Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.25 (
MEKK1
)
1,856
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kinase suppressor of ras (KSR) and
MEKK3
(
MAP kinase kinase kinase
) are integral members of the MAP kinase pathway. We have recently identified a new isoform of the KSR family named human
kinase suppressor of ras
-2 (hKSR-2), and demonstrated that hKSR-2 negatively regulates Cot, a
MAP3K
family member which is important in inflammation and oncogenesis [P.L. Channavajhala, L. Wu, J.W. Cuozzo, J.P. Hall, W. Liu, L.L. Lin, Y. Zhang, J. Biol. Chem. 278 (2003) 47089-47097]. In this report, we provide evidence that hKSR-2 also regulates the activity of
MEKK3
(another
MAP3K
family member) in HEK-293T cells. We demonstrate that hKSR-2 is a negative regulator of
MEKK3
-mediated activation of MAP kinase (specifically ERK and JNK) and NF-kappaB pathways, and concurrently inhibits
MEKK3
-mediated interleukin-8 production. We find that while hKSR-2 blocks
MEKK3
activation, it has little to no effect on other members of the
MAP3K
family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective.
...
PMID:hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. 1603 90
