Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.25 (
MEKK1
)
1,856
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
MEKK
1063
MEKK1
465
MAPK
423
MEK
357
p38
343
JNK
335
mitogen-activated protein kinase kinase kinase
285
Mol
273
MAP kinase
222
c-Jun
197
ERK
188
mitogen-activated protein
155
ERK1
144
MEKK3
138
MKK4
129
Sep
127
extracellular signal-regulated kinase
105
cytokine
102
TAK1
101
MEKK2
94
threonine
93
MEK1
93
AP-1
92
apoptosis signal-regulating kinase 1
84
JNK1
80
NS5
79
tumor necrosis factor
76
ASK1
73
MAP
67
Raf-1
65
MKK3
61
MKK7
61
ERK2
59
TNF
52
BRAF
50
IkappaB kinase
49
lipopolysaccharide
48
caspase-3
47
MKK6
46
IKK
44
more...
Disease
cancer
182
tumor
98
tumorigenesis
36
breast cancer
33
melanoma
24
Parkinson's disease
22
ischemia
20
leukemia
19
cold
19
tumor growth
18
tumor progression
15
carcinogenesis
15
Alzheimer's disease
15
atherosclerosis
13
metastases
13
diabetes
13
heart failure
11
carcinoma
11
lung cancer
11
prostate cancer
11
neuroblastoma
11
virus infection
11
ovarian cancer
10
rheumatoid arthritis
10
lymphoma
10
obesity
10
pertussis
9
ATM
8
stroke
8
CCM2
8
hepatocellular carcinoma
8
squamous cell carcinoma
8
MCF
7
cerebral ischemia
7
metastatic melanoma
7
colon cancer
7
adenocarcinoma
7
osteosarcoma
6
worms
6
dehydration
6
more...
Symptom
starvation
12
seizures
5
tremor
2
splenomegaly
2
hyperoxia
2
pain
2
collapse
2
acute stress
2
memory loss
1
bradykinesia
1
motor symptom
1
ataxia
1
hypotonia
1
anorexia
1
HSA
1
anesthesia
1
lethargy
1
dyspnea
1
Drug
MAP
68
lysine
22
ROS
11
Gel
7
TAK
6
CSF
5
caffeine
5
p75
5
Angiotensin II
4
IFN-gamma
4
Dermatol
3
Asn
3
uPA
3
IL-2
3
ETS
3
Magnesium sulfate
2
Indomethacin
2
Capsicum
2
IFN-beta
2
Activin
2
Nitric Oxide
2
Fluorescein
1
ascorbate
1
RFP
1
Emodin
1
MgSO4
1
Leaf
1
CED
1
Nexavar
1
NADH
1
CMZ
1
CaCl2
1
CaCl2
1
citric acid
1
Arsenic trioxide
1
Aprotinin
1
Parkin
1
DNase I
1
Vitamin A
1
AraC
1
more...
Enzyme
MEKK1
1856
mitogen-activated protein kinase
1152
MEK
574
protein kinase
300
ERK
224
protein kinase C
98
IKK
81
MAP
67
luciferase
45
caspase-3
36
focal adhesion kinase
32
calcineurin
27
proteasome
25
glutathione S-transferase
19
phosphatidylinositol 3-kinase
16
thrombin
15
phosphoinositide 3-kinase
13
kinesin
11
collagenase
11
ATPase
11
urokinase-type plasminogen activator
11
NADPH oxidase
10
phospholipase C
10
AMPK
10
NADPH oxidase
9
cdc2
8
CaMKII
8
catalase
8
caspase-9
8
superoxide dismutase
8
PARP
7
NSY
7
AMP-activated protein kinase
7
histidine kinase
6
protein phosphatase 2A
6
GSK
6
MIP
5
caspase-8
5
NO synthase
5
PHD
5
more...
Compound
MEK
188
Dec
141
DNA
136
threonine
135
serine
110
tyrosine
81
oxygen
68
MAP
67
calcium
56
TNF
52
acetate
47
NH2
40
GTP
36
ATP
36
leucine
30
cAMP
30
alanine
29
hydrogen
27
lysine
27
salt
26
glucose
22
glycerol
21
COS
20
sodium
19
nitric oxide
18
cysteine
17
Clin
17
AMP
16
salicylic acid
15
H2O2
15
water
14
proline
13
HOG
13
PMA
12
ATF
12
PMA
12
arginine
11
ABA
11
MDA
10
cGMP
9
more...