Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.25 (MEKK1)
 1,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEKK 1063
MEKK1 465
MAPK 423
MEK 357
p38 343
JNK 335
mitogen-activated protein kinase kinase kinase 285
Mol 273
MAP kinase 222
c-Jun 197
ERK 188
mitogen-activated protein 155
ERK1 144
MEKK3 138
MKK4 129
Sep 127
extracellular signal-regulated kinase 105
cytokine 102
TAK1 101
MEKK2 94
threonine 93
MEK1 93
AP-1 92
apoptosis signal-regulating kinase 1 84
JNK1 80
NS5 79
tumor necrosis factor 76
ASK1 73
MAP 67
Raf-1 65
MKK3 61
MKK7 61
ERK2 59
TNF 52
BRAF 50
IkappaB kinase 49
lipopolysaccharide 48
caspase-3 47
MKK6 46
p38 mitogen-activated protein kinase 44
IKK 44
phosphatase 40
ERK5 39
MAP2K1 39
tyrosine kinase 39
MEKK4 38
p38 MAP kinase 37
ubiquitin 37
PI3K 37
GTP 36
MEK5 36
ATP 36
serine/threonine kinase 35
insulin 35
epidermal growth factor 34
Rho 34
IL-1 34
p65 32
PKC 32
TNF-alpha 31
RhoA 31
TRAF6 30
p53 30
TRAF2 30
MEK2 30
JNK2 28
IL-6 26
p21 26
TPL-2 25
phosphorylating 25
proteasome 25
leucine zipper 25
GTPase 25
tumor necrosis factor alpha 24
AKT 24
SEK 23
TNF receptor 23
ras 22
Bcl-2 22
mixed lineage kinase 3 22
NIK 22
IkappaBalpha 21
14-3-3 20
endoplasmic reticulum 20
LPS 20
Fas 20
MLK 20
TAB1 20
axonal 20
RAF 20
H-ras 19
inducible nitric oxide synthase 19
TPL2 19
TGF-beta 18
TLR4 18
p42 17
cyclooxygenase-2 17
E3 ubiquitin ligase 17
MAPK/ERK kinase 17
thioredoxin 16
EGF 16
small GTPase 16
adaptor protein 16
phosphatidylinositol 3-kinase 16
AMP 16
epidermal growth factor receptor 16
Pseudomonas 16
platelet-derived growth factor 15
IL-8 15
ubiquitin ligase 15
extracellular signal-regulated kinase 1 15
interacting protein 15
thrombin 15
CREB 15
PG2 15
MLK3 15
serine/threonine protein kinase 15
c-fos 14
p38MAPK 14
collagen 14
calmodulin 14
p105 14
ZAK 14
PKA 13
urokinase-type plasminogen activator 13
transforming growth factor-beta 13
DLK 13
tumor necrosis factor receptor 13
AP1 13
TAB2 13
phosphoinositide 3-kinase 13
14-3-3 protein 13
EGFR 13
ATF2 13
MMP-9 12
proline-rich 12
protein phosphatase 12
ATF 12
IFN 12
Tumor necrosis factor 12
cyclin 12
nerve growth factor 12
like kinase 12
angiotensin II 12
involucrin 12
vascular endothelial growth factor 12
MKK5 11
calcineurin 11
ROS 11
STE20 11
HEK 11
fibronectin 11
CD28 11
mixed lineage kinase 11
chemokine 11
kinesin 11
VEGF 10
Smad1 10
p50 10
Cytokine 10
more...
Disease
cancer 182
tumor 98
tumorigenesis 36
breast cancer 33
melanoma 24
Parkinson's disease 22
ischemia 20
cold 19
leukemia 19
tumor growth 18
carcinogenesis 15
tumor progression 15
Alzheimer's disease 15
diabetes 13
metastases 13
atherosclerosis 13
heart failure 11
neuroblastoma 11
prostate cancer 11
virus infection 11
lung cancer 11
carcinoma 11
lymphoma 10
ovarian cancer 10
rheumatoid arthritis 10
obesity 10
pertussis 9
stroke 8
squamous cell carcinoma 8
ATM 8
hepatocellular carcinoma 8
CCM2 8
metastatic melanoma 7
adenocarcinoma 7
cerebral ischemia 7
colon cancer 7
MCF 7
Blocking 6
osteosarcoma 6
bacterial infection 6
worms 6
hepatitis B 6
dehydration 6
glioblastoma 5
immunodeficiency 5
hypercalcemia 5
non-small cell lung cancer 5
influenza 5
osteoarthritis 5
gastric cancer 5
MIP 5
hepatitis C 5
hypertension 5
pancreatic cancer 5
Epstein 5
colorectal cancer 4
Infection 4
asthma 4
myocardial infarction 4
acute myeloid leukemia 4
infectious diseases 4
HIV 4
multiple sclerosis 4
multiple myeloma 4
CCM3 4
amyotrophic lateral sclerosis 4
arthritis 4
neoplastic transformation 4
SDS 4
neurofibromatosis 4
GSH 4
APC 4
embryonal carcinoma 4
pheochromocytoma 4
sepsis 3
AGS 3
CEP 3
chronic obstructive pulmonary disease 3
pituitary tumor 3
myelofibrosis 3
oral cancer 3
FBS 3
psoriasis 3
fibrosarcoma 3
renal cancer 3
NOD 3
sarcoma 3
Leukemia 3
metabolic syndrome 3
retinoblastoma 3
sepsis 3
cervical cancer 3
liver fibrosis 3
glaucoma 3
glioma 3
cardiovascular disease 3
tumor initiation 3
Osteosarcoma 3
Osteosarcoma 3
chondrodysplasia 3
plant disease 3
chronic myeloid leukemia 2
myeloid leukemia 2
Melanoma 2
Buerger's disease 2
type 1 diabetes 2
Crohn's disease 2
erythroleukemia 2
autism 2
epilepsy 2
diabetic retinopathy 2
osteopetrosis 2
AIDS 2
primary tumor 2
emphysema 2
osteoporosis 2
myeloproliferative disorders 2
progressive supranuclear palsy 2
JIP 2
skin cancer 2
infectious endocarditis 2
anaphylaxis 2
cognitive impairment 2
systemic lupus erythematosus 2
Huntington's disease 2
fungal infection 2
Cryptococcus neoformans 2
immune deficiency 2
PHA 2
RGS 2
heart disease 2
acne 2
psychological stress 2
lymphadenopathy 2
dementia 2
Tumour necrosis 2
parkinsonism 2
ABL 2
NAME 2
lung carcinoma 2
pulmonary hypertension 2
Kawasaki disease 2
aggressiveness 2
NF2 2
renal ischemia 2
stomatitis 2
vascular disease 2
Dementia with Lewy bodies 2
cutaneous melanoma 2
Adenovirus 2
medulloblastoma 2
Contact Dermatitis 2
renal disease 2
plasmacytoma 2
HGF 2
hyperglycemia 2
ventricular hypertrophy 1
Ischemic stroke 1
Recruitment 1
hyperinsulinemia 1
more...
Symptom
starvation 12
seizures 5
tremor 2
splenomegaly 2
hyperoxia 2
pain 2
collapse 2
acute stress 2
memory loss 1
bradykinesia 1
motor symptom 1
ataxia 1
hypotonia 1
anorexia 1
HSA 1
anesthesia 1
lethargy 1
dyspnea 1
Drug
MAP 68
lysine 22
ROS 11
Gel 7
TAK 6
p75 5
caffeine 5
CSF 5
IFN-gamma 4
Angiotensin II 4
IL-2 3
uPA 3
Dermatol 3
Asn 3
ETS 3
Indomethacin 2
Nitric Oxide 2
IFN-beta 2
Capsicum 2
Magnesium sulfate 2
Activin 2
nitroglycerin 1
RFP 1
Ciglitazone 1
Emodin 1
MgSO4 1
Leaf 1
CED 1
Oxendolone 1
Fluorescein 1
NOV 1
ascorbate 1
Taxol 1
Batimastat 1
MRC 1
Arsenic trioxide 1
DNase I 1
Parkin 1
lactose 1
Aprotinin 1
Rosuvastatin 1
BH4 1
Cardiovasc 1
Vitamin A 1
AraC 1
Gefitinib 1
CoCl2 1
CoCl2 1
Alanine 1
Erlotinib 1
Tarceva 1
Luteinizing 1
CTX 1
vitamin E 1
TAT 1
EDR 1
Dial 1
Fluorescein 1
IL-11 1
Nexavar 1
NADH 1
Morphine sulfate 1
CMZ 1
K-252a 1
CaCl2 1
Emodin 1
Sorafenib 1
Batimastat 1
CaCl2 1
Estrogens 1
TAC 1
Parkin 1
citric acid 1
Ethanol 1
FAD 1
CaCl2 1
Fentanyl 1
Adriamycin 1
Enzyme
MEKK1 1856
mitogen-activated protein kinase 1152
MEK 574
protein kinase 300
ERK 224
protein kinase C 98
IKK 81
MAP 67
luciferase 45
caspase-3 36
focal adhesion kinase 32
calcineurin 27
proteasome 25
glutathione S-transferase 19
phosphatidylinositol 3-kinase 16
thrombin 15
phosphoinositide 3-kinase 13
urokinase-type plasminogen activator 11
ATPase 11
collagenase 11
kinesin 11
phospholipase C 10
NADPH oxidase 10
AMPK 10
NADPH oxidase 9
superoxide dismutase 8
CaMKII 8
caspase-9 8
cdc2 8
catalase 8
NSY 7
PARP 7
AMP-activated protein kinase 7
GSK 6
protein phosphatase 2A 6
histidine kinase 6
MIP 5
caspase-8 5
NO synthase 5
PHD 5
AMPK 4
myosin light chain kinase 4
peroxidase 4
transglutaminase 4
lactate dehydrogenase 3
CPT 3
CPT 3
CPT 3
CEP 3
ACS 3
CLK1 3
complex I 3
APC 3
chloramphenicol acetyltransferase 3
RNA polymerase 3
GRK2 3
CEP 3
peroxiredoxin 2
PDK1 2
NOS 2
heme oxygenase 2
DCF 2
MPP 2
p100 2
adenylate cyclase 2
guanylate cyclase 2
triphosphatase 2
caspase-2 2
chaperonin 2
GAS 2
tissue plasminogen activator 2
stilbene synthase 2
topoisomerase 2
phospholipase A2 2
polo-like kinase 1 2
thymidine kinase 2
PKG 2
reverse transcriptase 2
topoisomerase 2
matrix metalloproteinase 2 2
PGM 2
tyrosine hydroxylase 2
stilbene synthase 2
glyceraldehyde-3-phosphate dehydrogenase 1
caspase-7 1
ADP-ribosyltransferase 1
ADP-ribosyltransferase 1
nitrate reductase 1
peptidyl-prolyl cis-trans isomerase 1
nitrate reductase 1
xanthine oxidase 1
GTP cyclohydrolase I 1
glutathione reductase 1
xylose isomerase 1
phosphoribulokinase 1
lipoxygenase 1
glucokinase 1
alkaline phosphatase 1
thioredoxin reductase 1
cathepsin B 1
transcriptase 1
caspase-1 1
aspartate aminotransferase 1
cathepsin L 1
neuraminidase 1
MDP 1
uricase 1
isopeptidase 1
caspase-7 1
P-glycoprotein 1
PTPase 1
PIP kinase 1
prolyl hydroxylase 1
succinate dehydrogenase 1
trypsin 1
isochorismate synthase 1
nitrate reductase 1
glyceraldehyde-3-phosphate dehydrogenase 1
LPL 1
TMT 1
glyceraldehyde-3-phosphate dehydrogenase 1
alanine aminotransferase 1
GRK5 1
invertase 1
nitrate reductase 1
CYP7A1 1
ceramide kinase 1
xanthine dehydrogenase 1
nitrate reductase 1
TAT 1
phosphatidylserine synthase 1
beta-secretase 1
diaphorase 1
retinyl ester hydrolase 1
UDP-glucosyltransferase 1
thymidylate synthase 1
NQO1 1
caspase-11 1
phosphodiesterase 1
glyceraldehyde-3-phosphate dehydrogenase 1
Mg2+-ATPase 1
ribonucleotide reductase 1
caspase-2 1
cellulose synthase 1
ribonucleotide reductase 1
NADH dehydrogenase 1
hyaluronidase 1
MMP-3 1
6-phosphofructo-2-kinase 1
beta-lactamase 1
prostaglandin synthetase 1
lecithin:retinol acyltransferase 1
glyceraldehyde-3-phosphate dehydrogenase 1
MMP 1
hyaluronidase 1
phospholipase D 1
DNA methyltransferase 1
nitrate reductase 1
ornithine decarboxylase 1
ricin 1
more...
Compound
MEK 188
Dec 141
DNA 136
threonine 135
serine 110
tyrosine 81
oxygen 68
MAP 67
calcium 56
TNF 52
acetate 47
NH2 40
ATP 36
GTP 36
leucine 30
cAMP 30
alanine 29
hydrogen 27
lysine 27
salt 26
glucose 22
glycerol 21
COS 20
sodium 19
nitric oxide 18
cysteine 17
Clin 17
AMP 16
H2O2 15
salicylic acid 15
water 14
HOG 13
proline 13
PMA 12
ATF 12
PMA 12
arginine 11
ABA 11
MDA 10
phosphate 9
Curcumin 9
adenosylmethionine 9
ASK 9
cGMP 9
nitrogen 8
glutamate 8
zinc 8
Asp 7
THP 7
His 7
TPA 7
TPA 7
THP 7
methionine 6
Insulin 6
retinoic acid 6
Ang II 6
GDP 6
ethanol 6
ADP 6
N-acetylcysteine 6
ABA 6
PGE 6
CAT 5
Serine 5
tryptophan 5
caffeine 5
vitamin D 5
tryptophan 5
tryptophan 5
CAT 5
ADP 5
CAT 5
ADP 5
tryptophan 5
aspartic acid 4
PAM 4
sulfate 4
aspartic acid 4
GSH 4
GSH 4
urea 4
SCC 4
Phe 4
aspartic acid 4
aspartic acid 4
SDS 4
25-dihydroxycholecalciferol 4
Angiotensin II 4
iodine 4
Phosphatidylinositol 3
CPT 3
retinol 3
Triton X-100 3
PAS 3
Thioredoxin 3
Tamoxifen 3
Pac 3
ACS 3
ACS 3
Gly 3
CPT 3
Resveratrol 3
Ethylene 3
Cardiol 3
quinoline 3
MPTP 3
Cbl 3
Cer 3
boron 3
Tamoxifen 3
Leucine 3
iron 3
quinoline 3
DDP 3
ASA 3
MAK 3
DMSO 2
BCR 2
Emodin 2
Panam 2
Vitamin D 2
UTP 2
ASC 2
Tyrosine 2
TOF 2
ABL 2
Anthocyanin 2
valine 2
Neuronal 2
glutamic acid 2
potassium 2
Thrombin 2
Estrogen 2
1H-imidazole 2
CHIP 2
pyrimidine 2
NAD 2
quinazoline 2
naphthoquinone 2
AMPA 2
naphthoquinone 2
Magnesium sulfate 2
naphthoquinone 2
Wortmannin 2
naphthoquinone 2
MPP 2
naphthoquinone 2
Phorbol 12-myristate 13-acetate 2
cadmium 2
Sucrose 2
Apigenin 2
GF 109203X 2
cobalt 2
copper 2
Estrogen 2
naphthoquinone 2
naphthoquinone 2
phenol 2
Off 2
more...