Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.25 (MEKK1)
 1,856 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEKK 1063
MEKK1 465
MAPK 423
MEK 357
p38 343
JNK 335
mitogen-activated protein kinase kinase kinase 285
Mol 273
MAP kinase 222
c-Jun 197
ERK 188
mitogen-activated protein 155
ERK1 144
MEKK3 138
MKK4 129
Sep 127
extracellular signal-regulated kinase 105
cytokine 102
TAK1 101
MEKK2 94
threonine 93
MEK1 93
AP-1 92
apoptosis signal-regulating kinase 1 84
JNK1 80
NS5 79
tumor necrosis factor 76
ASK1 73
MAP 67
Raf-1 65
MKK3 61
MKK7 61
ERK2 59
TNF 52
BRAF 50
IkappaB kinase 49
lipopolysaccharide 48
caspase-3 47
MKK6 46
IKK 44
p38 mitogen-activated protein kinase 44
phosphatase 40
MAP2K1 39
ERK5 39
tyrosine kinase 39
MEKK4 38
PI3K 37
p38 MAP kinase 37
ubiquitin 37
GTP 36
ATP 36
MEK5 36
insulin 35
serine/threonine kinase 35
Rho 34
epidermal growth factor 34
IL-1 34
PKC 32
p65 32
RhoA 31
TNF-alpha 31
p53 30
TRAF2 30
MEK2 30
TRAF6 30
JNK2 28
p21 26
IL-6 26
proteasome 25
phosphorylating 25
TPL-2 25
GTPase 25
leucine zipper 25
AKT 24
tumor necrosis factor alpha 24
SEK 23
TNF receptor 23
ras 22
mixed lineage kinase 3 22
NIK 22
Bcl-2 22
IkappaBalpha 21
Fas 20
TAB1 20
LPS 20
endoplasmic reticulum 20
RAF 20
axonal 20
14-3-3 20
MLK 20
TPL2 19
H-ras 19
inducible nitric oxide synthase 19
TLR4 18
TGF-beta 18
MAPK/ERK kinase 17
cyclooxygenase-2 17
p42 17
E3 ubiquitin ligase 17
Pseudomonas 16
thioredoxin 16
adaptor protein 16
epidermal growth factor receptor 16
small GTPase 16
phosphatidylinositol 3-kinase 16
EGF 16
AMP 16
ubiquitin ligase 15
IL-8 15
extracellular signal-regulated kinase 1 15
CREB 15
interacting protein 15
MLK3 15
thrombin 15
platelet-derived growth factor 15
PG2 15
serine/threonine protein kinase 15
p38MAPK 14
c-fos 14
ZAK 14
calmodulin 14
p105 14
collagen 14
EGFR 13
ATF2 13
AP1 13
14-3-3 protein 13
TAB2 13
transforming growth factor-beta 13
urokinase-type plasminogen activator 13
phosphoinositide 3-kinase 13
PKA 13
tumor necrosis factor receptor 13
DLK 13
vascular endothelial growth factor 12
cyclin 12
proline-rich 12
like kinase 12
protein phosphatase 12
involucrin 12
MMP-9 12
nerve growth factor 12
angiotensin II 12
IFN 12
Tumor necrosis factor 12
ATF 12
ROS 11
mixed lineage kinase 11
MKK5 11
HEK 11
kinesin 11
fibronectin 11
calcineurin 11
STE20 11
chemokine 11
CD28 11
p44 10
p50 10
G protein-coupled receptor 10
CDC42 10
A20 10
VEGF 10
MyD118 10
GST 10
JUN N-terminal kinase 10
focal adhesion kinase 10
Smad1 10
Cytokine 10
TGF-beta-activated kinase 1 10
PB1 10
guanine nucleotide exchange factor 10
SOD 9
CD40 9
MMP-2 9
beta-catenin 9
interferon 9
COX-2 9
adapter protein 9
c-Myc 9
c-Src 9
ASK 9
extracellular signal-regulated kinase 5 9
FAK 9
IKK2 9
JNK3 9
polypeptide 9
Sp1 9
glutathione S-transferase 9
MAP3K5 9
SAM 9
IgE 9
cyclin D1 9
TCR 9
ATPase 9
KRIT1 8
mTOR 8
fused 8
TAK1-binding protein 1 8
receptor tyrosine kinase 8
proto-oncogene 8
Nck-interacting kinase 8
RIPK1 8
PDGF 8
caspase-9 8
MAP3 8
matrix metalloproteinase 8
Mixed lineage kinase 8
bone morphogenetic protein 8
leucine-rich repeat kinase 2 8
Axin 8
MyD88 8
MLTK 8
nuclear receptor 8
gut 8
CCM2 8
MAP3K8 8
PI3 8
estrogen receptor 8
Bot 8
ASK2 8
MAP3K7 8
p62 8
ribosomal S6 kinase 8
MAP kinase kinase 4 8
zinc finger 7
atrial natriuretic factor 7
p38delta 7
T cell receptor 7
transcriptional factor 7
P38 7
A kinase 7
lymphoid 7
CaMKII 7
MAP3K2 7
TPA 7
B55 7
protein kinase 2 7
myelin basic protein 7
COT 7
JIP1 7
p27 7
TNF-R1 7
Ang II 7
THP 7
interleukin-6 7
amyloid precursor protein 7
STAT3 7
EBP 7
insulin-like growth factor 7
TGF-beta activated kinase 1 7
cAMP-dependent protein kinase 6
Smad2 6
phosphoprotein 6
activating transcription factor 2 6
PHD domain 6
arrestin 6
TNF receptor-associated factor 2 6
MLK2 6
PARP 6
MEF2 6
receptor kinase 6
GDP 6
SMA 6
IKK1 6
p90 6
MMP-1 6
NMR 6
NRAS 6
catenin 6
PKC-alpha 6
caspase-8 6
P19 6
Fas ligand 6
TAO2 6
Ubiquitin 6
IB1 6
RANKL 6
transforming growth factor-beta-activated kinase 1 6
p300 6
CD4 6
dimeric 6
TAK 6
IRS-1 6
mast cell 6
kinesin-like protein 6
amyloid beta 6
ankyrin 6
MAP3K3 6
histone 6
ZPK 5
CA1 5
p75 5
cyclooxygenase 2 5
HPK1 5
RSK 5
membrane-bound 5
cytochrome c 5
STAT 5
Dictyostelium 5
Bak 5
TRAIL 5
GADD45 5
bcl-2 5
RIP 5
survival factor 5
MIP 5
prolactin 5
unknown function 5
nitric oxide synthase 5
transactivator 5
PP1 5
MAPK-activated protein kinase 5
CAT 5
IRAK-1 5
DJ-1 5
Daxx 5
PDCD10 5
KLF2 5
CDK2 5
smooth muscle actin 5
GCK 5
TCF 5
PTEN 5
reductase 5
ribosomal protein S6 5
protein kinase B 5
EDR1 5
NEMO 5
PKC zeta 5
ADP 5
collagenase 5
XIAP 5
heat shock protein 5
EGF receptor 5
PHD 5
osteosarcoma 5
interleukin-2 5
tyrosine phosphatase 5
Vascular endothelial growth factor 5
B-raf 5
novel kinase 5
mitogen-activated protein kinase kinase 1 5
inhibitor of apoptosis 5
Smad3 5
CTR1 5
extracellular signal regulated kinase 5
signal transducer and activator of transcription 3 4
protein serine/threonine kinase 4
GTPase-activating protein 4
p21-activated kinase 2 4
VIII 4
GSH 4
activin 4
GM-CSF 4
CCM3 4
catalase 4
PK1 4
androgen receptor 4
GRB2 4
AMPK 4
OSM 4
AMP-activated protein kinase 4
neurotrophin 4
E-cadherin 4
transcriptional regulator 4
MKP-1 4
LIT 4
AT1 4
osteogenic 4
CHOP 4
IL-10 4
MAPKAP kinase 4
pheromone receptor 4
UTR 4
p55 4
Aurora-A 4
ULK1 4
LZK 4
endothelin-1 4
Gen 4
alternatively spliced 4
anti-apoptotic protein 4
IL-13 4
superoxide dismutase 4
JSAP1 4
fibrinogen 4
Tumor necrosis factor alpha 4
GSK 4
SDS 4
mesothelin 4
cyclin-dependent kinase inhibitor 4
FUS1 4
transcriptional coactivator 4
transglutaminase 4
HSP70 4
RIP1 4
Hsp90 4
NF-IL6 4
PAK1 4
ATM 4
MEK kinase 2 4
NHE1 4
metalloproteinase 4
F-box protein 4
CREB-binding protein 4
NGF 4
TAB3 4
c-Rel 4
protein tyrosine kinase 4
PLC 4
glucan 4
TNFR1 4
CIP1 4
WAF1 4
ICAP-1 4
cyclin-dependent kinase 4
mucin 4
STAT1 4
p38b 4
CD95 4
pro-apoptotic protein 4
CCM1 4
BCL2 4
p70 4
hematopoietic progenitor kinase 1 4
c-myc 4
myosin light chain kinase 4
PR1 4
pleckstrin 4
MAP3K9 4
ELK 4
DNA-dependent protein kinase 4
spleen tyrosine kinase 4
MAP4K4 4
SCC 4
SOS1 4
MVA 4
IFN-gamma 4
serine-threonine phosphatase 4
GAL4 4
p52 3
S6K1 3
PLA 3
CCM 3
glutamate receptor 3
lactate dehydrogenase 3
mdm2 3
MINK 3
WNK1 3
MAP4K1 3
HGK 3
brain-derived neurotrophic factor 3
Thioredoxin 3
ACS 3
cyclooxygenase 3
CPT 3
PERK 3
cIAP1 3
TRAF5 3
BOD 3
TNFR2 3
STE 3
connective tissue growth factor 3
monocyte chemoattractant protein-1 3
FGF-2 3
IL-3 3
WNK4 3
PKS 3
GSK3 3
FBS 3
occludin 3
CEP 3
nerve growth factor receptor 3
p46 3
MAP4K3 3
p21-activated kinase 1 3
CD40L 3
LRRK2 3
growth hormone 3
SMRT 3
GLK 3
mitogen-activated protein kinase kinase kinase 3 3
MAPK1 3
Trx 3
peroxisome proliferator-activated receptor 3
pituitary adenylate cyclase-activating polypeptide 3
Smad7 3
N-CoR 3
CDK4 3
AGS 3
phospholipase 3
MOS 3
membrane protein 3
paxillin 3
TNF-alpha stimulated 3
JUN 3
contractile protein 3
Mcl-1 3
bax 3
plasminogen activator inhibitor-1 3
GLI1 3
macrophage colony-stimulating factor 3
BMK1 3
calpain 3
heme oxygenase-1 3
DAF 3
cytochrome 3
SAP 3
eNOS 3
serum response factor 3
IRF3 3
glycoprotein 3
MAP2K4 3
SOX9 3
TAK1-binding protein 2 3
MMP9 3
Transcription factor 3
MAP2K3 3
myosin 3
ECSIT 3
Elk1 3
MAP3K4 3
KRAS 3
ribosomal protein 3
peroxidase 3
IL1 3
serine-threonine protein kinase 3
RING-H2 3
BAD 3
RAC1 3
p75NTR 3
Ras association 3
IRE 3
interferon-gamma 3
APC 3
neurofibromatosis 3
PH domain 3
A431 3
poly(ADP-ribose) polymerase 3
K-ras 3
IL-2 3
RANTES 3
p38gamma 3
E2F1 3
Ubc13 3
SNAP 3
LSC 3
insulin receptor 3
PI-3 kinase 3
IL-17 3
gp130 3
vascular endothelial growth factor A 3
NOD 3
MAK 3
p40 3
retinoic acid receptor 3
IGF-1 3
adenylyl cyclase 3
small GTP-binding protein 3
ANP 3
PP2A 3
Epidermal growth factor 3
TLR2 3
CBP 3
MYC 3
CD44 3
PTI 3
SWI2 3
matrix metalloproteinase 2 3
protein-tyrosine kinase 3
SNF2 3
LHbeta 2
RKIP 2
PKG 2
FasL 2
ORF 2
BRCA1 2
PHA 2
MAPK-activated protein kinase 2 2
Rec 2
HAS2 2
CDC37 2
CHIP 2
RGS 2
RET 2
Kip2 2
Hip 2
telomeric 2
chaperonin 2
SARM 2
vasoactive intestinal peptide 2
G13 2
adhesion molecule 2
nuclear protein 2
BMP-2 2
ABI3 2
C/EBP homologous protein 2
MKP1 2
ICAM-1 2
methyltransferase 2
TRX1 2
Rho kinase 2
dishevelled 2
ECM 2
lectin 2
IkappaB alpha 2
PDK1 2
p100 2
HDAC4 2
TRIF 2
ATP-binding cassette 2
VPAC1 2
HIF-1alpha 2
Dectin-1 2
beta-myosin heavy chain 2
bFGF 2
PPAR gamma 2
PP5 2
plasminogen 2
CD36 2
ATF3 2
Beclin-1 2
deubiquitinating enzyme 2
beta-tubulin 2
p85 2
survivin 2
SBF 2
cyclin D2 2
TIMP1 2
IGF1 2
CCND2 2
hemoglobin 2
noggin 2
MSK1 2
SHP-2 2
transcriptional repressor 2
galectin-3 2
ROCK1 2
p115 2
MHC 2
transcriptional activator 2
BLNK 2
MAPK6 2
MLR 2
AP-2 2
TAZ 2
FOS 2
A-kinase anchoring protein 2
HIF-1 2
RNA-binding protein 2
thymus 2
granulocyte 2
NLRP3 2
calponin 2
RAF-1 2
FGF2 2
casein 2
RhoGEF 2
SREBP-1 2
HGF 2
adenylate cyclase 2
yeast) 2
GnRH receptor 2
GLR 2
TRAF1 2
PAC-1 2
cyclin B1 2
CR6 2
E11 2
GSK3A 2
NF-E2-related factor 2 2
protein tyrosine phosphatase 2
SRY 2
hepatocyte growth factor 2
GAS 2
cage 2
COX2 2
EST 2
tyrosine hydroxylase 2
MAP2K6 2
KIF3 2
MET 2
non-Hodgkin's lymphoma 2
CXCL9 2
NRC 2
GT1 2
glycolytic enzyme 2
p21-activated protein kinase 2
ASC 2
olfactory 2
ABIN-2 2
CD34 2
vascular endothelium 2
MEF2D 2
B-Raf protein 2
Myosin 2
DAXX 2
vitamin D receptor 2
cardiac muscle 2
ligand-dependent corepressor 2
annexin V 2
IAP 2
erythroid 2
NDR 2
ACTH 2
IGF-I receptor 2
PDGFR 2
DEAD-box RNA helicase 2
GLI 2
heat shock protein 90 2
TLR9 2
death-associated protein 2
Map3k1 2
tPA 2
Involucrin 2
BCR 2
histone deacetylase 1 2
Follistatin 2
rapa 2
PEST 2
oxidoreductase 2
osteopontin 2
MDS1 2
proteasome inhibitor 2
heavy chain 2
RSK2 2
interacting protein 1 2
eIF4E 2
Gag 2
uPAR 2
Rho GTPase-activating protein 2
cAMP-response element 2
immunophilin 2
STK38 2
nuclear hormone receptor 2
DNA-binding protein 2
WDR62 2
opioid receptor 2
MAP kinase kinase 1 2
tau protein 2
nuclear factor of activated T-cells 2
plasminogen activator inhibitor 2
Pin1 2
SMAD3 2
IL-5 2
Thyrotropin-releasing hormone 2
RPS5 2
mineralocorticoid receptor 2
PAR 2
APO-1 2
RAB 2
homeobox 2
FADD 2
4E-BP1 2
peptidase 2
Smad6 2
NF2 2
Drosophila) 2
galactosamine 2
MDR1 2
harmonin 2
MAP2 2
RANK 2
MMP-3 2
granulocyte-macrophage colony-stimulating factor 2
Rho-associated protein kinase 1 2
JIP 2
NHE3 2
huntingtin 2
TOF 2
NBR1 2
X-linked 2
calpain inhibitor 2
sonic hedgehog 2
guanine nucleotide exchange factor) 2
HER2 2
MKP-3 2
PPAR 2
IRAK1 2
MAP3K12 2
progesterone receptor 2
JAK1 2
LC3 2
MPP 2
MyoD 2
DHP 2
MLCK 2
TLR3 2
FLT3 2
IL-1 beta 2
thymidine kinase 2
MGC4607 2
MEF 2
apolipoprotein E 2
RNA polymerase II 2
transmembrane protein 2
Boc 2
Fn14 2
follistatin 2
vasoactive intestinal peptide (VIP) 2
CK2 2
c-MYC 2
IkappaBbeta 2
motor protein 2
LHRH 2
E1B 2
SUMO 2
LDL receptor 2
endoglin 2
kisspeptin 2
alpha2-macroglobulin 2
MAPK11 2
cytochrome P450 2E1 2
sterile 20 2
histone deacetylase 2
DNA-binding domain 2
SPS1 2
MSV 2
inhibitor 2 2
Bax protein 2
PI3-kinase 2
CDK1 2
ubiquitin-conjugating enzyme 2
PSK1 2
Yes 2
Sab 2
RAGE 2
TLR7 2
MMP-7 2
interleukin 6 2
PKI 2
MAPK4 2
CED 2
Sperm-associated antigen 9 2
LATS 2
CD14 2
TRADD 2
somatostatin 2
E2 ubiquitin-conjugating enzyme 2
PU.1 2
CEBP 2
FRAP 2
ATG9A 2
E2A 2
MAP3K15 2
glucose transporter 2
p16INK4a 2
serum albumin 2
STAT5 2
Mdm2 2
short isoform 2
aryl hydrocarbon receptor 2
ATR 2
G-protein-coupled receptor 2
H25 2
vimentin 2
ESR1 2
tumour suppressor 2
Ras-like 2
dynamin 2
E-selectin 2
adenomatous polyposis coli 2
cysteine protease 2
CA3 2
growth factor receptor-bound protein 2 2
FLIP 2
c-myc protein 2
protein phosphatase 2C 2
LBC 2
ABL 2
BCL10 2
CFP 2
DCF 2
Mil 2
Bid 2
IFN-beta 2
Bruton's tyrosine kinase 2
RalGDS 2
IL-18 2
xenobiotic 2
PP2C 2
p53 target 2
NAC 2
GRK2 2
MRK 2
Nrf2 2
RCAN1 2
ferredoxin 2
MAP4K5 2
basic helix-loop-helix transcription factor 2
CXCL1 1
filaggrin 1
Rap1GAP 1
p35 1
syntenin 1
PROTEIN PHOSPHATASE 1
IRF7 1
PINK1 1
ApoER2 1
HLA-DRB1 1
toll-like receptor 2 1
ATAC 1
p67 1
Apaf-1 1
bromodomain-containing protein 4 1
phosphatase and tensin homolog 1
POP 1
MAP4K2 1
Rhodopsin 1
cyclin E 1
FOXP3 1
CDKN1A 1
RFP 1
CXCL12 1
tyrosine protein kinase 1
E2F-5 1
Histone deacetylase 7 1
malectin 1
DRG1 1
myosin heavy chain 1
NLRC4 1
AT2 1
scratch 1
Nestin 1
glutathione reductase 1
ADD1 1
MMP2 1
ERM 1
NRX 1
TGIF 1
nov 1
MEF-2 1
scinderin 1
MAPK7 1
Calreticulin 1
MT3 1
GCN2 1
NAD+ 1
cholecystokinin 1
CCK 1
SMAD2 1
FCP 1
MLH1 1
calreticulin 1
IFNB 1
BGT1 1
GPR48 1
protocadherin 1
ZEB1 1
IRP 1
IRAK-2 1
Rho-associated, coiled-coil containing protein kinase 1 1
DDP 1
mss4 1
MMP-12 1
HSF1 1
TRAF7 1
CCNG2 1
SMYD3 1
p53 up-regulated modulator of apoptosis 1
TLR1 1
C/EBP alpha 1
Polo-like kinase 1 1
UBC 1
tristetraprolin 1
CYP4F 1
yeast homolog 1
PLZF 1
lipoxygenase 1
CD123 1
MKP-5 1
RET proto-oncogene 1
MD-2 1
glycogen synthase kinase 3 1
IL-7 1
GCP-2 1
endocan 1
retinitis pigmentosa GTPase regulator interacting protein 1 1
IL17R 1
VIK 1
MAO B 1
Nemo-like kinase 1
RECEPTOR 1
cathepsin L 1
thioredoxin peroxidase 1
PHR1 1
ubiquitin protease 1
G alpha q 1
Prolactin 1
insulin receptor substrate 1
TAP 1
cystatin A 1
MDS2 1
Grb14 1
GABA 1
DcR2 1
filamin B 1
spastin 1
activating transcription factor 3 1
H2A histone family member 1
transcription factor 7-like 2 1
muscle protein 1
germinal center kinase-like kinase 1
PKB 1
gelsolin 1
ASGP-1 1
vasodilator-stimulated phosphoprotein 1
protein kinase inhibitor 1
EP300 1
NOV 1
asymmetrical 1
CLIP 1
p70 S6 kinase 1
Mss4 1
GATA-3 1
GRASP-1 1
PARK8 1
thymidylate synthase 1
SOX5 1
APP 1
TP53-induced glycolysis and apoptosis regulator 1
acid sphingomyelinase 1
histone H1 1
JAK2 1
NOS2 1
cystatin D 1
MAD-3 1
CLP 1
ANGPT2 1
BIN2 1
cyclin A 1
p49 1
KIN 1
MEK kinase 4 1
alpha-tubulin 1
loricrin 1
endothelial nitric oxide synthase 1
dual specificity phosphatase 1
E14 1
IRAK4 1
TAOK1 1
HPCD 1
peptidoglycan recognition protein 1
CXCL10 1
pyruvate kinase 1
PIAS1 1
Chk1 1
dual specificity phosphatase 5 1
PTPN11 1
PP2 1
mouse) 1
SWI 1
AGE 1
serine/threonine-protein kinase 1
protease-activated receptor-1 1
PAX5 1
phosphotyrosine phosphatase 1
STAT5A 1
CD40 ligand 1
MUC5AC 1
MDP 1
Eotaxin 1
FSH 1
chemokine receptor 3 1
IL-11 1
CDC25C 1
C30 1
tumor suppressor protein 1
NR4A2 1
suppressor of cytokine signaling 3 1
MAP kinase kinase 3 1
Cysteine-rich secretory protein 2 1
Glycinamide ribonucleotide formyltransferase 1
erythropoietin 1
MMP1 1
NOD2 1
SLUG 1
TORC1 1
p63 1
CLA 1
PLB 1
arrestin 2 1
NLK 1
CD38 1
PC-3 1
BMP2 1
B protein 1
Peroxisome proliferator-activated receptor 1
BTK 1
NADH dehydrogenase 1
natriuretic peptide 1
megakaryocyte 1
CR3 1
IVA 1
UbcH6 1
TLF 1
versican 1
calcium-binding protein 1
kinase suppressor of Ras 1
Phosphoglycerate mutase 1
putative transcription factor 1
MAP kinase phosphatase 3 1
EphA2 1
PRL-1 1
junD 1
calcium channel 1
muted 1
chimeric protein 1
p160 1
MLC 1
erk 1
BAALC 1
DRG 1
sarcomeric 1
leucine-rich repeat protein 1
AAT 1
prolyl isomerase 1
MLK4 1
RalGDS-like factor 1
MALT1 1
enigma 1
FOXL2 1
tripartite motif-containing 48 1
GLUT-1 1
C-type lectin 1
AF6 1
UEV-3 1
SHC 1
EPO 1
pro-apoptotic Bcl-2 protein 1
FBXW5 1
insulin promoter factor 1 1
Leucine-rich repeat kinase 2 1
CARMA3 1
Grb7 1
HOS1 1
neuronal nitric oxide synthase 1
cell surface antigen 1
ADAM17 1
polo-like kinase 1 1
WFS1 1
SRC1 1
SRC 1
RAC 1
precursor protein 1
dopamine D2 receptor 1
aquaporin 1 1
JLP 1
talin 1
ubiquitin C-terminal hydrolase 1
superoxide dismutase 1 1
EPA 1
monocyte chemotactic protein 1
PPP 1
PKM 1
TNF-related apoptosis-inducing ligand 1
SREBP-1c 1
anchor protein 1
proximal tubule 1
Mitogen-activated protein kinase kinase 4 1
14-3-3 epsilon 1
DIAPH3 1
PRDX6 1
SOD1 1
WNK3 1
24 kDa protein 1
MKNK2 1
mitogen- and stress-activated protein kinase 1 1
CXCR1 1
P-glycoprotein 1
Cdc5 1
Met 1
Myt1 1
Wip1 1
Kv2.1 1
metabotropic glutamate receptor 1
OSMR 1
Mnk2 1
ubiquitin conjugating enzyme 1
PSA 1
Raf kinase inhibitor protein 1
Fc receptor 1
ERK3 1
SREBP-1a 1
Janus kinase 1
P100 1
NADPH oxidase 1 1
TCP1 1
thyrotropin-releasing hormone 1
SOCS1 1
FKBP 1
CDKN2A 1
Cu/Zn superoxide dismutase 1
TANK 1
MOB1 1
MUC5B 1
type I collagen 1
SCG10 1
Glutathione S-transferase 1
tyrosine kinase receptor 1
APH 1
HPT1 1
Mak3p 1
LEF1 1
GPX2 1
Smad5 1
PEN2 1
MEC 1
SNAI2 1
NRK 1
HT-1080 1
Skp2 1
DVD 1
p41 1
NRK1 1
SAK 1
acetyltransferase 1
CDC7 1
APE1 1
PG synthetase 1
basonuclin 1
OTA 1
MIZ1 1
p63RhoGEF 1
FGFR1 1
IRAK-4 1
Mint2 1
topoisomerase II alpha 1
kinase suppressor of ras 1
CXCL2 1
AXL 1
CML 1
LRP protein 1
RACK1 1
LEF-1 1
SAB 1
PBS 1
SH3BP5 1
ionotropic 1
WNT4 1
NFATc4 1
NADP 1
c-FLIP 1
MP1 1
transient receptor potential vanilloid 1 1
tight junction protein ZO-1 1
GSPT1 1
Stanniocalcin-1 1
GRK3 1
3-phosphoinositide-dependent protein kinase 1 1
IL-4 1
neural cell adhesion molecule 1
HSF2BP 1
PAC1 1
PC3 1
TDP-43 1
ER protein 1
ALS 1
Nkx-2.5 1
AC3 1
Smac 1
CREB1 1
SPAS-1 1
GLP-1 1
MAPK8 1
VDR mRNA 1
GPR74 1
TR3 1
leukemia inhibitory factor 1
N-cadherin 1
filamin A 1
PNP 1
Polymerase 1
core protein 1
MAPK10 1
PEG10 1
UBC13 1
suppressor of cytokine signaling 7 1
flavoprotein 1
B-3501 1
Disease
cancer 182
tumor 98
tumorigenesis 36
breast cancer 33
melanoma 24
Parkinson's disease 22
ischemia 20
leukemia 19
cold 19
tumor growth 18
carcinogenesis 15
Alzheimer's disease 15
tumor progression 15
atherosclerosis 13
diabetes 13
metastases 13
virus infection 11
carcinoma 11
neuroblastoma 11
lung cancer 11
prostate cancer 11
heart failure 11
ovarian cancer 10
rheumatoid arthritis 10
obesity 10
lymphoma 10
pertussis 9
squamous cell carcinoma 8
ATM 8
CCM2 8
hepatocellular carcinoma 8
stroke 8
colon cancer 7
metastatic melanoma 7
cerebral ischemia 7
adenocarcinoma 7
MCF 7
dehydration 6
Blocking 6
osteosarcoma 6
bacterial infection 6
worms 6
hepatitis B 6
osteoarthritis 5
hypertension 5
pancreatic cancer 5
influenza 5
glioblastoma 5
Epstein 5
hypercalcemia 5
non-small cell lung cancer 5
gastric cancer 5
MIP 5
immunodeficiency 5
hepatitis C 5
colorectal cancer 4
neurofibromatosis 4
SDS 4
arthritis 4
neoplastic transformation 4
amyotrophic lateral sclerosis 4
asthma 4
CCM3 4
acute myeloid leukemia 4
HIV 4
GSH 4
embryonal carcinoma 4
infectious diseases 4
multiple myeloma 4
myocardial infarction 4
APC 4
pheochromocytoma 4
multiple sclerosis 4
Infection 4
Osteosarcoma 3
glioma 3
sarcoma 3
myelofibrosis 3
sepsis 3
NOD 3
sepsis 3
oral cancer 3
chondrodysplasia 3
plant disease 3
AGS 3
fibrosarcoma 3
tumor initiation 3
cardiovascular disease 3
glaucoma 3
FBS 3
psoriasis 3
Leukemia 3
liver fibrosis 3
retinoblastoma 3
CEP 3
pituitary tumor 3
cervical cancer 3
chronic obstructive pulmonary disease 3
metabolic syndrome 3
Osteosarcoma 3
renal cancer 3
Crohn's disease 2
emphysema 2
anaphylaxis 2
systemic lupus erythematosus 2
Buerger's disease 2
Huntington's disease 2
Cryptococcus neoformans 2
immune deficiency 2
PHA 2
RGS 2
medulloblastoma 2
acne 2
lymphadenopathy 2
dementia 2
Tumour necrosis 2
parkinsonism 2
ABL 2
Melanoma 2
pulmonary hypertension 2
cognitive impairment 2
type 1 diabetes 2
aggressiveness 2
fungal infection 2
vascular disease 2
NF2 2
myeloproliferative disorders 2
renal ischemia 2
progressive supranuclear palsy 2
diabetic retinopathy 2
osteopetrosis 2
Dementia with Lewy bodies 2
infectious endocarditis 2
AIDS 2
osteoporosis 2
primary tumor 2
skin cancer 2
epilepsy 2
JIP 2
cutaneous melanoma 2
autism 2
Adenovirus 2
lung carcinoma 2
NAME 2
erythroleukemia 2
Kawasaki disease 2
stomatitis 2
renal disease 2
Contact Dermatitis 2
plasmacytoma 2
myeloid leukemia 2
chronic myeloid leukemia 2
psychological stress 2
heart disease 2
HGF 2
hyperglycemia 2
cholestasis 1
Ischemic stroke 1
muscular atrophy 1
xeroderma pigmentosum 1
Recruitment 1
hyperinsulinemia 1
malnutrition 1
Bladder outlet obstruction 1
encephalomyelitis 1
Mycobacterium 1
Langerhans cell histiocytosis 1
type 2 diabetes 1
hyperlipidemia 1
SPH1 1
Eosinophilic meningitis 1
Simpson-Golabi-Behmel syndrome 1
Shiga 1
Angiostrongylus cantonensis 1
minimal residual disease 1
gastritis 1
TAM 1
developmental delay 1
diabetic neuropathy 1
Syndrome 1
nephrotic syndrome 1
schwannoma 1
HOS 1
pulmonary edema 1
arteriosclerosis 1
pulmonary fibrosis 1
acute myocardial infarction 1
psoriatic arthritis 1
Optic nerve 1
bladder cancer 1
dysplastic nevi 1
CCD 1
eosinophilia 1
SEM 1
invasive cancer 1
neuritis 1
leishmaniasis 1
Apert syndrome 1
Persistent hyperinsulinemic hypoglycemia of infancy 1
T-cell lymphoma 1
aspergillosis 1
Esophageal squamous cell carcinoma 1
otitis media 1
Ewing's sarcoma 1
salivary gland cancer 1
telangiectasia 1
colitis 1
thyroid cancer 1
Ovarian Cancer 1
renal clear cell carcinoma 1
retinitis pigmentosa 1
HTLV-I 1
benign nevi 1
rabies 1
PSA 1
adrenocortical carcinoma 1
latent infection 1
middle ear 1
basal cell carcinoma 1
hairy cell leukemia 1
SCID 1
brain metastases 1
glomerulopathy 1
malignant ascites 1
renal failure 1
intraocular pressure 1
CEM 1
multiple endocrine neoplasia 1
Reovirus infection 1
MEC 1
neuropathy 1
acute nonlymphocytic leukemia 1
DDP 1
acute promyelocytic leukemia 1
HAM 1
myocardial ischemia 1
SMC 1
periodontitis 1
Disorder 1
uterus 1
infertility 1
pneumonia 1
hydrocephalus 1
hypertrophic cardiomyopathy 1
inflammatory bowel disease 1
listeriosis 1
schizophrenia 1
hyperosmolality 1
retinopathy 1
Beckwith-Wiedemann syndrome 1
Hippel 1
idiopathic pulmonary fibrosis 1
EMT 1
Wolfram syndrome 1
ventricular hypertrophy 1
CAM 1
PCP 1
cytomegalovirus 1
vaccinia 1
acute pancreatitis 1
insulinoma 1
liver cancer 1
plaque 1
Aeromonas hydrophila infection 1
leukoderma 1
opportunistic infection 1
MEN 2B 1
optic atrophy 1
cirrhosis 1
meningoencephalitis 1
chronic disease 1
blindness 1
memory impairment 1
diabetic nephropathy 1
SAR 1
juvenile myelomonocytic leukemia 1
fatty liver 1
MLC 1
ACS1 1
familial dysautonomia 1
gonadal dysgenesis 1
Brachydactyly 1
CLN3 1
AAS 1
EDS1 1
PPP 1
adenocarcinoma of the pancreas 1
IVA 1
Legionella 1
cerebral infarction 1
epithelial ovarian cancer 1
African trypanosomiasis 1
aldosteronism 1
Fox 1
gonococcal 1
endometrial adenocarcinoma 1
B-cell lymphomas 1
tuberous sclerosis 1
liver cancer 1
LDLR 1
cardiofaciocutaneous syndrome 1
Hepatocellular carcinoma 1
liver disease 1
adenoma 1
OCM 1
lymphopenia 1
right heart failure 1
DVD 1
fragile X syndrome 1
sickle cell disease 1
amphetamine abuse 1
dysplasia 1
dermatitis 1
DVD 1
Testis 1
Evans 1
Dissociation 1
PARK8 1
endometrial cancer 1
Adhesion 1
developmental disabilities 1
Chronic heart failure 1
craniosynostosis 1
hypercholesterolemia 1
atopic dermatitis 1
Testis 1
Chlamydia 1
degenerative disease 1
Hashimoto's thyroiditis 1
leukemogenesis 1
olivopontocerebellar atrophy 1
conductive hearing loss 1
kidney tumor 1
SM1 1
HCG 1
pruritus 1
PDB 1
colibacillosis 1
measles 1
drug withdrawal 1
pachygyria 1
Still's disease 1
addiction 1
cornea 1
chemical carcinogenesis 1
Bardet-Biedl syndrome 1
Menkes 1
medullary thyroid carcinoma 1
congestive heart failure 1
Symptom
starvation 12
seizures 5
tremor 2
splenomegaly 2
hyperoxia 2
pain 2
collapse 2
acute stress 2
memory loss 1
bradykinesia 1
motor symptom 1
ataxia 1
hypotonia 1
anorexia 1
HSA 1
anesthesia 1
lethargy 1
dyspnea 1
Drug
MAP 68
lysine 22
ROS 11
Gel 7
TAK 6
p75 5
caffeine 5
CSF 5
IFN-gamma 4
Angiotensin II 4
IL-2 3
uPA 3
Dermatol 3
Asn 3
ETS 3
Indomethacin 2
Nitric Oxide 2
IFN-beta 2
Capsicum 2
Magnesium sulfate 2
Activin 2
nitroglycerin 1
RFP 1
Ciglitazone 1
Emodin 1
MgSO4 1
Leaf 1
CED 1
Oxendolone 1
Fluorescein 1
NOV 1
ascorbate 1
Taxol 1
Batimastat 1
MRC 1
Arsenic trioxide 1
DNase I 1
Parkin 1
lactose 1
Aprotinin 1
Rosuvastatin 1
BH4 1
Cardiovasc 1
Vitamin A 1
AraC 1
Gefitinib 1
CoCl2 1
CoCl2 1
Alanine 1
Erlotinib 1
Tarceva 1
Luteinizing 1
CTX 1
vitamin E 1
TAT 1
EDR 1
Dial 1
Fluorescein 1
IL-11 1
Nexavar 1
NADH 1
Morphine sulfate 1
CMZ 1
K-252a 1
CaCl2 1
Emodin 1
Sorafenib 1
Batimastat 1
CaCl2 1
Estrogens 1
TAC 1
Parkin 1
citric acid 1
Ethanol 1
FAD 1
CaCl2 1
Fentanyl 1
Adriamycin 1
Enzyme
MEKK1 1856
mitogen-activated protein kinase 1152
MEK 574
protein kinase 300
ERK 224
protein kinase C 98
IKK 81
MAP 67
luciferase 45
caspase-3 36
focal adhesion kinase 32
calcineurin 27
proteasome 25
glutathione S-transferase 19
phosphatidylinositol 3-kinase 16
thrombin 15
phosphoinositide 3-kinase 13
collagenase 11
urokinase-type plasminogen activator 11
kinesin 11
ATPase 11
AMPK 10
NADPH oxidase 10
phospholipase C 10
NADPH oxidase 9
superoxide dismutase 8
catalase 8
caspase-9 8
CaMKII 8
cdc2 8
PARP 7
AMP-activated protein kinase 7
NSY 7
GSK 6
protein phosphatase 2A 6
histidine kinase 6
NO synthase 5
caspase-8 5
MIP 5
PHD 5
AMPK 4
myosin light chain kinase 4
peroxidase 4
transglutaminase 4
lactate dehydrogenase 3
CPT 3
CPT 3
CEP 3
ACS 3
RNA polymerase 3
CLK1 3
complex I 3
APC 3
CPT 3
chloramphenicol acetyltransferase 3
GRK2 3
CEP 3
peroxiredoxin 2
PDK1 2
NOS 2
heme oxygenase 2
DCF 2
thymidine kinase 2
MPP 2
p100 2
adenylate cyclase 2
guanylate cyclase 2
triphosphatase 2
caspase-2 2
chaperonin 2
stilbene synthase 2
GAS 2
tissue plasminogen activator 2
topoisomerase 2
phospholipase A2 2
reverse transcriptase 2
polo-like kinase 1 2
PKG 2
topoisomerase 2
matrix metalloproteinase 2 2
PGM 2
tyrosine hydroxylase 2
stilbene synthase 2
glyceraldehyde-3-phosphate dehydrogenase 1
caspase-7 1
ADP-ribosyltransferase 1
ADP-ribosyltransferase 1
nitrate reductase 1
peptidyl-prolyl cis-trans isomerase 1
nitrate reductase 1
xanthine oxidase 1
GTP cyclohydrolase I 1
glutathione reductase 1
xylose isomerase 1
phosphoribulokinase 1
lipoxygenase 1
glucokinase 1
alkaline phosphatase 1
thioredoxin reductase 1
cathepsin B 1
transcriptase 1
caspase-1 1
aspartate aminotransferase 1
cathepsin L 1
neuraminidase 1
MDP 1
isopeptidase 1
uricase 1
pyruvate kinase 1
caspase-7 1
P-glycoprotein 1
PTPase 1
PIP kinase 1
prolyl hydroxylase 1
succinate dehydrogenase 1
trypsin 1
isochorismate synthase 1
nitrate reductase 1
glyceraldehyde-3-phosphate dehydrogenase 1
LPL 1
TMT 1
glyceraldehyde-3-phosphate dehydrogenase 1
alanine aminotransferase 1
GRK5 1
invertase 1
ceramide kinase 1
xanthine dehydrogenase 1
nitrate reductase 1
CYP7A1 1
nitrate reductase 1
TAT 1
phosphatidylserine synthase 1
beta-secretase 1
diaphorase 1
retinyl ester hydrolase 1
UDP-glucosyltransferase 1
thymidylate synthase 1
NQO1 1
caspase-11 1
phosphodiesterase 1
glyceraldehyde-3-phosphate dehydrogenase 1
Mg2+-ATPase 1
ribonucleotide reductase 1
caspase-2 1
cellulose synthase 1
ribonucleotide reductase 1
NADH dehydrogenase 1
hyaluronidase 1
MMP-3 1
6-phosphofructo-2-kinase 1
beta-lactamase 1
prostaglandin synthetase 1
lecithin:retinol acyltransferase 1
glyceraldehyde-3-phosphate dehydrogenase 1
MMP 1
hyaluronidase 1
phospholipase D 1
DNA methyltransferase 1
nitrate reductase 1
ornithine decarboxylase 1
ricin 1
alpha-sarcin 1
caspase-11 1
Compound
MEK 188
Dec 141
DNA 136
threonine 135
serine 110
tyrosine 81
oxygen 68
MAP 67
calcium 56
TNF 52
acetate 47
NH2 40
GTP 36
ATP 36
leucine 30
cAMP 30
alanine 29
hydrogen 27
lysine 27
salt 26
glucose 22
glycerol 21
COS 20
sodium 19
nitric oxide 18
cysteine 17
Clin 17
AMP 16
H2O2 15
salicylic acid 15
water 14
HOG 13
proline 13
PMA 12
PMA 12
ATF 12
arginine 11
ABA 11
MDA 10
Curcumin 9
ASK 9
cGMP 9
adenosylmethionine 9
phosphate 9
glutamate 8
nitrogen 8
zinc 8
TPA 7
His 7
THP 7
Asp 7
TPA 7
THP 7
Insulin 6
retinoic acid 6
ADP 6
PGE 6
ABA 6
ethanol 6
GDP 6
methionine 6
Ang II 6
N-acetylcysteine 6
tryptophan 5
tryptophan 5
caffeine 5
CAT 5
vitamin D 5
CAT 5
Serine 5
ADP 5
CAT 5
ADP 5
tryptophan 5
tryptophan 5
aspartic acid 4
GSH 4
aspartic acid 4
GSH 4
aspartic acid 4
SDS 4
25-dihydroxycholecalciferol 4
Phe 4
sulfate 4
PAM 4
iodine 4
urea 4
Angiotensin II 4
SCC 4
aspartic acid 4
CPT 3
Cer 3
PAS 3
Thioredoxin 3
boron 3
Pac 3
ACS 3
quinoline 3
DDP 3
Ethylene 3
Tamoxifen 3
quinoline 3
Triton X-100 3
ACS 3
Leucine 3
Tamoxifen 3
CPT 3
Phosphatidylinositol 3
Gly 3
iron 3
MAK 3
retinol 3
MPTP 3
Cardiol 3
Resveratrol 3
ASA 3
Cbl 3
Panam 2
valine 2
TOF 2
cobalt 2
potassium 2
Tyrosine 2
glutamic acid 2
1H-imidazole 2
CHIP 2
pyrimidine 2
DMSO 2
quinazoline 2
naphthoquinone 2
Actinomycin D 2
Adriamycin 2
Estrogen 2
Neuronal 2
BCR 2
Emodin 2
DETA 2
Vitamin D 2
Optimal 2
UTP 2
AMPA 2
naphthoquinone 2
Wortmannin 2
PAR 2
Anthocyanin 2
Thrombin 2
quinazoline 2
Triton 2
MPP 2
naphthoquinone 2
GF 109203X 2
naphthoquinone 2
cadmium 2
ABL 2
Phorbol 12-myristate 13-acetate 2
copper 2
Estrogen 2
naphthoquinone 2
phenol 2
Off 2
naphthoquinone 2
ASC 2
Apigenin 2
Magnesium sulfate 2
Magnesium sulfate 2
naphthoquinone 2
MPP 2
TRH 2
NAD 2
HCl 2
ammonium 2
Anisomycin 2
Sucrose 2
ADR 1
pentose 1
Okadaic acid 1
Staurosporine 1
acridine 1
Serpentine 1
xylose 1
NAD 1
5-chloro-2-hydroxybenzamide 1
Farrerol 1
DPI 1
DEP 1
Progesterone 1
Phosphatidylcholine 1
Androgen 1
CTX 1
DBA 1
Quercetin 1
Phytol 1
9AA 1
Deguelin 1
diacetate 1
CUE 1
Glycogen synthase 1
Naloxone 1
Phorbol 1
AICAR 1
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1
Cys-Gly 1
LY 294002 1
Austin 1
DHA 1
Parthenolide 1
Isoproterenol 1
2-mercaptoethanol 1
pyrrolidine 1
TSH 1
glutamine 1
pentose 1
Statin 1
Phytol 1
uridine 1
Dial 1
LTC4 1
Sulindac 1
aldehyde 1
superoxide radical 1
DEP 1
phosphoric acid 1
fluorine 1
Alanine 1
Phenethyl isothiocyanate 1
DPP 1
isoleucine 1
NADPH 1
AF-2 1
Tween 20 1
betaine 1
pentose 1
pyrrolidine 1
DPG 1
Ochratoxin A 1
Ginsenoside Rg1 1
NEM 1
Vitamin A 1
PLA 1
PMSF 1
DHA 1
Chelerythrine 1
silver 1
isoleucine 1
5-HT 1
PGA1 1
HPT 1
sodium chloride 1
Rhodopsin 1
Dexamethasone 1
hydroxide 1
mercury 1
Cyt 1
KIV 1
DTT 1
TAP 1
Uridine 1
Hoechst 33342 1
Arsenite 1
PAC 1
Salt 1
GABA 1
GlcNAc 1
2-phosphoglycerate 1
Fucoidan 1
Parthenolide 1
Pioglitazone 1
TRU 1
Chelerythrine 1
GAP 1
(-)-Epigallocatechin 1
pyrimidine 1
ACES 1
ADP-ribose 1
dUDP 1
CaCl2 1
CCC 1
AGE 1
Diallyl sulfide 1
PNP 1
POP 1
Arsenate 1
Juglone 1
acetic acid 1
G11 1
MTT 1
Emodin 1
Morphine sulfate 1
ACTH 1
Estradiol 1
pentose 1
DTT 1
Fisetin 1
methyl methanesulfonate 1
PGE2 1
Testosterone 1
Pluronic 1
aldosterone 1
Testosterone 1
Tumor Necrosis Factor 1
Colchicine 1
NTA 1
Tetrahydrobiopterin 1
carbonate 1
KT-1 1
L-threonine 1
hyaluronic acid 1
SP-1 1
AAT 1
Metformin 1
Paclitaxel 1
SPD 1
FAD 1
S-adenosylhomocysteine 1
Fumarate 1
9AA 1
phosphorus 1
Cereb 1
Tanshinone 1
Neutral Red 1
nicotinamide 1
DPPH 1
THE 1
PDB 1
Inositol 1
D-Serine 1
A 1 1
Metformin 1
aldehyde 1
MAD 1
Paricalcitol 1
Bufalin 1
DHA 1
NADPH 1
PHB 1
NADP 1
palmitic acid 1
TAR 1
Rapamycin 1
Tiron 1
Formin 1
NADH 1
TEM 1
AEA 1
BHC 1
Ile 1
Biochanin A 1
Vinblastine 1
PYR 1
APH 1
piperazine 1
Morphine 1
Benzyl isothiocyanate 1
galactose 1
tin 1
Lithium 1
5-FU 1
Casein 1
VP-16 1
SAH 1
Guanine 1
Endosulfan 1
acrylamide 1
Staurosporine 1
GABA 1
AEA 1
FK506 1
Mg2+ 1
gallic acid 1