Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.25 (MEKK1)
 1,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
MLTK 14.1
mitogen-activated protein kinase kinase kinase 14.1
MRPL42 14.1
phosphodiesterase 3B, cGMP-inhibited 14.1
cellular modulator of immune recognition (c-MIR) 14.1
MEKK 14.1
MEKK3 14.0
MEKK2 13.9
MEKK1 13.5
TGF-beta activated kinase 1 13.1
UEV-3 13.1
tripartite motif-containing 48 13.1
MEKK4 13.0
MAP3K15 12.7
MUK-binding inhibitory protein 12.5
Cerebral cavernous malformation 2 12.5
MEK kinase 2 12.5
TAO2 12.4
MAP kinase kinase 4 12.2
MINK 12.2
Mixed lineage kinase 12.1
ZAK 12.1
MEK kinase 4 12.1
TGF-beta activated kinase 12.1
B-3501 12.1
proline-rich transcript in brain 12.1
ZPK 12.1
TPL2 12.1
suppressor of cytokine signaling 7 12.1
MKK5 11.9
MAP4K5 11.9
mixed lineage kinase 3 11.9
TAK1-binding protein 1 11.8
MDS2 11.7
AIR1 11.7
CCDC14 11.7
ASK2 11.7
MLK 11.7
MAP3K2 11.6
Nck-interacting kinase 11.6
MAP3K5 11.6
Glycinamide ribonucleotide formyltransferase 11.5
TNF receptor-associated factor 4 11.5
COP9 signalosome subunit 6 11.5
RalGDS-like factor 11.5
LZK 11.5
Cardiotrophin 1 11.5
MAD protein 11.5
MAPKBP1 11.5
MEK5 11.4
transforming growth factor-beta-activated kinase 1 11.4
TPL-2 11.4
MKK7 11.3
apoptosis signal-regulating kinase 1 11.3
mitogen-activated protein kinase kinase kinase 3 11.3
MAP3K3 11.3
PPEF-2 11.3
SSR3 11.3
MYLK3 11.3
MKK4 11.2
MAP4K1 11.2
ICAP-1 11.2
germinal center kinase-like kinase 11.1
STX5 11.1
PSK1 11.1
DLK 11.0
MyD118 11.0
HPK1 11.0
ECSIT 11.0
Protocadherin-8 10.9
MAPKK6 10.9
SPRK 10.9
CENTG1 10.9
HSF2BP 10.9
retinitis pigmentosa GTPase regulator interacting protein 1 10.9
kinase suppressor of ras 10.9
Mak3p 10.9
TAB1 10.9
ASK1 10.9
TAK1-binding protein 2 10.8
TAK1 10.8
EDR1 10.8
p38b 10.8
MLK3 10.8
MAP3K9 10.7
Histone deacetylase 7 10.7
GRASP-1 10.7
SPAS-1 10.7
Fetuin-B 10.7
MKK3 10.7
TGF-beta-activated kinase 1 10.7
MLK2 10.7
MKK6 10.7
MAP3K8 10.7
FBXW5 10.6
MAP4K2 10.6
VIK 10.6
MAP3 10.6
MAP3K12 10.5
LYK5 10.5
TANC1 10.5
MAP2K3 10.5
Rho-associated, coiled-coil containing protein kinase 1 10.5
MAPK8IP2 10.5
RBP7 10.5
BMP2K 10.5
MAP2K1 10.4
MAPK4 10.4
TAB2 10.4
GLK 10.4
TAOK2 10.4
COX16 10.4
S171 10.4
SEK 10.3
ERK5 10.3
mss4 10.3
RIN2 10.3
alphaSNAP 10.3
Mitogen-activated protein kinase kinase 4 10.3
MAP3K4 10.3
Ral guanine nucleotide exchange factor 10.3
NRK1 10.3
HGK 10.3
MEK2 10.2
TAB3 10.2
p38delta 10.2
B-Raf protein 10.2
MAP3K7 10.2
MLK4 10.2
MED7 10.2
STK38 10.1
GSK3A 10.1
mixed lineage kinase 10.1
JIP1 10.1
FSD2 10.1
SPRR1B 10.1
CNN3 10.1
vaccinia-related kinase 2 10.1
MAP kinase phosphatase 3 10.1
MAP4K3 10.0
extracellular signal-regulated kinase 5 10.0
MAP kinase kinase 3 10.0
dual specificity phosphatase 5 10.0
DIX domain containing 1 10.0
NIK 10.0
hematopoietic progenitor kinase 1 10.0
ABIN-2 9.9
TAO1 9.9
lin-10 9.9
IL17R 9.9
PSMC3 9.8
ATG16L 9.8
LRP protein 9.8
MKNK2 9.8
STX6 9.8
MAPK11 9.8
ligand-dependent corepressor 9.8
SH3P7 9.7
STE20 9.7
DRG1 9.7
more...
Disease
SPH1 10.3
CCM2 9.5
CCM3 8.6
Eosinophilic meningitis 8.6
Reovirus infection 8.6
Persistent hyperinsulinemic hypoglycemia of infancy 8.4
Bladder outlet obstruction 7.9
PARK8 7.8
Brachydactyly 7.8
cardiofaciocutaneous syndrome 7.7
amphetamine abuse 7.0
JIP 6.8
salivary gland cancer 6.8
Aeromonas hydrophila infection 6.7
EDS1 6.7
OCM 6.6
Simpson-Golabi-Behmel syndrome 6.2
ACS1 5.9
CEP 5.9
leukoderma 5.7
chondrodysplasia 5.6
pachygyria 5.6
Wolfram syndrome 5.5
renal clear cell carcinoma 5.4
Buerger's disease 5.3
familial dysautonomia 5.3
RGS 5.2
MEN 2B 5.2
benign nevi 5.2
olivopontocerebellar atrophy 5.1
SM1 5.1
plant disease 5.0
DVD 5.0
Chronic heart failure 5.0
DVD 5.0
juvenile myelomonocytic leukemia 5.0
Optic nerve 4.9
FBS 4.9
kidney tumor 4.8
Ovarian Cancer 4.7
Angiostrongylus cantonensis 4.7
infectious endocarditis 4.6
Osteosarcoma 4.5
Osteosarcoma 4.5
Apert syndrome 4.5
AGS 4.5
Still's disease 4.5
osteopetrosis 4.4
dysplastic nevi 4.4
CLN3 4.4
Dementia with Lewy bodies 4.4
embryonal carcinoma 4.3
Bardet-Biedl syndrome 4.3
malignant ascites 4.3
metastatic melanoma 4.3
hyperosmolality 4.3
MEC 4.2
pituitary tumor 4.2
Tumour necrosis 4.2
adenocarcinoma of the pancreas 4.1
MIP 4.1
Testis 4.1
Testis 4.1
Menkes 4.0
LDLR 3.9
HOS 3.9
SMC 3.9
neurofibromatosis 3.9
PPP 3.9
tumor initiation 3.9
neoplastic transformation 3.8
myelofibrosis 3.8
renal ischemia 3.8
gonadal dysgenesis 3.8
Beckwith-Wiedemann syndrome 3.7
NF2 3.7
HGF 3.7
Esophageal squamous cell carcinoma 3.7
chemical carcinogenesis 3.6
Ischemic stroke 3.6
acute nonlymphocytic leukemia 3.6
Fox 3.6
Blocking 3.5
conductive hearing loss 3.5
Adenovirus 3.5
tumorigenesis 3.4
ATM 3.4
AAS 3.4
plasmacytoma 3.4
renal cancer 3.4
colibacillosis 3.4
endometrial adenocarcinoma 3.3
progressive supranuclear palsy 3.3
adrenocortical carcinoma 3.3
oral cancer 3.2
cutaneous melanoma 3.2
immune deficiency 3.2
neuritis 3.1
myeloid leukemia 3.1
TAM 3.1
erythroleukemia 3.1
hypercalcemia 3.1
Kawasaki disease 3.1
MLC 3.0
IVA 3.0
pertussis 3.0
NOD 2.9
optic atrophy 2.9
ABL 2.9
drug withdrawal 2.9
medulloblastoma 2.9
glomerulopathy 2.9
HTLV-I 2.8
cerebral ischemia 2.8
fibrosarcoma 2.8
neuroblastoma 2.8
myeloproliferative disorders 2.8
bacterial infection 2.8
APC 2.7
telangiectasia 2.7
hairy cell leukemia 2.7
HAM 2.7
tumor progression 2.7
liver fibrosis 2.6
osteosarcoma 2.6
worms 2.6
ovarian cancer 2.6
degenerative disease 2.6
Parkinson's disease 2.6
EMT 2.6
listeriosis 2.6
melanoma 2.6
xeroderma pigmentosum 2.6
African trypanosomiasis 2.5
invasive cancer 2.5
psychological stress 2.5
aldosteronism 2.5
Recruitment 2.5
Langerhans cell histiocytosis 2.4
tumor growth 2.4
acne 2.4
latent infection 2.4
craniosynostosis 2.3
medullary thyroid carcinoma 2.3
fragile X syndrome 2.3
diabetic neuropathy 2.3
opportunistic infection 2.3
pheochromocytoma 2.2
glioblastoma 2.2
insulinoma 2.2
right heart failure 2.2
retinoblastoma 2.2
Dissociation 2.2
Melanoma 2.2
B-cell lymphomas 2.1
dehydration 2.1
anaphylaxis 2.1
MCF 2.1
leukemogenesis 2.1
Cryptococcus neoformans 2.1
more...
Symptom
motor symptom 5.2
starvation 3.0
acute stress 2.9
bradykinesia 2.9
hyperoxia 2.7
HSA 2.5
memory loss 2.2
splenomegaly 1.8
lethargy 1.6
hypotonia 1.6
tremor 0.9
anorexia 0.3
collapse 0.3
ataxia 0.1
seizures 0.1
dyspnea -0.7
anesthesia -2.7
pain -2.9
Drug
Oxendolone 10.7
Ciglitazone 7.8
Batimastat 7.5
Batimastat 7.5
CMZ 7.5
Nexavar 7.3
Morphine sulfate 7.2
Magnesium sulfate 7.1
TAK 6.7
NOV 6.3
Tarceva 6.3
MAP 6.2
EDR 5.7
K-252a 5.6
Rosuvastatin 5.2
Emodin 5.2
CED 4.9
Emodin 4.9
uPA 4.6
Erlotinib 4.5
p75 4.5
Activin 4.3
ETS 4.3
Aprotinin 4.2
Luteinizing 4.0
AraC 4.0
IL-11 3.9
Capsicum 3.9
Gefitinib 3.8
RFP 3.8
CoCl2 3.8
CoCl2 3.8
Angiotensin II 3.8
Arsenic trioxide 3.7
Fentanyl 3.7
Nitric Oxide 3.7
IFN-beta 3.5
Sorafenib 3.5
BH4 3.5
MgSO4 3.5
TAC 3.4
ROS 3.3
Parkin 3.2
Parkin 3.2
Gel 3.0
Estrogens 2.9
TAT 2.8
lysine 2.7
Fluorescein 2.7
Alanine 2.6
Vitamin A 2.5
Indomethacin 2.4
Taxol 2.4
MRC 2.3
Fluorescein 2.2
Asn 2.1
caffeine 2.0
Adriamycin 1.9
FAD 1.6
CSF 1.5
CaCl2 1.4
CaCl2 1.4
CaCl2 1.4
IFN-gamma 1.2
DNase I 1.0
nitroglycerin 0.9
IL-2 0.8
Ethanol 0.8
citric acid 0.8
CTX 0.8
lactose 0.0
vitamin E -0.0
Leaf -0.3
NADH -0.4
ascorbate -0.4
Dial -0.8
Dermatol -2.3
Cardiovasc -3.5
Enzyme
MEKK1 14.1
NSY 11.0
MEK 9.1
IKK 8.1
CLK1 8.1
retinyl ester hydrolase 7.7
mitogen-activated protein kinase 7.7
stilbene synthase 7.3
ceramide kinase 7.3
MAP 7.3
stilbene synthase 7.2
isochorismate synthase 6.9
UDP-glucosyltransferase 6.8
lecithin:retinol acyltransferase 6.7
PHD 6.6
phosphatidylserine synthase 6.5
PIP kinase 6.4
alpha-sarcin 6.3
CEP 6.1
protein kinase 6.0
GRK2 5.9
6-phosphofructo-2-kinase 5.7
caspase-11 5.6
caspase-11 5.6
CEP 5.5
histidine kinase 5.4
xylose isomerase 5.4
caspase-2 5.4
ERK 5.3
p100 5.3
phosphoinositide 3-kinase 5.2
kinesin 5.2
GAS 5.2
protein kinase C 5.1
CaMKII 5.1
protein phosphatase 2A 5.1
phosphoribulokinase 5.0
isopeptidase 4.9
calcineurin 4.8
GTP cyclohydrolase I 4.7
myosin light chain kinase 4.7
phosphatidylinositol 3-kinase 4.6
PGM 4.6
triphosphatase 4.5
polo-like kinase 1 4.5
caspase-2 4.5
peptidyl-prolyl cis-trans isomerase 4.5
TMT 4.4
luciferase 4.3
beta-secretase 4.3
caspase-7 4.3
caspase-7 4.2
MPP 4.2
caspase-9 4.2
urokinase-type plasminogen activator 4.1
DCF 4.1
MIP 4.1
CYP7A1 4.1
caspase-3 4.1
PTPase 4.1
ADP-ribosyltransferase 4.1
cdc2 4.0
ADP-ribosyltransferase 4.0
CPT 4.0
chaperonin 4.0
PDK1 3.9
GRK5 3.9
NADPH oxidase 3.9
GSK 3.9
NADPH oxidase 3.9
proteasome 3.9
CPT 3.9
matrix metalloproteinase 2 3.9
glutathione S-transferase 3.9
uricase 3.8
transglutaminase 3.8
xanthine dehydrogenase 3.8
AMPK 3.8
PKG 3.8
cellulose synthase 3.8
peroxiredoxin 3.7
caspase-8 3.7
LPL 3.6
focal adhesion kinase 3.6
Mg2+-ATPase 3.5
CPT 3.5
AMPK 3.4
collagenase 3.4
chloramphenicol acetyltransferase 3.3
prolyl hydroxylase 3.2
prostaglandin synthetase 3.2
phospholipase C 3.2
AMP-activated protein kinase 3.2
PARP 3.1
cathepsin L 3.1
heme oxygenase 3.0
NADH dehydrogenase 3.0
thrombin 3.0
TAT 2.8
thioredoxin reductase 2.8
MDP 2.7
ribonucleotide reductase 2.6
glucokinase 2.6
complex I 2.5
ribonucleotide reductase 2.5
NO synthase 2.4
ricin 2.4
MMP-3 2.3
thymidylate synthase 2.3
NOS 2.2
nitrate reductase 2.2
nitrate reductase 2.2
nitrate reductase 2.2
nitrate reductase 2.2
nitrate reductase 2.2
phospholipase D 2.2
thymidine kinase 2.2
nitrate reductase 2.2
cathepsin B 2.0
MMP 2.0
guanylate cyclase 2.0
glyceraldehyde-3-phosphate dehydrogenase 2.0
glyceraldehyde-3-phosphate dehydrogenase 2.0
topoisomerase 1.9
hyaluronidase 1.9
glyceraldehyde-3-phosphate dehydrogenase 1.9
invertase 1.8
topoisomerase 1.8
DNA methyltransferase 1.8
pyruvate kinase 1.7
APC 1.7
glyceraldehyde-3-phosphate dehydrogenase 1.6
tissue plasminogen activator 1.6
diaphorase 1.5
ATPase 1.5
NQO1 1.5
hyaluronidase 1.5
caspase-1 1.4
ornithine decarboxylase 1.4
glyceraldehyde-3-phosphate dehydrogenase 1.4
catalase 1.3
phospholipase A2 1.3
superoxide dismutase 1.2
tyrosine hydroxylase 1.2
succinate dehydrogenase 1.1
xanthine oxidase 1.0
lipoxygenase 1.0
transcriptase 0.9
glutathione reductase 0.8
adenylate cyclase 0.8
lactate dehydrogenase 0.8
RNA polymerase 0.6
P-glycoprotein 0.4
beta-lactamase 0.4
neuraminidase 0.2
reverse transcriptase 0.1
peroxidase 0.1
phosphodiesterase -0.1
aspartate aminotransferase -0.3
ACS -0.6
more...
Compound
5-chloro-2-hydroxybenzamide 10.6
Farrerol 9.5
ASK 9.3
HOG 8.7
KT-1 8.6
9AA 8.2
9AA 8.2
MEK 8.0
Deguelin 7.8
ACES 7.7
Diallyl sulfide 7.7
Benzyl isothiocyanate 7.5
Anisomycin 7.5
Morphine sulfate 7.4
Paricalcitol 7.3
Serpentine 7.2
Phenethyl isothiocyanate 7.2
Juglone 7.2
dUDP 7.2
TRU 7.0
Magnesium sulfate 6.9
MAP 6.9
Biochanin A 6.9
Magnesium sulfate 6.8
Bufalin 6.8
ATF 6.7
KIV 6.6
CUE 6.6
Ginsenoside Rg1 6.5
Parthenolide 6.4
MAK 6.4
GF 109203X 6.3
Chelerythrine 6.2
Chelerythrine 6.2
Parthenolide 6.2
(-)-Epigallocatechin 6.2
Fisetin 6.1
Anthocyanin 6.0
Formin 6.0
DETA 6.0
D-Serine 6.0
LY 294002 5.9
2-phosphoglycerate 5.8
PGA1 5.8
Thioredoxin 5.7
threonine 5.7
Sulindac 5.7
Phorbol 12-myristate 13-acetate 5.7
Tetrahydrobiopterin 5.6
Apigenin 5.5
CHIP 5.3
Fumarate 5.3
SP-1 5.3
Fucoidan 5.2
Emodin 5.2
Cys-Gly 5.2
G11 5.2
ABA 5.1
Endosulfan 5.1
Neutral Red 5.1
Tanshinone 5.1
Arsenate 5.1
BHC 5.0
Emodin 5.0
AF-2 5.0
APH 4.9
Wortmannin 4.9
25-dihydroxycholecalciferol 4.9
serine 4.8
Cbl 4.8
Arsenite 4.8
Vinblastine 4.8
COS 4.8
PAM 4.8
PYR 4.7
PMA 4.7
Serine 4.7
Cer 4.7
TPA 4.6
HPT 4.6
Rhodopsin 4.6
Tiron 4.6
Curcumin 4.6
ABA 4.5
salicylic acid 4.5
DEP 4.5
Uridine 4.4
Actinomycin D 4.4
TPA 4.4
Leucine 4.4
Pioglitazone 4.4
SAH 4.4
GTP 4.4
Ethylene 4.4
SCC 4.4
AEA 4.4
MAD 4.4
Okadaic acid 4.3
MPP 4.3
AAT 4.3
Tumor Necrosis Factor 4.3
MPP 4.3
1H-imidazole 4.3
Phosphatidylinositol 4.2
quinazoline 4.2
quinazoline 4.2
adenosylmethionine 4.2
DPI 4.1
NEM 4.1
DEP 4.1
AGE 4.1
PMA 4.1
Ochratoxin A 4.1
CPT 4.0
SPD 4.0
Staurosporine 3.9
Ang II 3.9
CPT 3.9
ASC 3.9
Staurosporine 3.9
NH2 3.9
TNF 3.9
Tamoxifen 3.9
Glycogen synthase 3.9
tyrosine 3.8
Tamoxifen 3.8
POP 3.8
Statin 3.8
PAR 3.7
AEA 3.7
naphthoquinone 3.6
naphthoquinone 3.6
naphthoquinone 3.6
naphthoquinone 3.6
naphthoquinone 3.6
naphthoquinone 3.6
PMSF 3.6
Guanine 3.6
PGE 3.6
naphthoquinone 3.5
THP 3.5
Resveratrol 3.5
AICAR 3.5
L-threonine 3.5
THP 3.5
Inositol 3.4
Phosphatidylcholine 3.4
TAP 3.4
Casein 3.3
MPTP 3.3
DPG 3.3
CAT 3.3
CAT 3.3
N-acetylcysteine 3.3
GDP 3.2
CCC 3.2
CAT 3.2
glycerol 3.2
cAMP 3.1
Tyrosine 3.1
more...