Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.22 (cdc2)
 8,319 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
STK25 11.9
ORC1L 11.9
LOC441204 11.9
ORC3L 11.9
RINGO C 11.9
SNXA 11.9
CP110 protein 11.9
ik3-2 11.9
tumor necrosis factor type 1 receptor associated protein 11.9
protein kinase C inhibitor protein-1 11.9
chaperonin 10-related protein 11.9
FAM103A1 11.9
cdk2 11.9
cyclin-dependent kinase 6 11.9
STK25 protein 11.3
cdc2-related protein kinase 11.2
PCTAIRE 11.0
CAK1 10.9
PCTK3 10.9
STK24 10.9
WW-domain binding protein 2 10.9
cerebral cavernous malformation 2 10.9
MIF4G domain containing 10.9
serum amyloid A-like 1 10.9
ZFP276 10.9
NUMB isoform 1 10.9
PNQALRE 10.9
minichromosome maintenance protein 4 10.9
SALL2 protein 10.9
UBE2V 10.9
Male germ cell-associated kinase 10.9
Serologically defined colon cancer antigen 1 10.9
CGI-121 10.9
CYCB3 10.9
wee1 tyrosine kinase 10.9
CCRK 10.9
PISSLRE 10.8
Cyclin-dependent kinase 11 10.7
CDK3 10.6
Nin1p 10.6
cyclin T2a 10.6
p34 10.6
cdc25C protein 10.5
PCTK1 10.4
E2F transcription factor 6 10.3
CNAP1 10.3
cell division protein kinase 6 10.3
PFTAIRE protein kinase 1 10.3
serine/threonine kinase 24 10.3
CKS2 protein 10.3
serine/threonine protein kinase MST4 10.3
minichromosome maintenance complex component 5 10.3
Cyclin-dependent kinase-like 2 10.3
SAAL1 10.3
cycB2 10.3
PITSLRE beta 1 10.3
CDK-activating kinase 10.3
cyclin T2 10.1
NPAT 10.1
CAK 10.0
CHED 10.0
cyclin E 10.0
Cdc25B phosphatase 10.0
cyclin A 10.0
cdc25B 10.0
WD repeat and SOCS box-containing protein 1 9.9
cdk inhibitor p27KIP1 9.9
NKIAMRE 9.9
CTTNBP2NL 9.9
synaptonemal complex protein 2 9.9
DDX49 9.9
CRYBG3 9.9
THG-1 9.9
Cyclin-dependent kinases regulatory subunit 2 9.9
NPDC-1 protein 9.9
RFC40 9.9
FBL2 9.9
CDK5 protein 9.9
PAQR4 9.9
FAM133B 9.9
MST4 9.9
SOK1 9.8
P34 9.8
smk1 9.7
D-type cyclin 9.7
cyclin dependent protein kinase 9.7
Spy1 9.6
p27Kip1 9.6
CDK11 9.6
THAP4 9.6
KKIALRE 9.6
PITSLRE 9.6
Apoptosis repressor with CARD 9.6
NPDC-1 9.6
Epithelial membrane protein 1 9.6
BS-63 9.6
cyclin 9.6
Cyclin C 9.5
cyclin D 9.5
MST3 9.5
cyclin D3 9.5
cyclin C 9.5
CLK4 9.5
cyclin B1 9.5
cyclin B2 9.4
p47 protein 9.4
CLK3 9.4
SET and MYND domain containing 3 9.3
cyclin L2 9.3
PARP-10 9.3
p150(Sal2) 9.3
NBP1 9.3
Zinc finger protein 1 9.3
COP9 signalosome subunit 6 9.3
cyclin L1 9.3
EKI 9.3
XPMC2 9.3
ZNF44 9.3
INK4d 9.3
LNX3 9.3
TAFI110 9.3
CDC2-related kinase 9.3
hMAP126 9.3
Cyclin-dependent kinase inhibitor 1B 9.3
RNA-binding motif 3 9.3
SCAPER 9.3
cell division cycle 25A 9.3
B99 9.3
SRcyp 9.3
p27(KIP1) 9.3
cyclin K 9.3
CDK5R1 9.2
cyclin-dependent kinase 9.2
SPAT 9.2
Cyclin 9.2
cyclin D2 9.2
HiNF-P 9.2
PFTK1 9.1
KIP1 9.1
Cyclin-dependent kinase 9.1
cyclin A1 9.1
Nucleoside diphosphokinase 9.1
RACK7 9.1
PHF20L1 9.1
SWM1 9.1
p27kip1 protein 9.1
CAMTA2 9.1
Cytoskeleton-associated protein 2 9.1
KKIAMRE 9.1
p107 9.1
KIP 9.1
cyclin Y 9.1
CDK7 9.0
cornifin 9.0
CTD kinase 9.0
p50Cdc37 9.0
cyclin-dependent kinase 4 9.0
CDK4 protein 9.0
trkE 9.0
CDK2 9.0
more...
Disease
CFM1 11.9
Congenital knee dislocation 10.3
CHED 9.3
MDD2 8.4
Acute glaucoma 8.2
retinoblastoma 7.9
Hereditary canine spinal muscular atrophy 7.9
esophageal irritation 7.6
Mesangioproliferative glomerulonephritis 7.6
CCM3 7.3
PCAP 7.3
EDS5 7.1
XPB 7.0
Dedifferentiated liposarcoma 6.8
CHR 6.7
mouse leukemia L1210 6.7
salivary gland adenoid cystic carcinoma 6.7
NINA 6.7
CLN1 6.6
CLN2 6.5
megalocytosis 6.5
Feline panleukopenia 6.4
XPD 6.3
benign ovarian cyst 6.2
Liver regeneration 6.2
STY 6.2
testicular choriocarcinoma 6.1
HFH 6.1
brittle hair 6.1
OCM 6.0
CCM2 6.0
adrenocortical cancer 6.0
Renal interstitial fibrosis 5.8
culture shock 5.8
CASS 5.8
Oral Cancer 5.8
EIC 5.6
Brachydactyly 5.6
HEP 5.6
large cell lung cancer 5.6
NLS 5.6
CRD1 5.5
western equine encephalomyelitis 5.5
endotheliosis 5.4
EL1 5.4
trichothiodystrophy 5.4
monocytic leukemia 5.3
AIDS-related malignancies 5.3
pseudopseudohypoparathyroidism 5.2
CLN3 5.0
XPG 5.0
adrenal cancer 4.9
Alveolar rhabdomyosarcoma 4.9
low-grade lymphomas 4.8
ATM 4.8
POH 4.8
LIN 4.8
MCPH1 4.8
vulval cancer 4.8
relapsed CLL 4.8
FANCJ 4.8
Shope fibroma 4.7
MDM 4.6
APC 4.6
Gingival overgrowth 4.6
AGS 4.6
PSN 4.6
CCA1 4.6
MCF 4.5
VES 4.5
ARF 4.4
AML/MDS 4.4
Mouse hepatitis 4.4
Papillomas 4.3
tumorigenesis 4.3
Medulloblastoma 4.3
hereditary fructose intolerance 4.3
GS2 4.3
anaplastic thyroid cancer 4.3
kidney hypertrophy 4.2
retrograde menstruation 4.2
CDT 4.2
Gull 4.2
CLL/SLL 4.1
uterine sarcoma 4.1
Autosomal dominant polycystic kidney disease 4.0
HGF 4.0
myeloid leukemia 4.0
human papilloma virus 4.0
human papilloma virus 4.0
neoplastic transformation 4.0
Retinal degeneration 4.0
malignant meningioma 4.0
erythroleukemia 4.0
Rhabdomyosarcoma 4.0
xeroderma pigmentosum 4.0
Human immunodeficiency virus type 4.0
familial Alzheimer disease 3.9
Krabbe disease 3.9
pediatric brain tumor 3.9
Enzyme inhibition 3.9
African swine fever 3.9
CPX 3.9
radiation carcinogenesis 3.9
skin tumor 3.8
refractory cancer 3.8
ABL 3.8
leukemogenesis 3.8
mammary tumor 3.8
PCT 3.8
embryonal tumor 3.8
colon cancer 3.8
CNS cancer 3.8
centronuclear myopathy 3.7
acute promyelocytic leukemia 3.7
liposarcoma 3.7
Cockayne syndrome 3.7
Cholangiocarcinoma 3.7
obstipation 3.7
Nasopharyngeal carcinoma 3.7
MTS 3.7
Costello syndrome 3.7
tumor growth 3.7
mantle cell lymphoma 3.7
EGC 3.7
Lipoma 3.7
Hepatocellular carcinoma 3.7
PML 3.7
Canavan 3.6
Carcinogenicity 3.6
AS1 3.6
blood cancer 3.6
HTS 3.6
hypertensive nephropathy 3.6
Meningioma 3.6
Meningioma 3.6
SAR 3.6
osteosarcoma 3.6
Cholangiocarcinoma 3.6
Liposarcoma 3.5
pharyngeal cancer 3.5
AIDS-related Kaposi's sarcoma 3.5
biliary tract cancer 3.5
Esophageal squamous cell carcinoma 3.5
endometrial adenocarcinoma 3.5
CM1 3.5
hepatic neoplasm 3.5
nevoid basal cell carcinoma syndrome 3.5
hepatoblastoma 3.5
refractory CLL 3.4
cancer relapse 3.4
Superinfection 3.4
metastatic breast cancer 3.4
carcinogenesis 3.4
large cell carcinomas 3.4
medulloblastoma 3.4
HMR 3.4
cervical squamous cell carcinoma 3.4
Osteosarcoma 3.4
Osteosarcoma 3.4
more...
Symptom
No toxic effect 5.6
ataxic gait 3.8
starvation 3.6
HSA 2.4
joint stiffness 1.9
decreased appetite 1.7
fasciculation 1.6
hyperoxia 1.6
collapse 1.2
memory loss 1.1
hepatomegaly 0.4
functional recovery 0.2
exhaustion 0.2
cerebellar ataxia 0.1
ataxia -0.1
pelvic pain -0.1
acute stress -0.3
wheezing -0.3
seizures -0.7
diarrhea -0.7
distraction -1.3
thinning -1.6
nausea -1.6
fatigue -1.8
hypothermia -2.2
tremor -2.3
weakness -2.3
respiratory distress -2.4
discomfort -2.6
discomfort -2.7
pain -2.8
overweight -2.8
headache -2.9
analgesia -2.9
abdominal pain -3.0
vomiting -3.1
anesthesia -3.8
Drug
Olomoucine 10.4
Purvalanol 10.0
7-Hydroxystaurosporine 9.7
Flavopiridol 9.1
Ilmofosine 8.2
Alvocidib 8.1
Mevastatin 8.1
Maduramicin 7.1
Adozelesin 7.1
2-Methoxyestradiol 6.8
Trenbolone acetate 6.5
Rapamune 6.4
Mizoribine 6.3
Sevelamer hydrochloride 6.3
Zebularine 5.8
Marimastat 5.7
Velban 5.7
Vesnarinone 5.6
Compound 19 5.4
Fulvestrant 5.4
Vorinostat 5.4
Bosutinib 5.3
Casodex 5.3
Nexavar 5.2
Sevelamer 5.1
CA-074 5.1
Romidepsin 5.1
K-252a 5.1
Safflower 5.0
DMAP 4.9
Pertuzumab 4.9
MDM 4.8
Epigallocatechin 4.7
Arsenic trioxide 4.6
Lovastatin 4.5
Swainsonine 4.5
Estrogens 4.5
Bromelain 4.5
Troglitazone 4.4
Gatifloxacin 4.4
Bortezomib 4.4
Retinoic Acid 4.3
Lipidex 4.3
Cetrorelix 4.3
Lupron 4.2
Pravastatin 4.2
Cinacalcet 4.2
Glide 4.2
NOV 4.2
Herceptin 4.1
Spiegel 4.0
Emodin 4.0
Ginger 4.0
Miltefosine 4.0
Gefitinib 4.0
PFT 4.0
Compound 9 3.9
RAL 3.9
Taxol 3.8
Nebivolol 3.8
ICI 3.8
BLM 3.8
Areca 3.8
Activin 3.8
Emodin 3.7
CLS 3.7
MAP 3.7
Myricetin 3.6
Monensin 3.6
NVP 3.6
TAK 3.5
Isotretinoin 3.5
DEL 3.5
Artesunate 3.5
TAT 3.5
AraC 3.4
SPP 3.3
Tannic acid 3.3
SMP 3.3
Orlistat 3.3
TEL 3.3
Rosiglitazone 3.2
CTT 3.2
Simvastatin 3.2
Dihydrotestosterone 3.2
Aminoguanidine 3.2
Rolipram 3.2
Finasteride 3.1
ROS 3.1
G418 3.1
Fludarabine 3.0
Valsartan 3.0
Gleevec 3.0
Retinoic acid 3.0
Zoledronic acid 2.9
MTC 2.9
Leucovorin 2.9
Glutamic acid 2.9
Dihydro 2.9
uPA 2.9
DM1 2.9
Doxycycline 2.8
caffeine 2.8
CED 2.7
Docetaxel 2.7
Dasatinib 2.7
Imatinib 2.6
R1881 2.6
Lenalidomide 2.6
PDL 2.5
NBT 2.5
Meth 2.5
ADR 2.5
Glycyrrhiza 2.4
PMEA 2.4
Erlotinib 2.4
IL-2 2.3
Adriamycin 2.3
p75 2.3
Zoledronic acid 2.3
Angiotensin II 2.2
Mutagen 2.2
MRC 2.2
Forskolin 2.1
Oxaliplatin 2.1
ALA 2.0
lysine 2.0
Gel 1.9
EPI 1.9
OTC 1.8
BCG vaccine 1.8
Etoposide 1.8
Fragment 1.7
DNase I 1.7
Nitric Oxide 1.6
ZnCl2 1.5
ZnCl2 1.5
ETS 1.5
Alanine 1.5
PCB 1.4
IFN-beta 1.3
Sorafenib 1.3
BH4 1.3
Heme 1.3
EE2 1.3
GEO 1.3
VCR 1.3
Triclosan 1.3
Ranitidine 1.3
Vitamin E 1.2
G-CSF 1.1
Parkin 1.0
TTC 1.0
Parkin 1.0
CPT-11 1.0
ROC 1.0
Itraconazole 1.0
-deoxyadenosine 0.9
CaCl2 0.9
CaCl2 0.9
more...
Enzyme
cdc2 11.9
CTD kinase 8.9
SMP-I 8.7
STK4 8.1
chondroitin 4-sulfotransferase 7.4
CLK1 7.4
STK3 7.1
polo-like kinase 1 6.7
AO1 6.7
STK2 6.4
nucleoside diphosphokinase 6.1
protein kinase 6.1
CTS2 6.1
poly(A)-specific ribonuclease 6.0
separase 5.8
GSK 5.8
phosphatidate phosphatase 5.8
STK 5.7
caspase-7 5.7
PARP 5.7
caspase-7 5.6
poly(A)-specific ribonuclease 5.6
type 1 protein phosphatase 5.5
splicing endonuclease 5.5
caspase-9 5.5
CYP8B1 5.4
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.3
protein phosphatase 2A 5.2
20beta-hydroxysteroid dehydrogenase 5.2
galactose-1-phosphate uridylyltransferase 5.2
poly(A) polymerase 5.1
mu-calpain 5.1
eEF2 kinase 5.0
CTP synthase 5.0
MEK 5.0
caspase-8 5.0
factor C 4.9
stromelysin-3 4.9
caspase-3 4.9
succinyl-CoA synthetase 4.8
ribonucleotide reductase 4.7
ribonucleotide reductase 4.7
calcineurin 4.7
proteasome 4.6
calpain 3 4.6
peptidyl-prolyl cis-trans isomerase 4.6
MAP 4.6
mitogen-activated protein kinase 4.6
ubiquitin-protein ligase 4.6
dCMP deaminase 4.5
caspase-10 4.4
caspase-10 4.4
PDK1 4.4
GD3 synthase 4.4
sphingosine kinase 4.4
isopeptidase 4.3
histone demethylase 4.3
aspartoacylase 4.3
topoisomerase 4.3
valyl-tRNA synthetase 4.3
phosphatidylinositol 3-kinase 4.3
dUTPase 4.2
RNA polymerase 4.2
histone acetyltransferase 4.2
phosphocholine cytidylyltransferase 4.2
beta-1,4-galactosyltransferase 4.2
phosphoinositide 3-kinase 4.1
topoisomerase 4.1
pyridoxal kinase 4.1
MEKK1 4.0
AP lyase 4.0
sphingomyelin synthase 4.0
caspase-6 4.0
NCP 4.0
pantothenate kinase 4.0
spermidine/spermine N1-acetyltransferase 3.9
caspase-6 3.9
APC 3.9
N-acetylglucosaminyltransferase 3.9
protein kinase C 3.9
farnesyltransferase 3.9
CaMKII 3.8
m-calpain 3.8
proline oxidase 3.8
ERK 3.8
myrosinase 3.7
TOR 3.7
p100 3.7
farnesyltransferase 3.7
glutathione S-transferase 3.6
DNA polymerase 3.6
PKG 3.6
MsrA 3.5
inositol phosphatase 3.5
TAT 3.5
dihydrofolate reductase 3.5
Omi/HtrA2 3.5
Lys4 3.5
kinesin 3.4
thymidylate synthase 3.4
3-hydroxy-3-methylglutaryl-CoA reductase 3.4
caspase-2 3.3
myosin light chain kinase 3.3
TSA 3.3
caspase-2 3.2
HCS 3.2
focal adhesion kinase 3.2
BAT 3.2
cellulose synthase 3.2
Protein 2 3.2
calpain 3 3.2
choline kinase 3.1
prolyl hydroxylase 3.1
IMP dehydrogenase 3.1
polyamine oxidase 3.1
STK11 3.0
AMPK 3.0
DMT 3.0
MAT 2.9
O-GlcNAc transferase 2.9
angiotensin-converting enzyme 2 2.9
luciferase 2.9
SPT 2.8
CNPase 2.8
p80 2.8
HK2 2.8
prenyltransferase 2.8
MAT 2.7
Thy1 2.7
MMP 2.7
transglutaminase 2.7
IKK 2.6
NAT 2.5
phosphatidylinositol 4-kinase 2.5
acrosin 2.5
monoacylglycerol lipase 2.5
SMP 2.5
methionine adenosyltransferase 2.5
argininosuccinate synthetase 2.5
cathepsin B 2.5
DNA methyltransferase 2.4
chaperonin 2.4
chloramphenicol acetyltransferase 2.4
beta-galactosidase 2.4
insulin-degrading enzyme 2.4
rhodanese 2.4
CEP 2.4
thymidine kinase 2.3
triphosphatase 2.3
glutamate synthase 2.3
matrix metalloproteinase 2 2.3
MCS 2.3
glutamate synthase 2.3
glutamate synthase 2.3
SPS 2.2
glyceraldehyde-3-phosphate dehydrogenase 2.2
dipeptidyl peptidase IV 2.2
PAT 2.2
12-lipoxygenase 2.2
PHD 2.1
more...
Compound
Orbencarb 11.9
AB 48 10.9
Withaperuvin B 10.9
Longikaurin A 10.3
phenylmethanesulfonamide 10.3
Spectinabilin 10.3
3,5-dibromopyridine 9.7
Valtrate 9.6
Decylubiquinone 9.6
Quinalizarin 9.4
methyl dihydrogen phosphate 9.1
Undecylprodigiosin 8.9
Sinularin 8.9
Methylselenocysteine 8.8
Corydaline 8.6
Apigetrin 8.4
Squamocin 8.4
Oxypeucedanin 8.4
Tricetin 8.2
Pancratistatin 8.1
S152 8.0
delta12,14-PGJ2 8.0
1'-Acetoxychavicol acetate 7.9
AR 1 7.9
C2H4O2 7.8
Endothall 7.8
GBL 7.8
C2H5NO2 7.7
Deoxyelephantopin 7.7
Ver A 7.7
C2H4O2 7.7
Dehydrocostus lactone 7.7
Chelidonine 7.4
Camphorquinone 7.4
G 1 7.4
Sennoside A 7.4
Destruxin A 7.3
N-methylvaline 7.3
Indirubin 7.3
Echinacoside 7.3
Tuberin 7.3
Decursin 7.2
Pristimerin 7.2
Pristimerin 7.2
Pristimerin 7.2
Pristimerin 7.2
Octyl gallate 7.1
Ciclopirox olamine 7.1
Scutellarein 7.1
Hinokitiol 7.0
Cercosporin 6.9
Pactamycin 6.9
2-Methoxyestradiol 6.8
Ophiobolin A 6.8
Costunolide 6.7
Sclareol 6.6
Deoxypodophyllotoxin 6.6
Pheophorbide a 6.6
Combretum caffrum 6.6
Tetrahydropalmatine 6.6
Pheophorbide a 6.6
Mimosine 6.6
Mangostin 6.5
Pinoresinol 6.5
Metanil yellow 6.5
Amygdalin 6.5
Amygdalin 6.5
Mimosine 6.5
Microcephalin 6.4
Evodiamine 6.4
N-phenylbenzamide 6.4
Evodiamine 6.3
SC-58125 6.3
ML-236B 6.3
Nikkomycin Z 6.3
Oridonin 6.2
Phorbol-12,13-dibutyrate 6.2
Lupeol 6.2
Flavone acetic acid 6.2
Phenethyl isothiocyanate 6.1
Anacardic acid 6.1
Eupatilin 6.0
Calpeptin 6.0
Monocrotaline 6.0
Velban 6.0
Okadaic acid 6.0
Diosmetin 5.9
Cholesterol sulfate 5.9
4-methyl-2-pentanone 5.9
4-methyl-2-pentanone 5.9
Guggulsterone 5.9
ICI 164384 5.9
Garcinol 5.8
indole-3-carbinol 5.7
Calyculin A 5.7
Combretum caffrum 5.7
Tangeretin 5.7
Flubendazole 5.7
Sphinganine 5.7
Zeranol 5.6
Honokiol 5.6
Aphidicolin 5.6
Aphidicolin 5.6
HEP 5.6
DMAP 5.6
DMAP 5.6
azepane 5.6
chelidonine 5.6
Azoxymethane 5.5
Withaferin A 5.4
Sterigmatocystin 5.4
Cepharanthine 5.4
Benzyl isothiocyanate 5.4
Fucoxanthin 5.3
Combretastatin A4 5.3
LY 294002 5.3
CIPC 5.3
BQ 123 5.2
threonine 5.2
Aristolochic acid 5.2
Arecoline 5.2
Magnolol 5.2
Canavanine 5.2
Aloe-emodin 5.1
suberic acid 5.1
Piperlongumine 5.1
Tryptamine 5.1
2-butenal 5.1
Asiatic acid 5.0
Glycogen synthase 5.0
Zinc protoporphyrin 5.0
G17 5.0
Daidzein 5.0
DMAP 5.0
ASK 5.0
Phosphoserine 5.0
Harmine 5.0
NOXA 4.9
Galangin 4.9
Digitoxin 4.9
MEK 4.9
ZD1694 4.9
Norharman 4.9
TRU 4.9
Histone 4.9
Phorbol 12-myristate 13-acetate 4.8
HN2 4.8
Prodigiosin 4.8
Ionophore A23187 4.8
phosphoserine 4.8
Prodigiosin 4.8
BNPP 4.8
BON 4.8
FBF 4.8
Benzothiazole 4.8
Biochanin A 4.8
Lovastatin 4.7
prostaglandin J2 4.7
PGJ2 4.7
TFF 4.7
more...