Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.24 (mitogen-activated protein kinase)
 95,810 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nanotoxicity of two natural minerals, talc and silica were evaluated in vitro studying their effects on cell viability, LDH leakage, LPO induction, ROS production, GSH depletion, modulation of GR and GPx activities. Both mineral particles mediated their toxicity through oxidative stress. Differently, silica nanoparticles showed insignificant effect on GSH depletion. Talc nanoparticles significantly enhanced transcription and translation of TNF-alpha which was mediated by both ERK1/2 and P38. This aspect of study on silica nanoparticles is in progress.
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PMID:Nanotoxicity of natural minerals: an emerging area of nanotoxicology. 2148 89

Particle size reduction of talc from micro- to nanoscale gradually enhanced its cytotoxicity however its inflammatory potential is still not explored. In the current study we observed increased TNF-alpha, IL-1beta and IL-6 mRNA levels in macrophages exposed to Nano-Talc (NT). Further, NT particles also showed constituent phosphorylation of both p38 and ERK1/2 pathway however JNK phosphorylation was transient. Pre-treatment of macrophages with p38 and ERK1/2 inhibitors either alone or in combination showed significant reduction in TNF-alpha mRNA stability, clearly suggesting their role in TNF-alpha mRNA stabilization and expression. Our observations clearly demonstrated the inflammatory potential of NT particles which might be at least partial and potential mechanism in talc mediated pathogenecity in the exposed population.
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PMID:Nano-talc stabilizes TNF-alpha m-RNA in human macrophages. 2148 29