Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.11.22 (
cdc2
)
8,319
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
cyclin
2129
p21
1396
cyclin E
1254
Mol
1107
cdk2
1105
p27
998
p53
969
cyclin A
961
cyclin D1
949
cyclin-dependent kinase
855
Sep
570
cyclin B1
509
CDK2
391
Cyclin
368
cyclin D
342
p16
340
pRb
332
caspase-3
330
CDK4
322
p34
304
Bcl-2
303
phosphatase
296
proliferating cell nuclear antigen
283
threonine
265
MAPK
234
WAF1
213
histone H1
204
cyclin dependent kinase
192
ATP
192
proteasome
187
histone
185
ubiquitin
180
p27Kip1
177
PARP
170
CIP1
168
cyclin D3
165
cyclin-dependent kinase 6
159
c-myc
150
ERK
147
INK4a
144
more...
Disease
cancer
1713
tumor
1209
retinoblastoma
712
breast cancer
424
tumorigenesis
302
carcinoma
246
tumor growth
196
carcinogenesis
181
hepatocellular carcinoma
175
MCF
173
leukemia
172
Alzheimer's disease
151
prostate cancer
131
melanoma
107
lung cancer
106
colon cancer
102
ATM
96
squamous cell carcinoma
94
tumor progression
85
lymphoma
82
adenocarcinoma
80
glioma
66
neuroblastoma
65
APC
65
HIV
61
non-small cell lung cancer
57
diabetes
54
pancreatic cancer
52
osteosarcoma
51
acute myeloid leukemia
50
colorectal cancer
48
ovarian cancer
46
cervical cancer
43
glioblastoma
42
lung carcinoma
41
gastric cancer
41
liver cancer
40
metastases
38
multiple myeloma
35
ARF
33
more...
Symptom
starvation
81
collapse
17
seizures
13
pain
10
diarrhea
9
functional recovery
4
exhaustion
4
hyperoxia
4
ataxia
4
fatigue
4
HSA
4
weakness
2
nausea
2
memory loss
2
headache
2
anesthesia
2
ataxic gait
2
hepatomegaly
2
cerebellar ataxia
1
distraction
1
fasciculation
1
abdominal pain
1
discomfort
1
analgesia
1
discomfort
1
vomiting
1
respiratory distress
1
pelvic pain
1
decreased appetite
1
wheezing
1
hypothermia
1
thinning
1
No toxic effect
1
overweight
1
tremor
1
joint stiffness
1
acute stress
1
Drug
lysine
61
MAP
54
ROS
44
caffeine
39
IL-2
38
Flavopiridol
30
ICI
20
Dermatol
19
Gel
15
Olomoucine
15
Estrogens
13
CSF
13
Taxol
12
Herceptin
10
DMAP
9
IFN-gamma
9
Arsenic trioxide
8
Bortezomib
8
Lovastatin
8
Monit
8
DNase I
7
Mutagen
7
Retinoic acid
7
TAT
7
Purvalanol
6
Adriamycin
6
Angiotensin II
6
Activin
6
BLM
5
EE2
5
Asn
5
2-Methoxyestradiol
5
p75
5
Gefitinib
5
G418
5
Leaf
5
Pravastatin
4
MRC
4
ROC
4
Fulvestrant
4
more...
Enzyme
cdc2
8319
protein kinase
1494
mitogen-activated protein kinase
607
ERK
338
caspase-3
270
protein kinase C
193
proteasome
188
PARP
179
RNA polymerase
172
MEK
149
calcineurin
115
focal adhesion kinase
106
GSK
100
caspase-9
88
glutathione S-transferase
74
luciferase
72
APC
65
caspase-8
56
phosphatidylinositol 3-kinase
56
DNA polymerase
55
topoisomerase
52
ATPase
50
MAP
47
polo-like kinase 1
43
topoisomerase
42
protein phosphatase 2A
30
phosphoinositide 3-kinase
27
AMPK
26
reverse transcriptase
25
catalase
21
ribonucleotide reductase
21
ribonucleotide reductase
20
beta-galactosidase
20
superoxide dismutase
18
dihydrofolate reductase
17
CTD kinase
17
CaMKII
15
kinesin
14
phosphodiesterase
13
histone acetyltransferase
13
more...
Compound
DNA
1987
Dec
629
threonine
431
serine
367
tyrosine
356
ATP
192
oxygen
163
alanine
147
calcium
127
MTT
110
MDA
104
MEK
102
phosphate
94
lysine
85
cAMP
76
proline
73
glucose
73
Clin
69
cysteine
67
retinoic acid
63
arginine
60
sodium
56
acetate
56
MAP
47
urea
46
Asp
46
water
40
caffeine
39
bromide
38
Histone
37
iodine
36
pyrimidine
36
pyrimidine
36
hydrogen
35
NH2
34
leucine
34
methionine
34
SDS
32
nitrogen
31
GTP
27
more...