Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.22 (cdc2)
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Human Gene/Protein
chaperonin 10-related protein 11.9
ORC3L 11.9
FAM103A1 11.9
ik3-2 11.9
STK25 11.9
SNXA 11.9
tumor necrosis factor type 1 receptor associated protein 11.9
protein kinase C inhibitor protein-1 11.9
CP110 protein 11.9
ORC1L 11.9
RINGO C 11.9
LOC441204 11.9
cdk2 11.9
cyclin-dependent kinase 6 11.9
STK25 protein 11.3
cdc2-related protein kinase 11.2
PCTAIRE 11.0
CAK1 10.9
WW-domain binding protein 2 10.9
PCTK3 10.9
minichromosome maintenance protein 4 10.9
SALL2 protein 10.9
MIF4G domain containing 10.9
STK24 10.9
cerebral cavernous malformation 2 10.9
wee1 tyrosine kinase 10.9
CGI-121 10.9
CYCB3 10.9
Male germ cell-associated kinase 10.9
NUMB isoform 1 10.9
PNQALRE 10.9
UBE2V 10.9
ZFP276 10.9
CCRK 10.9
serum amyloid A-like 1 10.9
Serologically defined colon cancer antigen 1 10.9
PISSLRE 10.8
Cyclin-dependent kinase 11 10.7
CDK3 10.6
Nin1p 10.6
cyclin T2a 10.6
p34 10.6
cdc25C protein 10.5
PCTK1 10.4
serine/threonine kinase 24 10.3
PITSLRE beta 1 10.3
cell division protein kinase 6 10.3
E2F transcription factor 6 10.3
CKS2 protein 10.3
serine/threonine protein kinase MST4 10.3
CNAP1 10.3
Cyclin-dependent kinase-like 2 10.3
SAAL1 10.3
minichromosome maintenance complex component 5 10.3
cycB2 10.3
PFTAIRE protein kinase 1 10.3
CDK-activating kinase 10.3
cyclin T2 10.1
NPAT 10.1
CAK 10.0
CHED 10.0
cyclin E 10.0
Cdc25B phosphatase 10.0
cyclin A 10.0
cdc25B 10.0
DDX49 9.9
RFC40 9.9
PAQR4 9.9
WD repeat and SOCS box-containing protein 1 9.9
NKIAMRE 9.9
synaptonemal complex protein 2 9.9
CRYBG3 9.9
CTTNBP2NL 9.9
THG-1 9.9
cdk inhibitor p27KIP1 9.9
NPDC-1 protein 9.9
FBL2 9.9
FAM133B 9.9
Cyclin-dependent kinases regulatory subunit 2 9.9
CDK5 protein 9.9
more...
Disease
CFM1 11.9
Congenital knee dislocation 10.3
CHED 9.3
MDD2 8.4
Acute glaucoma 8.2
retinoblastoma 7.9
Hereditary canine spinal muscular atrophy 7.9
esophageal irritation 7.6
Mesangioproliferative glomerulonephritis 7.6
CCM3 7.3
PCAP 7.3
EDS5 7.1
XPB 7.0
Dedifferentiated liposarcoma 6.8
mouse leukemia L1210 6.7
CHR 6.7
NINA 6.7
salivary gland adenoid cystic carcinoma 6.7
CLN1 6.6
CLN2 6.5
megalocytosis 6.5
Feline panleukopenia 6.4
XPD 6.3
benign ovarian cyst 6.2
Liver regeneration 6.2
STY 6.2
HFH 6.1
testicular choriocarcinoma 6.1
brittle hair 6.1
OCM 6.0
CCM2 6.0
adrenocortical cancer 6.0
culture shock 5.8
Renal interstitial fibrosis 5.8
CASS 5.8
Oral Cancer 5.8
EIC 5.6
Brachydactyly 5.6
HEP 5.6
large cell lung cancer 5.6
NLS 5.6
CRD1 5.5
western equine encephalomyelitis 5.5
endotheliosis 5.4
EL1 5.4
trichothiodystrophy 5.4
monocytic leukemia 5.3
AIDS-related malignancies 5.3
pseudopseudohypoparathyroidism 5.2
CLN3 5.0
XPG 5.0
adrenal cancer 4.9
Alveolar rhabdomyosarcoma 4.9
low-grade lymphomas 4.8
ATM 4.8
LIN 4.8
POH 4.8
MCPH1 4.8
vulval cancer 4.8
relapsed CLL 4.8
FANCJ 4.8
Shope fibroma 4.7
MDM 4.6
APC 4.6
Gingival overgrowth 4.6
AGS 4.6
PSN 4.6
CCA1 4.6
MCF 4.5
VES 4.5
ARF 4.4
AML/MDS 4.4
Mouse hepatitis 4.4
Papillomas 4.3
tumorigenesis 4.3
Medulloblastoma 4.3
hereditary fructose intolerance 4.3
GS2 4.3
anaplastic thyroid cancer 4.3
kidney hypertrophy 4.2
more...
Symptom
No toxic effect 5.6
ataxic gait 3.8
starvation 3.6
HSA 2.4
joint stiffness 1.9
decreased appetite 1.7
fasciculation 1.6
hyperoxia 1.6
collapse 1.2
memory loss 1.1
hepatomegaly 0.4
functional recovery 0.2
exhaustion 0.2
cerebellar ataxia 0.1
ataxia -0.1
pelvic pain -0.1
acute stress -0.3
wheezing -0.3
seizures -0.7
diarrhea -0.7
distraction -1.3
thinning -1.6
nausea -1.6
fatigue -1.8
hypothermia -2.2
tremor -2.3
weakness -2.3
respiratory distress -2.4
discomfort -2.6
discomfort -2.7
pain -2.8
overweight -2.8
headache -2.9
analgesia -2.9
abdominal pain -3.0
vomiting -3.1
anesthesia -3.8
Drug
Olomoucine 10.4
Purvalanol 10.0
7-Hydroxystaurosporine 9.7
Flavopiridol 9.1
Ilmofosine 8.2
Alvocidib 8.1
Mevastatin 8.1
Adozelesin 7.1
Maduramicin 7.1
2-Methoxyestradiol 6.8
Trenbolone acetate 6.5
Rapamune 6.4
Mizoribine 6.3
Sevelamer hydrochloride 6.3
Zebularine 5.8
Marimastat 5.7
Velban 5.7
Vesnarinone 5.6
Compound 19 5.4
Fulvestrant 5.4
Vorinostat 5.4
Bosutinib 5.3
Casodex 5.3
Nexavar 5.2
Sevelamer 5.1
CA-074 5.1
Romidepsin 5.1
K-252a 5.1
Safflower 5.0
DMAP 4.9
Pertuzumab 4.9
MDM 4.8
Epigallocatechin 4.7
Arsenic trioxide 4.6
Lovastatin 4.5
Swainsonine 4.5
Estrogens 4.5
Bromelain 4.5
Troglitazone 4.4
Gatifloxacin 4.4
Bortezomib 4.4
Retinoic Acid 4.3
Lipidex 4.3
Cetrorelix 4.3
Lupron 4.2
Pravastatin 4.2
Cinacalcet 4.2
Glide 4.2
NOV 4.2
Herceptin 4.1
Spiegel 4.0
Emodin 4.0
Ginger 4.0
Miltefosine 4.0
Gefitinib 4.0
PFT 4.0
Compound 9 3.9
RAL 3.9
Taxol 3.8
Nebivolol 3.8
ICI 3.8
BLM 3.8
Areca 3.8
Activin 3.8
Emodin 3.7
CLS 3.7
MAP 3.7
Myricetin 3.6
Monensin 3.6
NVP 3.6
TAK 3.5
Isotretinoin 3.5
DEL 3.5
Artesunate 3.5
TAT 3.5
AraC 3.4
SPP 3.3
Tannic acid 3.3
SMP 3.3
Orlistat 3.3
more...
Enzyme
cdc2 11.9
CTD kinase 8.9
SMP-I 8.7
STK4 8.1
chondroitin 4-sulfotransferase 7.4
CLK1 7.4
STK3 7.1
polo-like kinase 1 6.7
AO1 6.7
STK2 6.4
nucleoside diphosphokinase 6.1
protein kinase 6.1
CTS2 6.1
poly(A)-specific ribonuclease 6.0
separase 5.8
GSK 5.8
phosphatidate phosphatase 5.8
STK 5.7
caspase-7 5.7
PARP 5.7
caspase-7 5.6
poly(A)-specific ribonuclease 5.6
type 1 protein phosphatase 5.5
splicing endonuclease 5.5
caspase-9 5.5
CYP8B1 5.4
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.3
protein phosphatase 2A 5.2
20beta-hydroxysteroid dehydrogenase 5.2
galactose-1-phosphate uridylyltransferase 5.2
poly(A) polymerase 5.1
mu-calpain 5.1
eEF2 kinase 5.0
CTP synthase 5.0
MEK 5.0
caspase-8 5.0
factor C 4.9
stromelysin-3 4.9
caspase-3 4.9
succinyl-CoA synthetase 4.8
ribonucleotide reductase 4.7
ribonucleotide reductase 4.7
calcineurin 4.7
proteasome 4.6
calpain 3 4.6
peptidyl-prolyl cis-trans isomerase 4.6
MAP 4.6
mitogen-activated protein kinase 4.6
ubiquitin-protein ligase 4.6
dCMP deaminase 4.5
caspase-10 4.4
caspase-10 4.4
PDK1 4.4
sphingosine kinase 4.4
GD3 synthase 4.4
isopeptidase 4.3
histone demethylase 4.3
aspartoacylase 4.3
topoisomerase 4.3
valyl-tRNA synthetase 4.3
phosphatidylinositol 3-kinase 4.3
dUTPase 4.2
RNA polymerase 4.2
histone acetyltransferase 4.2
phosphocholine cytidylyltransferase 4.2
beta-1,4-galactosyltransferase 4.2
phosphoinositide 3-kinase 4.1
topoisomerase 4.1
pyridoxal kinase 4.1
MEKK1 4.0
AP lyase 4.0
sphingomyelin synthase 4.0
caspase-6 4.0
NCP 4.0
pantothenate kinase 4.0
spermidine/spermine N1-acetyltransferase 3.9
caspase-6 3.9
APC 3.9
N-acetylglucosaminyltransferase 3.9
protein kinase C 3.9
more...
Compound
Orbencarb 11.9
Withaperuvin B 10.9
AB 48 10.9
Longikaurin A 10.3
Spectinabilin 10.3
phenylmethanesulfonamide 10.3
3,5-dibromopyridine 9.7
Decylubiquinone 9.6
Valtrate 9.6
Quinalizarin 9.4
methyl dihydrogen phosphate 9.1
Undecylprodigiosin 8.9
Sinularin 8.9
Methylselenocysteine 8.8
Corydaline 8.6
Squamocin 8.4
Oxypeucedanin 8.4
Apigetrin 8.4
Tricetin 8.2
Pancratistatin 8.1
delta12,14-PGJ2 8.0
S152 8.0
AR 1 7.9
1'-Acetoxychavicol acetate 7.9
C2H4O2 7.8
Endothall 7.8
GBL 7.8
C2H5NO2 7.7
Ver A 7.7
Deoxyelephantopin 7.7
Dehydrocostus lactone 7.7
C2H4O2 7.7
Camphorquinone 7.4
Chelidonine 7.4
G 1 7.4
Sennoside A 7.4
N-methylvaline 7.3
Destruxin A 7.3
Indirubin 7.3
Echinacoside 7.3
Tuberin 7.3
Pristimerin 7.2
Pristimerin 7.2
Decursin 7.2
Pristimerin 7.2
Pristimerin 7.2
Octyl gallate 7.1
Ciclopirox olamine 7.1
Scutellarein 7.1
Hinokitiol 7.0
Cercosporin 6.9
Pactamycin 6.9
2-Methoxyestradiol 6.8
Ophiobolin A 6.8
Costunolide 6.7
Sclareol 6.6
Pheophorbide a 6.6
Deoxypodophyllotoxin 6.6
Combretum caffrum 6.6
Tetrahydropalmatine 6.6
Pheophorbide a 6.6
Mimosine 6.6
Mangostin 6.5
Amygdalin 6.5
Metanil yellow 6.5
Pinoresinol 6.5
Amygdalin 6.5
Mimosine 6.5
Microcephalin 6.4
Evodiamine 6.4
N-phenylbenzamide 6.4
Evodiamine 6.3
SC-58125 6.3
ML-236B 6.3
Nikkomycin Z 6.3
Oridonin 6.2
Lupeol 6.2
Phorbol-12,13-dibutyrate 6.2
Flavone acetic acid 6.2
Phenethyl isothiocyanate 6.1
more...