Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.11.22 (cdc2)
8,319 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein cyclin 2129 p21 1396 cyclin E 1254 Mol 1107 cdk2 1105 p27 998 p53 969 cyclin A 961 cyclin D1 949 cyclin-dependent kinase 855 Sep 570 cyclin B1 509 CDK2 391 Cyclin 368 cyclin D 342 p16 340 pRb 332 caspase-3 330 CDK4 322 p34 304 Bcl-2 303 phosphatase 296 proliferating cell nuclear antigen 283 threonine 265 MAPK 234 WAF1 213 histone H1 204 cyclin dependent kinase 192 ATP 192 proteasome 187 histone 185 ubiquitin 180 p27Kip1 177 PARP 170 CIP1 168 cyclin D3 165 cyclin-dependent kinase 6 159 c-myc 150 ERK 147 INK4a 144 p38 143 RNA polymerase II 140 CDK1 139 p107 137 Cyclin D1 137 cyclin D2 135 MAP kinase 133 p16INK4a 132 cyclin-dependent kinase inhibitor 129 Cyclin-dependent kinase 125 Chk1 125 PI3K 121 E2F-1 121 CDK6 120 p35 117 p130 116 MEK 116 mTOR 115 E2F1 115 caspase-9 109 cyclin-dependent kinase 4 109 cyclin-dependent kinase 2 108 tyrosine kinase 107 ERK1 107 JNK 106 AKT 105 phosphorylating 101 c-Myc 100 cytochrome c 100 SCF 97 p15 91 estrogen receptor 85 Skp2 85 P34 83 protein phosphatase 82 GSK 82 p25 81 insulin 80 p21 protein 80 ATM 79 more...

Disease cancer 1713 tumor 1209 retinoblastoma 712 breast cancer 424 tumorigenesis 302 carcinoma 246 tumor growth 196 carcinogenesis 181 hepatocellular carcinoma 175 MCF 173 leukemia 172 Alzheimer's disease 151 prostate cancer 131 melanoma 107 lung cancer 106 colon cancer 102 ATM 96 squamous cell carcinoma 94 tumor progression 85 lymphoma 82 adenocarcinoma 80 glioma 66 APC 65 neuroblastoma 65 HIV 61 non-small cell lung cancer 57 diabetes 54 pancreatic cancer 52 osteosarcoma 51 acute myeloid leukemia 50 colorectal cancer 48 ovarian cancer 46 cervical cancer 43 glioblastoma 42 gastric cancer 41 lung carcinoma 41 liver cancer 40 metastases 38 multiple myeloma 35 ARF 33 SDS 32 bladder cancer 30 Epstein 30 atherosclerosis 30 sarcoma 28 herpes simplex 28 liver cancer 28 immunodeficiency 27 chronic myeloid leukemia 27 acute promyelocytic leukemia 27 B-cell lymphoma 26 AIDS 25 cytomegalovirus 25 chronic lymphocytic leukemia 25 Leukemia 25 mammary tumor 24 Kaposi's sarcoma 24 ischemia 24 chronic lymphocytic leukemia 23 SAR 23 skin cancer 23 cold 23 metastatic breast cancer 22 infectious diseases 21 Hepatocellular carcinoma 21 neoplastic transformation 21 Infection 20 epithelial ovarian cancer 20 aggressiveness 20 Blocking 19 Parkinson's disease 19 glioblastoma multiforme 18 obesity 18 XPD 18 ABL 17 myeloid leukemia 17 erythroleukemia 17 renal cell carcinoma 17 endometrial cancer 17 solid tumor 16 more...

Symptom starvation 81 collapse 17 seizures 13 pain 10 diarrhea 9 functional recovery 4 exhaustion 4 hyperoxia 4 ataxia 4 fatigue 4 HSA 4 weakness 2 nausea 2 memory loss 2 headache 2 anesthesia 2 ataxic gait 2 hepatomegaly 2 cerebellar ataxia 1 distraction 1 fasciculation 1 abdominal pain 1 discomfort 1 analgesia 1 discomfort 1 vomiting 1 respiratory distress 1 pelvic pain 1 decreased appetite 1 wheezing 1 hypothermia 1 thinning 1 No toxic effect 1 overweight 1 tremor 1 joint stiffness 1 acute stress 1

Drug lysine 61 MAP 54 ROS 44 caffeine 39 IL-2 38 Flavopiridol 30 ICI 20 Dermatol 19 Olomoucine 15 Gel 15 CSF 13 Estrogens 13 Taxol 12 Herceptin 10 DMAP 9 IFN-gamma 9 Arsenic trioxide 8 Monit 8 Lovastatin 8 Bortezomib 8 DNase I 7 TAT 7 Mutagen 7 Retinoic acid 7 Purvalanol 6 Adriamycin 6 Activin 6 Angiotensin II 6 BLM 5 p75 5 G418 5 Gefitinib 5 Asn 5 EE2 5 2-Methoxyestradiol 5 Leaf 5 MRC 4 ROC 4 ascorbate 4 Imatinib 4 Vorinostat 4 Simvastatin 4 uPA 4 Pravastatin 4 Fulvestrant 4 PTH 3 Cardiovasc 3 AraC 3 ALA 3 Glide 3 K-252a 3 DM1 3 MDM 3 Mevastatin 3 Forskolin 3 ADR 3 NVP 3 NADH 3 Troglitazone 3 PCB 3 TAK 3 CaCl2 3 Docetaxel 3 Monensin 3 Gleevec 3 Ethanol 3 CaCl2 3 G-CSF 3 Epigallocatechin 3 CaCl2 3 PFT 2 nitroglycerin 2 vitamin E 2 IFN-beta 2 Fragment 2 Mizoribine 2 TEL 2 Casodex 2 Isotretinoin 2 Nitric Oxide 2 more...

Enzyme cdc2 8319 protein kinase 1494 mitogen-activated protein kinase 607 ERK 338 caspase-3 270 protein kinase C 193 proteasome 188 PARP 179 RNA polymerase 172 MEK 149 calcineurin 115 focal adhesion kinase 106 GSK 100 caspase-9 88 glutathione S-transferase 74 luciferase 72 APC 65 caspase-8 56 phosphatidylinositol 3-kinase 56 DNA polymerase 55 topoisomerase 52 ATPase 50 MAP 47 polo-like kinase 1 43 topoisomerase 42 protein phosphatase 2A 30 phosphoinositide 3-kinase 27 AMPK 26 reverse transcriptase 25 catalase 21 ribonucleotide reductase 21 ribonucleotide reductase 20 beta-galactosidase 20 superoxide dismutase 18 dihydrofolate reductase 17 CTD kinase 17 CaMKII 15 kinesin 14 histone acetyltransferase 13 phosphodiesterase 13 caspase-7 12 RNase 12 RNase 12 PDK1 12 alkaline phosphatase 12 caspase-7 12 AMP-activated protein kinase 11 thymidylate synthase 10 thymidine kinase 10 urokinase-type plasminogen activator 8 acid phosphatase 8 CLK1 8 P-glycoprotein 8 IKK 8 transglutaminase 8 glyceraldehyde-3-phosphate dehydrogenase 8 MEKK1 8 PKG 8 caspase-1 7 chloramphenicol acetyltransferase 7 TAT 7 DNA methyltransferase 7 AMPK 7 thrombin 7 ornithine decarboxylase 7 endonuclease 7 MMP 7 myosin light chain kinase 7 transcriptase 6 cathepsin B 6 poly(A) polymerase 6 adenylate cyclase 6 mu-calpain 6 lactate dehydrogenase 6 trypsin 6 TOR 5 prostate-specific antigen 5 ubiquitin-protein ligase 5 renin 5 peroxidase 5 more...

Compound DNA 1987 Dec 629 threonine 431 serine 367 tyrosine 356 ATP 192 oxygen 163 alanine 147 calcium 127 MTT 110 MDA 104 MEK 102 phosphate 94 lysine 85 cAMP 76 proline 73 glucose 73 Clin 69 cysteine 67 retinoic acid 63 arginine 60 acetate 56 sodium 56 MAP 47 Asp 46 urea 46 water 40 caffeine 39 bromide 38 Histone 37 iodine 36 pyrimidine 36 pyrimidine 36 hydrogen 35 methionine 34 leucine 34 NH2 34 SDS 32 nitrogen 31 GTP 27 zinc 26 ethanol 26 ADP-ribose 24 salt 23 TNF 22 AMP 22 His 22 Neuronal 21 aspartic acid 20 ICI 20 nitric oxide 20 aspartic acid 19 aspartic acid 19 phosphoserine 19 aspartic acid 19 N-acetylcysteine 19 Serine 18 ADP 18 APAP 17 ADP 17 PMA 17 ADP 17 Tyrosine 17 dUTP 17 ABL 17 iron 16 COS 16 Phe 16 TPA 15 PMA 15 selenium 15 BCR 15 TPA 15 Rapamycin 15 H2O2 14 pyridine 14 Okadaic acid 14 tryptophan 14 boron 14 GBL 14 more...

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