Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.24 (mitogen-activated protein kinase)
 95,810 document(s) hit in 31,850,051 MEDLINE articles (0.09 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MAPK 30542
p38 22730
ERK1 22200
JNK 16370
ERK 13210
extracellular signal-regulated kinase 12069
Mol 11016
MAP kinase 8816
MEK 6851
mitogen-activated protein 6382
Sep 6225
cytokine 5952
PI3K 5145
c-Jun 5022
AKT 4957
caspase-3 4383
TNF 4243
p38 mitogen-activated protein kinase 3919
insulin 3869
IL-6 3678
tumor necrosis factor 3427
lipopolysaccharide 3245
ERK2 3123
MEK1 3063
p53 2993
Bcl-2 2944
tyrosine kinase 2885
mTOR 2647
phosphatidylinositol 3-kinase 2594
phosphatase 2497
AP-1 2488
collagen 2185
p42 2166
p65 2093
p44 2091
epidermal growth factor receptor 2080
extracellular signal-regulated kinase 1 2056
PKC 1996
BRAF 1952
inducible nitric oxide synthase 1929
MAP 1906
epidermal growth factor 1899
LPS 1798
IL-8 1763
JNK1 1699
p21 1653
TLR4 1565
protein kinase B 1539
threonine 1533
STAT3 1527
ATP 1495
ROS 1484
cyclooxygenase-2 1423
endoplasmic reticulum 1390
EGFR 1365
vascular endothelial growth factor 1347
cyclin D1 1340
STAT 1334
Raf-1 1318
matrix metalloproteinase 1297
chemokine 1287
TNF-alpha 1286
EGF 1211
interleukin-6 1173
p38 MAP kinase 1147
cytochrome c 1138
phosphoinositide 3-kinase 1121
Rho 1088
COX-2 1080
receptor tyrosine kinase 1034
c-fos 1033
CREB 1027
IL-10 1018
P38 1017
PARP 997
angiotensin II 996
p38MAPK 994
PKA 977
MMP-9 972
fibronectin 966
estrogen receptor 938
IFN 912
catenin 904
caspase-9 897
VEGF 865
EGF receptor 846
Ang II 842
proteasome 830
nerve growth factor 819
superoxide dismutase 812
caspase-8 804
focal adhesion kinase 801
platelet-derived growth factor 800
nitric oxide synthase 792
brain-derived neurotrophic factor 792
PI3 788
AMP 785
IRS-1 780
catalase 766
ubiquitin 766
GSH 760
calmodulin 754
RAF 748
TLR2 742
interferon 738
THP 734
GTP 718
E-cadherin 717
IL-1 711
ras 704
MEKK 701
KRAS 686
heme oxygenase-1 686
MMP-2 682
MKK4 680
insulin receptor 679
CD4 667
RhoA 620
p27 618
osteogenic 614
Nrf2 608
tumor necrosis factor alpha 607
histone 607
GTPase 600
Fas 585
cyclin 584
c-Src 580
JNK2 576
G protein-coupled receptor 572
GSK 571
AMPK 569
erythroid 559
PKB 549
IL-4 549
alkaline phosphatase 548
FAK 543
PTEN 538
TGF-beta 532
MCP-1 532
insulin-like growth factor 529
PDGF 526
cyclooxygenase 525
proliferating cell nuclear antigen 523
RANKL 523
AMP-activated protein kinase 521
annexin V 519
adaptor protein 519
IL-2 519
leptin 515
thrombin 501
serine/threonine kinase 499
JAK2 493
MyD88 487
FGF 487
IKK 482
hepatocyte growth factor 480
Smad2 479
HER2 468
PLC 464
calcineurin 463
more...
Disease
cancer 14230
tumor 10060
breast cancer 3003
tumorigenesis 2221
tumor growth 2193
melanoma 1960
diabetes 1719
ischemia 1638
hepatocellular carcinoma 1601
carcinoma 1595
Alzheimer's disease 1485
carcinogenesis 1484
tumor progression 1355
atherosclerosis 1330
obesity 1243
leukemia 1224
lung cancer 1217
MCF 1177
prostate cancer 1029
pertussis 994
colorectal cancer 989
adenocarcinoma 976
hypertension 921
neuroblastoma 870
glioma 830
colon cancer 813
GSH 760
Parkinson's disease 725
asthma 675
metastases 668
type 2 diabetes 647
squamous cell carcinoma 636
rheumatoid arthritis 632
gastric cancer 628
ovarian cancer 625
stroke 618
non-small cell lung cancer 596
depression 577
glioblastoma 554
Blocking 545
pancreatic cancer 544
heart failure 525
sepsis 521
sepsis 506
acute myeloid leukemia 492
osteoporosis 469
ATM 454
hyperglycemia 452
HIV 446
multiple myeloma 439
arthritis 430
lymphoma 428
cerebral ischemia 419
cardiovascular disease 404
osteoarthritis 376
myocardial infarction 373
infectious diseases 370
B-cell lymphoma 366
virus infection 364
osteosarcoma 348
retinoblastoma 339
liver cancer 335
colitis 325
lung carcinoma 312
cold 311
pheochromocytoma 308
cognitive impairment 296
Mycobacterium 293
chronic myeloid leukemia 293
diabetic nephropathy 292
myocardial ischemia 282
Melanoma 281
plaque 276
chronic obstructive pulmonary disease 269
metastatic melanoma 264
liver cancer 262
bladder cancer 252
tumor angiogenesis 249
skin cancer 246
inflammatory bowel disease 243
immunodeficiency 241
sarcoma 240
tuberculosis 240
multiple sclerosis 239
Infection 237
thyroid cancer 235
cervical cancer 232
bacterial infection 227
liver fibrosis 227
metabolic syndrome 223
fatty liver 211
psoriasis 210
renal disease 210
dementia 209
MIP 200
renal cell carcinoma 195
epithelial ovarian cancer 191
astrocytoma 187
Epstein 186
NAME 183
glioblastoma multiforme 182
aggressiveness 181
periodontitis 180
SDS 180
Leukemia 177
Hepatocellular carcinoma 177
AGS 176
autoimmune disease 171
epilepsy 167
cardiomyopathy 166
brain tumor 162
fibrosarcoma 162
acute promyelocytic leukemia 161
schizophrenia 160
HGF 160
NOD 159
pulmonary fibrosis 157
vascular disease 156
systemic lupus erythematosus 153
primary tumor 152
SCID 151
hyperinsulinemia 148
hepatitis B 147
proteinuria 147
influenza 147
endometrial cancer 146
cirrhosis 146
atopic dermatitis 143
uterus 142
chronic pain 139
addiction 136
diabetic retinopathy 133
dermatitis 132
APC 132
papillary thyroid cancer 131
mammary tumor 129
myeloid leukemia 128
DDP 127
liver disease 126
Adhesion 124
chronic lymphocytic leukemia 124
neoplastic transformation 123
memory impairment 123
neurofibromatosis type 1 123
amyotrophic lateral sclerosis 121
acute lymphoblastic leukemia 121
pulmonary hypertension 121
encephalomyelitis 121
heart disease 121
hepatitis C 120
tumor initiation 119
Crohn's disease 117
type 1 diabetes 115
AIDS 113
pneumonia 112
EMT 111
oral cancer 111
ABL 111
hepatitis 110
dysplasia 109
more...
Symptom
pain 923
starvation 395
seizures 202
functional recovery 145
diarrhea 132
collapse 115
anesthesia 79
respiratory distress 78
analgesia 75
hyperoxia 73
fatigue 62
hypothermia 62
skin damage 62
headache 45
Neuropathic pain 42
cachexia 42
exhaustion 41
acute stress 39
memory loss 35
splenomegaly 34
weakness 34
erythema 31
ataxia 31
cough 29
overweight 28
arthralgia 25
thinning 24
nausea 23
bone pain 23
vomiting 21
low back pain 21
angina 18
anorexia 18
Scratch 16
dyspnea 15
pelvic pain 14
despair 14
dry eye 14
hypotonia 14
tremor 13
HSA 13
abdominal pain 12
hypercapnia 12
back pain 11
constipation 11
Inflammatory pain 11
myalgia 10
hepatomegaly 10
acidity 9
orofacial pain 9
acute pain 9
hepatosplenomegaly 9
cancer pain 9
insomnia 7
spasm 7
dry skin 7
flushing 6
sore throat 6
neurological disability 6
incoordination 6
fasciculation 6
skin irritation 6
menopausal symptoms 6
bradykinesia 6
stigma 5
distraction 5
discomfort 5
numbness 5
chest pain 5
agitation 5
lethargy 5
decreased appetite 5
dizziness 5
bladder pain 5
twitching 5
discomfort 5
muscle cramps 5
neuralgia 4
wheezing 4
cerebellar ataxia 4
Depressive symptoms 4
microbial colonization 4
dystonia 4
Anoxia 4
scaly skin 3
facial pain 3
Wind 3
impaired motor coordination 3
polyuria 3
vertigo 3
myoclonus 3
sciatica 3
polydipsia 3
masculinization 3
nasal congestion 3
muscle stiffness 3
Ear swelling 3
spasticity 3
dental pain 3
nausea and vomiting 3
tinnitus 3
rundown 2
paresthesia 2
asthenia 2
Halo 2
Mills 2
Noise-induced hearing loss 2
Macula 2
hemiplegia 2
hoarseness 2
chills 2
ENT 2
ataxic gait 2
paraparesis 2
swollen joints 2
chorea 2
Decreased activity 2
Organ failure 2
ACHE 2
rhinorrhea 2
sleepiness 2
dysarthria 2
hunger 2
regurgitation 2
paresis 2
Ill 2
loss of balance 2
bitter taste 2
female puberty 2
bedwetting 1
impaired body balance 1
abnormal gait 1
bradypnea 1
disturbed balance 1
tonic-clonic seizure 1
Hudson 1
stomach cramps 1
halitosis 1
periorbital edema 1
SYMPTOMS 1
GI irritation 1
heartburn 1
Motor dysfunction 1
Behavioral symptoms 1
hemoptysis 1
night sweats 1
male subfertility 1
Incisional pain 1
prostration 1
livedo 1
Bladder distention 1
delayed language development 1
Thalamic pain 1
POA 1
catatonia 1
muscle rigidity 1
abdominal cramps 1
Central post-stroke pain 1
catarrh 1
neck pain 1
more...
Drug
MAP 1988
ROS 1484
Dermatol 541
IL-2 519
IFN-gamma 421
lysine 369
CSF 368
Angiotensin II 344
ICI 251
Cardiovasc 212
p75 164
ETS 161
Sorafenib 131
Monit 128
vitamin E 124
ascorbate 121
caffeine 119
Gefitinib 114
Ethanol 112
Arsenic trioxide 99
EE2 94
Heme 92
Forskolin 89
Gel 88
uPA 86
Taxol 83
IFN-beta 73
Imatinib 71
Herceptin 69
TAK 69
Retinoic acid 64
ETA 63
Activin 63
TAT 61
Simvastatin 61
NVP 61
NADH 60
Estrogens 59
G-CSF 58
Glutathione 58
Indomethacin 56
IL-11 53
Nitric Oxide 53
Asthma 53
GEO 53
CCL 53
Glucagon 51
PTH 51
Histamine 50
Cetuximab 50
Gelatin 50
Nephron 50
ADR 49
Ouabain 49
CTX 49
Rosiglitazone 44
Growth hormone 44
PTC 44
Growth hormone 44
Asn 43
Gleevec 43
Glycyrrhiza 41
Epigallocatechin 41
Bortezomib 41
Erlotinib 40
ABC 40
Lovastatin 38
MRC 37
CAM 36
Emodin 34
Leaf 34
Emodin 34
Propofol 32
Parkin 32
PCP 32
Parkin 32
Portal 31
Dasatinib 30
IL-1ra 29
Ginseng 28
Albumin 28
CTX 28
CTX 27
Mutagen 27
Bifidobacterium 27
CoCl2 26
CoCl2 26
Adriamycin 24
Docetaxel 24
Fulvestrant 24
lactose 24
K-252a 23
Vitamin E 23
EPA 23
ZnO 22
GHRP 22
PFT 22
Myricetin 22
TiO2 21
Rutin 21
nitroglycerin 20
Alanine 19
DNase I 19
DEX 19
Oxaliplatin 19
Pravastatin 18
RAL 18
TEL 17
Troglitazone 17
Silica 17
-deoxyadenosine 17
Glycerol 16
ALA 16
Etoposide 16
KGF 16
Bevacizumab 16
Fluorescein 16
Tarceva 16
Rituximab 16
ADM 16
Photofrin 15
Liraglutide 15
GRF 15
citric acid 15
TTC 14
Doxycycline 14
DHT 14
Kenyan 14
RFP 14
CED 14
G418 14
DHT 14
Triclosan 13
3-Methyladenine 13
Olmesartan 13
PDL 13
ROC 13
Capsicum 13
Paraffin 13
Ciglitazone 13
2-Methoxyestradiol 13
Everolimus 12
Zoledronic acid 12
BH4 12
niacin 12
Ginger 12
Rosuvastatin 12
NBT 12
FAD 12
Vandetanib 11
Amiloride 11
Fructose 11
Raloxifene 11
DMAP 11
HCH 11
ENT 11
Cilostazol 11
Alliance 10
Sodium nitroprusside 10
Luteinizing 10
more...
Enzyme
mitogen-activated protein kinase 95810
ERK 16661
MEK 10639
protein kinase 8941
protein kinase C 5579
caspase-3 3450
focal adhesion kinase 3173
phosphatidylinositol 3-kinase 2598
MAP 1909
luciferase 1613
MEKK1 1152
phosphoinositide 3-kinase 1121
superoxide dismutase 1114
PARP 1114
calcineurin 1083
NADPH oxidase 1072
AMP-activated protein kinase 1050
phospholipase C 1048
NADPH oxidase 948
catalase 894
proteasome 848
AMPK 817
IKK 725
caspase-9 721
GSK 642
caspase-8 613
cdc2 607
NO synthase 597
collagenase 571
AMPK 570
alkaline phosphatase 549
ATPase 502
thrombin 494
glutathione S-transferase 474
peroxidase 464
phospholipase A2 455
lactate dehydrogenase 412
CaMKII 385
urokinase-type plasminogen activator 342
alanine aminotransferase 339
adenylate cyclase 315
glutathione peroxidase 314
renin 289
protein phosphatase 2A 281
MMP 270
aspartate aminotransferase 268
tyrosine hydroxylase 250
caspase-1 232
reverse transcriptase 224
MMP-3 224
phosphodiesterase 223
heme oxygenase 205
MIP 200
RNA polymerase 191
tyrosinase 190
NOS 190
APC 188
PKG 181
phospholipase D 176
ACS 175
PDK1 175
guanylate cyclase 165
trypsin 163
cathepsin K 157
P-glycoprotein 154
NQO1 129
myosin light chain kinase 127
acetylcholinesterase 117
matrix metalloproteinase 9 110
GRK5 106
complex I 103
AST 103
farnesyltransferase 99
DCF 99
sphingosine kinase 98
lipoxygenase 98
creatine kinase 98
xanthine oxidase 97
MPP 97
glutathione reductase 92
farnesyltransferase 90
tissue plasminogen activator 88
histidine kinase 86
kinesin 84
TOR 83
GRK2 83
topoisomerase 82
acetyl-CoA carboxylase 80
matrix metalloproteinase 2 75
caspase-7 75
caspase-7 75
topoisomerase 74
ACE 74
PTPase 74
ornithine decarboxylase 70
RNase 70
hexosaminidase 69
lipase 68
RNase 66
beta-galactosidase 65
hormone-sensitive lipase 64
elastase 64
cathepsin B 62
TAT 61
inositol 3-kinase 60
CPT 59
CEP 59
histone acetyltransferase 58
CEP 58
gamma-glutamylcysteine synthetase 58
plasmin 57
TdT 56
arginase 55
CD10 55
neutrophil elastase 54
acid phosphatase 54
peroxiredoxin 53
aldose reductase 52
CPT 51
phosphoenolpyruvate carboxykinase 51
TACE 50
CPT 50
thioredoxin reductase 49
succinate dehydrogenase 49
choline acetyltransferase 47
DNA methyltransferase 47
transcriptase 46
interstitial collagenase 46
polo-like kinase 1 46
lysozyme 45
lipoprotein lipase 44
neutral sphingomyelinase 44
furin 42
neuraminidase 42
glyceraldehyde-3-phosphate dehydrogenase 42
tryptase 41
aldehyde dehydrogenase 40
chloramphenicol acetyltransferase 39
triphosphatase 39
cathepsin D 39
HSD 39
phosphoenolpyruvate carboxykinase 38
thromboplastin 38
phosphoenolpyruvate carboxykinase 38
prostate-specific antigen 37
kallikrein 37
caspase-2 37
caspase-4 36
caspase-2 36
transglutaminase 35
aldehyde dehydrogenase 34
granzyme B 34
PDE 34
caspase-4 33
aldehyde dehydrogenase 33
monoamine oxidase 33
aldehyde dehydrogenase 33
aldehyde dehydrogenase 33
PCP 32
15-lipoxygenase 32
more...
Compound
DNA 7460
Dec 6800
oxygen 6780
MEK 6032
tyrosine 5762
calcium 4543
TNF 4243
glucose 3076
serine 2693
cAMP 2673
nitric oxide 2498
threonine 2301
MAP 1912
acetate 1741
Clin 1531
ATP 1499
sodium 1325
MTT 1324
water 1271
cysteine 1242
phosphate 1198
hydrogen 1106
MDA 1053
glutamate 970
NH2 911
N-acetylcysteine 838
AMP 822
Insulin 818
GSH 795
GSH 795
THP 736
THP 735
GTP 720
H2O2 718
alanine 683
arginine 654
PGE 645
Ang II 639
ethanol 633
methionine 591
leucine 576
lysine 550
sulfate 528
PMA 465
retinoic acid 451
PMA 451
Phe 435
nitrogen 430
Angiotensin II 419
salt 416
cGMP 413
glycerol 399
bromide 397
zinc 396
ATF 388
galactose 375
Cardiol 372
ADP 363
proline 355
iodine 352
PGE2 350
NMDA 350
iron 350
potassium 347
COS 340
Asp 332
dUTP 331
ADP 320
ADP 317
Curcumin 294
5-HT 274
urea 263
cadmium 261
ICI 252
Panam 244
Wortmannin 237
NAD 231
Resveratrol 230
Tyrosine 219
ADP-ribose 210
aldosterone 202
DDP 202
Estrogen 196
Gly 194
His 193
pyrimidine 193
nicotinamide 192
Estrogen 192
boron 191
ASA 188
pyrimidine 188
creatinine 187
salicylic acid 185
SDS 183
vitamin D 182
BCR 179
TPA 179
TPA 179
palmitic acid 177
NADPH 176
pyrrolidine 175
NADPH 175
ACS 175
ACS 175
GDP 175
Melatonin 166
NAD 166
Neuronal 166
Phosphatidylinositol 164
Rapamycin 163
APAP 158
glutamine 155
Quercetin 153
diacetate 153
pyrrolidine 152
AMPA 149
Thrombin 147
copper 147
H2S 145
CO2 142
Genistein 141
CAT 140
Cbl 139
CAT 139
CAT 139
Estradiol 136
ADR 135
GABA 135
Serine 134
GABA 131
Collagen 131
1H-imidazole 129
PEG 129
ALP 129
aldehyde 128
MPTP 128
DMSO 127
manganese 127
selenium 125
ethyl acetate 123
ABL 120
caffeine 120
HOG 116
prostacyclin 116
UTP 114
tryptophan 112
Adriamycin 110
Glutamate 110
aldehyde 109
Adenosine 108
glutamic acid 107
PLA 107
Cer 104
noradrenaline 104
acetic acid 104
aspartic acid 103
pyridine 102
1H-imidazole 102
FK506 100
palmitic acid 99
more...