Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.25 (MEKK1)
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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
phosphodiesterase 3B, cGMP-inhibited 14.1
cellular modulator of immune recognition (c-MIR) 14.1
MRPL42 14.1
mitogen-activated protein kinase kinase kinase 14.1
MLTK 14.1
MEKK 14.1
MEKK3 14.0
MEKK2 13.9
MEKK1 13.5
tripartite motif-containing 48 13.1
UEV-3 13.1
TGF-beta activated kinase 1 13.1
MEKK4 13.0
MAP3K15 12.7
Cerebral cavernous malformation 2 12.5
MUK-binding inhibitory protein 12.5
MEK kinase 2 12.5
TAO2 12.4
MAP kinase kinase 4 12.2
MINK 12.2
more...
Disease
SPH1 10.3
CCM2 9.5
CCM3 8.6
Eosinophilic meningitis 8.6
Reovirus infection 8.6
Persistent hyperinsulinemic hypoglycemia of infancy 8.4
Bladder outlet obstruction 7.9
Brachydactyly 7.8
PARK8 7.8
cardiofaciocutaneous syndrome 7.7
amphetamine abuse 7.0
JIP 6.8
salivary gland cancer 6.8
Aeromonas hydrophila infection 6.7
EDS1 6.7
OCM 6.6
Simpson-Golabi-Behmel syndrome 6.2
ACS1 5.9
CEP 5.9
leukoderma 5.7
more...
Symptom
motor symptom 5.2
starvation 3.0
acute stress 2.9
bradykinesia 2.9
hyperoxia 2.7
HSA 2.5
memory loss 2.2
splenomegaly 1.8
lethargy 1.6
hypotonia 1.6
tremor 0.9
anorexia 0.3
collapse 0.3
ataxia 0.1
seizures 0.1
dyspnea -0.7
anesthesia -2.7
pain -2.9
Drug
Oxendolone 10.7
Ciglitazone 7.8
Batimastat 7.5
Batimastat 7.5
CMZ 7.5
Nexavar 7.3
Morphine sulfate 7.2
Magnesium sulfate 7.1
TAK 6.7
NOV 6.3
Tarceva 6.3
MAP 6.2
EDR 5.7
K-252a 5.6
Rosuvastatin 5.2
Emodin 5.2
CED 4.9
Emodin 4.9
uPA 4.6
Erlotinib 4.5
more...
Enzyme
MEKK1 14.1
NSY 11.0
MEK 9.1
IKK 8.1
CLK1 8.1
retinyl ester hydrolase 7.7
mitogen-activated protein kinase 7.7
stilbene synthase 7.3
ceramide kinase 7.3
MAP 7.3
stilbene synthase 7.2
isochorismate synthase 6.9
UDP-glucosyltransferase 6.8
lecithin:retinol acyltransferase 6.7
PHD 6.6
phosphatidylserine synthase 6.5
PIP kinase 6.4
alpha-sarcin 6.3
CEP 6.1
protein kinase 6.0
more...
Compound
5-chloro-2-hydroxybenzamide 10.6
Farrerol 9.5
ASK 9.3
HOG 8.7
KT-1 8.6
9AA 8.2
9AA 8.2
MEK 8.0
Deguelin 7.8
ACES 7.7
Diallyl sulfide 7.7
Benzyl isothiocyanate 7.5
Anisomycin 7.5
Morphine sulfate 7.4
Paricalcitol 7.3
Phenethyl isothiocyanate 7.2
Serpentine 7.2
Juglone 7.2
dUDP 7.2
TRU 7.0
more...