Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.24 (
mitogen-activated protein kinase
)
95,810
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We showed previously that a novel protein,
transmembrane protein 126A
(
TMEM126A
), binds to CD137 ligand (CD137L, 4-1BBL) and couples with its reverse signals in macrophages. Here, we present data showing that
TMEM126A
relays TLR4 signaling. Thus, up-regulation of CD54 (ICAM-1), MHC II, CD86 and CD40 expression in response to TLR4 activation was diminished in
TMEM126A
-deficient macrophages. Moreover in
TMEM126A
-deficient RAW264.7 cells, LPS/TLR4-induced late-phase
JNK
/
SAPK
and IRF-3 phosphorylation was abolished. These findings indicate that
TMEM126A
contributes to the TLR4 signal up-regulating the expression of genes whose products are involved in antigen presentation.
...
PMID:TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages. 2554 46
