Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.22 (cdc2)
8,319 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cyclin 2129
p21 1396
cyclin E 1254
Mol 1107
cdk2 1105
p27 998
p53 969
cyclin A 961
cyclin D1 949
cyclin-dependent kinase 855
Sep 570
cyclin B1 509
CDK2 391
Cyclin 368
cyclin D 342
p16 340
pRb 332
caspase-3 330
CDK4 322
p34 304
Bcl-2 303
phosphatase 296
proliferating cell nuclear antigen 283
threonine 265
MAPK 234
WAF1 213
histone H1 204
cyclin dependent kinase 192
ATP 192
proteasome 187
histone 185
ubiquitin 180
p27Kip1 177
PARP 170
CIP1 168
cyclin D3 165
cyclin-dependent kinase 6 159
c-myc 150
ERK 147
INK4a 144
more...
Disease
cancer 1713
tumor 1209
retinoblastoma 712
breast cancer 424
tumorigenesis 302
carcinoma 246
tumor growth 196
carcinogenesis 181
hepatocellular carcinoma 175
MCF 173
leukemia 172
Alzheimer's disease 151
prostate cancer 131
melanoma 107
lung cancer 106
colon cancer 102
ATM 96
squamous cell carcinoma 94
tumor progression 85
lymphoma 82
adenocarcinoma 80
glioma 66
neuroblastoma 65
APC 65
HIV 61
non-small cell lung cancer 57
diabetes 54
pancreatic cancer 52
osteosarcoma 51
acute myeloid leukemia 50
colorectal cancer 48
ovarian cancer 46
cervical cancer 43
glioblastoma 42
lung carcinoma 41
gastric cancer 41
liver cancer 40
metastases 38
multiple myeloma 35
ARF 33
more...
Symptom
starvation 81
collapse 17
seizures 13
pain 10
diarrhea 9
functional recovery 4
exhaustion 4
hyperoxia 4
ataxia 4
fatigue 4
HSA 4
weakness 2
nausea 2
memory loss 2
headache 2
anesthesia 2
ataxic gait 2
hepatomegaly 2
cerebellar ataxia 1
distraction 1
fasciculation 1
abdominal pain 1
discomfort 1
analgesia 1
discomfort 1
vomiting 1
respiratory distress 1
pelvic pain 1
decreased appetite 1
wheezing 1
hypothermia 1
thinning 1
No toxic effect 1
overweight 1
tremor 1
joint stiffness 1
acute stress 1
Drug
lysine 61
MAP 54
ROS 44
caffeine 39
IL-2 38
Flavopiridol 30
ICI 20
Dermatol 19
Gel 15
Olomoucine 15
Estrogens 13
CSF 13
Taxol 12
Herceptin 10
DMAP 9
IFN-gamma 9
Arsenic trioxide 8
Bortezomib 8
Lovastatin 8
Monit 8
DNase I 7
Mutagen 7
Retinoic acid 7
TAT 7
Purvalanol 6
Adriamycin 6
Angiotensin II 6
Activin 6
BLM 5
EE2 5
Asn 5
2-Methoxyestradiol 5
p75 5
Gefitinib 5
G418 5
Leaf 5
Pravastatin 4
MRC 4
ROC 4
Fulvestrant 4
more...
Enzyme
cdc2 8319
protein kinase 1494
mitogen-activated protein kinase 607
ERK 338
caspase-3 270
protein kinase C 193
proteasome 188
PARP 179
RNA polymerase 172
MEK 149
calcineurin 115
focal adhesion kinase 106
GSK 100
caspase-9 88
glutathione S-transferase 74
luciferase 72
APC 65
caspase-8 56
phosphatidylinositol 3-kinase 56
DNA polymerase 55
topoisomerase 52
ATPase 50
MAP 47
polo-like kinase 1 43
topoisomerase 42
protein phosphatase 2A 30
phosphoinositide 3-kinase 27
AMPK 26
reverse transcriptase 25
catalase 21
ribonucleotide reductase 21
ribonucleotide reductase 20
beta-galactosidase 20
superoxide dismutase 18
dihydrofolate reductase 17
CTD kinase 17
CaMKII 15
kinesin 14
phosphodiesterase 13
histone acetyltransferase 13
more...
Compound
DNA 1987
Dec 629
threonine 431
serine 367
tyrosine 356
ATP 192
oxygen 163
alanine 147
calcium 127
MTT 110
MDA 104
MEK 102
phosphate 94
lysine 85
cAMP 76
proline 73
glucose 73
Clin 69
cysteine 67
retinoic acid 63
arginine 60
sodium 56
acetate 56
MAP 47
urea 46
Asp 46
water 40
caffeine 39
bromide 38
Histone 37
iodine 36
pyrimidine 36
pyrimidine 36
hydrogen 35
NH2 34
leucine 34
methionine 34
SDS 32
nitrogen 31
GTP 27
more...