Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.11.22 (cdc2)
 8,319 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cyclin 2129
p21 1396
cyclin E 1254
Mol 1107
cdk2 1105
p27 998
p53 969
cyclin A 961
cyclin D1 949
cyclin-dependent kinase 855
Sep 570
cyclin B1 509
CDK2 391
Cyclin 368
cyclin D 342
p16 340
pRb 332
caspase-3 330
CDK4 322
p34 304
Bcl-2 303
phosphatase 296
proliferating cell nuclear antigen 283
threonine 265
MAPK 234
WAF1 213
histone H1 204
cyclin dependent kinase 192
ATP 192
proteasome 187
histone 185
ubiquitin 180
p27Kip1 177
PARP 170
CIP1 168
cyclin D3 165
cyclin-dependent kinase 6 159
c-myc 150
ERK 147
INK4a 144
p38 143
RNA polymerase II 140
CDK1 139
Cyclin D1 137
p107 137
cyclin D2 135
MAP kinase 133
p16INK4a 132
cyclin-dependent kinase inhibitor 129
Cyclin-dependent kinase 125
Chk1 125
E2F-1 121
PI3K 121
CDK6 120
p35 117
p130 116
MEK 116
mTOR 115
E2F1 115
caspase-9 109
cyclin-dependent kinase 4 109
cyclin-dependent kinase 2 108
tyrosine kinase 107
ERK1 107
JNK 106
AKT 105
phosphorylating 101
c-Myc 100
cytochrome c 100
SCF 97
p15 91
estrogen receptor 85
Skp2 85
P34 83
protein phosphatase 82
GSK 82
p25 81
p21 protein 80
insulin 80
ATM 79
mitogen-activated protein 77
ubiquitin ligase 77
PKC 75
p57 71
caspase-8 71
cytokine 70
histone deacetylase 67
ATR 66
p27(KIP1) 66
polypeptide 65
APC 64
mesothelin 64
TGF-beta 63
survivin 61
CDK7 59
calmodulin 58
ras 57
histone H3 57
tau protein 57
p18 57
phosphatidylinositol 3-kinase 56
CDC25A 55
like kinase 55
Ki-67 55
helicase 55
Chk2 54
TFIIH 54
bcl-2 53
serine/threonine kinase 53
CDC2 52
Cyclin B1 51
Mcl-1 51
CIP1/WAF1 50
epidermal growth factor 50
p19 50
tumor suppressor protein 49
annexin V 49
fused 48
tumour suppressor 47
D-type cyclin 47
MAP 47
Fas 47
ATPase 46
HER2 46
GST 46
E3 ubiquitin ligase 45
p27kip1 45
phosphoprotein 45
E2F4 45
c-Jun 44
p15INK4B 44
ROS 44
poly(ADP-ribose) polymerase 44
mutant p53 43
Kip2 43
epidermal growth factor receptor 43
c-fos 43
MDM2 42
nuclear protein 42
osteosarcoma 42
CDK5 40
EGFR 40
CDK9 40
p300 40
proto-oncogene 40
lymphoid 40
Pol 40
STAT3 40
catenin 39
NMR 39
extracellular signal-regulated kinase 39
fibronectin 39
CK2 39
Gen 38
PKA 38
calpain 38
IL-2 38
PTEN 37
Sp1 37
endoplasmic reticulum 37
more...
Disease
cancer 1713
tumor 1209
retinoblastoma 712
breast cancer 424
tumorigenesis 302
carcinoma 246
tumor growth 196
carcinogenesis 181
hepatocellular carcinoma 175
MCF 173
leukemia 172
Alzheimer's disease 151
prostate cancer 131
melanoma 107
lung cancer 106
colon cancer 102
ATM 96
squamous cell carcinoma 94
tumor progression 85
lymphoma 82
adenocarcinoma 80
glioma 66
APC 65
neuroblastoma 65
HIV 61
non-small cell lung cancer 57
diabetes 54
pancreatic cancer 52
osteosarcoma 51
acute myeloid leukemia 50
colorectal cancer 48
ovarian cancer 46
cervical cancer 43
glioblastoma 42
gastric cancer 41
lung carcinoma 41
liver cancer 40
metastases 38
multiple myeloma 35
ARF 33
SDS 32
bladder cancer 30
Epstein 30
atherosclerosis 30
liver cancer 28
herpes simplex 28
sarcoma 28
immunodeficiency 27
acute promyelocytic leukemia 27
chronic myeloid leukemia 27
B-cell lymphoma 26
cytomegalovirus 25
Leukemia 25
AIDS 25
chronic lymphocytic leukemia 25
mammary tumor 24
ischemia 24
Kaposi's sarcoma 24
chronic lymphocytic leukemia 23
cold 23
skin cancer 23
SAR 23
metastatic breast cancer 22
Hepatocellular carcinoma 21
infectious diseases 21
neoplastic transformation 21
aggressiveness 20
epithelial ovarian cancer 20
Infection 20
Blocking 19
Parkinson's disease 19
glioblastoma multiforme 18
obesity 18
XPD 18
renal cell carcinoma 17
myeloid leukemia 17
ABL 17
erythroleukemia 17
endometrial cancer 17
anemia 16
solid tumor 16
primary tumor 15
oral cancer 15
leukemogenesis 15
type 2 diabetes 15
acute lymphoblastic leukemia 14
AGS 14
stroke 14
infertility 14
PML 14
non-Hodgkin's lymphoma 14
hypertension 13
medulloblastoma 13
amyotrophic lateral sclerosis 13
virus infection 13
hepatitis B 13
CHR 12
mantle cell lymphoma 12
xeroderma pigmentosum 12
brain tumor 12
DDP 12
diabetic nephropathy 12
dysplasia 12
renal disease 12
liposarcoma 12
human papilloma virus 11
Burkitt's lymphoma 11
HGF 11
CEM 11
astrocytoma 11
XPB 11
hyperglycemia 11
human papilloma virus 11
tuberous sclerosis 11
plaque 11
Melanoma 11
dementia 10
SCID 10
uterus 10
small cell lung cancer 10
PHA 10
NLS 10
GSH 10
acute leukemia 9
worms 9
leiomyoma 9
cirrhosis 9
HEP 9
MTS 9
CLN2 9
mole 9
polycystic kidney 9
rheumatoid arthritis 9
pheochromocytoma 9
genetic disorder 9
rhabdomyosarcoma 9
adenoma 8
lymphoblastic leukemia 8
esophageal cancer 8
carcinoma in situ 8
tumor initiation 8
Hodgkin's disease 8
CLN1 8
B-cell lymphomas 8
HCC 8
lymphoproliferative disorders 8
monocytic leukemia 8
hepatitis C 8
hepatoblastoma 8
cutaneous melanoma 8
cardiovascular disease 8
Fanconi 8
malaria 8
thyroid cancer 7
CLN3 7
abdominal aortic aneurysm 7
CCM3 7
liver fibrosis 7
skin tumor 7
tumor angiogenesis 7
more...
Symptom
starvation 81
collapse 17
seizures 13
pain 10
diarrhea 9
functional recovery 4
exhaustion 4
hyperoxia 4
ataxia 4
fatigue 4
HSA 4
weakness 2
nausea 2
memory loss 2
headache 2
anesthesia 2
ataxic gait 2
hepatomegaly 2
cerebellar ataxia 1
distraction 1
fasciculation 1
abdominal pain 1
discomfort 1
analgesia 1
discomfort 1
vomiting 1
respiratory distress 1
pelvic pain 1
decreased appetite 1
wheezing 1
hypothermia 1
thinning 1
No toxic effect 1
overweight 1
tremor 1
joint stiffness 1
acute stress 1
Drug
lysine 61
MAP 54
ROS 44
caffeine 39
IL-2 38
Flavopiridol 30
ICI 20
Dermatol 19
Olomoucine 15
Gel 15
Estrogens 13
CSF 13
Taxol 12
Herceptin 10
DMAP 9
IFN-gamma 9
Monit 8
Bortezomib 8
Lovastatin 8
Arsenic trioxide 8
TAT 7
Retinoic acid 7
Mutagen 7
DNase I 7
Purvalanol 6
Adriamycin 6
Angiotensin II 6
Activin 6
Gefitinib 5
BLM 5
Asn 5
EE2 5
2-Methoxyestradiol 5
Leaf 5
p75 5
G418 5
Vorinostat 4
ascorbate 4
Imatinib 4
Simvastatin 4
uPA 4
ROC 4
Fulvestrant 4
MRC 4
Pravastatin 4
K-252a 3
Glide 3
AraC 3
Mevastatin 3
CaCl2 3
Cardiovasc 3
ADR 3
Epigallocatechin 3
Ethanol 3
MDM 3
Forskolin 3
ALA 3
Troglitazone 3
TAK 3
PTH 3
PCB 3
DM1 3
Docetaxel 3
Monensin 3
NVP 3
CaCl2 3
G-CSF 3
CaCl2 3
Gleevec 3
NADH 3
Glycyrrhiza 2
Mizoribine 2
NBT 2
Nitric Oxide 2
CAM 2
nitroglycerin 2
Vitamin E 2
Meth 2
vitamin E 2
Emodin 2
Retinoic Acid 2
ETS 2
Casodex 2
TEL 2
ABC 2
Fragment 2
Doxycycline 2
PFT 2
7-Hydroxystaurosporine 2
Ginger 2
Rosiglitazone 2
Alanine 2
Heme 2
IFN-beta 2
Emodin 2
Isotretinoin 2
EPI 2
Dial 2
Artesunate 1
Swainsonine 1
Parkin 1
Dasatinib 1
Zoledronic acid 1
PDL 1
MOF 1
Sevelamer hydrochloride 1
Romidepsin 1
Maduramicin 1
Adozelesin 1
Trenbolone acetate 1
Histamine 1
CPT-11 1
PMEA 1
Rolipram 1
Finasteride 1
THF 1
CTT 1
Rapamune 1
ZnCl2 1
Erlotinib 1
Spiegel 1
Aminoguanidine 1
-deoxyadenosine 1
SPP 1
Dihydrotestosterone 1
ampicillin 1
Marimastat 1
OTC 1
Oxaliplatin 1
Miltefosine 1
Triclosan 1
Indomethacin 1
Etoposide 1
SMP 1
Myricetin 1
Vitamin A 1
Bosutinib 1
Alvocidib 1
CTX 1
Areca 1
lactose 1
GEO 1
MDS 1
CTX 1
DEL 1
ACT 1
Sevelamer 1
CED 1
Nebivolol 1
ENT 1
R1881 1
Cetrorelix 1
Valsartan 1
TTC 1
Portal 1
Parkin 1
TiO2 1
Bromelain 1
Fludarabine 1
NOV 1
more...
Enzyme
cdc2 8319
protein kinase 1494
mitogen-activated protein kinase 607
ERK 338
caspase-3 270
protein kinase C 193
proteasome 188
PARP 179
RNA polymerase 172
MEK 149
calcineurin 115
focal adhesion kinase 106
GSK 100
caspase-9 88
glutathione S-transferase 74
luciferase 72
APC 65
phosphatidylinositol 3-kinase 56
caspase-8 56
DNA polymerase 55
topoisomerase 52
ATPase 50
MAP 47
polo-like kinase 1 43
topoisomerase 42
protein phosphatase 2A 30
phosphoinositide 3-kinase 27
AMPK 26
reverse transcriptase 25
catalase 21
ribonucleotide reductase 21
ribonucleotide reductase 20
beta-galactosidase 20
superoxide dismutase 18
CTD kinase 17
dihydrofolate reductase 17
CaMKII 15
kinesin 14
histone acetyltransferase 13
phosphodiesterase 13
PDK1 12
alkaline phosphatase 12
caspase-7 12
caspase-7 12
RNase 12
RNase 12
AMP-activated protein kinase 11
thymidylate synthase 10
thymidine kinase 10
acid phosphatase 8
transglutaminase 8
PKG 8
IKK 8
P-glycoprotein 8
MEKK1 8
glyceraldehyde-3-phosphate dehydrogenase 8
urokinase-type plasminogen activator 8
CLK1 8
TAT 7
chloramphenicol acetyltransferase 7
myosin light chain kinase 7
DNA methyltransferase 7
thrombin 7
endonuclease 7
AMPK 7
ornithine decarboxylase 7
MMP 7
caspase-1 7
adenylate cyclase 6
lactate dehydrogenase 6
trypsin 6
mu-calpain 6
cathepsin B 6
transcriptase 6
poly(A) polymerase 6
histone demethylase 5
TOR 5
phospholipase C 5
peroxidase 5
glutathione peroxidase 5
acetylcholinesterase 5
farnesyltransferase 5
separase 5
ubiquitin-protein ligase 5
factor C 5
collagenase 5
renin 5
peptidyl-prolyl cis-trans isomerase 5
prostate-specific antigen 5
NADPH oxidase 4
HSD 4
glyceraldehyde-3-phosphate dehydrogenase 4
sphingosine kinase 4
tyrosine hydroxylase 4
glyceraldehyde-3-phosphate dehydrogenase 4
ribonuclease 4
demethylase 4
farnesyltransferase 4
NOS 4
ribonuclease 4
alanine aminotransferase 4
glyceraldehyde-3-phosphate dehydrogenase 4
glyceraldehyde-3-phosphate dehydrogenase 4
ACS 4
prolyl hydroxylase 4
chaperonin 3
MAT 3
3-hydroxy-3-methylglutaryl-CoA reductase 3
micrococcal nuclease 3
creatine kinase 3
cathepsin D 3
NADPH oxidase 3
TSA 3
hyaluronidase 3
CYP3A4 3
nucleoside diphosphokinase 3
hyaluronidase 3
DNA ligase 3
MAT 3
succinyl-CoA synthetase 3
phosphatidate phosphatase 3
cellulose synthase 3
m-calpain 3
p100 3
phosphorylase 3
STK3 3
STK4 3
matrix metalloproteinase 2 3
monoamine oxidase 3
carbonic anhydrase 3
NO synthase 3
DNase 3
phospholipase A2 3
isopeptidase 3
granzyme B 3
NADPH-diaphorase 2
type 1 protein phosphatase 2
dipeptidyl peptidase IV 2
complex I 2
aspartate aminotransferase 2
BAT 2
PDE 2
enolase 2
succinate dehydrogenase 2
beta-glucuronidase 2
caspase-2 2
adenosine deaminase 2
DNA ligase 2
phosphatidylinositol-4,5-bisphosphate 3-kinase 2
N-acetylglucosaminyltransferase 2
elastase 2
adenosine deaminase 2
myrosinase 2
caspase-6 2
chitinase 2
Thy1 2
CD10 2
cholinesterase 2
eEF2 kinase 2
caspase-2 2
more...
Compound
DNA 1987
Dec 629
threonine 431
serine 367
tyrosine 356
ATP 192
oxygen 163
alanine 147
calcium 127
MTT 110
MDA 104
MEK 102
phosphate 94
lysine 85
cAMP 76
glucose 73
proline 73
Clin 69
cysteine 67
retinoic acid 63
arginine 60
acetate 56
sodium 56
MAP 47
urea 46
Asp 46
water 40
caffeine 39
bromide 38
Histone 37
pyrimidine 36
pyrimidine 36
iodine 36
hydrogen 35
methionine 34
NH2 34
leucine 34
SDS 32
nitrogen 31
GTP 27
zinc 26
ethanol 26
ADP-ribose 24
salt 23
TNF 22
AMP 22
His 22
Neuronal 21
nitric oxide 20
aspartic acid 20
ICI 20
N-acetylcysteine 19
phosphoserine 19
aspartic acid 19
aspartic acid 19
aspartic acid 19
ADP 18
Serine 18
APAP 17
ADP 17
ABL 17
ADP 17
dUTP 17
PMA 17
Tyrosine 17
iron 16
Phe 16
COS 16
PMA 15
TPA 15
TPA 15
BCR 15
selenium 15
Rapamycin 15
boron 14
Okadaic acid 14
Adriamycin 14
pyridine 14
GBL 14
H2O2 14
tryptophan 14
Genistein 13
Resveratrol 13
Estrogen 13
glutamate 13
Ile 13
Progesterone 12
galactose 12
5-FU 12
Estrogen 12
Curcumin 12
Ubiquitin 12
DDP 11
G 1 11
ADR 11
indole-3-carbinol 11
glycerol 11
valine 11
Insulin 10
MIA 10
GSH 10
CAT 10
GSH 10
THP 10
Glycogen synthase 10
THP 10
glutamine 10
pyrene 10
Ang II 10
methyl methanesulfonate 10
DMAP 9
MTS 9
potassium 9
TBP 9
VP-16 9
glutamic acid 9
Casein 9
HEP 9
TSH 9
DMAP 9
butyric acid 9
TBP 9
DMAP 9
Panam 9
CAT 8
TNM 8
TEM 8
Gly 8
isoleucine 8
ASA 8
CAT 8
DMSO 8
Paclitaxel 8
Hoechst 33342 8
sulfate 8
isoleucine 8
vitamin D 8
tryptophan 7
PAP 7
cadmium 7
Staurosporine 7
PAP 7
cGMP 7
tryptophan 7
NAD 7
PAP 7
Cardiol 7
ammonium 7
SCC 7
AAA 7
BUdR 7
PAP 7
FK506 7
Staurosporine 7
tryptophan 7
TOF 7
copper 6
naphthoquinone 6
40S 6
TAR 6
more...