Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.24 (
mitogen-activated protein kinase
)
95,810
document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
MAPK
30542
p38
22730
ERK1
22200
JNK
16370
ERK
13210
extracellular signal-regulated kinase
12069
Mol
11016
MAP kinase
8816
MEK
6851
mitogen-activated protein
6382
Sep
6225
cytokine
5952
PI3K
5145
c-Jun
5022
AKT
4957
caspase-3
4383
TNF
4243
p38 mitogen-activated protein kinase
3919
insulin
3869
IL-6
3678
tumor necrosis factor
3427
lipopolysaccharide
3245
ERK2
3123
MEK1
3063
p53
2993
Bcl-2
2944
tyrosine kinase
2885
mTOR
2647
phosphatidylinositol 3-kinase
2594
phosphatase
2497
AP-1
2488
collagen
2185
p42
2166
p65
2093
p44
2091
epidermal growth factor receptor
2080
extracellular signal-regulated kinase 1
2056
PKC
1996
BRAF
1952
inducible nitric oxide synthase
1929
more...
Disease
cancer
14230
tumor
10060
breast cancer
3003
tumorigenesis
2221
tumor growth
2193
melanoma
1960
diabetes
1719
ischemia
1638
hepatocellular carcinoma
1601
carcinoma
1595
Alzheimer's disease
1485
carcinogenesis
1484
tumor progression
1355
atherosclerosis
1330
obesity
1243
leukemia
1224
lung cancer
1217
MCF
1177
prostate cancer
1029
pertussis
994
colorectal cancer
989
adenocarcinoma
976
hypertension
921
neuroblastoma
870
glioma
830
colon cancer
813
GSH
760
Parkinson's disease
725
asthma
675
metastases
668
type 2 diabetes
647
squamous cell carcinoma
636
rheumatoid arthritis
632
gastric cancer
628
ovarian cancer
625
stroke
618
non-small cell lung cancer
596
depression
577
glioblastoma
554
Blocking
545
more...
Symptom
pain
923
starvation
395
seizures
202
functional recovery
145
diarrhea
132
collapse
115
anesthesia
79
respiratory distress
78
analgesia
75
hyperoxia
73
hypothermia
62
fatigue
62
skin damage
62
headache
45
Neuropathic pain
42
cachexia
42
exhaustion
41
acute stress
39
memory loss
35
splenomegaly
34
weakness
34
erythema
31
ataxia
31
cough
29
overweight
28
arthralgia
25
thinning
24
bone pain
23
nausea
23
low back pain
21
vomiting
21
anorexia
18
angina
18
Scratch
16
dyspnea
15
despair
14
pelvic pain
14
dry eye
14
hypotonia
14
HSA
13
more...
Drug
MAP
1988
ROS
1484
Dermatol
541
IL-2
519
IFN-gamma
421
lysine
369
CSF
368
Angiotensin II
344
ICI
251
Cardiovasc
212
p75
164
ETS
161
Sorafenib
131
Monit
128
vitamin E
124
ascorbate
121
caffeine
119
Gefitinib
114
Ethanol
112
Arsenic trioxide
99
EE2
94
Heme
92
Forskolin
89
Gel
88
uPA
86
Taxol
83
IFN-beta
73
Imatinib
71
TAK
69
Herceptin
69
Retinoic acid
64
Activin
63
ETA
63
Simvastatin
61
NVP
61
TAT
61
NADH
60
Estrogens
59
Glutathione
58
G-CSF
58
more...
Enzyme
mitogen-activated protein kinase
95810
ERK
16661
MEK
10639
protein kinase
8941
protein kinase C
5579
caspase-3
3450
focal adhesion kinase
3173
phosphatidylinositol 3-kinase
2598
MAP
1909
luciferase
1613
MEKK1
1152
phosphoinositide 3-kinase
1121
superoxide dismutase
1114
PARP
1114
calcineurin
1083
NADPH oxidase
1072
AMP-activated protein kinase
1050
phospholipase C
1048
NADPH oxidase
948
catalase
894
proteasome
848
AMPK
817
IKK
725
caspase-9
721
GSK
642
caspase-8
613
cdc2
607
NO synthase
597
collagenase
571
AMPK
570
alkaline phosphatase
549
ATPase
502
thrombin
494
glutathione S-transferase
474
peroxidase
464
phospholipase A2
455
lactate dehydrogenase
412
CaMKII
385
urokinase-type plasminogen activator
342
alanine aminotransferase
339
more...
Compound
DNA
7460
Dec
6800
oxygen
6780
MEK
6032
tyrosine
5762
calcium
4543
TNF
4243
glucose
3076
serine
2693
cAMP
2673
nitric oxide
2498
threonine
2301
MAP
1912
acetate
1741
Clin
1531
ATP
1499
sodium
1325
MTT
1324
water
1271
cysteine
1242
phosphate
1198
hydrogen
1106
MDA
1053
glutamate
970
NH2
911
N-acetylcysteine
838
AMP
822
Insulin
818
GSH
795
GSH
795
THP
736
THP
735
GTP
720
H2O2
718
alanine
683
arginine
654
PGE
645
Ang II
639
ethanol
633
methionine
591
more...