Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.25 (MEKK1)
 1,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEKK 1063
MEKK1 465
MAPK 423
MEK 357
p38 343
JNK 335
mitogen-activated protein kinase kinase kinase 285
Mol 273
MAP kinase 222
c-Jun 197
ERK 188
mitogen-activated protein 155
ERK1 144
MEKK3 138
MKK4 129
Sep 127
extracellular signal-regulated kinase 105
cytokine 102
TAK1 101
MEKK2 94
more...
Disease
cancer 182
tumor 98
tumorigenesis 36
breast cancer 33
melanoma 24
Parkinson's disease 22
ischemia 20
cold 19
leukemia 19
tumor growth 18
tumor progression 15
carcinogenesis 15
Alzheimer's disease 15
diabetes 13
metastases 13
atherosclerosis 13
prostate cancer 11
neuroblastoma 11
lung cancer 11
heart failure 11
more...
Symptom
starvation 12
seizures 5
tremor 2
splenomegaly 2
hyperoxia 2
pain 2
collapse 2
acute stress 2
memory loss 1
bradykinesia 1
motor symptom 1
ataxia 1
hypotonia 1
anorexia 1
HSA 1
anesthesia 1
lethargy 1
dyspnea 1
Drug
MAP 68
lysine 22
ROS 11
Gel 7
TAK 6
caffeine 5
CSF 5
p75 5
Angiotensin II 4
IFN-gamma 4
uPA 3
Dermatol 3
IL-2 3
Asn 3
ETS 3
Capsicum 2
Magnesium sulfate 2
Activin 2
Nitric Oxide 2
IFN-beta 2
more...
Enzyme
MEKK1 1856
mitogen-activated protein kinase 1152
MEK 574
protein kinase 300
ERK 224
protein kinase C 98
IKK 81
MAP 67
luciferase 45
caspase-3 36
focal adhesion kinase 32
calcineurin 27
proteasome 25
glutathione S-transferase 19
phosphatidylinositol 3-kinase 16
thrombin 15
phosphoinositide 3-kinase 13
urokinase-type plasminogen activator 11
ATPase 11
collagenase 11
more...
Compound
MEK 188
Dec 141
DNA 136
threonine 135
serine 110
tyrosine 81
oxygen 68
MAP 67
calcium 56
TNF 52
acetate 47
NH2 40
ATP 36
GTP 36
cAMP 30
leucine 30
alanine 29
hydrogen 27
lysine 27
salt 26
more...