Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.25 (
MEKK1
)
1,856
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
T cell Ig and mucin domain protein 2 (TIM-2) has been shown to regulate T cell activation in vitro and T cell-mediated disease in vivo. However, it is still not clear whether
TIM
-2 acts mainly to augment T cell function or to inhibit it. We have directly examined the function of
TIM
-2 in murine and human T cell lines. Our results indicate that expression of
TIM
-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters by not only TCR ligation but also by the pharmacological stimuli PMA and ionomycin. This does not appear to be due to a general effect on cell viability, and the block in NFAT activation can be bypassed by expression of activated alleles of Ras or calcineurin, or
MEK kinase
, in the case of AP-1. Thus, our data are consistent with a model whereby
TIM
-2 inhibits T cell activation.
...
PMID:Cutting edge: inhibition of T cell activation by TIM-2. 1701 78
