Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.11.24 (mitogen-activated protein kinase)
95,810 document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein MAPK 30542 p38 22730 ERK1 22200 JNK 16370 ERK 13210 extracellular signal-regulated kinase 12069 Mol 11016 MAP kinase 8816 MEK 6851 mitogen-activated protein 6382 Sep 6225 cytokine 5952 PI3K 5145 c-Jun 5022 AKT 4957 caspase-3 4383 TNF 4243 p38 mitogen-activated protein kinase 3919 insulin 3869 IL-6 3678 tumor necrosis factor 3427 lipopolysaccharide 3245 ERK2 3123 MEK1 3063 p53 2993 Bcl-2 2944 tyrosine kinase 2885 mTOR 2647 phosphatidylinositol 3-kinase 2594 phosphatase 2497 AP-1 2488 collagen 2185 p42 2166 p65 2093 p44 2091 epidermal growth factor receptor 2080 extracellular signal-regulated kinase 1 2056 PKC 1996 BRAF 1952 inducible nitric oxide synthase 1929 MAP 1906 epidermal growth factor 1899 LPS 1798 IL-8 1763 JNK1 1699 p21 1653 TLR4 1565 protein kinase B 1539 threonine 1533 STAT3 1527 ATP 1495 ROS 1484 cyclooxygenase-2 1423 endoplasmic reticulum 1390 EGFR 1365 vascular endothelial growth factor 1347 cyclin D1 1340 STAT 1334 Raf-1 1318 matrix metalloproteinase 1297 chemokine 1287 TNF-alpha 1286 EGF 1211 interleukin-6 1173 p38 MAP kinase 1147 cytochrome c 1138 phosphoinositide 3-kinase 1121 Rho 1088 COX-2 1080 receptor tyrosine kinase 1034 c-fos 1033 CREB 1027 IL-10 1018 P38 1017 PARP 997 angiotensin II 996 p38MAPK 994 PKA 977 MMP-9 972 fibronectin 966 more...

Disease cancer 14230 tumor 10060 breast cancer 3003 tumorigenesis 2221 tumor growth 2193 melanoma 1960 diabetes 1719 ischemia 1638 hepatocellular carcinoma 1601 carcinoma 1595 Alzheimer's disease 1485 carcinogenesis 1484 tumor progression 1355 atherosclerosis 1330 obesity 1243 leukemia 1224 lung cancer 1217 MCF 1177 prostate cancer 1029 pertussis 994 colorectal cancer 989 adenocarcinoma 976 hypertension 921 neuroblastoma 870 glioma 830 colon cancer 813 GSH 760 Parkinson's disease 725 asthma 675 metastases 668 type 2 diabetes 647 squamous cell carcinoma 636 rheumatoid arthritis 632 gastric cancer 628 ovarian cancer 625 stroke 618 non-small cell lung cancer 596 depression 577 glioblastoma 554 Blocking 545 pancreatic cancer 544 heart failure 525 sepsis 521 sepsis 506 acute myeloid leukemia 492 osteoporosis 469 ATM 454 hyperglycemia 452 HIV 446 multiple myeloma 439 arthritis 430 lymphoma 428 cerebral ischemia 419 cardiovascular disease 404 osteoarthritis 376 myocardial infarction 373 infectious diseases 370 B-cell lymphoma 366 virus infection 364 osteosarcoma 348 retinoblastoma 339 liver cancer 335 colitis 325 lung carcinoma 312 cold 311 pheochromocytoma 308 cognitive impairment 296 Mycobacterium 293 chronic myeloid leukemia 293 diabetic nephropathy 292 myocardial ischemia 282 Melanoma 281 plaque 276 chronic obstructive pulmonary disease 269 metastatic melanoma 264 liver cancer 262 bladder cancer 252 tumor angiogenesis 249 skin cancer 246 inflammatory bowel disease 243 more...

Symptom pain 923 starvation 395 seizures 202 functional recovery 145 diarrhea 132 collapse 115 anesthesia 79 respiratory distress 78 analgesia 75 hyperoxia 73 fatigue 62 hypothermia 62 skin damage 62 headache 45 cachexia 42 Neuropathic pain 42 exhaustion 41 acute stress 39 memory loss 35 weakness 34 splenomegaly 34 erythema 31 ataxia 31 cough 29 overweight 28 arthralgia 25 thinning 24 bone pain 23 nausea 23 low back pain 21 vomiting 21 angina 18 anorexia 18 Scratch 16 dyspnea 15 pelvic pain 14 dry eye 14 hypotonia 14 despair 14 tremor 13 HSA 13 hypercapnia 12 abdominal pain 12 constipation 11 back pain 11 Inflammatory pain 11 myalgia 10 hepatomegaly 10 acidity 9 cancer pain 9 acute pain 9 orofacial pain 9 hepatosplenomegaly 9 dry skin 7 insomnia 7 spasm 7 flushing 6 sore throat 6 incoordination 6 fasciculation 6 menopausal symptoms 6 skin irritation 6 neurological disability 6 bradykinesia 6 dizziness 5 muscle cramps 5 decreased appetite 5 discomfort 5 twitching 5 distraction 5 agitation 5 chest pain 5 lethargy 5 discomfort 5 numbness 5 stigma 5 bladder pain 5 neuralgia 4 microbial colonization 4 Depressive symptoms 4 more...

Drug MAP 1988 ROS 1484 Dermatol 541 IL-2 519 IFN-gamma 421 lysine 369 CSF 368 Angiotensin II 344 ICI 251 Cardiovasc 212 p75 164 ETS 161 Sorafenib 131 Monit 128 vitamin E 124 ascorbate 121 caffeine 119 Gefitinib 114 Ethanol 112 Arsenic trioxide 99 EE2 94 Heme 92 Forskolin 89 Gel 88 uPA 86 Taxol 83 IFN-beta 73 Imatinib 71 Herceptin 69 TAK 69 Retinoic acid 64 Activin 63 ETA 63 Simvastatin 61 TAT 61 NVP 61 NADH 60 Estrogens 59 G-CSF 58 Glutathione 58 Indomethacin 56 IL-11 53 Nitric Oxide 53 CCL 53 GEO 53 Asthma 53 Glucagon 51 PTH 51 Gelatin 50 Cetuximab 50 Histamine 50 Nephron 50 ADR 49 CTX 49 Ouabain 49 Growth hormone 44 PTC 44 Growth hormone 44 Rosiglitazone 44 Asn 43 Gleevec 43 Epigallocatechin 41 Bortezomib 41 Glycyrrhiza 41 Erlotinib 40 ABC 40 Lovastatin 38 MRC 37 CAM 36 Emodin 34 Leaf 34 Emodin 34 Parkin 32 Parkin 32 Propofol 32 PCP 32 Portal 31 Dasatinib 30 IL-1ra 29 CTX 28 more...

Enzyme mitogen-activated protein kinase 95810 ERK 16661 MEK 10639 protein kinase 8941 protein kinase C 5579 caspase-3 3450 focal adhesion kinase 3173 phosphatidylinositol 3-kinase 2598 MAP 1909 luciferase 1613 MEKK1 1152 phosphoinositide 3-kinase 1121 superoxide dismutase 1114 PARP 1114 calcineurin 1083 NADPH oxidase 1072 AMP-activated protein kinase 1050 phospholipase C 1048 NADPH oxidase 948 catalase 894 proteasome 848 AMPK 817 IKK 725 caspase-9 721 GSK 642 caspase-8 613 cdc2 607 NO synthase 597 collagenase 571 AMPK 570 alkaline phosphatase 549 ATPase 502 thrombin 494 glutathione S-transferase 474 peroxidase 464 phospholipase A2 455 lactate dehydrogenase 412 CaMKII 385 urokinase-type plasminogen activator 342 alanine aminotransferase 339 adenylate cyclase 315 glutathione peroxidase 314 renin 289 protein phosphatase 2A 281 MMP 270 aspartate aminotransferase 268 tyrosine hydroxylase 250 caspase-1 232 MMP-3 224 reverse transcriptase 224 phosphodiesterase 223 heme oxygenase 205 MIP 200 RNA polymerase 191 tyrosinase 190 NOS 190 APC 188 PKG 181 phospholipase D 176 ACS 175 PDK1 175 guanylate cyclase 165 trypsin 163 cathepsin K 157 P-glycoprotein 154 NQO1 129 myosin light chain kinase 127 acetylcholinesterase 117 matrix metalloproteinase 9 110 GRK5 106 AST 103 complex I 103 farnesyltransferase 99 DCF 99 sphingosine kinase 98 lipoxygenase 98 creatine kinase 98 xanthine oxidase 97 MPP 97 glutathione reductase 92 more...

Compound DNA 7460 Dec 6800 oxygen 6780 MEK 6032 tyrosine 5762 calcium 4543 TNF 4243 glucose 3076 serine 2693 cAMP 2673 nitric oxide 2498 threonine 2301 MAP 1912 acetate 1741 Clin 1531 ATP 1499 sodium 1325 MTT 1324 water 1271 cysteine 1242 phosphate 1198 hydrogen 1106 MDA 1053 glutamate 970 NH2 911 N-acetylcysteine 838 AMP 822 Insulin 818 GSH 795 GSH 795 THP 736 THP 735 GTP 720 H2O2 718 alanine 683 arginine 654 PGE 645 Ang II 639 ethanol 633 methionine 591 leucine 576 lysine 550 sulfate 528 PMA 465 PMA 451 retinoic acid 451 Phe 435 nitrogen 430 Angiotensin II 419 salt 416 cGMP 413 glycerol 399 bromide 397 zinc 396 ATF 388 galactose 375 Cardiol 372 ADP 363 proline 355 iodine 352 iron 350 PGE2 350 NMDA 350 potassium 347 COS 340 Asp 332 dUTP 331 ADP 320 ADP 317 Curcumin 294 5-HT 274 urea 263 cadmium 261 ICI 252 Panam 244 Wortmannin 237 NAD 231 Resveratrol 230 Tyrosine 219 ADP-ribose 210 more...

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