NADPH oxidase 9
cdc2 8
CaMKII 8
catalase 8
caspase-9 8
superoxide dismutase 8
PARP 7
NSY 7
AMP-activated protein kinase 7
histidine kinase 6
protein phosphatase 2A 6
GSK 6
MIP 5
caspase-8 5
NO synthase 5
PHD 5
more...
Compound
MEK 188
Dec 141
DNA 136
threonine 135
serine 110
tyrosine 81
oxygen 68
MAP 67
calcium 56
TNF 52
acetate 47
NH2 40
GTP 36
ATP 36
leucine 30
cAMP 30
alanine 29
hydrogen 27
lysine 27
salt 26
glucose 22
glycerol 21
COS 20
sodium 19
nitric oxide 18
cysteine 17
Clin 17
AMP 16
salicylic acid 15
H2O2 15
water 14
proline 13
HOG 13
PMA 12
ATF 12
PMA 12
arginine 11
ABA 11
MDA 10
cGMP 9
more...