Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.24 (mitogen-activated protein kinase)
95,810 document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MAPK 30542
p38 22730
ERK1 22200
JNK 16370
ERK 13210
extracellular signal-regulated kinase 12069
Mol 11016
MAP kinase 8816
MEK 6851
mitogen-activated protein 6382
Sep 6225
cytokine 5952
PI3K 5145
c-Jun 5022
AKT 4957
caspase-3 4383
TNF 4243
p38 mitogen-activated protein kinase 3919
insulin 3869
IL-6 3678
tumor necrosis factor 3427
lipopolysaccharide 3245
ERK2 3123
MEK1 3063
p53 2993
Bcl-2 2944
tyrosine kinase 2885
mTOR 2647
phosphatidylinositol 3-kinase 2594
phosphatase 2497
AP-1 2488
collagen 2185
p42 2166
p65 2093
p44 2091
epidermal growth factor receptor 2080
extracellular signal-regulated kinase 1 2056
PKC 1996
BRAF 1952
inducible nitric oxide synthase 1929
more...
Disease
cancer 14230
tumor 10060
breast cancer 3003
tumorigenesis 2221
tumor growth 2193
melanoma 1960
diabetes 1719
ischemia 1638
hepatocellular carcinoma 1601
carcinoma 1595
Alzheimer's disease 1485
carcinogenesis 1484
tumor progression 1355
atherosclerosis 1330
obesity 1243
leukemia 1224
lung cancer 1217
MCF 1177
prostate cancer 1029
pertussis 994
colorectal cancer 989
adenocarcinoma 976
hypertension 921
neuroblastoma 870
glioma 830
colon cancer 813
GSH 760
Parkinson's disease 725
asthma 675
metastases 668
type 2 diabetes 647
squamous cell carcinoma 636
rheumatoid arthritis 632
gastric cancer 628
ovarian cancer 625
stroke 618
non-small cell lung cancer 596
depression 577
glioblastoma 554
Blocking 545
more...
Symptom
pain 923
starvation 395
seizures 202
functional recovery 145
diarrhea 132
collapse 115
anesthesia 79
respiratory distress 78
analgesia 75
hyperoxia 73
hypothermia 62
fatigue 62
skin damage 62
headache 45
Neuropathic pain 42
cachexia 42
exhaustion 41
acute stress 39
memory loss 35
splenomegaly 34
weakness 34
erythema 31
ataxia 31
cough 29
overweight 28
arthralgia 25
thinning 24
bone pain 23
nausea 23
low back pain 21
vomiting 21
anorexia 18
angina 18
Scratch 16
dyspnea 15
despair 14
pelvic pain 14
dry eye 14
hypotonia 14
HSA 13
more...
Drug
MAP 1988
ROS 1484
Dermatol 541
IL-2 519
IFN-gamma 421
lysine 369
CSF 368
Angiotensin II 344
ICI 251
Cardiovasc 212
p75 164
ETS 161
Sorafenib 131
Monit 128
vitamin E 124
ascorbate 121
caffeine 119
Gefitinib 114
Ethanol 112
Arsenic trioxide 99
EE2 94
Heme 92
Forskolin 89
Gel 88
uPA 86
Taxol 83
IFN-beta 73
Imatinib 71
TAK 69
Herceptin 69
Retinoic acid 64
Activin 63
ETA 63
Simvastatin 61
NVP 61
TAT 61
NADH 60
Estrogens 59
Glutathione 58
G-CSF 58
more...
Enzyme
mitogen-activated protein kinase 95810
ERK 16661
MEK 10639
protein kinase 8941
protein kinase C 5579
caspase-3 3450
focal adhesion kinase 3173
phosphatidylinositol 3-kinase 2598
MAP 1909
luciferase 1613
MEKK1 1152
phosphoinositide 3-kinase 1121
superoxide dismutase 1114
PARP 1114
calcineurin 1083
NADPH oxidase 1072
AMP-activated protein kinase 1050
phospholipase C 1048
NADPH oxidase 948
catalase 894
proteasome 848
AMPK 817
IKK 725
caspase-9 721
GSK 642
caspase-8 613
cdc2 607
NO synthase 597
collagenase 571
AMPK 570
alkaline phosphatase 549
ATPase 502
thrombin 494
glutathione S-transferase 474
peroxidase 464
phospholipase A2 455
lactate dehydrogenase 412
CaMKII 385
urokinase-type plasminogen activator 342
alanine aminotransferase 339
more...
Compound
DNA 7460
Dec 6800
oxygen 6780
MEK 6032
tyrosine 5762
calcium 4543
TNF 4243
glucose 3076
serine 2693
cAMP 2673
nitric oxide 2498
threonine 2301
MAP 1912
acetate 1741
Clin 1531
ATP 1499
sodium 1325
MTT 1324
water 1271
cysteine 1242
phosphate 1198
hydrogen 1106
MDA 1053
glutamate 970
NH2 911
N-acetylcysteine 838
AMP 822
Insulin 818
GSH 795
GSH 795
THP 736
THP 735
GTP 720
H2O2 718
alanine 683
arginine 654
PGE 645
Ang II 639
ethanol 633
methionine 591
more...