Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.25 (
MEKK1
)
1,856
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
GRASP-1
is a neuronally enriched protein that interacts with the AMPA-type glutamate receptor/GRIP complex.
GRASP-1
can be cleaved by Caspase-3 in both normal and ischemic brains although the functional significance of this cleavage remains elusive. We investigated signal transduction pathways that might lie downstream of
GRASP-1
and found that
GRASP-1
potently activates JNK pathway signaling, with no effect on ERK signaling. Such JNK pathway activating activity requires binding of
GRASP-1
to both JNK and the upstream JNK pathway activator
MEKK
-1. Furthermore, mutations that prevent Caspase 3-cleavage of
GRASP-1
dramatically inhibit the JNK pathway activating activity of
GRASP-1
, suggesting a novel link between Caspase-3 activation and JNK pathway signaling. These results suggest that
GRASP-1
serves as a scaffold protein to facilitate
MEKK
-1 activation of JNK signaling in neurons.
...
PMID:GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. 1776 Nov 73
